Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Moesin/ezrin/radixin homolog 2

Gene

Mer

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.2 Publications

GO - Molecular functioni

  • cytoskeletal protein binding Source: FlyBase
  • identical protein binding Source: IntAct

GO - Biological processi

  • axis specification Source: FlyBase
  • cell-cell signaling Source: UniProtKB
  • cell cycle arrest Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • compound eye photoreceptor cell differentiation Source: FlyBase
  • decapentaplegic signaling pathway Source: FlyBase
  • endocytic recycling Source: FlyBase
  • endocytosis Source: UniProtKB
  • hippo signaling Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • male meiosis cytokinesis Source: FlyBase
  • meiotic chromosome separation Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of glial cell proliferation Source: FlyBase
  • negative regulation of organ growth Source: FlyBase
  • olfactory behavior Source: FlyBase
  • pole plasm mRNA localization Source: FlyBase
  • positive regulation of phosphorylation Source: FlyBase
  • positive regulation of protein phosphorylation Source: FlyBase
  • protein localization to plasma membrane Source: FlyBase
  • regulation of apoptotic process Source: FlyBase
  • regulation of cell differentiation Source: FlyBase
  • regulation of cell growth Source: UniProtKB
  • regulation of cell proliferation Source: FlyBase
  • regulation of compound eye retinal cell programmed cell death Source: FlyBase
  • regulation of hippo signaling Source: UniProtKB
  • regulation of signal transduction Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Moesin/ezrin/radixin homolog 2
Alternative name(s):
Ezrin-moesin-radixin 2
Merlin
Short name:
dMerlin
Gene namesi
Name:Mer
Synonyms:EMR2
ORF Names:CG14228
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0086384. Mer.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • apical plasma membrane Source: FlyBase
  • cell cortex Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytoskeleton Source: UniProtKB-SubCell
  • extrinsic component of membrane Source: InterPro
  • Kibra-Ex-Mer complex Source: UniProtKB
  • membrane Source: FlyBase
  • Nebenkern Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Moesin/ezrin/radixin homolog 2PRO_0000219426Add
BLAST

Proteomic databases

PaxDbiQ24564.
PRIDEiQ24564.

Expressioni

Tissue specificityi

Expressed predominantly in the germline. Expressed in the developing oocyte from stage 6 to the end of oogenesis and in the apical ends of follical cells from stage 10. Ubiquitous expression throughout embryogenesis with enhanced expression in mesoderm of early embryos and midgut of late embryos. In embryonic CNS, expression is seen in neuropil and developing brain and is enhanced in neuronal cell bodies. In embryonic PNS, expression is seen within the cell body. In third instar larvae, expression is uniform in the eye imaginal disk and is enhanced at the morphogenetic furrow. In pupal eyes, expression is seen in the cytoplasm of secondary and tertiary pigment cells, bristle precursor cells and rhabdomeres.1 Publication

Developmental stagei

Expressed maternally and zygotically in embryos.1 Publication

Gene expression databases

BgeeiFBgn0086384.
ExpressionAtlasiQ24564. differential.
GenevisibleiQ24564. DM.

Interactioni

Subunit structurei

Interacts with Moe and arm at the adherens junction (PubMed:8666669). Forms a complex with Kibra and Ex (PubMed:20159598). Interacts (via FERM domain) with Sav (via FBM motif) (PubMed:20159598). Interacts with Schip1 (PubMed:26954546).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-180142,EBI-180142
wtsQ9VA388EBI-180142,EBI-82717

GO - Molecular functioni

  • cytoskeletal protein binding Source: FlyBase
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi59275. 132 interactions.
DIPiDIP-17087N.
IntActiQ24564. 7 interactions.
MINTiMINT-308080.
STRINGi7227.FBpp0074523.

Structurei

3D structure databases

ProteinModelPortaliQ24564.
SMRiQ24564. Positions 10-444, 554-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 305294FERMPROSITE-ProRule annotationCuratedAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
InParanoidiQ24564.
KOiK16684.
OMAiACYAEHR.
OrthoDBiEOG091G06UO.
PhylomeDBiQ24564.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR015788. EMR2.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23281:SF23. PTHR23281:SF23. 2 hits.
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW
60 70 80 90 100
YFGLQYVDTR SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS
110 120 130 140 150
EELIQEITQH LFFLQVKQSI LSMDIYCRPE ASVLLASYAV HVQYGPYDYE
160 170 180 190 200
TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE RIKTWYMDHE PMTRDEVEME
210 220 230 240 250
YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE RDKLTPKTTF
260 270 280 290 300
QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL
310 320 330 340 350
YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL
360 370 380 390 400
EKSMEHLQNE MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK
410 420 430 440 450
TEMDRLRERQ MKIEREKHDL EKKIRDADFY VHQLTVENDK REAETEKLRK
460 470 480 490 500
ELICAKMAER EATARLLEFL NSGRKSSTDS LLTASSVSHA ANTASSMAAI
510 520 530 540 550
STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS DDFEPKEFIL
560 570 580 590 600
TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD
610 620 630
ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL
Length:635
Mass (Da):74,492
Last modified:November 1, 1996 - v1
Checksum:i940D6B8A0D160A3F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661G → R in AAM11326 (PubMed:12537569).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49724 mRNA. Translation: AAB08449.1.
AE014298 Genomic DNA. Translation: AAF49005.1.
AY094998 mRNA. Translation: AAM11326.1.
U23799 mRNA. Translation: AAA65060.1.
RefSeqiNP_001285458.1. NM_001298529.1.
NP_523413.1. NM_078689.4.
UniGeneiDm.2765.

Genome annotation databases

EnsemblMetazoaiFBtr0074754; FBpp0074523; FBgn0086384.
FBtr0345992; FBpp0311877; FBgn0086384.
GeneIDi32979.
KEGGidme:Dmel_CG14228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49724 mRNA. Translation: AAB08449.1.
AE014298 Genomic DNA. Translation: AAF49005.1.
AY094998 mRNA. Translation: AAM11326.1.
U23799 mRNA. Translation: AAA65060.1.
RefSeqiNP_001285458.1. NM_001298529.1.
NP_523413.1. NM_078689.4.
UniGeneiDm.2765.

3D structure databases

ProteinModelPortaliQ24564.
SMRiQ24564. Positions 10-444, 554-635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59275. 132 interactions.
DIPiDIP-17087N.
IntActiQ24564. 7 interactions.
MINTiMINT-308080.
STRINGi7227.FBpp0074523.

Proteomic databases

PaxDbiQ24564.
PRIDEiQ24564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074754; FBpp0074523; FBgn0086384.
FBtr0345992; FBpp0311877; FBgn0086384.
GeneIDi32979.
KEGGidme:Dmel_CG14228.

Organism-specific databases

CTDi32979.
FlyBaseiFBgn0086384. Mer.

Phylogenomic databases

eggNOGiKOG3529. Eukaryota.
ENOG410XQFP. LUCA.
InParanoidiQ24564.
KOiK16684.
OMAiACYAEHR.
OrthoDBiEOG091G06UO.
PhylomeDBiQ24564.

Enzyme and pathway databases

ReactomeiR-DME-5627123. RHO GTPases activate PAKs.

Miscellaneous databases

GenomeRNAii32979.
PROiQ24564.

Gene expression databases

BgeeiFBgn0086384.
ExpressionAtlasiQ24564. differential.
GenevisibleiQ24564. DM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR015788. EMR2.
IPR011174. ERM.
IPR011259. ERM_C_dom.
IPR000798. Ez/rad/moesin-like.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR008954. Moesin_tail.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23281:SF23. PTHR23281:SF23. 2 hits.
PfamiPF00769. ERM. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PIRSFiPIRSF002305. ERM. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF48678. SSF48678. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMERH_DROME
AccessioniPrimary (citable) accession number: Q24564
Secondary accession number(s): Q24054, Q8SWY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.