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Q24478

- CP190_DROME

UniProt

Q24478 - CP190_DROME

Protein

Centrosome-associated zinc finger protein CP190

Gene

Cp190

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri538 – 56124C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 59024C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. chromatin insulator sequence binding Source: FlyBase
    3. DNA binding Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. microtubule binding Source: UniProtKB
    6. POZ domain binding Source: FlyBase
    7. protein binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. gene looping Source: FlyBase
    3. microtubule-based process Source: FlyBase
    4. nuclear axial expansion Source: FlyBase
    5. regulation of cytoskeleton organization Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ24478.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosome-associated zinc finger protein CP190
    Alternative name(s):
    Protein enhancer of mod(mdg4)4-1
    dMAP190
    Gene namesi
    Name:Cp190
    Synonyms:E(mod)4-1
    ORF Names:CG6384
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0000283. Cp190.

    Subcellular locationi

    Nucleus. Cytoplasmcytoskeleton. Chromosome
    Note: Nucleus in interphase. Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. microtubule Source: UniProtKB-KW
    4. microtubule associated complex Source: FlyBase
    5. nucleus Source: UniProtKB
    6. polytene chromosome Source: UniProtKB
    7. polytene chromosome band Source: FlyBase

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10961096Centrosome-associated zinc finger protein CP190PRO_0000232629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei197 – 1971Phosphoserine1 Publication
    Modified residuei211 – 2111Phosphoserine1 Publication
    Modified residuei229 – 2291Phosphothreonine1 Publication
    Modified residuei233 – 2331Phosphoserine1 Publication
    Modified residuei298 – 2981Phosphoserine1 Publication
    Modified residuei319 – 3191Phosphoserine1 Publication
    Modified residuei603 – 6031Phosphothreonine1 Publication
    Modified residuei610 – 6101Phosphoserine1 Publication
    Modified residuei708 – 7081Phosphoserine1 Publication
    Modified residuei723 – 7231Phosphoserine1 Publication
    Modified residuei727 – 7271Phosphothreonine1 Publication
    Modified residuei745 – 7451Phosphoserine1 Publication
    Modified residuei748 – 7481Phosphoserine1 Publication
    Modified residuei757 – 7571Phosphoserine1 Publication
    Modified residuei760 – 7601Phosphoserine1 Publication
    Modified residuei817 – 8171Phosphothreonine1 Publication
    Modified residuei920 – 9201Phosphoserine2 Publications
    Modified residuei925 – 9251Phosphoserine1 Publication
    Modified residuei927 – 9271Phosphoserine1 Publication
    Modified residuei936 – 9361Phosphothreonine1 Publication
    Modified residuei938 – 9381Phosphoserine1 Publication
    Modified residuei1071 – 10711Phosphoserine1 Publication
    Modified residuei1074 – 10741Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ24478.
    PRIDEiQ24478.

    Expressioni

    Tissue specificityi

    Expressed in spermatids but not in mature spermatozoa. Localizes within the spermatids to a sheath of microtubules around the nucleus and to microtubules within the tail.1 Publication

    Developmental stagei

    Localizes to the centrosome throughout the nuclear division cycle in early syncytial embryos. Localization to the interphase nucleus is seen from nuclear cycle 9 onwards.4 Publications

    Gene expression databases

    BgeeiQ24478.

    Interactioni

    Subunit structurei

    Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw). Interacts with Cp60 and microtubules.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTCFQ8TA445EBI-868840,EBI-466743
    Dmel_CG8436Q9VHG53EBI-868840,EBI-141691
    Dmel_CG9740Q9VHG63EBI-868840,EBI-157022
    mod(mdg4)Q86B87-14EBI-868840,EBI-1433422
    su(Hw)P089704EBI-868840,EBI-101373

    Protein-protein interaction databases

    BioGridi66912. 11 interactions.
    IntActiQ24478. 13 interactions.
    MINTiMINT-1899376.
    STRINGi7227.FBpp0082580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24478.
    SMRiQ24478. Positions 369-405, 469-594.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9768BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 27165Nuclear localizationAdd
    BLAST
    Regioni385 – 508124Centrosomal localization and interaction with microtubulesAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri538 – 56124C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri567 – 59024C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG279218.
    InParanoidiQ24478.
    OMAiINTHKET.
    OrthoDBiEOG7992PZ.
    PhylomeDBiQ24478.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24478-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEVKSVKVD NWGVFFLQKL QNFFNKTDYC DLTLQFRDNS QLKVHRLVLS     50
    ACTDYFNVLE QTCEIVDDAL IMPNEFQADV VVPIVNFMYT GTLEFELKMY 100
    GKLLRTAKEM NMTVLLKLLE AHRRTMENVN RQQRPPSPKG IRRRTVGQPS 150
    SGLPQQRVLG PSPQSRNVAT PIAQRANTQR GSTGNTMSRT SGGSNRSPYG 200
    DSSNVKQEPT SPFEQLRKGY NNNKRPAQTS LLSPPSKKPS LEEVKEFAEQ 250
    QRMRKQIAAE YGDNDPEYDG GMLYDDVHAG DDDDDDMPPQ PSTSKQQSPQ 300
    GTQTQLEHGS TTIILKQDSP SQTPTIIVKD SSNAKLNHTK IIAEVLRQYP 350
    HIVKGHKNIK LKIMPNTPAA PTEKSAPATV KPPANQSSAT TSPHKKLHVS 400
    FKADKSTPLI TAQQKAASSQ QKSGTSQTTG NQGTGANPPA NTAAAQKRRI 450
    DSKTMHALIA QGAENTTGPW LCLRCGVNGR PISIPSYRGF RRHLINTHKE 500
    TIDPALCEHC GWRSVNNREL HFHMYMEHQT KSLLYTFAEC ALCNQSYRTK 550
    GELEAHINEV HTDDNKQQCI YCNKVFEQEL QLYRHMKSYH KEQALEDGII 600
    DETDEEFLGS QDEEEEAEGD EEQEPEQTGK VRILSDISLP ATSAITVQQA 650
    QQEQLQEEDV EQVQQEVKFV GADGNEVELT DEQRKEILSQ LNQQQAGATA 700
    GGVVMVLSEP EAEHVKQETD EKSLAGTEEE YDDSQIYSEL GAADSVESAK 750
    KNIADESKES IDNLEWAENL IAESEEQSNK EPKSDKPRDD ISEKLKELTG 800
    DWTEDENDDD VDDKPATAEL ASELANKDPE PTVHEEEDDI DLALQSLHKG 850
    PEEATEEKAS EESVTSADDA VDAVPNINSQ PEKMDVDSEA ADEKASKAEV 900
    QIKKEAELEN DQEEFIKEDS PIPHSDSVAE LREAVTASEG EDDVHLEADN 950
    IRKELLDELI AEAEKPDQEK DIVQSEENAT TEALDRSVTD EDDLVPPTQV 1000
    STEQMEIDEP AAEKAAENNE DTRTADEKEA VEDKPNQTQD VTTAEKPTLE 1050
    SAKAGDEATS GEAASVDKVK SLISEWGDDD EDEDENGVSA AAKEEL 1096
    Length:1,096
    Mass (Da):121,679
    Last modified:April 18, 2006 - v2
    Checksum:i5CD5C5492B948D39
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1061 – 10611G → D in CAA90324. (PubMed:8586650)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50021 mRNA. Translation: CAA90324.1.
    AE014297 Genomic DNA. Translation: AAF55159.1.
    AE014297 Genomic DNA. Translation: AAN13643.1.
    BT010090 mRNA. Translation: AAQ22559.1.
    PIRiT13802.
    RefSeqiNP_524359.2. NM_079635.3.
    NP_731998.1. NM_169632.2.
    UniGeneiDm.2423.

    Genome annotation databases

    EnsemblMetazoaiFBtr0083126; FBpp0082580; FBgn0000283.
    FBtr0083127; FBpp0082581; FBgn0000283.
    GeneIDi41848.
    KEGGidme:Dmel_CG6384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50021 mRNA. Translation: CAA90324.1 .
    AE014297 Genomic DNA. Translation: AAF55159.1 .
    AE014297 Genomic DNA. Translation: AAN13643.1 .
    BT010090 mRNA. Translation: AAQ22559.1 .
    PIRi T13802.
    RefSeqi NP_524359.2. NM_079635.3.
    NP_731998.1. NM_169632.2.
    UniGenei Dm.2423.

    3D structure databases

    ProteinModelPortali Q24478.
    SMRi Q24478. Positions 369-405, 469-594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66912. 11 interactions.
    IntActi Q24478. 13 interactions.
    MINTi MINT-1899376.
    STRINGi 7227.FBpp0082580.

    Proteomic databases

    PaxDbi Q24478.
    PRIDEi Q24478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0083126 ; FBpp0082580 ; FBgn0000283 .
    FBtr0083127 ; FBpp0082581 ; FBgn0000283 .
    GeneIDi 41848.
    KEGGi dme:Dmel_CG6384.

    Organism-specific databases

    CTDi 41848.
    FlyBasei FBgn0000283. Cp190.

    Phylogenomic databases

    eggNOGi NOG279218.
    InParanoidi Q24478.
    OMAi INTHKET.
    OrthoDBi EOG7992PZ.
    PhylomeDBi Q24478.

    Enzyme and pathway databases

    SignaLinki Q24478.

    Miscellaneous databases

    GenomeRNAii 41848.
    NextBioi 825881.

    Gene expression databases

    Bgeei Q24478.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes."
      Whitfield W.G.F., Chaplin M.A., Oegema K., Parry H., Glover D.M.
      J. Cell Sci. 108:3377-3387(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
      Strain: Oregon-R.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    5. "Purification of a multiprotein complex containing centrosomal proteins from the Drosophila embryo by chromatography with low-affinity polyclonal antibodies."
      Kellogg D.R., Alberts B.M.
      Mol. Biol. Cell 3:1-11(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CP60, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    6. "Drosophila gamma-tubulin is part of a complex containing two previously identified centrosomal MAPs."
      Raff J.W., Kellogg D.R., Alberts B.M.
      J. Cell Biol. 121:823-835(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CP60 AND MICROTUBULES, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    7. "The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains."
      Oegema K., Whitfield W.G.F., Alberts B.M.
      J. Cell Biol. 131:1261-1273(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MICROTUBULES, SUBCELLULAR LOCATION.
    8. "CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner."
      Kellogg D.R., Oegema K., Raff J., Schneider K., Alberts B.M.
      Mol. Biol. Cell 6:1673-1684(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CP60, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    9. "Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190."
      Oegema K., Marshall W.F., Sedat J.W., Alberts B.M.
      J. Cell Sci. 110:1573-1583(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. "Assembly of the zygotic centrosome in the fertilized Drosophila egg."
      Riparbelli M.G., Whitfield W.G.F., Dallai R., Callaini G.
      Mech. Dev. 65:135-144(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds."
      Moritz M., Zheng Y., Alberts B.M., Oegema K.
      J. Cell Biol. 142:775-786(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CP60.
    12. "The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division."
      Butcher R.D.J., Chodagam S., Basto R., Wakefield J.G., Henderson D.S., Raff J.W., Whitfield W.G.F.
      J. Cell Sci. 117:1191-1199(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MICROTUBULES, SUBCELLULAR LOCATION.
    13. "Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells."
      Raynaud-Messina B., Mazzolini L., Moisand A., Cirinesi A.-M., Wright M.
      J. Cell Sci. 117:5497-5507(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    14. "The centrosomal protein CP190 is a component of the gypsy chromatin insulator."
      Pai C.-Y., Lei E.P., Ghosh D., Corces V.G.
      Mol. Cell 16:737-748(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH MOD(MDG4) AND SU(HW), SUBCELLULAR LOCATION.
    15. "The centrosomal protein CP190 regulates myosin function during early Drosophila development."
      Chodagam S., Royou A., Whitfield W.G.F., Karess R., Raff J.W.
      Curr. Biol. 15:1308-1313(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    16. "The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator."
      Capelson M., Corces V.G.
      Mol. Cell 20:105-116(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    17. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
      Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
      Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-319; SER-920 AND SER-925, IDENTIFICATION BY MASS SPECTROMETRY.
    18. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; THR-229; SER-233; SER-298; THR-603; SER-610; SER-708; SER-723; THR-727; SER-745; SER-748; SER-757; SER-760; THR-817; SER-920; SER-927; THR-936; SER-938; SER-1071 AND SER-1074, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiCP190_DROME
    AccessioniPrimary (citable) accession number: Q24478
    Secondary accession number(s): A4V2Y3, Q9VFA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3