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Protein

Syntaxin-1A

Gene

Syx1A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:7834751). Essential for embryonic viability and development (PubMed:7834751). Required for coordinated peristaltic contractions (PubMed:7834751). Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens in tracheal fusion cells (Fcs) by interacting with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells (PubMed:27323327).2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: FlyBase

GO - Biological processi

  • cellularization Source: FlyBase
  • haltere development Source: FlyBase
  • intracellular protein transport Source: GO_Central
  • mitotic cytokinesis Source: FlyBase
  • neuromuscular synaptic transmission Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • regulation of exocytosis Source: InterPro
  • regulation of pole plasm oskar mRNA localization Source: FlyBase
  • synaptic vesicle docking Source: FlyBase
  • synaptic vesicle fusion to presynaptic active zone membrane Source: FlyBase
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-449836 Other interleukin signaling
R-DME-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1A
Alternative name(s):
dSynt1
Gene namesi
Name:Syx1A
Synonyms:syx-1A
ORF Names:CG31136
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013343 Syx1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 268CytoplasmicSequence analysisAdd BLAST268
Transmembranei269 – 289Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini290 – 291VesicularSequence analysis2

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Lysosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102351 – 291Syntaxin-1AAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24547
PRIDEiQ24547

PTM databases

iPTMnetiQ24547

Expressioni

Tissue specificityi

Prior to embryonic stage 12 expression is ubiquitous, then it becomes concentrated in the neuropil. In third instar larvae, expression is seen at the synaptic boutons of the ventral muscles. In adult brain, expression is seen in the optic lobe neuropils.1 Publication

Developmental stagei

Expressed throughout development.

Gene expression databases

BgeeiFBgn0013343
ExpressionAtlasiQ24547 differential

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: FlyBase

Protein-protein interaction databases

BioGridi67788, 58 interactors
DIPiDIP-19389N
IntActiQ24547, 17 interactors
STRINGi7227.FBpp0292260

Structurei

3D structure databases

ProteinModelPortaliQ24547
SMRiQ24547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 257t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 117Sequence analysisAdd BLAST85

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
InParanoidiQ24547
KOiK04560
OrthoDBiEOG091G0EUK
PhylomeDBiQ24547

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028669 STX1A
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF84 PTHR19957:SF84, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q24547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDRLAALH AAQSDDEEET EVAVNVDGHD SYMDDFFAQV EEIRGMIDKV
60 70 80 90 100
QDNVEEVKKK HSAILSAPQT DEKTKQELED LMADIKKNAN RVRGKLKGIE
110 120 130 140 150
QNIEQEEQQN KSSADLRIRK TQHSTLSRKF VEVMTEYNRT QTDYRERCKG
160 170 180 190 200
RIQRQLEITG RPTNDDELEK MLEEGNSSVF TQGIIMETQQ AKQTLADIEA
210 220 230 240 250
RHQDIMKLET SIKELHDMFM DMAMLVESQG EMIDRIEYHV EHAMDYVQTA
260 270 280 290
TQDTKKALKY QSKARRKKIM ILICLTVLGI LAASYVSSYF M
Length:291
Mass (Da):33,648
Last modified:November 1, 1996 - v1
Checksum:iBD0AB88ABC5DD7B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122Q → E (PubMed:7609612).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37732 mRNA Translation: AAA75649.1
AE014297 Genomic DNA Translation: AAF56232.1
AY061472 mRNA Translation: AAL29020.1
PIRiA55673
RefSeqiNP_001303545.1, NM_001316616.1
NP_524475.1, NM_079751.5
UniGeneiDm.2366

Genome annotation databases

EnsemblMetazoaiFBtr0084588; FBpp0083973; FBgn0013343
FBtr0392904; FBpp0352246; FBgn0013343
GeneIDi42854
KEGGidme:Dmel_CG31136

Similar proteinsi

Entry informationi

Entry nameiSTX1A_DROME
AccessioniPrimary (citable) accession number: Q24547
Secondary accession number(s): Q9TX14, Q9VCD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health