Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Receptor protein tyrosine phosphatase

Gene

Ptp4E

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • open tracheal system development Source: FlyBase
  • protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor protein tyrosine phosphataseImported
Gene namesi
Name:Ptp4EImported
ORF Names:CG6899Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0004368. Ptp4E.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1254 – 127522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: FlyBase
  • axon Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ24495.
PRIDEiQ24495.

Expressioni

Gene expression databases

BgeeiQ24495.
ExpressionAtlasiQ24495. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070692.

Structurei

3D structure databases

ProteinModelPortaliQ24495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 15296Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini153 – 24593Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini246 – 34297Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini433 – 53199Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini532 – 62392Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini708 – 80699Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini811 – 90191Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini902 – 99190Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1006 – 1106101Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1329 – 1584256Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1501 – 157575TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
OrthoDBiEOG7PCJFZ.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCATRKQQQ LRAHHQQQQI QIQTHGRKRQ QLQKQRHNHH HYYQNPQQQQ
60 70 80 90 100
KHFVWLVVGI LTIFLARHAN AADLVINVPN ASSNANAFYR IDYSAPFGFP
110 120 130 140 150
EPNTTIPASD IGKDIKNSRA LPGTEYNFWL YYTNSTHREQ LTWTVNITTA
160 170 180 190 200
PDPPANLSVQ LRSSKSAFIT WRPPGSGRYS GFRIRVLGLT DLPFERSYSL
210 220 230 240 250
EGNETLQLSA KELTPGGSYQ VQAYSVYQGK ESVAYTSRNF TTKPNTPGKF
260 270 280 290 300
IVWFRNETTL LVLWQPPFPA GIYTHYRVSI TPDDAIQSVL YVEREGEPPG
310 320 330 340 350
PAQAAFKGLV PGREYNISVQ TVSEDETSSV PTTARYLTYR SAWLNVTFDE
360 370 380 390 400
AYTTSSSFRV RWEPPRTYSE FDAYQVMLST SRRIFNVPRA ANGDSVYFDY
410 420 430 440 450
SDILEPGRTY EVVVKTIADN VNSWPASGEV TLRPRPVRSL GGFLDDRSNA
460 470 480 490 500
LHISWEPAET GRQDSYRISY HEQTNASEVP APFPVAAESQ ITTNLTEYTL
510 520 530 540 550
DSLLAGRRYL IAVQALSKGV ASNASDITRY TRPAAPLIQE LRSIDQGLML
560 570 580 590 600
SWRSDVNSRQ DRYEVHYQRN GTREERTMAT NETSLTIHYL HPGSGYEVKV
610 620 630 640 650
HAISHGVRSE PHSYFQAVFP KPPQNLTLQT VHTNLVVLHW QAPEGSDFSE
660 670 680 690 700
YVVRYRTDAS PWQRISGLHE NEARIKDMHY GERYLVQVNT VSFGVESPHP
710 720 730 740 750
LELNVTMPPQ PVSNVVPLVD SRNLTLEWPR PDGHVDFYTL KWWPTDEEDR
760 770 780 790 800
VEFKNVTQLE DLSSPSVRIP IEDLSPGRQY RFEVQASSNG IRSGTTHLST
810 820 830 840 850
RTMPLIQSDV FIANAGHEQG QDETITLSYT PTPADSTRFD IYRFSMGDPT
860 870 880 890 900
IKDKEKLAND TERKLSFSGL TPGKLYNVTV WTVSGGVASL PVQRVYRLHP
910 920 930 940 950
LPISDLKAIQ VAAREITLHW TAPAGEYTDF ELQYLSADEE APQLLQNVTK
960 970 980 990 1000
NTEITLQGLR PYHNYTFTVV VRSGSIQGTD FADVSVSTLM RSSAPISASY
1010 1020 1030 1040 1050
QTLTAPPGKV DYFQPSDVQP GEVTFEWSLE PAEQHGPIDY FRITCQNADD
1060 1070 1080 1090 1100
AADVSSYEFP VNATQGKIDG LVPGNHYIFR IQAKSALGYG AEREHIQTMP
1110 1120 1130 1140 1150
ILAPPVPEPS VTPLEVSRTS STIEISFRQG YFSNAHGMVR SYTIIIAEDV
1160 1170 1180 1190 1200
GKIASGLEMP SWQDVQAYTV WLPYQAIEPY NPFLTSNGSR KSSLEAEHLT
1210 1220 1230 1240 1250
IGTANCDKHQ AGYCNGPLRA GTTYRIKIRA FTDEDKFTDT VYSSPITTER
1260 1270 1280 1290 1300
SDTVIVAATV SAVLLVAMVL VVVYCQHRCQ LIRRASKLAR MQDELAALPE
1310 1320 1330 1340 1350
AYITPNRPVH VKDFSEHYRI MSADSDFRFS EEFEELKHVG RDQACSFANL
1360 1370 1380 1390 1400
PCNRPKNRFT NILPYDHSRF KLQPVDDDDG SDYINANYMP GHNSPREFIV
1410 1420 1430 1440 1450
TQGPFHSTRE EFWRMCWESN SRAIVMLTRC FEKGREKCDQ YWPVDRVAMF
1460 1470 1480 1490 1500
YGDIKVQLII DTHYHDWSIS EFMVSRNCES RIMRHFHFTT WPDFGVPEPP
1510 1520 1530 1540 1550
LSLVRFVRAF RDVIGTDMRP IIVHCSAGVG RSGTFIALDR ILQHIHKSDY
1560 1570 1580 1590 1600
VDIFGIVFAM RKERVFMVQT EQQYVCIHQC LLAVLEGKEH LLADSLELHA
1610 1620 1630 1640 1650
NDGYEVTKIY LERQPQTKMG TLPIRASLAM AEKLDADLMT NKDEDEDQEQ
1660 1670 1680 1690 1700
QHEQQLQLAT EVKPKGSNDD EEDEEDDDDD DDDQQPLNNE TTATLSSASC
1710 1720 1730 1740 1750
SSSTHDVHVV LQEAIEQPKQ EQERICAGTQ SHADTESDNT DSDDDDEDGD
1760
GKVAKDGAVA DEDGWWY
Length:1,767
Mass (Da):200,121
Last modified:November 1, 1996 - v1
Checksum:i70E06692B8D4B89C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20894 mRNA. Translation: AAA76834.1.
PIRiA49502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20894 mRNA. Translation: AAA76834.1.
PIRiA49502.

3D structure databases

ProteinModelPortaliQ24495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070692.

Proteomic databases

PaxDbiQ24495.
PRIDEiQ24495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0004368. Ptp4E.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
OrthoDBiEOG7PCJFZ.

Miscellaneous databases

ChiTaRSiPtp4E. fly.

Gene expression databases

BgeeiQ24495.
ExpressionAtlasiQ24495. differential.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 8 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 11 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative splicing in a novel tyrosine phosphatase gene (DPTP4E) of Drosophila melanogaster generates two large receptor-like proteins which differ in their carboxyl termini."
    Oon S.H., Hong A., Yang X., Chia W.
    J. Biol. Chem. 268:23964-23971(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ24495_DROME
AccessioniPrimary (citable) accession number: Q24495
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.