Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

18w protein

Gene

18w

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  • anatomical structure morphogenesis Source: FlyBase
  • antibacterial humoral response Source: FlyBase
  • axis elongation Source: FlyBase
  • cell adhesion Source: FlyBase
  • convergent extension Source: FlyBase
  • defense response Source: FlyBase
  • eggshell formation Source: FlyBase
  • embryonic morphogenesis Source: FlyBase
  • immune response Source: FlyBase
  • multicellular organism development Source: FlyBase
  • ovarian follicle cell migration Source: FlyBase
  • ventral cord development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

ReceptorSAAS annotation

Keywords - Biological processi

Immunity, Innate immunitySAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-109704. PI3K Cascade.
R-DME-1679131. Trafficking and processing of endosomal TLR.
R-DME-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-DME-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-DME-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DME-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DME-975155. MyD88 dependent cascade initiated on endosome.

Names & Taxonomyi

Protein namesi
Submitted name:
18w proteinImported
Gene namesi
Name:18wImported
ORF Names:CG8896Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0004364. 18w.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei998 – 101720HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 13891363Sequence analysisPRO_5004202144Add
BLAST

Proteomic databases

PaxDbiQ24591.
PRIDEiQ24591.

Expressioni

Gene expression databases

BgeeiFBgn0004364.
ExpressionAtlasiQ24591. differential.

Interactioni

Protein-protein interaction databases

IntActiQ24591. 1 interaction.
STRINGi7227.FBpp0085620.

Structurei

3D structure databases

ProteinModelPortaliQ24591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1043 – 1183141TIRInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
OrthoDBiEOG091G0137.
PhylomeDBiQ24591.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 7 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 21 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 25 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPATSSIITI IAVAACLLLL VADAHAQQQC NWQYGLTTMD IRCSVRALES
60 70 80 90 100
GTGSPLDLQV AEAAGRLDLQ CSQELLHASE LAPGLFRQLQ KLSELRIDAC
110 120 130 140 150
KLQRVPPNAF EGLMSLKRLT LESHNAVWGP GKTLELHGQS FQGLKELSEL
160 170 180 190 200
HLGDNNIRQL PEGVWCSMPS LQLLNLTQNR IRSAEFLGFS EKLCAGSALS
210 220 230 240 250
NANGAVSGGS ELQTLDVSFN ELRSLPDAWG ASRLRRLQTL SLQHNNISTL
260 270 280 290 300
APNALAGLSS LRVLNISYNH LVSLPSEAFA GNKELRELHL QGNDLYELPK
310 320 330 340 350
GLLHRLEQLL VLDLSGNQLT SHHVDNSTFA GLIRLIVLNL SNNALTRIGS
360 370 380 390 400
KTFKELYFLQ ILDMRNNSIG HIEEGAFLPL YNLHTLNLAE NRLHTLDNRI
410 420 430 440 450
FNGLYVLTKL TLNNNLVSIV ESQAFRNCSD LKELDLSSNQ LTEVPEAVQD
460 470 480 490 500
LSMLKTLDLG ENQISEFKNN TFRNLNQLTG LRLIDNRIGN ITVGMFQDLP
510 520 530 540 550
RLSVLNLAKN RIQSIERGAF DKNTEIEAIR LDKNFLTDIN GIFATLASLL
560 570 580 590 600
WLNLSENHLV WFDYAFIPSN LKWLDIHGNY IEALGNYYKL QEEIRVTTLD
610 620 630 640 650
ASHNRITEIG AMSVPNSIEL LFINNNIIGQ IQANTFVDKT RLARVDLYAN
660 670 680 690 700
VLSKISLNAL RVAPVSAEKP VPEFYLGGNP FECDCSMEWL QRINNLTTRQ
710 720 730 740 750
HPHVVDLGNI ECLMPHSRSA PLRPLASLSA SDFVCKYESH CPPTCHCCEY
760 770 780 790 800
EQCECEVICP GNCSCFHDAT WATNIVDCGR QDLAALPNRI PQDVSDLYLD
810 820 830 840 850
GNNMPELEVG HLTGRRNLRA LYLNASNLMT LQNGSLAQLV NLRVLHLENN
860 870 880 890 900
KLTALEGTEF RSLGLLRELY LHNNMLTHIS NATFEPLVSL EVLRLDNNRL
910 920 930 940 950
SSLPHLQYRH SLQGLTLGRN AWSCRCQQLR ELAQFVSDNA MVVRDAHDIY
960 970 980 990 1000
CLDAGIKREL ELIGNLANGP DCSDLLDASA SNISSSQDLA GAIGCPCWPA
1010 1020 1030 1040 1050
VLVLIFLVVV LIIVFVFRES VRMWLFAHYG VRVCEPRFED AGKLYDAIIL
1060 1070 1080 1090 1100
HSEKDYEFVC RNIAAELEHG RPPFRLCIQQ RDLPPQASHL QLVEGARASR
1110 1120 1130 1140 1150
KIILVLTRNL LATEWNRIEF RNAFHESLRG LAQKLVIIEE TSVSAEAEDV
1160 1170 1180 1190 1200
AELSPYLKSV PSNRLLTCDR YFWEKLRYAI PIELSPRGNN YTLDHHERFK
1210 1220 1230 1240 1250
QPVSPGMIFR QAPPPPAYYC TEEMEANYSS ATTATPSPRP TRPGGAARIV
1260 1270 1280 1290 1300
DSMPMPMRPP SEHIYHSIES EYSAYDQHEA LSMIPTGLMH QHQQQQLRLH
1310 1320 1330 1340 1350
QQQQQQQQQR LLQPQFRAMP QQAIPAPSAP VHLRSGSGLS QASTSTQSTA
1360 1370 1380
QASTSAAAAQ QQQQQQQQQQ QQQAAGSEAA NKNGQAFLV
Length:1,389
Mass (Da):155,262
Last modified:November 1, 1996 - v1
Checksum:iFB47D0688FF78357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23171 mRNA. Translation: AAA79208.1.
PIRiT13852.
T13887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23171 mRNA. Translation: AAA79208.1.
PIRiT13852.
T13887.

3D structure databases

ProteinModelPortaliQ24591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ24591. 1 interaction.
STRINGi7227.FBpp0085620.

Proteomic databases

PaxDbiQ24591.
PRIDEiQ24591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0004364. 18w.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
OrthoDBiEOG091G0137.
PhylomeDBiQ24591.

Enzyme and pathway databases

ReactomeiR-DME-109704. PI3K Cascade.
R-DME-1679131. Trafficking and processing of endosomal TLR.
R-DME-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-DME-168181. Toll Like Receptor 7/8 (TLR7/8) Cascade.
R-DME-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DME-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DME-975155. MyD88 dependent cascade initiated on endosome.

Gene expression databases

BgeeiFBgn0004364.
ExpressionAtlasiQ24591. differential.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 7 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 21 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 25 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24591_DROME
AccessioniPrimary (citable) accession number: Q24591
Secondary accession number(s): Q26388
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.