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Protein

Synapsin

Gene

Syn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behavior.1 Publication

Miscellaneous

Readthrough of the terminator UGA may occur between the codons for 581-Met and 583-Glu.

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • male courtship behavior Source: FlyBase
  • memory Source: FlyBase
  • olfactory learning Source: FlyBase
  • optomotor response Source: FlyBase
  • response to heat Source: FlyBase
  • synaptic growth at neuromuscular junction Source: FlyBase
  • synaptic vesicle exocytosis Source: FlyBase
  • terminal button organization Source: FlyBase

Keywordsi

Biological processBehavior

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin
Cleaved into the following 2 chains:
Synapsin-1
Short name:
Syn1
Alternative name(s):
Syn1-S
Synapsin-2
Short name:
Syn2
Gene namesi
Name:Syn
Synonyms:Syn-1, Syn-2
ORF Names:CG3985
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004575 Syn

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutants show no obvious defects in brain morphology and no striking qualitative changes in behavior are observed. Quantitative differenes are seen: mutants show faster habituation of an olfactory jump response, enhanced ethanol tolerance, and significant defects in learning and memory as measured using three different paradigms.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000334951 – 1025SynapsinAdd BLAST1025
ChainiPRO_00000334961 – 581Synapsin-1Add BLAST581
ChainiPRO_0000033497583 – 1025Synapsin-2Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei539Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24546
PeptideAtlasiQ24546
PRIDEiQ24546

PTM databases

iPTMnetiQ24546

Expressioni

Tissue specificityi

Widely expressed in the embryonic and adult nervous system synaptic terminals.1 Publication

Developmental stagei

Detected at all developmental stages after mid-embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0004575
ExpressionAtlasiQ24546 baseline and differential
GenevisibleiQ24546 DM

Interactioni

Protein-protein interaction databases

BioGridi66396, 5 interactors
IntActiQ24546, 2 interactors
STRINGi7227.FBpp0099901

Structurei

3D structure databases

ProteinModelPortaliQ24546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 51Poly-Pro6
Compositional biasi472 – 497Pro-richAdd BLAST26
Compositional biasi506 – 546Ser-richAdd BLAST41
Compositional biasi702 – 787Ser-richAdd BLAST86
Compositional biasi737 – 748Pro-richAdd BLAST12
Compositional biasi785 – 840Thr-richAdd BLAST56

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
InParanoidiQ24546
KOiK19941
OrthoDBiEOG091G0BZ1

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform F (identifier: Q24546-1) [UniParc]FASTAAdd to basket
Also known as: Syn1-RT

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRGFSSGDL SSEVDDVDPN SLPPAARPIQ DQPTKPPVAG GPPNMPPPPA
60 70 80 90 100
PGQPAGAAPE LSLSFGAGKT PATAAPAPPR GVSAPTSPAK SRESLLQRVQ
110 120 130 140 150
SLTGAARDQG ASILGAAVQS ATQRAPAFSK DKYFTLLVLD DQNTDWSKYF
160 170 180 190 200
RGRRLHGDFD IRVEQAEFRD ITVVSSADTG PVVTMAAYRS GTRVARSFRP
210 220 230 240 250
DFVLIRQPPR DGSSDYRSTI LGLKYGGVPS INSLHSIYQF QDKPWVFSHL
260 270 280 290 300
LQLQRRLGRD GFPLIEQTFF PNPRDLFQFT KFPSVLKAGH CHGGVATARL
310 320 330 340 350
ENQSALQDAA GLVSGAGNDS HCYCTIEPYI DAKFSVHIQK IGNNYKAFMR
360 370 380 390 400
KSITGNWKTN QGSAMLEQIT LTEKYKSWVD EISELFGGME VCGLSVVVAK
410 420 430 440 450
DGREYIISAC DSTFALIGDT QEEDRRQIAD LVSGRMQNVC RPSMAQTGPG
460 470 480 490 500
KLPSRSSVSS RAESPTDEGV APTPPLPAGP RPAPMGGPPP IPERTSPAVG
510 520 530 540 550
SIGRLSSRSS ISEVPEEPSS SGPSTVGGVR RDSQTSQSST ISSSVSRAGQ
560 570 580 590 600
RPPQTQNSVV EDAEDTMKNL RKTFAGIFGD MXEIANKKRG RTASETSSGS
610 620 630 640 650
GPGSVPSSAG PGSGFSSSFL GKQFSFAGKG EGVISTQPTQ RPSEEPPAIP
660 670 680 690 700
TTASSAVRPE SSVSVSDSRN TDTLTERAGA GYQPVTNYEQ QERVNPFDKE
710 720 730 740 750
PSKSGSAASI HTSSSSSISS SSISSRINRN GNAIQSPPPP AGPPPPPPTN
760 770 780 790 800
VTAVGSNANS SSGYRNSFSS SLSKDKTSYG NYGSTTSVET ITRMDTNTTN
810 820 830 840 850
IGATATEAGE ASGVTAITNI SNSDGIVAPT TGTITTSVTT NDWRSAIGMR
860 870 880 890 900
SASVYSAPAA VTTVLPGDTS GYDSNSIASQ GEGLNNPSDL PSYTRPSYSR
910 920 930 940 950
SESNASKHSD LDVIFGDSKT TPASYGNGKY TRAAGSISDA DMIFGGPPSN
960 970 980 990 1000
YKTDRFGASK SMSMTSGGVG SGNGSGSGLG GYKIYDSIQN AAFSDFSDSG
1010 1020
SMSSIGSHTK RWSASKEEDD ELDLK
Length:1,025
Mass (Da):107,539
Last modified:March 29, 2005 - v2
Checksum:iD18B5AE0F8EE360C
GO
Isoform C (identifier: Q24546-3) [UniParc]FASTAAdd to basket
Also known as: Syn2

The sequence of this isoform differs from the canonical sequence as follows:
     438-532: NVCRPSMAQT...PSTVGGVRRD → VERLPSQHGA...GTQHSGWGAS
     533-1025: Missing.

Show »
Length:532
Mass (Da):57,487
Checksum:iF79067F651FDB35E
GO

Sequence cautioni

The sequence AAN13462 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAN13464 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAO41538 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA64722 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA64723 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94S → G in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti94S → G in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti163V → G in CAA64724 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64722 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti411D → N in CAA64724 (PubMed:8627354).Curated1
Sequence conflicti735Q → K in CAA64723 (PubMed:8627354).Curated1
Sequence conflicti987S → G in CAA64723 (PubMed:8627354).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013200438 – 532NVCRP…GVRRD → VERLPSQHGADGSGQVALPL LGLFPSRESHGRGRGSNTTT PSWTKTRAHGWTTTDTGAYL TRRGFHWAAEQSQQHFGGAG GTLLVGTQHSGWGAS in isoform C. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_013201533 – 1025Missing in isoform C. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95453 mRNA Translation: CAA64722.1 Different initiation.
X95453 mRNA Translation: CAA64723.1 Different initiation.
X95454 mRNA Translation: CAA64724.1
AE014297 Genomic DNA Translation: AAN13462.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN13464.2 Sequence problems.
AE014297 Genomic DNA Translation: AAO41538.2 Sequence problems.
RefSeqiNP_731457.2, NM_169332.3
NP_788628.2, NM_176451.3
UniGeneiDm.6815

Genome annotation databases

GeneIDi41247
KEGGidme:Dmel_CG3985
UCSCiCG3985-RA d. melanogaster [Q24546-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYN_DROME
AccessioniPrimary (citable) accession number: Q24546
Secondary accession number(s): Q24544
, Q24545, Q86BA0, Q8INM4, Q8INM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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