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Protein

Synapsin

Gene

Syn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behavior.1 Publication

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • male courtship behavior Source: FlyBase
  • memory Source: FlyBase
  • olfactory learning Source: FlyBase
  • optomotor response Source: FlyBase
  • response to heat Source: FlyBase
  • synaptic growth at neuromuscular junction Source: FlyBase
  • synaptic vesicle exocytosis Source: FlyBase
  • terminal button organization Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin
Cleaved into the following 2 chains:
Synapsin-1
Short name:
Syn1
Alternative name(s):
Syn1-S
Synapsin-2
Short name:
Syn2
Gene namesi
Name:Syn
Synonyms:Syn-1, Syn-2
ORF Names:CG3985
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004575. Syn.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • synapse Source: FlyBase
  • synaptic vesicle Source: InterPro
  • terminal bouton Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutants show no obvious defects in brain morphology and no striking qualitative changes in behavior are observed. Quantitative differenes are seen: mutants show faster habituation of an olfactory jump response, enhanced ethanol tolerance, and significant defects in learning and memory as measured using three different paradigms.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10251025SynapsinPRO_0000033495Add
BLAST
Chaini1 – 581581Synapsin-1PRO_0000033496Add
BLAST
Chaini583 – 1025443Synapsin-2PRO_0000033497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei539 – 5391Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24546.
PeptideAtlasiQ24546.

PTM databases

iPTMnetiQ24546.

Expressioni

Tissue specificityi

Widely expressed in the embryonic and adult nervous system synaptic terminals.1 Publication

Developmental stagei

Detected at all developmental stages after mid-embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0004575.
ExpressionAtlasiQ24546. differential.
GenevisibleiQ24546. DM.

Interactioni

Protein-protein interaction databases

BioGridi66396. 3 interactions.
IntActiQ24546. 2 interactions.
MINTiMINT-810478.
STRINGi7227.FBpp0099901.

Structurei

3D structure databases

ProteinModelPortaliQ24546.
SMRiQ24546. Positions 136-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 516Poly-Pro
Compositional biasi472 – 49726Pro-richAdd
BLAST
Compositional biasi506 – 54641Ser-richAdd
BLAST
Compositional biasi702 – 78786Ser-richAdd
BLAST
Compositional biasi737 – 74812Pro-richAdd
BLAST
Compositional biasi785 – 84056Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
InParanoidiQ24546.
KOiK19941.
OrthoDBiEOG091G0BZ1.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform F (identifier: Q24546-1) [UniParc]FASTAAdd to basket
Also known as: Syn1-RT

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGFSSGDL SSEVDDVDPN SLPPAARPIQ DQPTKPPVAG GPPNMPPPPA
60 70 80 90 100
PGQPAGAAPE LSLSFGAGKT PATAAPAPPR GVSAPTSPAK SRESLLQRVQ
110 120 130 140 150
SLTGAARDQG ASILGAAVQS ATQRAPAFSK DKYFTLLVLD DQNTDWSKYF
160 170 180 190 200
RGRRLHGDFD IRVEQAEFRD ITVVSSADTG PVVTMAAYRS GTRVARSFRP
210 220 230 240 250
DFVLIRQPPR DGSSDYRSTI LGLKYGGVPS INSLHSIYQF QDKPWVFSHL
260 270 280 290 300
LQLQRRLGRD GFPLIEQTFF PNPRDLFQFT KFPSVLKAGH CHGGVATARL
310 320 330 340 350
ENQSALQDAA GLVSGAGNDS HCYCTIEPYI DAKFSVHIQK IGNNYKAFMR
360 370 380 390 400
KSITGNWKTN QGSAMLEQIT LTEKYKSWVD EISELFGGME VCGLSVVVAK
410 420 430 440 450
DGREYIISAC DSTFALIGDT QEEDRRQIAD LVSGRMQNVC RPSMAQTGPG
460 470 480 490 500
KLPSRSSVSS RAESPTDEGV APTPPLPAGP RPAPMGGPPP IPERTSPAVG
510 520 530 540 550
SIGRLSSRSS ISEVPEEPSS SGPSTVGGVR RDSQTSQSST ISSSVSRAGQ
560 570 580 590 600
RPPQTQNSVV EDAEDTMKNL RKTFAGIFGD MXEIANKKRG RTASETSSGS
610 620 630 640 650
GPGSVPSSAG PGSGFSSSFL GKQFSFAGKG EGVISTQPTQ RPSEEPPAIP
660 670 680 690 700
TTASSAVRPE SSVSVSDSRN TDTLTERAGA GYQPVTNYEQ QERVNPFDKE
710 720 730 740 750
PSKSGSAASI HTSSSSSISS SSISSRINRN GNAIQSPPPP AGPPPPPPTN
760 770 780 790 800
VTAVGSNANS SSGYRNSFSS SLSKDKTSYG NYGSTTSVET ITRMDTNTTN
810 820 830 840 850
IGATATEAGE ASGVTAITNI SNSDGIVAPT TGTITTSVTT NDWRSAIGMR
860 870 880 890 900
SASVYSAPAA VTTVLPGDTS GYDSNSIASQ GEGLNNPSDL PSYTRPSYSR
910 920 930 940 950
SESNASKHSD LDVIFGDSKT TPASYGNGKY TRAAGSISDA DMIFGGPPSN
960 970 980 990 1000
YKTDRFGASK SMSMTSGGVG SGNGSGSGLG GYKIYDSIQN AAFSDFSDSG
1010 1020
SMSSIGSHTK RWSASKEEDD ELDLK
Length:1,025
Mass (Da):107,539
Last modified:March 29, 2005 - v2
Checksum:iD18B5AE0F8EE360C
GO
Isoform C (identifier: Q24546-3) [UniParc]FASTAAdd to basket
Also known as: Syn2

The sequence of this isoform differs from the canonical sequence as follows:
     438-532: NVCRPSMAQT...PSTVGGVRRD → VERLPSQHGA...GTQHSGWGAS
     533-1025: Missing.

Show »
Length:532
Mass (Da):57,487
Checksum:iF79067F651FDB35E
GO

Sequence cautioni

The sequence AAN13462 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAN13464 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAO41538 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA64722 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA64723 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941S → G in CAA64722 (PubMed:8627354).Curated
Sequence conflicti94 – 941S → G in CAA64723 (PubMed:8627354).Curated
Sequence conflicti163 – 1631V → G in CAA64722 (PubMed:8627354).Curated
Sequence conflicti163 – 1631V → G in CAA64723 (PubMed:8627354).Curated
Sequence conflicti163 – 1631V → G in CAA64724 (PubMed:8627354).Curated
Sequence conflicti411 – 4111D → N in CAA64722 (PubMed:8627354).Curated
Sequence conflicti411 – 4111D → N in CAA64723 (PubMed:8627354).Curated
Sequence conflicti411 – 4111D → N in CAA64724 (PubMed:8627354).Curated
Sequence conflicti735 – 7351Q → K in CAA64723 (PubMed:8627354).Curated
Sequence conflicti987 – 9871S → G in CAA64723 (PubMed:8627354).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei438 – 53295NVCRP…GVRRD → VERLPSQHGADGSGQVALPL LGLFPSRESHGRGRGSNTTT PSWTKTRAHGWTTTDTGAYL TRRGFHWAAEQSQQHFGGAG GTLLVGTQHSGWGAS in isoform C. 1 PublicationVSP_013200Add
BLAST
Alternative sequencei533 – 1025493Missing in isoform C. 1 PublicationVSP_013201Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95453 mRNA. Translation: CAA64722.1. Different initiation.
X95453 mRNA. Translation: CAA64723.1. Different initiation.
X95454 mRNA. Translation: CAA64724.1.
AE014297 Genomic DNA. Translation: AAN13462.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAN13464.2. Sequence problems.
AE014297 Genomic DNA. Translation: AAO41538.2. Sequence problems.
RefSeqiNP_731457.2. NM_169332.3.
NP_788628.2. NM_176451.3.
UniGeneiDm.6815.

Genome annotation databases

GeneIDi41247.
KEGGidme:Dmel_CG3985.
UCSCiCG3985-RA. d. melanogaster. [Q24546-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95453 mRNA. Translation: CAA64722.1. Different initiation.
X95453 mRNA. Translation: CAA64723.1. Different initiation.
X95454 mRNA. Translation: CAA64724.1.
AE014297 Genomic DNA. Translation: AAN13462.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAN13464.2. Sequence problems.
AE014297 Genomic DNA. Translation: AAO41538.2. Sequence problems.
RefSeqiNP_731457.2. NM_169332.3.
NP_788628.2. NM_176451.3.
UniGeneiDm.6815.

3D structure databases

ProteinModelPortaliQ24546.
SMRiQ24546. Positions 136-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66396. 3 interactions.
IntActiQ24546. 2 interactions.
MINTiMINT-810478.
STRINGi7227.FBpp0099901.

PTM databases

iPTMnetiQ24546.

Proteomic databases

PaxDbiQ24546.
PeptideAtlasiQ24546.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi41247.
KEGGidme:Dmel_CG3985.
UCSCiCG3985-RA. d. melanogaster. [Q24546-1]

Organism-specific databases

CTDi41247.
FlyBaseiFBgn0004575. Syn.

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
InParanoidiQ24546.
KOiK19941.
OrthoDBiEOG091G0BZ1.

Miscellaneous databases

GenomeRNAii41247.
PROiQ24546.

Gene expression databases

BgeeiFBgn0004575.
ExpressionAtlasiQ24546. differential.
GenevisibleiQ24546. DM.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSYN_DROME
AccessioniPrimary (citable) accession number: Q24546
Secondary accession number(s): Q24544
, Q24545, Q86BA0, Q8INM4, Q8INM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Readthrough of the terminator UGA may occur between the codons for 581-Met and 583-Glu.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.