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Q24625 (G6PD_DROSI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Alternative name(s):
Zwischenferment
Gene names
Name:Zw
Synonyms:G6pd
OrganismDrosophila simulans (Fruit fly)
Taxonomic identifier7240 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length153 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenase
PRO_0000068093

Regions

Region150 – 1534Substrate binding By similarity

Sites

Binding site211NADP 1 By similarity
Binding site1201NADP 1; via carbonyl oxygen By similarity
Binding site1201Substrate By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1531

Sequences

Sequence LengthMass (Da)Tools
Q24625 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2E8980CD5E8E66A0

FASTA15318,086
        10         20         30         40         50         60 
LWWLYRDDLL PKPTKFCGYA RSMLTTETLK EQCLPYMKVQ PHEQNKYEEF WALNDYVSGR 

        70         80         90        100        110        120 
YDGRTSFEVL NQRLEMMENK NKANRIFYLA LPPSVFEEVT VNIKQVCMSL CGWNRVIIEK 

       130        140        150 
PFGRDDASSQ ALSDHLAGLF NEDQLYRIDH YLG 

« Hide

References

[1]"Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
Soto-Adames F.N., Robertson H.M., Berlocher S.H.
Ann. Entomol. Soc. Am. 87:723-736(1994) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09035 mRNA. Translation: AAB02779.1.

3D structure databases

ProteinModelPortalQ24625.
SMRQ24625. Positions 1-153.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0012860. Dsim\Zw.

Phylogenomic databases

OrthoDBEOG7DRJ2T.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSPR00079. G6PDHDRGNASE.
ProtoNetSearch...

Entry information

Entry nameG6PD_DROSI
AccessionPrimary (citable) accession number: Q24625
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase