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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

Zw

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Dsim\GD12078)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21NADP 1By similarity1
Binding sitei120NADP 1; via carbonyl oxygenBy similarity1
Binding sitei120SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Alternative name(s):
Zwischenferment
Gene namesi
Name:Zw
Synonyms:G6pd
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012860 Dsim\Zw

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000068093‹1 – ›153Glucose-6-phosphate 1-dehydrogenaseAdd BLAST›153

Proteomic databases

PRIDEiQ24625

Structurei

3D structure databases

ProteinModelPortaliQ24625
SMRiQ24625
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 153Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG091G06FN

Family and domain databases

InterProiView protein in InterPro
IPR001282 G6P_DH
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF00479 G6PD_N, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Fragment.

Q24625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LWWLYRDDLL PKPTKFCGYA RSMLTTETLK EQCLPYMKVQ PHEQNKYEEF
60 70 80 90 100
WALNDYVSGR YDGRTSFEVL NQRLEMMENK NKANRIFYLA LPPSVFEEVT
110 120 130 140 150
VNIKQVCMSL CGWNRVIIEK PFGRDDASSQ ALSDHLAGLF NEDQLYRIDH

YLG
Length:153
Mass (Da):18,086
Last modified:November 1, 1996 - v1
Checksum:i2E8980CD5E8E66A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1531

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09035 mRNA Translation: AAB02779.1

Similar proteinsi

Entry informationi

Entry nameiG6PD_DROSI
AccessioniPrimary (citable) accession number: Q24625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

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