Reviewed, UniProtKB/Swiss-Prot Q24625 (G6PD_DROSI)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49
Alternative name(s):
    Zwischenferment

Gene names

Name:	Zw
Synonyms:	G6pd

Organism

Drosophila simulans (Fruit fly)

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	153 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›153	›153	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068093
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	153	1

Sequences

	Sequence		Length	Mass (Da)
	Q24625-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2E8980CD5E8E66A0	FASTA	153	18,086
	10 20 30 40 50 60 LWWLYRDDLL PKPTKFCGYA RSMLTTETLK EQCLPYMKVQ PHEQNKYEEF WALNDYVSGR 70 80 90 100 110 120 YDGRTSFEVL NQRLEMMENK NKANRIFYLA LPPSVFEEVT VNIKQVCMSL CGWNRVIIEK 130 140 150 PFGRDDASSQ ALSDHLAGLF NEDQLYRIDH YLG

References

[1]	"Phylogenetic utility of partial DNA sequences of G6PDH at different taxonomic levels in Hexapoda with emphasis on Diptera." Soto-Adames F.N., Robertson H.M., Berlocher S.H. Ann. Entomol. Soc. Am. 87:723-736(1994) [Agricola: IND20440286] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09035 mRNA. Translation: AAB02779.1.
3D structure databases
SMR	Q24625. Positions 1-153.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0012860. Dsim\Zw.
Enzyme and pathway databases
BRENDA	1.1.1.49. 189309.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF00479. G6PD_N. 1 hit. [Graphical view]
PRINTS	PR00079. G6PDHDRGNASE.
PROSITE	PS00069. G6P_DEHYDROGENASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_DROSI

Accession

Primary (citable) accession number: Q24625

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project