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Protein

Moesin/ezrin/radixin homolog 2

Gene

Mer

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.2 Publications

GO - Molecular functioni

  • actin binding Source: InterPro
  • cytoskeletal protein binding Source: FlyBase
  • identical protein binding Source: IntAct

GO - Biological processi

  • axis specification Source: FlyBase
  • cell-cell signaling Source: UniProtKB
  • cell cycle arrest Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • compound eye photoreceptor cell differentiation Source: FlyBase
  • decapentaplegic signaling pathway Source: FlyBase
  • endocytic recycling Source: FlyBase
  • endocytosis Source: UniProtKB
  • hippo signaling Source: FlyBase
  • male meiosis cytokinesis Source: FlyBase
  • meiotic chromosome separation Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of glial cell proliferation Source: FlyBase
  • negative regulation of organ growth Source: FlyBase
  • pole plasm mRNA localization Source: FlyBase
  • positive regulation of phosphorylation Source: FlyBase
  • positive regulation of protein phosphorylation Source: FlyBase
  • protein localization to plasma membrane Source: FlyBase
  • regulation of apoptotic process Source: FlyBase
  • regulation of cell differentiation Source: FlyBase
  • regulation of cell growth Source: UniProtKB
  • regulation of cell proliferation Source: FlyBase
  • regulation of compound eye retinal cell programmed cell death Source: FlyBase
  • regulation of hippo signaling Source: UniProtKB
  • regulation of signal transduction Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processEndocytosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Moesin/ezrin/radixin homolog 2
Alternative name(s):
Ezrin-moesin-radixin 2
Merlin
Short name:
dMerlin
Gene namesi
Name:Mer
Synonyms:EMR2
ORF Names:CG14228
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0086384 Mer

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194261 – 635Moesin/ezrin/radixin homolog 2Add BLAST635

Proteomic databases

PaxDbiQ24564
PRIDEiQ24564

PTM databases

iPTMnetiQ24564

Expressioni

Tissue specificityi

Expressed predominantly in the germline. Expressed in the developing oocyte from stage 6 to the end of oogenesis and in the apical ends of follical cells from stage 10. Ubiquitous expression throughout embryogenesis with enhanced expression in mesoderm of early embryos and midgut of late embryos. In embryonic CNS, expression is seen in neuropil and developing brain and is enhanced in neuronal cell bodies. In embryonic PNS, expression is seen within the cell body. In third instar larvae, expression is uniform in the eye imaginal disk and is enhanced at the morphogenetic furrow. In pupal eyes, expression is seen in the cytoplasm of secondary and tertiary pigment cells, bristle precursor cells and rhabdomeres.1 Publication

Developmental stagei

Expressed maternally and zygotically in embryos.1 Publication

Gene expression databases

BgeeiFBgn0086384
ExpressionAtlasiQ24564 differential
GenevisibleiQ24564 DM

Interactioni

Subunit structurei

Interacts with Moe and arm at the adherens junction (PubMed:8666669). Forms a complex with Kibra and Ex (PubMed:20159598). Interacts (via FERM domain) with Sav (via FBM motif) (PubMed:20159598). Interacts with Schip1 (PubMed:26954546).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: InterPro
  • cytoskeletal protein binding Source: FlyBase
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi59275, 170 interactors
DIPiDIP-17087N
IntActiQ24564, 136 interactors
STRINGi7227.FBpp0074523

Structurei

3D structure databases

ProteinModelPortaliQ24564
SMRiQ24564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 305FERMPROSITE-ProRule annotationCuratedAdd BLAST294

Phylogenomic databases

eggNOGiKOG3529 Eukaryota
ENOG410XQFP LUCA
InParanoidiQ24564
KOiK16684
OMAiMQRIKVT
OrthoDBiEOG091G06UO
PhylomeDBiQ24564

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.1020, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR015788 EMR2
IPR011174 ERM
IPR011259 ERM_C_dom
IPR000798 Ez/rad/moesin-like
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR008954 Moesin_tail_sf
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23281:SF23 PTHR23281:SF23, 1 hit
PfamiView protein in Pfam
PF00769 ERM, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PIRSFiPIRSF002305 ERM, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48678 SSF48678, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q24564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW
60 70 80 90 100
YFGLQYVDTR SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS
110 120 130 140 150
EELIQEITQH LFFLQVKQSI LSMDIYCRPE ASVLLASYAV HVQYGPYDYE
160 170 180 190 200
TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE RIKTWYMDHE PMTRDEVEME
210 220 230 240 250
YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE RDKLTPKTTF
260 270 280 290 300
QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL
310 320 330 340 350
YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL
360 370 380 390 400
EKSMEHLQNE MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK
410 420 430 440 450
TEMDRLRERQ MKIEREKHDL EKKIRDADFY VHQLTVENDK REAETEKLRK
460 470 480 490 500
ELICAKMAER EATARLLEFL NSGRKSSTDS LLTASSVSHA ANTASSMAAI
510 520 530 540 550
STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS DDFEPKEFIL
560 570 580 590 600
TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD
610 620 630
ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL
Length:635
Mass (Da):74,492
Last modified:November 1, 1996 - v1
Checksum:i940D6B8A0D160A3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166G → R in AAM11326 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49724 mRNA Translation: AAB08449.1
AE014298 Genomic DNA Translation: AAF49005.1
AY094998 mRNA Translation: AAM11326.1
U23799 mRNA Translation: AAA65060.1
RefSeqiNP_001285458.1, NM_001298529.1
NP_523413.1, NM_078689.4

Genome annotation databases

EnsemblMetazoaiFBtr0074754; FBpp0074523; FBgn0086384
FBtr0345992; FBpp0311877; FBgn0086384
GeneIDi32979
KEGGidme:Dmel_CG14228

Similar proteinsi

Entry informationi

Entry nameiMERH_DROME
AccessioniPrimary (citable) accession number: Q24564
Secondary accession number(s): Q24054, Q8SWY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health