Unreviewed, UniProtKB/TrEMBL Q24591 (Q24591_DROME)

Names and origin

Protein names

Submitted name:
    18w protein EMBL AAA79208.1

Gene names

Name:	18w EMBL AAA79208.1
ORF Names:	CG8896 FlyBase FBgn0004364

Organism

Drosophila melanogaster (Fruit fly) EMBL AAA79208.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. Spearmint SPM000157

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat Spearmint SPM003591 Repeat Spearmint SPM003591 Transmembrane Spearmint SPM000483
Gene Ontology (GO)
Biological process	antibacterial humoral response Inferred from mutant phenotype. Source: FlyBase cell adhesion Ref.1 Inferred from direct assay. Source: FlyBase embryonic morphogenesis Traceable author statement. Source: FlyBase innate immune response Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase intrinsic to membrane Inferred from electronic annotation. Source: InterPro membrane fraction Ref.1 Inferred from direct assay. Source: FlyBase plasma membrane Inferred from direct assay. Source: FlyBase
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro transmembrane receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q24591-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FB47D0688FF78357	FASTA	1,389	155,262
	10 20 30 40 50 60 MPATSSIITI IAVAACLLLL VADAHAQQQC NWQYGLTTMD IRCSVRALES GTGSPLDLQV 70 80 90 100 110 120 AEAAGRLDLQ CSQELLHASE LAPGLFRQLQ KLSELRIDAC KLQRVPPNAF EGLMSLKRLT 130 140 150 160 170 180 LESHNAVWGP GKTLELHGQS FQGLKELSEL HLGDNNIRQL PEGVWCSMPS LQLLNLTQNR 190 200 210 220 230 240 IRSAEFLGFS EKLCAGSALS NANGAVSGGS ELQTLDVSFN ELRSLPDAWG ASRLRRLQTL 250 260 270 280 290 300 SLQHNNISTL APNALAGLSS LRVLNISYNH LVSLPSEAFA GNKELRELHL QGNDLYELPK 310 320 330 340 350 360 GLLHRLEQLL VLDLSGNQLT SHHVDNSTFA GLIRLIVLNL SNNALTRIGS KTFKELYFLQ 370 380 390 400 410 420 ILDMRNNSIG HIEEGAFLPL YNLHTLNLAE NRLHTLDNRI FNGLYVLTKL TLNNNLVSIV 430 440 450 460 470 480 ESQAFRNCSD LKELDLSSNQ LTEVPEAVQD LSMLKTLDLG ENQISEFKNN TFRNLNQLTG 490 500 510 520 530 540 LRLIDNRIGN ITVGMFQDLP RLSVLNLAKN RIQSIERGAF DKNTEIEAIR LDKNFLTDIN 550 560 570 580 590 600 GIFATLASLL WLNLSENHLV WFDYAFIPSN LKWLDIHGNY IEALGNYYKL QEEIRVTTLD 610 620 630 640 650 660 ASHNRITEIG AMSVPNSIEL LFINNNIIGQ IQANTFVDKT RLARVDLYAN VLSKISLNAL 670 680 690 700 710 720 RVAPVSAEKP VPEFYLGGNP FECDCSMEWL QRINNLTTRQ HPHVVDLGNI ECLMPHSRSA 730 740 750 760 770 780 PLRPLASLSA SDFVCKYESH CPPTCHCCEY EQCECEVICP GNCSCFHDAT WATNIVDCGR 790 800 810 820 830 840 QDLAALPNRI PQDVSDLYLD GNNMPELEVG HLTGRRNLRA LYLNASNLMT LQNGSLAQLV 850 860 870 880 890 900 NLRVLHLENN KLTALEGTEF RSLGLLRELY LHNNMLTHIS NATFEPLVSL EVLRLDNNRL 910 920 930 940 950 960 SSLPHLQYRH SLQGLTLGRN AWSCRCQQLR ELAQFVSDNA MVVRDAHDIY CLDAGIKREL 970 980 990 1000 1010 1020 ELIGNLANGP DCSDLLDASA SNISSSQDLA GAIGCPCWPA VLVLIFLVVV LIIVFVFRES 1030 1040 1050 1060 1070 1080 VRMWLFAHYG VRVCEPRFED AGKLYDAIIL HSEKDYEFVC RNIAAELEHG RPPFRLCIQQ 1090 1100 1110 1120 1130 1140 RDLPPQASHL QLVEGARASR KIILVLTRNL LATEWNRIEF RNAFHESLRG LAQKLVIIEE 1150 1160 1170 1180 1190 1200 TSVSAEAEDV AELSPYLKSV PSNRLLTCDR YFWEKLRYAI PIELSPRGNN YTLDHHERFK 1210 1220 1230 1240 1250 1260 QPVSPGMIFR QAPPPPAYYC TEEMEANYSS ATTATPSPRP TRPGGAARIV DSMPMPMRPP 1270 1280 1290 1300 1310 1320 SEHIYHSIES EYSAYDQHEA LSMIPTGLMH QHQQQQLRLH QQQQQQQQQR LLQPQFRAMP 1330 1340 1350 1360 1370 1380 QQAIPAPSAP VHLRSGSGLS QASTSTQSTA QASTSAAAAQ QQQQQQQQQQ QQQAAGSEAA NKNGQAFLV

References

[1]	"The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll." Eldon E., Kooyer S., D'Evelyn D., Duman M., Lawinger P., Botas J., Bellen H. Development 120:885-899(1994) [PubMed: 7600965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila." Chiang C., Beachy P.A. Mech. Dev. 47:225-239(1994) [PubMed: 7848870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L23171 mRNA. Translation: AAA79208.1.
PIR	T13852. T13887.
3D structure databases
HSSP	HSSP built from PDB template 1O77 based on UniProtKB O60603.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q24591. 1 interaction.
Proteomic databases
PRIDE	Q24591.
Genome annotation databases
Ensembl	FBgn0004364. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0004364. 18w.
Phylogenomic databases
HOGENOM	Q24591.
Gene expression databases
ArrayExpress	Q24591.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR000372. Leu-rich_rpt_Cys-rich-reg_N. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000483. LRR_C. IPR000157. Toll-Interleukin_rcpt. [Graphical view]
Pfam	PF00560. LRR_1. 14 hits. PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 9 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
PROSITE	PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q24591_DROME

Accession

Primary (citable) accession number: Q24591
Secondary accession number(s): Q26388

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)