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Q24625

- G6PD_DROSI

UniProt

Q24625 - G6PD_DROSI

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
Zw, G6pd
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211NADP 1 By similarity
Binding sitei120 – 1201NADP 1; via carbonyl oxygen By similarity
Binding sitei120 – 1201Substrate By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Alternative name(s):
Zwischenferment
Gene namesi
Name:Zw
Synonyms:G6pd
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012860. Dsim\Zw.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›153›153Glucose-6-phosphate 1-dehydrogenasePRO_0000068093Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ24625.
SMRiQ24625. Positions 1-153.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1534Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7DRJ2T.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF00479. G6PD_N. 1 hit.
[Graphical view]
PRINTSiPR00079. G6PDHDRGNASE.

Sequencei

Sequence statusi: Fragment.

Q24625-1 [UniParc]FASTAAdd to Basket

« Hide

LWWLYRDDLL PKPTKFCGYA RSMLTTETLK EQCLPYMKVQ PHEQNKYEEF    50
WALNDYVSGR YDGRTSFEVL NQRLEMMENK NKANRIFYLA LPPSVFEEVT 100
VNIKQVCMSL CGWNRVIIEK PFGRDDASSQ ALSDHLAGLF NEDQLYRIDH 150
YLG 153
Length:153
Mass (Da):18,086
Last modified:November 1, 1996 - v1
Checksum:i2E8980CD5E8E66A0
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei153 – 1531

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09035 mRNA. Translation: AAB02779.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09035 mRNA. Translation: AAB02779.1 .

3D structure databases

ProteinModelPortali Q24625.
SMRi Q24625. Positions 1-153.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0012860. Dsim\Zw.

Phylogenomic databases

OrthoDBi EOG7DRJ2T.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001282. G6P_DH.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF00479. G6PD_N. 1 hit.
[Graphical view ]
PRINTSi PR00079. G6PDHDRGNASE.
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera."
    Soto-Adames F.N., Robertson H.M., Berlocher S.H.
    Ann. Entomol. Soc. Am. 87:723-736(1994)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PD_DROSI
AccessioniPrimary (citable) accession number: Q24625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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