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Protein

Tyrosine-protein kinase transmembrane receptor Ror

Gene

Ror

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei442 – 4421ATPPROSITE-ProRule annotation
Active sitei539 – 5391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi416 – 4249ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transmembrane receptor Ror (EC:2.7.10.1)
Short name:
dRor
Gene namesi
Name:Ror
ORF Names:CG4926
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010407. Ror.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 317293ExtracellularSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Topological domaini339 – 685347CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 685661Tyrosine-protein kinase transmembrane receptor RorPRO_0000024462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 106By similarity
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 99By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi90 ↔ 192By similarity
Modified residuei112 – 1121Phosphothreonine1 Publication
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Modified residuei131 – 1311Phosphoserine1 Publication
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi180 ↔ 222By similarity
Disulfide bondi184 ↔ 213By similarity
Disulfide bondi237 ↔ 310By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi258 ↔ 292By similarity
Disulfide bondi280 ↔ 305By similarity
Modified residuei565 – 5651Phosphotyrosine; by autocatalysisBy similarity
Modified residuei569 – 5691Phosphotyrosine; by autocatalysisBy similarity
Modified residuei570 – 5701Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ24488.
PRIDEiQ24488.

PTM databases

iPTMnetiQ24488.

Expressioni

Tissue specificityi

Expressed in neurons of the developing nervous system.1 Publication

Gene expression databases

BgeeiFBgn0010407.
ExpressionAtlasiQ24488. differential.
GenevisibleiQ24488. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079568.

Structurei

3D structure databases

ProteinModelPortaliQ24488.
SMRiQ24488. Positions 156-313, 365-671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 225190FZPROSITE-ProRule annotationCuratedAdd
BLAST
Domaini236 – 31075KringlePROSITE-ProRule annotationAdd
BLAST
Domaini410 – 677268Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.PROSITE-ProRule annotation
Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
InParanoidiQ24488.
KOiK05122.
OMAiWAEFQQE.
OrthoDBiEOG091G02W3.
PhylomeDBiQ24488.

Family and domain databases

InterProiIPR020067. Frizzled_dom.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00130. KR. 1 hit.
SM00220. S_TKc. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYSAFIVC ISLVLLFTKK DVGSHNVDSR IYGFQQSSGI CHIYNGTICR
60 70 80 90 100
DVLSNAHVFV SPNLTMNDLE ERLKAAYGVI KESKDMNANC RMYALPSLCF
110 120 130 140 150
SSMPICRTPE RTNLLYFANV ATNAKQLKNV SIRRKRTKSK DIKNISIFKK
160 170 180 190 200
KSTIYEDVFS TDISSKYPPT RESENLKRIC REECELLENE LCQKEYAIAK
210 220 230 240 250
RHPVIGMVGV EDCQKLPQHK DCLSLGITIE VDKTENCYWE DGSTYRGVAN
260 270 280 290 300
VSASGKPCLR WSWLMKEISD FPELIGQNYC RNPGSVENSP WCFVDSSRER
310 320 330 340 350
IIELCDIPKC ADKIWIAIVG TTAAIILIFI IIFAIILFKR RTIMHYGMRN
360 370 380 390 400
IHNINTPSAD KNIYGNSQLN NAQDAGRGNL GNLSDHVALN SKLIERNTLL
410 420 430 440 450
RINHFTLQDV EFLEELGEGA FGKVYKGQLL QPNKTTITVA IKALKENASV
460 470 480 490 500
KTQQDFKREI ELISDLKHQN IVCILGVVLN KEPYCMLFEY MANGDLHEFL
510 520 530 540 550
ISNSPTEGKS LSQLEFLQIA LQISEGMQYL SAHHYVHRDL AARNCLVNEG
560 570 580 590 600
LVVKISDFGL SRDIYSSDYY RVQSKSLLPV RWMPSESILY GKFTTESDVW
610 620 630 640 650
SFGVVLWEIY SYGMQPYYGF SNQEVINLIR SRQLLSAPEN CPTAVYSLMI
660 670 680
ECWHEQSVKR PTFTDISNRL KTWHEGHFKA SNPEM
Length:685
Mass (Da):78,143
Last modified:November 1, 1996 - v1
Checksum:i526162D27D5FD7C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20297 mRNA. Translation: AAA28860.1.
AE014134 Genomic DNA. Translation: AAF52885.1.
AJ002908 Genomic DNA. Translation: CAA05743.1.
PIRiA48289.
RefSeqiNP_476962.1. NM_057614.3.
UniGeneiDm.4808.

Genome annotation databases

EnsemblMetazoaiFBtr0079978; FBpp0079568; FBgn0010407.
GeneIDi34367.
KEGGidme:Dmel_CG4926.
UCSCiCG4926-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20297 mRNA. Translation: AAA28860.1.
AE014134 Genomic DNA. Translation: AAF52885.1.
AJ002908 Genomic DNA. Translation: CAA05743.1.
PIRiA48289.
RefSeqiNP_476962.1. NM_057614.3.
UniGeneiDm.4808.

3D structure databases

ProteinModelPortaliQ24488.
SMRiQ24488. Positions 156-313, 365-671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079568.

PTM databases

iPTMnetiQ24488.

Proteomic databases

PaxDbiQ24488.
PRIDEiQ24488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079978; FBpp0079568; FBgn0010407.
GeneIDi34367.
KEGGidme:Dmel_CG4926.
UCSCiCG4926-RA. d. melanogaster.

Organism-specific databases

CTDi34367.
FlyBaseiFBgn0010407. Ror.

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
InParanoidiQ24488.
KOiK05122.
OMAiWAEFQQE.
OrthoDBiEOG091G02W3.
PhylomeDBiQ24488.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.

Miscellaneous databases

GenomeRNAii34367.
PROiQ24488.

Gene expression databases

BgeeiFBgn0010407.
ExpressionAtlasiQ24488. differential.
GenevisibleiQ24488. DM.

Family and domain databases

InterProiIPR020067. Frizzled_dom.
IPR011009. Kinase-like_dom.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00130. KR. 1 hit.
SM00220. S_TKc. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROR1_DROME
AccessioniPrimary (citable) accession number: Q24488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.