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Protein

Protein singed

Gene

sn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Probably acts as an actin bundling protein. May have a role in the asymmetric organization and/or movement of cytoplasmic components. It has a role in somatic cells during the formation of adult bristles and hairs, and in the female germline during oogenesis.

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • actin filament organization Source: FlyBase
  • antennal morphogenesis Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • cuticle pattern formation Source: FlyBase
  • dendrite development Source: FlyBase
  • epidermal cell differentiation Source: FlyBase
  • establishment or maintenance of cell polarity Source: FlyBase
  • filopodium assembly Source: FlyBase
  • hemocyte migration Source: FlyBase
  • imaginal disc-derived wing hair organization Source: FlyBase
  • microvillar actin bundle assembly Source: FlyBase
  • neuron projection morphogenesis Source: FlyBase
  • oogenesis Source: FlyBase
  • wound healing Source: FlyBase

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Oogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein singed
Gene namesi
Name:sn
ORF Names:CG1536
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003447. sn.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: FlyBase
  • cytoplasm Source: FlyBase
  • neuronal cell body Source: FlyBase
  • neuron projection Source: FlyBase

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193871 – 512Protein singedAdd BLAST512

Proteomic databases

PaxDbiQ24524.
PRIDEiQ24524.

Expressioni

Gene expression databases

BgeeiFBgn0003447.
ExpressionAtlasiQ24524. differential.
GenevisibleiQ24524. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58189. 4 interactors.
MINTiMINT-295848.
STRINGi7227.FBpp0290893.

Structurei

3D structure databases

ProteinModelPortaliQ24524.
SMRiQ24524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E. Eukaryota.
ENOG410XPHV. LUCA.
InParanoidiQ24524.
KOiK17455.
OMAiCTAKAPG.
OrthoDBiEOG091G0C6S.
PhylomeDBiQ24524.

Family and domain databases

CDDicd00257. Fascin. 4 hits.
InterProiView protein in InterPro
IPR008999. Actin_cross-linking.
IPR010431. Fascin.
IPR022768. Fascin-domain.
IPR024703. Fascin_metazoans.
PANTHERiPTHR10551. PTHR10551. 1 hit.
PfamiView protein in Pfam
PF06268. Fascin. 4 hits.
PIRSFiPIRSF005682. Fascin. 1 hit.
SUPFAMiSSF50405. SSF50405. 4 hits.

Sequencei

Sequence statusi: Complete.

Q24524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGQGCELGH SNGDIISQNQ QKGWWTIGLI NGQHKYMTAE TFGFKLNANG
60 70 80 90 100
ASLKKKQLWT LEPSNTGESI IYLRSHLNKY LSVDQFGNVL CESDERDAGS
110 120 130 140 150
RFQISISEDG SGRWALKNES RGYFLGGTPD KLVCTAKTPG ASEFWTVHLA
160 170 180 190 200
ARPQVNLRSI GRKRFAHLSE SQDEIHVDAN IPWGEDTLFT LEFRAEEGGR
210 220 230 240 250
YALHTCNNKY LNANGKLQVV CNEDCLFSAE YHGGHLALRD RQGQYLSPIG
260 270 280 290 300
SKAVLKSRSS SVTRDELFSL EDSLPQASFI AGLNLRYVSV KQGVDVTANQ
310 320 330 340 350
DEVGENETFQ LEYDWSAHRW ALRTTQDRYW CLSAGGGIQA TGNRRCADAL
360 370 380 390 400
FELIWHGDGS LSFRANNGKF LATKRSGHLF ATSESIEEIA KFYFYLINRP
410 420 430 440 450
ILVLKCEQGF VGYRTPGNLK LECNKATYET ILVERAQKGL VHLKAHSGKY
460 470 480 490 500
WRIEGESISV DADAPSDGFF LELREPTRIC IRSQQGKYLG ATKNGAFKLL
510
DDGTDSATQW EF
Length:512
Mass (Da):57,279
Last modified:November 1, 1996 - v1
Checksum:iA021886A9C7B6C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17549, X17550 Genomic DNA. Translation: CAA35585.1.
AE014298 Genomic DNA. Translation: AAF46307.1.
RefSeqiNP_001162697.1. NM_001169226.2.
NP_511076.3. NM_078521.3.
NP_727226.1. NM_167142.3.
NP_727227.1. NM_167143.3.
UniGeneiDm.7274.

Genome annotation databases

EnsemblMetazoaiFBtr0071101; FBpp0071057; FBgn0003447.
FBtr0071102; FBpp0071058; FBgn0003447.
FBtr0301677; FBpp0290891; FBgn0003447.
FBtr0301679; FBpp0290893; FBgn0003447.
GeneIDi31717.
KEGGidme:Dmel_CG32858.
UCSCiCG32858-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSING_DROME
AccessioniPrimary (citable) accession number: Q24524
Secondary accession number(s): Q9W3L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families