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Protein
Submitted name:

Tumor suppressor

Gene

wts

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ24590.

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressorImported
Gene namesi
Name:wtsImported
ORF Names:CG12072Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0011739. wts.

PTM / Processingi

Proteomic databases

PaxDbiQ24590.
PRIDEiQ24590.

Expressioni

Gene expression databases

BgeeiFBgn0011739.

Interactioni

Protein-protein interaction databases

IntActiQ24590. 2 interactors.
MINTiMINT-4787599.
STRINGi7227.FBpp0085082.

Structurei

3D structure databases

ProteinModelPortaliQ24590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 1014Protein kinaseInterPro annotationAdd BLAST302
Domaini1015 – 1085AGC-kinase C-terminalInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili475 – 530Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0605. Eukaryota.
ENOG410XQC0. LUCA.
OrthoDBiEOG091G028J.

Family and domain databases

InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPAGEKRGG RPNDKYTAEA LESIKQDLTR FEVQNNHRNN QNYTPLRYTA
60 70 80 90 100
TNGRNDALTP DYHHAKQPME PPPSASPAPD VVIPPPPAIV GQPGAGSISV
110 120 130 140 150
SGVGVGVVGV ANGRVPKMMT ALMPNKLIRK PSIERDTASS HYLRCSPALD
160 170 180 190 200
SGAGSSRSDS PHSHHTHQPS SRTVGNPGGN GGFSPSPSGF SEVAPPAPPP
210 220 230 240 250
RNPTASSAAT PPPPVPPTSQ AYVKRRSPAL NNRPPAIAPP TQRGNSPVIT
260 270 280 290 300
QNGLKNPQQQ LTQQLKSLNL YPGGGSGAVV EPPPPYLIQG GAGGAAPPPP
310 320 330 340 350
PPSYTASMQS RQSPTQSQQS DYRKSPSSGI YSATSAGSPS PITVSLPPAP
360 370 380 390 400
LAKPQPRVYQ ARSQQPIIMQ SVKSTQVQKP VLQTAVAPQS PSSASASNSP
410 420 430 440 450
VHVLAAPPSY PQKSAAVVQQ QQQAAAAAHQ QQHQHQQSKP ATPTTPPLVG
460 470 480 490 500
LNSKPNCLEP PSYAKSMQAK AATVVQQQQQ QQQQQQVQQQ QVQQQQQQQQ
510 520 530 540 550
QQLQALRVLQ AQAQRERDQR ERERDQQKLA NGNPGRQMLP PPPYQSNNNN
560 570 580 590 600
NSEIKPPSCN NNNIQISNSN LATTPPIPPA KYNNNSSNTG ANSSGGSNGS
610 620 630 640 650
TGTTASSSTS CKKIKHASPI PERKKISKEK EEERKEFRIR QYSPQAFKFF
660 670 680 690 700
MEQHIENVIK SYRQRTYRKN QLEKEMHKVG LPDQTQIEMR KMLNQKESNY
710 720 730 740 750
IRLKRAKMDK SMFVKLKPIG VGAFGEVTLV SKIDTSNHLY AMKTLRKADV
760 770 780 790 800
LKRNQVAHVK AERDILAEAD NNWVVKLYYS FQDKDNLYFV MDYIPGGDLM
810 820 830 840 850
SLLIKLGIFE EELARFYIAE VTCAVDSVHK MGFIHRDIKP DNILIDRDGH
860 870 880 890 900
IKLTDFGLCT GFRWTHNSKY YQENGNHSRQ DSMEPWEEYS ENGPKPTVLE
910 920 930 940 950
RRRMRDHQRV LAHSLVGTPN YIAPEVLERS GYTQLCDYWS VGVILYEMLV
960 970 980 990 1000
GQPPFLANSP LETQQKVINW EKTLHIPPQA ELSREATDLI RRLCASADKR
1010 1020 1030 1040 1050
LGKSVDEVKS HDFFKGIDFA DMRKQKAPYI PEIKHPTDTS NFDPVDPEKL
1060 1070 1080 1090
RSNDSTMSSG DDVDQNDRTF HGFFEFTFRR FFDDKQPPDM TDDQAPVYV
Length:1,099
Mass (Da):121,634
Last modified:November 1, 1996 - v1
Checksum:iEB35192A10470805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39837 mRNA. Translation: AAA73959.1.
PIRiA56155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39837 mRNA. Translation: AAA73959.1.
PIRiA56155.

3D structure databases

ProteinModelPortaliQ24590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ24590. 2 interactors.
MINTiMINT-4787599.
STRINGi7227.FBpp0085082.

Proteomic databases

PaxDbiQ24590.
PRIDEiQ24590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0011739. wts.

Phylogenomic databases

eggNOGiKOG0605. Eukaryota.
ENOG410XQC0. LUCA.
OrthoDBiEOG091G028J.

Enzyme and pathway databases

SignaLinkiQ24590.

Gene expression databases

BgeeiFBgn0011739.

Family and domain databases

InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ24590_DROME
AccessioniPrimary (citable) accession number: Q24590
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.