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Q24478

- CP190_DROME

UniProt

Q24478 - CP190_DROME

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Protein

Centrosome-associated zinc finger protein CP190

Gene

Cp190

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri538 – 56124C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. chromatin insulator sequence binding Source: FlyBase
  3. DNA binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. microtubule binding Source: UniProtKB
  6. POZ domain binding Source: FlyBase

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. gene looping Source: FlyBase
  3. microtubule-based process Source: FlyBase
  4. nuclear axial expansion Source: FlyBase
  5. positive regulation of chromatin silencing Source: FlyBase
  6. regulation of cytoskeleton organization Source: UniProtKB
  7. regulation of gene expression Source: FlyBase
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ24478.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosome-associated zinc finger protein CP190
Alternative name(s):
Protein enhancer of mod(mdg4)4-1
dMAP190
Gene namesi
Name:Cp190
Synonyms:E(mod)4-1
ORF Names:CG6384
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000283. Cp190.

Subcellular locationi

Nucleus. Cytoplasmcytoskeleton. Chromosome
Note: Nucleus in interphase. Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. microtubule Source: UniProtKB-KW
  4. microtubule associated complex Source: FlyBase
  5. nucleus Source: UniProtKB
  6. polytene chromosome Source: UniProtKB
  7. polytene chromosome band Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10961096Centrosome-associated zinc finger protein CP190PRO_0000232629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971Phosphoserine1 Publication
Modified residuei211 – 2111Phosphoserine1 Publication
Modified residuei229 – 2291Phosphothreonine1 Publication
Modified residuei233 – 2331Phosphoserine1 Publication
Modified residuei298 – 2981Phosphoserine1 Publication
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei603 – 6031Phosphothreonine1 Publication
Modified residuei610 – 6101Phosphoserine1 Publication
Modified residuei708 – 7081Phosphoserine1 Publication
Modified residuei723 – 7231Phosphoserine1 Publication
Modified residuei727 – 7271Phosphothreonine1 Publication
Modified residuei745 – 7451Phosphoserine1 Publication
Modified residuei748 – 7481Phosphoserine1 Publication
Modified residuei757 – 7571Phosphoserine1 Publication
Modified residuei760 – 7601Phosphoserine1 Publication
Modified residuei817 – 8171Phosphothreonine1 Publication
Modified residuei920 – 9201Phosphoserine2 Publications
Modified residuei925 – 9251Phosphoserine1 Publication
Modified residuei927 – 9271Phosphoserine1 Publication
Modified residuei936 – 9361Phosphothreonine1 Publication
Modified residuei938 – 9381Phosphoserine1 Publication
Modified residuei1071 – 10711Phosphoserine1 Publication
Modified residuei1074 – 10741Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24478.
PRIDEiQ24478.

Expressioni

Tissue specificityi

Expressed in spermatids but not in mature spermatozoa. Localizes within the spermatids to a sheath of microtubules around the nucleus and to microtubules within the tail.1 Publication

Developmental stagei

Localizes to the centrosome throughout the nuclear division cycle in early syncytial embryos. Localization to the interphase nucleus is seen from nuclear cycle 9 onwards.4 Publications

Gene expression databases

BgeeiQ24478.

Interactioni

Subunit structurei

Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw). Interacts with Cp60 and microtubules.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTCFQ8TA445EBI-868840,EBI-466743
Dmel_CG8436Q9VHG53EBI-868840,EBI-141691
Dmel_CG9740Q9VHG63EBI-868840,EBI-157022
mod(mdg4)Q86B87-14EBI-868840,EBI-1433422
su(Hw)P089704EBI-868840,EBI-101373

Protein-protein interaction databases

BioGridi66912. 11 interactions.
IntActiQ24478. 13 interactions.
MINTiMINT-1899376.
STRINGi7227.FBpp0082580.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4U77X-ray2.03A1-134[»]
ProteinModelPortaliQ24478.
SMRiQ24478. Positions 368-405, 467-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9768BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 27165Nuclear localizationAdd
BLAST
Regioni385 – 508124Centrosomal localization and interaction with microtubulesAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri538 – 56124C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri567 – 59024C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG279218.
InParanoidiQ24478.
OMAiINTHKET.
OrthoDBiEOG7992PZ.
PhylomeDBiQ24478.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEVKSVKVD NWGVFFLQKL QNFFNKTDYC DLTLQFRDNS QLKVHRLVLS
60 70 80 90 100
ACTDYFNVLE QTCEIVDDAL IMPNEFQADV VVPIVNFMYT GTLEFELKMY
110 120 130 140 150
GKLLRTAKEM NMTVLLKLLE AHRRTMENVN RQQRPPSPKG IRRRTVGQPS
160 170 180 190 200
SGLPQQRVLG PSPQSRNVAT PIAQRANTQR GSTGNTMSRT SGGSNRSPYG
210 220 230 240 250
DSSNVKQEPT SPFEQLRKGY NNNKRPAQTS LLSPPSKKPS LEEVKEFAEQ
260 270 280 290 300
QRMRKQIAAE YGDNDPEYDG GMLYDDVHAG DDDDDDMPPQ PSTSKQQSPQ
310 320 330 340 350
GTQTQLEHGS TTIILKQDSP SQTPTIIVKD SSNAKLNHTK IIAEVLRQYP
360 370 380 390 400
HIVKGHKNIK LKIMPNTPAA PTEKSAPATV KPPANQSSAT TSPHKKLHVS
410 420 430 440 450
FKADKSTPLI TAQQKAASSQ QKSGTSQTTG NQGTGANPPA NTAAAQKRRI
460 470 480 490 500
DSKTMHALIA QGAENTTGPW LCLRCGVNGR PISIPSYRGF RRHLINTHKE
510 520 530 540 550
TIDPALCEHC GWRSVNNREL HFHMYMEHQT KSLLYTFAEC ALCNQSYRTK
560 570 580 590 600
GELEAHINEV HTDDNKQQCI YCNKVFEQEL QLYRHMKSYH KEQALEDGII
610 620 630 640 650
DETDEEFLGS QDEEEEAEGD EEQEPEQTGK VRILSDISLP ATSAITVQQA
660 670 680 690 700
QQEQLQEEDV EQVQQEVKFV GADGNEVELT DEQRKEILSQ LNQQQAGATA
710 720 730 740 750
GGVVMVLSEP EAEHVKQETD EKSLAGTEEE YDDSQIYSEL GAADSVESAK
760 770 780 790 800
KNIADESKES IDNLEWAENL IAESEEQSNK EPKSDKPRDD ISEKLKELTG
810 820 830 840 850
DWTEDENDDD VDDKPATAEL ASELANKDPE PTVHEEEDDI DLALQSLHKG
860 870 880 890 900
PEEATEEKAS EESVTSADDA VDAVPNINSQ PEKMDVDSEA ADEKASKAEV
910 920 930 940 950
QIKKEAELEN DQEEFIKEDS PIPHSDSVAE LREAVTASEG EDDVHLEADN
960 970 980 990 1000
IRKELLDELI AEAEKPDQEK DIVQSEENAT TEALDRSVTD EDDLVPPTQV
1010 1020 1030 1040 1050
STEQMEIDEP AAEKAAENNE DTRTADEKEA VEDKPNQTQD VTTAEKPTLE
1060 1070 1080 1090
SAKAGDEATS GEAASVDKVK SLISEWGDDD EDEDENGVSA AAKEEL
Length:1,096
Mass (Da):121,679
Last modified:April 18, 2006 - v2
Checksum:i5CD5C5492B948D39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1061 – 10611G → D in CAA90324. (PubMed:8586650)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50021 mRNA. Translation: CAA90324.1.
AE014297 Genomic DNA. Translation: AAF55159.1.
AE014297 Genomic DNA. Translation: AAN13643.1.
BT010090 mRNA. Translation: AAQ22559.1.
PIRiT13802.
RefSeqiNP_524359.2. NM_079635.3.
NP_731998.1. NM_169632.2.
UniGeneiDm.2423.

Genome annotation databases

EnsemblMetazoaiFBtr0083126; FBpp0082580; FBgn0000283.
FBtr0083127; FBpp0082581; FBgn0000283.
GeneIDi41848.
KEGGidme:Dmel_CG6384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50021 mRNA. Translation: CAA90324.1 .
AE014297 Genomic DNA. Translation: AAF55159.1 .
AE014297 Genomic DNA. Translation: AAN13643.1 .
BT010090 mRNA. Translation: AAQ22559.1 .
PIRi T13802.
RefSeqi NP_524359.2. NM_079635.3.
NP_731998.1. NM_169632.2.
UniGenei Dm.2423.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4U77 X-ray 2.03 A 1-134 [» ]
ProteinModelPortali Q24478.
SMRi Q24478. Positions 368-405, 467-592.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66912. 11 interactions.
IntActi Q24478. 13 interactions.
MINTi MINT-1899376.
STRINGi 7227.FBpp0082580.

Proteomic databases

PaxDbi Q24478.
PRIDEi Q24478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0083126 ; FBpp0082580 ; FBgn0000283 .
FBtr0083127 ; FBpp0082581 ; FBgn0000283 .
GeneIDi 41848.
KEGGi dme:Dmel_CG6384.

Organism-specific databases

CTDi 41848.
FlyBasei FBgn0000283. Cp190.

Phylogenomic databases

eggNOGi NOG279218.
InParanoidi Q24478.
OMAi INTHKET.
OrthoDBi EOG7992PZ.
PhylomeDBi Q24478.

Enzyme and pathway databases

SignaLinki Q24478.

Miscellaneous databases

GenomeRNAii 41848.
NextBioi 825881.

Gene expression databases

Bgeei Q24478.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes."
    Whitfield W.G.F., Chaplin M.A., Oegema K., Parry H., Glover D.M.
    J. Cell Sci. 108:3377-3387(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Purification of a multiprotein complex containing centrosomal proteins from the Drosophila embryo by chromatography with low-affinity polyclonal antibodies."
    Kellogg D.R., Alberts B.M.
    Mol. Biol. Cell 3:1-11(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CP60, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  6. "Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs."
    Raff J.W., Kellogg D.R., Alberts B.M.
    J. Cell Biol. 121:823-835(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CP60 AND MICROTUBULES, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  7. "The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains."
    Oegema K., Whitfield W.G.F., Alberts B.M.
    J. Cell Biol. 131:1261-1273(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MICROTUBULES, SUBCELLULAR LOCATION.
  8. "CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner."
    Kellogg D.R., Oegema K., Raff J., Schneider K., Alberts B.M.
    Mol. Biol. Cell 6:1673-1684(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CP60, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  9. "Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190."
    Oegema K., Marshall W.F., Sedat J.W., Alberts B.M.
    J. Cell Sci. 110:1573-1583(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Assembly of the zygotic centrosome in the fertilized Drosophila egg."
    Riparbelli M.G., Whitfield W.G.F., Dallai R., Callaini G.
    Mech. Dev. 65:135-144(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds."
    Moritz M., Zheng Y., Alberts B.M., Oegema K.
    J. Cell Biol. 142:775-786(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CP60.
  12. "The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division."
    Butcher R.D.J., Chodagam S., Basto R., Wakefield J.G., Henderson D.S., Raff J.W., Whitfield W.G.F.
    J. Cell Sci. 117:1191-1199(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MICROTUBULES, SUBCELLULAR LOCATION.
  13. "Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells."
    Raynaud-Messina B., Mazzolini L., Moisand A., Cirinesi A.-M., Wright M.
    J. Cell Sci. 117:5497-5507(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "The centrosomal protein CP190 is a component of the gypsy chromatin insulator."
    Pai C.-Y., Lei E.P., Ghosh D., Corces V.G.
    Mol. Cell 16:737-748(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH MOD(MDG4) AND SU(HW), SUBCELLULAR LOCATION.
  15. "The centrosomal protein CP190 regulates myosin function during early Drosophila development."
    Chodagam S., Royou A., Whitfield W.G.F., Karess R., Raff J.W.
    Curr. Biol. 15:1308-1313(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  16. "The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator."
    Capelson M., Corces V.G.
    Mol. Cell 20:105-116(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  17. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-319; SER-920 AND SER-925, IDENTIFICATION BY MASS SPECTROMETRY.
  18. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; THR-229; SER-233; SER-298; THR-603; SER-610; SER-708; SER-723; THR-727; SER-745; SER-748; SER-757; SER-760; THR-817; SER-920; SER-927; THR-936; SER-938; SER-1071 AND SER-1074, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCP190_DROME
AccessioniPrimary (citable) accession number: Q24478
Secondary accession number(s): A4V2Y3, Q9VFA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3