UniProtKB - Q24592 (JAK_DROME)
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Protein
Tyrosine-protein kinase hopscotch
Gene
hop
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.2 Publications
Catalytic activityi
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 926 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1014 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 898 – 906 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein tyrosine kinase activity Source: FlyBase
- receptor binding Source: GO_Central
GO - Biological processi
- apical constriction Source: FlyBase
- blastoderm segmentation Source: FlyBase
- border follicle cell migration Source: FlyBase
- cell proliferation Source: FlyBase
- cellular defense response Source: FlyBase
- compound eye development Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- compound eye photoreceptor cell differentiation Source: FlyBase
- defense response to virus Source: FlyBase
- encapsulation of foreign target Source: FlyBase
- equator specification Source: FlyBase
- establishment of ommatidial planar polarity Source: FlyBase
- eye-antennal disc morphogenesis Source: FlyBase
- germ-line stem cell division Source: FlyBase
- hemocyte differentiation Source: FlyBase
- hemocyte proliferation Source: FlyBase
- hemopoiesis Source: FlyBase
- hindgut morphogenesis Source: FlyBase
- humoral immune response Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- imaginal disc-derived wing morphogenesis Source: FlyBase
- immune response Source: FlyBase
- innate immune response Source: GO_Central
- JAK-STAT cascade Source: FlyBase
- lamellocyte differentiation Source: FlyBase
- larval lymph gland hemopoiesis Source: FlyBase
- locomotor rhythm Source: FlyBase
- long-term memory Source: FlyBase
- mediolateral intercalation Source: FlyBase
- nervous system development Source: FlyBase
- ommatidial rotation Source: FlyBase
- oogenesis Source: FlyBase
- open tracheal system development Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- ovarian follicle cell stalk formation Source: FlyBase
- peptidyl-tyrosine autophosphorylation Source: FlyBase
- periodic partitioning Source: FlyBase
- positive regulation of heterochromatin assembly Source: FlyBase
- primary sex determination Source: FlyBase
- protein phosphorylation Source: FlyBase
- regulation of embryonic cell shape Source: FlyBase
- regulation of hemocyte differentiation Source: FlyBase
- regulation of hemocyte proliferation Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- sex determination Source: FlyBase
- somatic stem cell division Source: FlyBase
- STAT protein import into nucleus Source: FlyBase
- stem cell population maintenance Source: FlyBase
- transcription, DNA-templated Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- tyrosine phosphorylation of STAT protein Source: FlyBase
Keywordsi
Molecular function | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2. 1994. |
Reactomei | R-DME-1169408. ISG15 antiviral mechanism. R-DME-1433557. Signaling by SCF-KIT. R-DME-209209. Formation of the activated receptor complex. R-DME-209228. Formation of the activated STAT92E dimer and transport to the nucleus. R-DME-210688. Dephosphorylation by PTP61F phosphatases. R-DME-5673000. RAF activation. R-DME-983231. Factors involved in megakaryocyte development and platelet production. |
SignaLinki | Q24592. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:hop Synonyms:HD-160 ORF Names:CG1594 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004864. hop. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088118 | 1 – 1177 | Tyrosine-protein kinase hopscotchAdd BLAST | 1177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | Phosphoserine1 Publication | 1 | |
Modified residuei | 321 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1047 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1048 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q24592. |
PRIDEi | Q24592. |
PTM databases
iPTMneti | Q24592. |
Expressioni
Developmental stagei
Expressed both maternally and zygotically throughout development.1 Publication
Gene expression databases
Bgeei | FBgn0004864. |
ExpressionAtlasi | Q24592. differential. |
Genevisiblei | Q24592. DM. |
Interactioni
Subunit structurei
Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.
GO - Molecular functioni
- receptor binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 58492. 40 interactors. |
DIPi | DIP-61595N. |
IntActi | Q24592. 4 interactors. |
STRINGi | 7227.FBpp0073313. |
Structurei
3D structure databases
ProteinModelPortali | Q24592. |
SMRi | Q24592. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 414 | FERMPROSITE-ProRule annotationAdd BLAST | 369 | |
Domaini | 433 – 539 | SH2; atypicalAdd BLAST | 107 | |
Domaini | 582 – 843 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 892 – 1164 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 273 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 542 – 547 | Poly-Leu | 6 |
Domaini
Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 (By similarity).By similarity
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, SH2 domainPhylogenomic databases
eggNOGi | KOG0197. Eukaryota. COG0515. LUCA. |
GeneTreei | ENSGT00900000140909. |
InParanoidi | Q24592. |
KOi | K04447. |
OMAi | NCMESFL. |
OrthoDBi | EOG091G01IS. |
PhylomeDBi | Q24592. |
Family and domain databases
InterProi | View protein in InterPro IPR019749. Band_41_domain. IPR000299. FERM_domain. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR036860. SH2_dom_sf. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. |
Pfami | View protein in Pfam PF07714. Pkinase_Tyr. 2 hits. |
PRINTSi | PR00109. TYRKINASE. |
SMARTi | View protein in SMART SM00295. B41. 1 hit. SM00219. TyrKc. 1 hit. |
SUPFAMi | SSF55550. SSF55550. 1 hit. SSF56112. SSF56112. 2 hits. |
PROSITEi | View protein in PROSITE PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q24592-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALANGGEDR MDDSSSGRTS LADSASLTNS SLRSGTSSQS IHTNDGTIRV
60 70 80 90 100
FNFTTGEFER FHPNMLCEEI CNTMCRQLGI APIAQLLYGI REHSTSRRPS
110 120 130 140 150
PLVRLDLTWC LPGERLNCQL VYCFRMRFRV PELDSQLELI DGRSHKFLYR
160 170 180 190 200
QMRYDMRTEQ IPEIRYPEHK DKSTGLAVMD MLIDDQEQSE DQQAMRSIEK
210 220 230 240 250
LYKLYLPPSL WRAHSFFVGS KIREVFRSLK ANSLSVERLK WHYVHQVSHL
260 270 280 290 300
APTYMTEQFT CTVQYLPNEE VARGSGPIGT SLAHSTSTLA SSGSTNTLST
310 320 330 340 350
LTTNTNSVAL GGSGKKAKRR STSGGIDVYV RVFPHDSLEP GLKVARVTSE
360 370 380 390 400
ATLKWILVGA VEGIFMISKI NDTSVRLEIV GLPKGYEMQF QTEKEMKSFI
410 420 430 440 450
SYLGIYIRLS SKWMQDLCHS YRTPSLEELS SLHCHGPIGG AYSLMKLHEN
460 470 480 490 500
GDKCGSYIVR ECDREYNIYY IDINTKIMAK KTDQERCKTE TFRIVRKDSQ
510 520 530 540 550
WKLSYNNGEH VLNSLHEVAH IIQADSPDRY RIPASKYDKP PLLLLLLPKN
560 570 580 590 600
LKAKKTDLQL SEAELQRRNP QIFNPRTDLQ WYPDSISLSD DGMMFTMRGD
610 620 630 640 650
WIQQSPVKDV SVTMKMLKSD GNFMEFFRLA QTWSLIQSPQ FLKLYGLTLA
660 670 680 690 700
DPYTMVMEYS RYGPLNKFLH SMPNVTLHCL LDLMHGLVRG MHYLEDNKII
710 720 730 740 750
HNYIRCSNLY VTKYDPNSYV LDAKISDPGY PRPYRESDSP WIPVKYYRNL
760 770 780 790 800
QAAKTDQFAQ LWAFATTIYE IFSRCKEDLS TLRQEQLLRQ KNLDGNILKM
810 820 830 840 850
LDQDICPAPI FETIMDGWSD DETKRFSHHD IFSRLNTIKA EILPNYMPPP
860 870 880 890 900
EIATNGTGDE TVIDRSDIPF LPFPRSNMLM VIPLTSECRV IYNMENMIGR
910 920 930 940 950
GHYGTVYKGH LEFNDKDQPR EQVAIKMLNT MQVSTDFHRE IGIMRTLSHP
960 970 980 990 1000
NIVKFKYWAE KSHCIIMEYL QSGSFDIYLR FTAPNLNNPR LVSFALDIAN
1010 1020 1030 1040 1050
GMKYLSDMGL IHRDLAARNI LVDHNGDGDC VKISDFGLAQ FANSDGYYYA
1060 1070 1080 1090 1100
KSKRDIPIRW YSPEAISTCR FSSYSDVWSY GVTLFEMFSR GEEPNLVPIQ
1110 1120 1130 1140 1150
TSQEDFLNRL QSGERLNRPA SCPDFIYDLM QLCWHATPRS RPSFATIVDI
1160 1170
ITREVATKVT HPTDGHQSPP NQPTDAE
Sequence cautioni
The sequence AAL48491 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 365 | F → V in AAA62441 (PubMed:8314084).Curated | 1 | |
Sequence conflicti | 592 | G → A in AAA62441 (PubMed:8314084).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26975 mRNA. Translation: AAA62441.1. AE014298 Genomic DNA. Translation: AAF48035.1. BT006331 mRNA. Translation: AAP20030.1. AY070869 mRNA. Translation: AAL48491.1. Different initiation. AJ002915 Genomic DNA. Translation: CAA05750.1. |
PIRi | A36984. |
RefSeqi | NP_511119.2. NM_078564.3. |
UniGenei | Dm.2926. |
Genome annotation databases
EnsemblMetazoai | FBtr0073457; FBpp0073313; FBgn0004864. |
GeneIDi | 32080. |
KEGGi | dme:Dmel_CG1594. |
Similar proteinsi
Entry informationi
Entry namei | JAK_DROME | |
Accessioni | Q24592Primary (citable) accession number: Q24592 Secondary accession number(s): Q712V3, Q8SZI9, Q9VYZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 1, 2005 | |
Last modified: | March 28, 2018 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |