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Protein
Submitted name:

Toll protein

Gene

Tl

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Toll proteinImported
Gene namesi
Name:TlImported
Synonyms:Dpse\TlImported
ORF Names:GA18922Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012714. Dpse\Tl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei807 – 83024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 11001074Sequence analysisPRO_5004202000Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ24622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini859 – 998140TIRInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

OrthoDBiEOG761BT1.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000372. LRRNT.
IPR000157. TIR_dom.
IPR027202. Toll.
[Graphical view]
PANTHERiPTHR24365:SF325. PTHR24365:SF325. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLRAGGKV LLVVLLQVLQ WQAGETAFGR DECNRLSVSS PCQCAPSMAE
60 70 80 90 100
YEIYCPANAY NVFPKFRLAI RPNSNVQIEC NLTDANEYKQ LPPLRIGEIE
110 120 130 140 150
RVQIQRCPLP GHTPIAGILE HLGIRSPKML IFESDNLGVN ITRRHLDRLQ
160 170 180 190 200
NLKRLRFTSR RFTYIPADFL ADLRNLSWLD LRANIVELPA HLFDNLENLE
210 220 230 240 250
SLELGSNGLK HLPHGVFSRM PKLRHLNLWS NQLHNLTKHD FEGASSVVDV
260 270 280 290 300
DLHANGIEQL PRDVFSLLTN LTEINLSANH FRSLPEGLFE HNKQLRQVRL
310 320 330 340 350
LNNRVPLSTL PDRLFANQPE LRVLLLRCDL ETLPSDLLEQ STEITNISLR
360 370 380 390 400
DNYLSTLPAK LLEHQTNLLS LDLSNNKLTY LPDALFEHTT KLVDLNLAEN
410 420 430 440 450
MLTDISSDIF SKLEKLETLN MNNNLVKNIA SNAFASNTAL LHISMEHNLI
460 470 480 490 500
DLQQPLLGSI LQEQLNSPFS YLASLQSLNL RNNSIMFIYR DWNFNLINLQ
510 520 530 540 550
ELDLSYNNIS SLIYEDLQFL SKANLFVNIT HNQISRINFY PQLPVMPDGE
560 570 580 590 600
VSTSVLRMDL NDNPLVCDCT LLWFVQLVRG AHVPDYAKQF KFDTDRLTCS
610 620 630 640 650
QPHNLQDLPV RLVPPKELYC SIGSAEEPGQ RQCTRGCRCW VRTFDKALVI
660 670 680 690 700
KCHEGNLTKV PELPTLYDNL HIMELHMDNN TLLGPRAAHS PAYANVTSLH
710 720 730 740 750
LAGNNVTHID VDRLPPNLKH LDVRRNHLQA LNTTVLGFLN RTMPRRSLML
760 770 780 790 800
SGNPWICNCE AKPLLLFTQS NYERIGDRGE MLCMDAEMPT RMAELSTNDI
810 820 830 840 850
CPVEKGVFIA MAVVISLAGF LAGITAALYY KYQTEIKIWL YAHNMFLWFV
860 870 880 890 900
TEEELDKDKK FDAFISYSHK DQSFIEQYLV PQLEHGPQKF QLCVHERDWL
910 920 930 940 950
VGGFIPENIV RSVADSRRTI IVLSQNFIES EWARMEFRAA HRSALNEGRA
960 970 980 990 1000
RIIVVIYSDI GDVEKLDEEL KAYLKMNTYL KWGDPWFWDK LRFGVPHRKP
1010 1020 1030 1040 1050
LGNVGNGALA KSPLKGSTDD KLELIKPSPV TPPLTTPPAE ATKNPLVAQL
1060 1070 1080 1090 1100
NGGTPHTAIT IANGKNGLTN LYTPHNGKSH ANGHINGAFI INTNAKQSSV
Length:1,100
Mass (Da):124,812
Last modified:November 1, 1996 - v1
Checksum:i69A6F8A8326F5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25390 Genomic DNA. Translation: AAA28942.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25390 Genomic DNA. Translation: AAA28942.1.

3D structure databases

ProteinModelPortaliQ24622.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012714. Dpse\Tl.

Phylogenomic databases

OrthoDBiEOG761BT1.

Miscellaneous databases

ChiTaRSiTl. fly.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000372. LRRNT.
IPR000157. TIR_dom.
IPR027202. Toll.
[Graphical view]
PANTHERiPTHR24365:SF325. PTHR24365:SF325. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Interspecific comparisons reveal conserved features of the Drosophila Toll protein."
    Yamagata M., Merlie J.P., Sanes J.R.
    Gene 139:223-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ24622_DROPS
AccessioniPrimary (citable) accession number: Q24622
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.