Q24475 (RPR_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell death protein rpr

Alternative name(s):
Protein reaper

Gene names

Name:	rpr
ORF Names:	CG4319

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activator of apoptosis, as well as grim and W, that acts on the effector, Dredd. Ref.1 Ref.5
Developmental stage	Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development. Ref.1
Miscellaneous	Ectopic expression in the developing eye results in a small eye owing to excess cell death.

Ontologies

Keywords
Biological process	Apoptosis
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA damage response, signal transduction resulting in induction of apoptosis Inferred from mutant phenotype. Source: FlyBase apoptotic process Inferred from mutant phenotype Ref.1. Source: FlyBase ecdysone-mediated induction of salivary gland cell autophagic cell death Inferred from expression pattern. Source: FlyBase embryonic development via the syncytial blastoderm Traceable author statement. Source: FlyBase imaginal disc-derived male genitalia morphogenesis Inferred from mutant phenotype. Source: FlyBase induction of apoptosis by ionic changes Traceable author statement. Source: FlyBase larval central nervous system remodeling Traceable author statement. Source: FlyBase larval midgut cell programmed cell death Inferred from genetic interaction. Source: FlyBase negative regulation of neuron apoptosis Inferred from mutant phenotype. Source: FlyBase negative regulation of translation Traceable author statement. Source: FlyBase protein ubiquitination Traceable author statement. Source: FlyBase regulation of protein catabolic process Inferred from direct assay. Source: FlyBase regulation of proteolysis Traceable author statement. Source: FlyBase
Cellular component	mitochondrial outer membrane Inferred from direct assay. Source: FlyBase
Molecular function	phospholipid binding Inferred from direct assay. Source: FlyBase protein homodimerization activity Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
th	Q24306	6	EBI-106786,EBI-456419

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 65	65	Cell death protein rpr		PRO_0000097437

Sequences

	Sequence		Length	Mass (Da)
	Q24475 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 57F231379AFEEA3C	FASTA	65	7,682
	10 20 30 40 50 60 MAVAFYIPDQ ATLLREAEQK EQQILRLRES QWRFLATVVL ETLRQYTSCH PKTGRKSGKY RKPSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic control of programmed cell death in Drosophila." White K., Grether M.E., Abrams J.M., Young L., Farrell K., Steller H. Science 264:677-683(1994) [PubMed: 8171319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Strain: Oregon-R. Tissue: Eye imaginal disk.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[5]	"Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila." Chen P., Rodriguez A., Erskine R., Thach T., Abrams J.M. Dev. Biol. 201:202-216(1998) [PubMed: 9740659] [Abstract] Cited for: FUNCTION. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L31631 mRNA. Translation: AAA18983.1. AE014296 Genomic DNA. Translation: AAF49264.1. BT023284 mRNA. Translation: AAY55700.1. BT029413 mRNA. Translation: ABK57070.1.
RefSeq	NP_524138.1. NM_079414.2.
UniGene	Dm.2529.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-21897N.
IntAct	Q24475. 2 interactions.
MINT	MINT-937693.
STRING	Q24475.
Proteomic databases
PRIDE	Q24475.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0075120; FBpp0074886; FBgn0011706.
GeneID	40015.
KEGG	dme:Dmel_CG4319.
NMPDR	fig|7227.3.peg.10415.
Organism-specific databases
CTD	40015.
FlyBase	FBgn0011706. rpr.
Phylogenomic databases
GeneTree	EMGT00050000022562.
InParanoid	Q24475.
OMA	VAFYIPD.
OrthoDB	EOG4XGXGW.
PhylomeDB	Q24475.
Gene expression databases
Bgee	Q24475.
GermOnline	CG4319. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other
NextBio	816567.

Entry information

Entry name

RPR_DROME

Accession

Primary (citable) accession number: Q24475
Secondary accession number(s): A0JQ43, Q4V3S2, Q9VVP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project