Q24488 (ROR1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transmembrane receptor Ror
Short name=dRor
EC=2.7.10.1

Gene names

Name:	Ror
ORF Names:	CG4926

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	685 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tyrosine-protein kinase receptor that functions during early stages of neuronal development. Ref.1
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in neurons of the developing nervous system. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Contains 1 FZ (frizzled) domain. Contains 1 kringle domain. UniProtKB Q01973 Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Kringle Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	central nervous system development Inferred from expression pattern Ref.1. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 685	661	Tyrosine-protein kinase transmembrane receptor Ror		PRO_0000024462
Regions
	Topological domain	25 – 317	293	Extracellular Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Topological domain	339 – 685	347	Cytoplasmic Potential
	Domain	36 – 225	190	FZ
	Domain	236 – 310	75	Kringle
	Domain	410 – 677	268	Protein kinase
	Nucleotide binding	416 – 424	9	ATP By similarity
Sites
	Active site	539	1	Proton acceptor By similarity
	Binding site	442	1	ATP By similarity
Amino acid modifications
	Modified residue	112	1	Phosphothreonine Ref.5
	Modified residue	131	1	Phosphoserine Ref.5
	Modified residue	565	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	569	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	570	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	129	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	250	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 106		By similarity
	Disulfide bond	49 ↔ 99		By similarity
	Disulfide bond	90 ↔ 192		By similarity
	Disulfide bond	180 ↔ 222		By similarity
	Disulfide bond	184 ↔ 213		By similarity
	Disulfide bond	237 ↔ 310		By similarity
	Disulfide bond	258 ↔ 292		By similarity
	Disulfide bond	280 ↔ 305		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q24488 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 526162D27D5FD7C7	FASTA	685	78,143
	10 20 30 40 50 60 MNKYSAFIVC ISLVLLFTKK DVGSHNVDSR IYGFQQSSGI CHIYNGTICR DVLSNAHVFV 70 80 90 100 110 120 SPNLTMNDLE ERLKAAYGVI KESKDMNANC RMYALPSLCF SSMPICRTPE RTNLLYFANV 130 140 150 160 170 180 ATNAKQLKNV SIRRKRTKSK DIKNISIFKK KSTIYEDVFS TDISSKYPPT RESENLKRIC 190 200 210 220 230 240 REECELLENE LCQKEYAIAK RHPVIGMVGV EDCQKLPQHK DCLSLGITIE VDKTENCYWE 250 260 270 280 290 300 DGSTYRGVAN VSASGKPCLR WSWLMKEISD FPELIGQNYC RNPGSVENSP WCFVDSSRER 310 320 330 340 350 360 IIELCDIPKC ADKIWIAIVG TTAAIILIFI IIFAIILFKR RTIMHYGMRN IHNINTPSAD 370 380 390 400 410 420 KNIYGNSQLN NAQDAGRGNL GNLSDHVALN SKLIERNTLL RINHFTLQDV EFLEELGEGA 430 440 450 460 470 480 FGKVYKGQLL QPNKTTITVA IKALKENASV KTQQDFKREI ELISDLKHQN IVCILGVVLN 490 500 510 520 530 540 KEPYCMLFEY MANGDLHEFL ISNSPTEGKS LSQLEFLQIA LQISEGMQYL SAHHYVHRDL 550 560 570 580 590 600 AARNCLVNEG LVVKISDFGL SRDIYSSDYY RVQSKSLLPV RWMPSESILY GKFTTESDVW 610 620 630 640 650 660 SFGVVLWEIY SYGMQPYYGF SNQEVINLIR SRQLLSAPEN CPTAVYSLMI ECWHEQSVKR 670 680 PTFTDISNRL KTWHEGHFKA SNPEM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases." Wilson C., Goberdhan D.C.I., Steller H. Proc. Natl. Acad. Sci. U.S.A. 90:7109-7113(1993) [PubMed: 8394009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Canton-S. Tissue: Larval brain.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA." Oates A.C., Wollberg P., Achen M.G., Wilks A.F. Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed: 9731193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 545-597.
[5]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-112 AND SER-131, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L20297 mRNA. Translation: AAA28860.1. AE014134 Genomic DNA. Translation: AAF52885.1. AJ002908 Genomic DNA. Translation: CAA05743.1.
PIR	A48289.
RefSeq	NP_476962.1. NM_057614.2.
UniGene	Dm.4808.
3D structure databases
ProteinModelPortal	Q24488.
SMR	Q24488. Positions 176-313, 403-673.
ModBase	Search...
Protein-protein interaction databases
STRING	Q24488.
Proteomic databases
PRIDE	Q24488.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0079978; FBpp0079568; FBgn0010407.
GeneID	34367.
KEGG	dme:Dmel_CG4926.
NMPDR	fig|7227.3.peg.1747.
UCSC	CG4926-RA. d. melanogaster.
Organism-specific databases
CTD	34367.
FlyBase	FBgn0010407. Ror.
Phylogenomic databases
eggNOG	inNOG06945.
GeneTree	EMGT00050000002732.
InParanoid	Q24488.
OMA	YCMLFEY.
OrthoDB	EOG4G1JXC.
PhylomeDB	Q24488.
Enzyme and pathway databases
BRENDA	2.7.10.1. 1994.
Gene expression databases
Bgee	Q24488.
GermOnline	CG4926. Drosophila melanogaster.
Family and domain databases
InterPro	IPR020067. Frizzled_dom. IPR011009. Kinase-like_dom. IPR000001. Kringle. IPR013806. Kringle-like. IPR018056. Kringle_CS. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Gene3D	G3DSA:2.40.20.10. Kringle. 1 hit.
KO	K05122.
Pfam	PF00051. Kringle. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00018. KRINGLE. PR00109. TYRKINASE.
SMART	SM00130. KR. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF57440. Kringle-like. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS00021. KRINGLE_1. 1 hit. PS50070. KRINGLE_2. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	788146.

Entry information

Entry name

ROR1_DROME

Accession

Primary (citable) accession number: Q24488

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project