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Protein

Tyrosine-protein kinase transmembrane receptor Ror

Gene

Ror

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei442ATPPROSITE-ProRule annotation1
Active sitei539Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi416 – 424ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 1994

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor Ror (EC:2.7.10.1)
Short name:
dRor
Gene namesi
Name:Ror
ORF Names:CG4926
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010407 Ror

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 317ExtracellularSequence analysisAdd BLAST293
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 685CytoplasmicSequence analysisAdd BLAST347

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002446225 – 685Tyrosine-protein kinase transmembrane receptor RorAdd BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 106By similarity
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 99By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 192By similarity
Modified residuei112Phosphothreonine1 Publication1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei131Phosphoserine1 Publication1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 222By similarity
Disulfide bondi184 ↔ 213By similarity
Disulfide bondi237 ↔ 310By similarity
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi258 ↔ 292By similarity
Disulfide bondi280 ↔ 305By similarity
Modified residuei565Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei569Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei570Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ24488
PRIDEiQ24488

PTM databases

iPTMnetiQ24488

Expressioni

Tissue specificityi

Expressed in neurons of the developing nervous system.1 Publication

Gene expression databases

BgeeiFBgn0010407
ExpressionAtlasiQ24488 baseline and differential
GenevisibleiQ24488 DM

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079568

Structurei

3D structure databases

ProteinModelPortaliQ24488
SMRiQ24488
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 225FZPROSITE-ProRule annotationCuratedAdd BLAST190
Domaini236 – 310KringlePROSITE-ProRule annotationAdd BLAST75
Domaini410 – 677Protein kinasePROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
InParanoidiQ24488
KOiK05122
OMAiECWHEQS
OrthoDBiEOG091G02W3
PhylomeDBiQ24488

Family and domain databases

Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00130 KR, 1 hit
SM00220 S_TKc, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYSAFIVC ISLVLLFTKK DVGSHNVDSR IYGFQQSSGI CHIYNGTICR
60 70 80 90 100
DVLSNAHVFV SPNLTMNDLE ERLKAAYGVI KESKDMNANC RMYALPSLCF
110 120 130 140 150
SSMPICRTPE RTNLLYFANV ATNAKQLKNV SIRRKRTKSK DIKNISIFKK
160 170 180 190 200
KSTIYEDVFS TDISSKYPPT RESENLKRIC REECELLENE LCQKEYAIAK
210 220 230 240 250
RHPVIGMVGV EDCQKLPQHK DCLSLGITIE VDKTENCYWE DGSTYRGVAN
260 270 280 290 300
VSASGKPCLR WSWLMKEISD FPELIGQNYC RNPGSVENSP WCFVDSSRER
310 320 330 340 350
IIELCDIPKC ADKIWIAIVG TTAAIILIFI IIFAIILFKR RTIMHYGMRN
360 370 380 390 400
IHNINTPSAD KNIYGNSQLN NAQDAGRGNL GNLSDHVALN SKLIERNTLL
410 420 430 440 450
RINHFTLQDV EFLEELGEGA FGKVYKGQLL QPNKTTITVA IKALKENASV
460 470 480 490 500
KTQQDFKREI ELISDLKHQN IVCILGVVLN KEPYCMLFEY MANGDLHEFL
510 520 530 540 550
ISNSPTEGKS LSQLEFLQIA LQISEGMQYL SAHHYVHRDL AARNCLVNEG
560 570 580 590 600
LVVKISDFGL SRDIYSSDYY RVQSKSLLPV RWMPSESILY GKFTTESDVW
610 620 630 640 650
SFGVVLWEIY SYGMQPYYGF SNQEVINLIR SRQLLSAPEN CPTAVYSLMI
660 670 680
ECWHEQSVKR PTFTDISNRL KTWHEGHFKA SNPEM
Length:685
Mass (Da):78,143
Last modified:November 1, 1996 - v1
Checksum:i526162D27D5FD7C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20297 mRNA Translation: AAA28860.1
AE014134 Genomic DNA Translation: AAF52885.1
AJ002908 Genomic DNA Translation: CAA05743.1
PIRiA48289
RefSeqiNP_476962.1, NM_057614.3
UniGeneiDm.4808

Genome annotation databases

EnsemblMetazoaiFBtr0079978; FBpp0079568; FBgn0010407
GeneIDi34367
KEGGidme:Dmel_CG4926
UCSCiCG4926-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiROR1_DROME
AccessioniPrimary (citable) accession number: Q24488
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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