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Protein
Submitted name:

Toll protein

Gene

Tl

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotation
Biological processImmunity, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Toll proteinImported
Gene namesi
Name:TlImported
Synonyms:Dpse\TlImported
ORF Names:GA18922Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012714 Dpse\Tl

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei807 – 830HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500420200027 – 1100Sequence analysisAdd BLAST1074

Structurei

3D structure databases

ProteinModelPortaliQ24622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini859 – 998TIRInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR026906 LRR_5
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF13306 LRR_5, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 2 hits
SM00013 LRRNT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q24622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLRAGGKV LLVVLLQVLQ WQAGETAFGR DECNRLSVSS PCQCAPSMAE
60 70 80 90 100
YEIYCPANAY NVFPKFRLAI RPNSNVQIEC NLTDANEYKQ LPPLRIGEIE
110 120 130 140 150
RVQIQRCPLP GHTPIAGILE HLGIRSPKML IFESDNLGVN ITRRHLDRLQ
160 170 180 190 200
NLKRLRFTSR RFTYIPADFL ADLRNLSWLD LRANIVELPA HLFDNLENLE
210 220 230 240 250
SLELGSNGLK HLPHGVFSRM PKLRHLNLWS NQLHNLTKHD FEGASSVVDV
260 270 280 290 300
DLHANGIEQL PRDVFSLLTN LTEINLSANH FRSLPEGLFE HNKQLRQVRL
310 320 330 340 350
LNNRVPLSTL PDRLFANQPE LRVLLLRCDL ETLPSDLLEQ STEITNISLR
360 370 380 390 400
DNYLSTLPAK LLEHQTNLLS LDLSNNKLTY LPDALFEHTT KLVDLNLAEN
410 420 430 440 450
MLTDISSDIF SKLEKLETLN MNNNLVKNIA SNAFASNTAL LHISMEHNLI
460 470 480 490 500
DLQQPLLGSI LQEQLNSPFS YLASLQSLNL RNNSIMFIYR DWNFNLINLQ
510 520 530 540 550
ELDLSYNNIS SLIYEDLQFL SKANLFVNIT HNQISRINFY PQLPVMPDGE
560 570 580 590 600
VSTSVLRMDL NDNPLVCDCT LLWFVQLVRG AHVPDYAKQF KFDTDRLTCS
610 620 630 640 650
QPHNLQDLPV RLVPPKELYC SIGSAEEPGQ RQCTRGCRCW VRTFDKALVI
660 670 680 690 700
KCHEGNLTKV PELPTLYDNL HIMELHMDNN TLLGPRAAHS PAYANVTSLH
710 720 730 740 750
LAGNNVTHID VDRLPPNLKH LDVRRNHLQA LNTTVLGFLN RTMPRRSLML
760 770 780 790 800
SGNPWICNCE AKPLLLFTQS NYERIGDRGE MLCMDAEMPT RMAELSTNDI
810 820 830 840 850
CPVEKGVFIA MAVVISLAGF LAGITAALYY KYQTEIKIWL YAHNMFLWFV
860 870 880 890 900
TEEELDKDKK FDAFISYSHK DQSFIEQYLV PQLEHGPQKF QLCVHERDWL
910 920 930 940 950
VGGFIPENIV RSVADSRRTI IVLSQNFIES EWARMEFRAA HRSALNEGRA
960 970 980 990 1000
RIIVVIYSDI GDVEKLDEEL KAYLKMNTYL KWGDPWFWDK LRFGVPHRKP
1010 1020 1030 1040 1050
LGNVGNGALA KSPLKGSTDD KLELIKPSPV TPPLTTPPAE ATKNPLVAQL
1060 1070 1080 1090 1100
NGGTPHTAIT IANGKNGLTN LYTPHNGKSH ANGHINGAFI INTNAKQSSV
Length:1,100
Mass (Da):124,812
Last modified:November 1, 1996 - v1
Checksum:i69A6F8A8326F5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25390 Genomic DNA Translation: AAA28942.1

Similar proteinsi

Entry informationi

Entry nameiQ24622_DROPS
AccessioniPrimary (citable) accession number: Q24622
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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