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Q24625

- G6PD_DROSI

UniProt

Q24625 - G6PD_DROSI

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

Zw

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211NADP 1By similarity
    Binding sitei120 – 1201NADP 1; via carbonyl oxygenBy similarity
    Binding sitei120 – 1201SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Alternative name(s):
    Zwischenferment
    Gene namesi
    Name:Zw
    Synonyms:G6pd
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0012860. Dsim\Zw.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenasePRO_0000068093Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ24625.
    SMRiQ24625. Positions 1-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 1534Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7DRJ2T.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001282. G6P_DH.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF00479. G6PD_N. 1 hit.
    [Graphical view]
    PRINTSiPR00079. G6PDHDRGNASE.

    Sequencei

    Sequence statusi: Fragment.

    Q24625-1 [UniParc]FASTAAdd to Basket

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    LWWLYRDDLL PKPTKFCGYA RSMLTTETLK EQCLPYMKVQ PHEQNKYEEF    50
    WALNDYVSGR YDGRTSFEVL NQRLEMMENK NKANRIFYLA LPPSVFEEVT 100
    VNIKQVCMSL CGWNRVIIEK PFGRDDASSQ ALSDHLAGLF NEDQLYRIDH 150
    YLG 153
    Length:153
    Mass (Da):18,086
    Last modified:November 1, 1996 - v1
    Checksum:i2E8980CD5E8E66A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei153 – 1531

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09035 mRNA. Translation: AAB02779.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09035 mRNA. Translation: AAB02779.1 .

    3D structure databases

    ProteinModelPortali Q24625.
    SMRi Q24625. Positions 1-153.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0012860. Dsim\Zw.

    Phylogenomic databases

    OrthoDBi EOG7DRJ2T.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001282. G6P_DH.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00079. G6PDHDRGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
      Soto-Adames F.N., Robertson H.M., Berlocher S.H.
      Ann. Entomol. Soc. Am. 87:723-736(1994)
      [AGRICOLA] [Europe PMC]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiG6PD_DROSI
    AccessioniPrimary (citable) accession number: Q24625
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3