Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High mobility group protein DSP1

Gene

Dsp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi179 – 249HMG box 1PROSITE-ProRule annotationAdd BLAST71
DNA bindingi271 – 339HMG box 2PROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • DNA binding, bending Source: FlyBase
  • single-stranded DNA binding Source: UniProtKB
  • TBP-class protein binding Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • chromatin remodeling Source: FlyBase
  • developmental process Source: FlyBase
  • DNA unwinding involved in DNA replication Source: UniProtKB
  • leg disc development Source: FlyBase
  • negative regulation of antimicrobial humoral response Source: FlyBase
  • negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • positive regulation of DNA binding Source: FlyBase
  • segment specification Source: FlyBase

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-211227 Activation of DNA fragmentation factor
R-DME-5686938 Regulation of TLR by endogenous ligand
R-DME-6798695 Neutrophil degranulation
SignaLinkiQ24537

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein DSP1
Alternative name(s):
Protein dorsal switch 1
Gene namesi
Name:Dsp1
Synonyms:ssrp2
ORF Names:CG12223
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0278608 Dsp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485431 – 393High mobility group protein DSP1Add BLAST393

Proteomic databases

PaxDbiQ24537
PRIDEiQ24537

Expressioni

Gene expression databases

BgeeiFBgn0011764
ExpressionAtlasiQ24537 differential
GenevisibleiQ24537 DM

Interactioni

GO - Molecular functioni

  • TBP-class protein binding Source: FlyBase
  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi72866, 18 interactors
DIPiDIP-29511N
IntActiQ24537, 7 interactors
STRINGi7227.FBpp0288398

Structurei

3D structure databases

ProteinModelPortaliQ24537
SMRiQ24537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 162Gln-richAdd BLAST156
Compositional biasi99 – 106Poly-Ala8
Compositional biasi376 – 391Asp/Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the HMGB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00760000119164
InParanoidiQ24537
KOiK10802
OMAiQWWYPGG

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017967 HMG_boxA_CS
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SUPFAMiSSF47095 SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS00353 HMG_BOX_1, 1 hit
PS50118 HMG_BOX_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform E (identifier: Q24537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHFHQIQQT IQHYQQQLAA QQQQQVQQQQ LQQHQVVVQQ NQQQAHQNSS
60 70 80 90 100
NTTAGVGTQQ LFTYKMASSF PNPATTMAQV VATSNAAGTT GYDYRLNMAQ
110 120 130 140 150
AAAAAAVPGS QWWYSAANQG QVDANTAAQL QHQQQQQQQQ QQQQQQQHQQ
160 170 180 190 200
QQQMQQQQQQ QNVINSASPM SRVKADAKPR GRMTAYAYFV QTCREEHKKK
210 220 230 240 250
HPDETVIFAE FSRKCAERWK TMVDKEKKRF HEMAEKDKQR YEAEMQNYVP
260 270 280 290 300
PKGAVVGRGK KRKQIKDPNA PKRSLSAFFW FCNDERNKVK ALNPEFGVGD
310 320 330 340 350
IAKELGRKWS DVDPEVKQKY ESMAERDKAR YEREMTEYKT SGKIAMSAPS
360 370 380 390
MQASMQAQAQ KAALLAAAAQ QQHQQLEEQH DDDDGDGDDD ENQ
Length:393
Mass (Da):44,935
Last modified:November 1, 1996 - v1
Checksum:iFD270250B723FD31
GO
Isoform D (identifier: Q24537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-14: Missing.

Show »
Length:386
Mass (Da):44,036
Checksum:iF0B018B47D2ECE54
GO
Isoform A (identifier: Q24537-3) [UniParc]FASTAAdd to basket
Also known as: B, C

The sequence of this isoform differs from the canonical sequence as follows:
     8-15: Missing.

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):43,908
Checksum:iE1837A90D2F850F9
GO

Sequence cautioni

The sequence CAA57212 differs from that shown. Reason: Frameshift at position 31.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129Q → T in AAA50238 (PubMed:8072548).Curated1
Sequence conflicti255 – 257VVG → LWD in AAA50238 (PubMed:8072548).Curated3
Sequence conflicti368A → R in AAA50238 (PubMed:8072548).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0021848 – 15Missing in isoform A. 1 Publication8
Alternative sequenceiVSP_0021838 – 14Missing in isoform D. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13881 mRNA Translation: AAA50238.1
X89811 Genomic DNA Translation: CAA61938.1
X81456 mRNA Translation: CAA57212.1 Frameshift.
AE014298 Genomic DNA Translation: AAF48594.2
AE014298 Genomic DNA Translation: AAN09394.2
AE014298 Genomic DNA Translation: AAN09395.1
AE014298 Genomic DNA Translation: AAN09396.1
AE014298 Genomic DNA Translation: AAS65386.1
AY060841 mRNA Translation: AAL28389.1
PIRiJC6179
S50068
RefSeqiNP_001285322.1, NM_001298393.1 [Q24537-2]
NP_542446.2, NM_080715.4 [Q24537-3]
NP_727959.2, NM_167502.3 [Q24537-2]
NP_727960.1, NM_167503.3 [Q24537-3]
NP_727961.1, NM_167504.2 [Q24537-3]
NP_996485.1, NM_206762.3 [Q24537-1]
UniGeneiDm.2879

Genome annotation databases

EnsemblMetazoaiFBtr0089259; FBpp0088318; FBgn0278608 [Q24537-3]
FBtr0089260; FBpp0088319; FBgn0278608 [Q24537-3]
FBtr0089261; FBpp0088320; FBgn0278608 [Q24537-3]
FBtr0089262; FBpp0089257; FBgn0278608 [Q24537-2]
FBtr0089263; FBpp0089258; FBgn0278608 [Q24537-1]
FBtr0339766; FBpp0308813; FBgn0278608 [Q24537-2]
GeneIDi117294
KEGGidme:Dmel_CG12223
UCSCiCG12223-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHMG2_DROME
AccessioniPrimary (citable) accession number: Q24537
Secondary accession number(s): A4V4L8
, Q23998, Q24285, Q95SD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health