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Protein
Submitted name:

Zinc finger protein

Gene

shn

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • RNA polymerase II activating transcription factor binding Source: FlyBase
  • RNA polymerase II transcription coactivator activity Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell proliferation Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • dorsal closure Source: FlyBase
  • ectoderm development Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • learning or memory Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • midgut development Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of salivary gland boundary specification Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • olfactory learning Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • transforming growth factor beta receptor signaling pathway Source: FlyBase
  • wing disc anterior/posterior pattern formation Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger proteinImported
Gene namesi
Name:shnImported
ORF Names:CG7734Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0003396. shn.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ24605.
PRIDEiQ24605.

Expressioni

Gene expression databases

BgeeiFBgn0003396.
ExpressionAtlasiQ24605. differential.

Interactioni

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0303470.

Structurei

3D structure databases

ProteinModelPortaliQ24605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 46528C2H2-typeInterPro annotationAdd
BLAST
Domaini466 – 49530C2H2-typeInterPro annotationAdd
BLAST
Domaini1770 – 179728C2H2-typeInterPro annotationAdd
BLAST
Domaini1798 – 182225C2H2-typeInterPro annotationAdd
BLAST
Domaini2258 – 228528C2H2-typeInterPro annotationAdd
BLAST
Domaini2286 – 231530C2H2-typeInterPro annotationAdd
BLAST
Domaini2331 – 236030C2H2-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili607 – 63630Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
OrthoDBiEOG091G02DY.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENATITTAK HYKTAGKQYK TNKVNNTRRA TAAAAAAAAA AATTTVTTAA
60 70 80 90 100
TPTKKRTYRE TATATTVTQR STNKANIAAA IALAAATEAT ASASASATAT
110 120 130 140 150
ATDATLTASK AAATAAATTD AASGNSNSSS KPSTSTRDKL GEVPLPTVDS
160 170 180 190 200
NHIISNNNNN NNNNNTSNNN NNNHHSDNSI SENNYEFKSR DKASLSDSKM
210 220 230 240 250
TLQQMAAVSS NQEPVAPNVA NTMSNSSIIN SQQTTVNATP ATDEAPLGDR
260 270 280 290 300
SNISRYLHKK FKRLASTTEV DSWSATNGGG ALQASGDAVR TTSLSSNSSL
310 320 330 340 350
SPPPTTPLAN GHHLMTQQQS HQQVQQQQQQ QTPPPSVAIH EFSANFVNSN
360 370 380 390 400
HVNAIGHEES IISNSGYKAA GRTRTPLANS NSNTNSTSNS NSNHAANATL
410 420 430 440 450
SPASFAQHQQ LTQPTTVSPG IPGGAAAPNP ACEKSGRYVC QYCNLICAKP
460 470 480 490 500
SVLEKHIRAH TNERPYPCDT CGIAFKTKSN LYKHCRSRSH AARARGLEVP
510 520 530 540 550
ADADDGLSDQ DAELSNSSSE LPSRAGSPYE EPINSPTPSP STLSAAKSAY
560 570 580 590 600
IQQPPLPTYM QQLPLGSPAA GTLPPTTADN HHSATAQHRQ SIDYKPYKPK
610 620 630 640 650
FHNASLYSCS SKELQQQQQQ LQIQQQQQQH QLAQQKLSIQ LPLVQQPSLA
660 670 680 690 700
HPTLSPSTQM KMKHHINSHQ IQLQLQQQQS LLAQQSLLAA MPPGGVYYLG
710 720 730 740 750
QPSYYNQDTA AAIHQHALAI QQFQIHLAQQ QQQQQQQHPP LVKATPPMQQ
760 770 780 790 800
PPSLPPQQLV RANSQISSVA TAPATPTPAA NLSTFASSSG GKQVNVAKVQ
810 820 830 840 850
EHISKLISQN EAIVENKEIL LQKKYPKQLS RSRSFNNANS NNASQHGSNA
860 870 880 890 900
SALHANNSHN NTNAQMPERE TKVNLAQAIF QKQQHQLQQQ QQQQITQQQQ
910 920 930 940 950
QQLEQQNYYT YIQQQQECQQ QQLEPPNGVV KRNAYKPGVV MTTPVKQQQQ
960 970 980 990 1000
LPPPPSPLPM QTMQYRQDPA TPVTKIEQPT TAVPVMPLNL SAKPKPTLVT
1010 1020 1030 1040 1050
VPVSSLSTSS LAPTPTTSTN PTSSSKTAPP PAQVNNSIIK NLLLNARGLA
1060 1070 1080 1090 1100
VPIGEGDDAV YSCPICASEF RSADDLKLHN STYCQDASSS APMSPASSPF
1110 1120 1130 1140 1150
RSNSISLSLP ELKSHMANSK NPLSLAKLAW SQLKTKRSSL VLSRLSAAQT
1160 1170 1180 1190 1200
PARTSTVTAP TVTASAPAPA VATVTAPSSA PAPQIEALRF VDAPLPSPGP
1210 1220 1230 1240 1250
LLGKTPLVDY AQQSTPRKAQ DSVVITKMHE DRQFVIEAQP AKRIKTSDLV
1260 1270 1280 1290 1300
VASSSQQPTS FNFSFNNQNS SNSVPELQSS KEERLRRFTS SGGSMIPISE
1310 1320 1330 1340 1350
CPDLDNSPKM IRTPLLSGGS FQDVSVKVNN ETGSSSKERK LMALVSGSGL
1360 1370 1380 1390 1400
LGVSSGPQHF QSPPINSITA FNPLTLPPMS GGDKTTPVTP IPHVPGMPGP
1410 1420 1430 1440 1450
GSLTPQMPLL PPPPQQLQLP IPSSRGRSPN RKQPSPLLLG GGSGELKALS
1460 1470 1480 1490 1500
PFGGVQNVPS EFSRQPPTPA QRQALQWNSK ETPKKAPFNF LRMADNVKTT
1510 1520 1530 1540 1550
EPEVRHFNLE NVISGKQQEL PLTPLHVDTP NGNAPEETSP VASASASAKS
1560 1570 1580 1590 1600
KFLRPTSLPL KPGTFTPKRH HGITPTANTL PLISPETPRP SKSCVQLYLN
1610 1620 1630 1640 1650
GHAYTYLGLK CSTKMFYCTV NCPQPSYVAG MHKLSMYSVW QVCEENQPHP
1660 1670 1680 1690 1700
LGFKLKQVMA LYDSRQRMLG NGSSTAMAGS GKLSYNLVAS QQIVSSPSTS
1710 1720 1730 1740 1750
STSSAFYQGP LKTPPTVTIA ALSEANVAAK ANEEAQAKKL ETSPSGQPLV
1760 1770 1780 1790 1800
GGYESHEDYT YIRGRGRGRY VCSECGIRCK KPSMLKKHIR THTDVRPFTC
1810 1820 1830 1840 1850
SHCNFSFKTK GNLTKHMQSK THFKKCIELG INPGPMPPDS EFLDVDMDFD
1860 1870 1880 1890 1900
QQSSTSAGGR TSSMAGESDS DDYSDNESES SDTDESKSRQ KEHEAARGLL
1910 1920 1930 1940 1950
SLSMTPPIPQ SVSPYPQLQD TPLPAASPAN SIGSSGSQPK RLVCSFTSPK
1960 1970 1980 1990 2000
PPFDYQKQEQ YYSNPEESKP KRSVANEESA PMDLTKPRGS ILLISPSPVS
2010 2020 2030 2040 2050
VPAHDLPKSQ AQQMHDVIFG TSGNESGFMK TLISVSDKVR ISAEMEEQAK
2060 2070 2080 2090 2100
HEAEGEDVQL QTYIKEHALH QAKIKQSQFS RSYLINTLYT AASPVMSSSS
2110 2120 2130 2140 2150
TLFTANSRPV MSVNEVPSIE VHEVKTPEAI ESPRSAPEQA PVILAQIAQE
2160 2170 2180 2190 2200
ENEEPNIAEP HNANLPAAVQ QPDVNEFTGV LVNPTAPPTS SVAPTSTTTA
2210 2220 2230 2240 2250
APVAPSSTAN STQPAQRTVI VGEDGFKSST PTSKSGDLQH VSYGRGVPPA
2260 2270 2280 2290 2300
PIAGDARPTC TMCSKTFQRQ HQLTLHMNIH YMERKFKCEP CSISFRTQGH
2310 2320 2330 2340 2350
LQKHERSEAH KNKVMMTSTF GVPTTSNPRP FECTDCKIAF RIHGHLAKHL
2360 2370 2380 2390 2400
RSKTHVQKLE CLQKLPFGTY AEIERAGISL TEIDTSDCEN SLISLKLLAQ
2410 2420 2430 2440 2450
KLQEKDPGKL SSYTTPSGMM QLAQDAAGPV SQDSASEDGF SAAIASAIAS
2460 2470 2480 2490 2500
LDNDSAGNTP KRASSMSEDE TVANGLNHSL KRRLPGSFSS TGEESDNPPE
2510 2520
SSGEKRARSG QELPVPVAVP VAASAAASN
Length:2,529
Mass (Da):271,566
Last modified:November 1, 1996 - v1
Checksum:i27407A9658F1D682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42311 mRNA. Translation: AAA98814.1.
PIRiA56923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42311 mRNA. Translation: AAA98814.1.
PIRiA56923.

3D structure databases

ProteinModelPortaliQ24605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0303470.

Proteomic databases

PaxDbiQ24605.
PRIDEiQ24605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0003396. shn.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
OrthoDBiEOG091G02DY.

Miscellaneous databases

ChiTaRSishn. fly.

Gene expression databases

BgeeiFBgn0003396.
ExpressionAtlasiQ24605. differential.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24605_DROME
AccessioniPrimary (citable) accession number: Q24605
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.