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Protein
Submitted name:

Protein kinase

Gene

Ask1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • MAP kinase kinase kinase activity Source: FlyBase

GO - Biological processi

  • activation of MAPKK activity Source: FlyBase
  • MAPK cascade Source: FlyBase
  • positive regulation of JNK cascade Source: FlyBase
  • positive regulation of stress-activated MAPK cascade Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of adult chitin-containing cuticle pigmentation Source: FlyBase

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-2559580 Oxidative Stress Induced Senescence
SignaLinkiQ24458

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinaseImported
Gene namesi
Name:Ask1Imported
Synonyms:Pk92BImported
ORF Names:CG4720Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0014006 Ask1

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiQ24458
PRIDEiQ24458

Expressioni

Gene expression databases

BgeeiFBgn0014006
ExpressionAtlasiQ24458 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ24458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 344Protein kinaseInterPro annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili506 – 526Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
OrthoDBiEOG091G00SJ

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q24458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRKSTTSF FVASKIKSVS LYKRDDRCAY LYVHHNSDDF QIYFPSTERR
60 70 80 90 100
QKFYDMILEM TADQVVFVNL SNDDANIEYE YDYDEQNRKM VLGKGTYGTV
110 120 130 140 150
YAARDKQTQV RIAIKEVPEK NSQDVQPLHE EIKLHSQLRH RNIVRYLGSC
160 170 180 190 200
SENGFFKIFM EQVPGGSLSD LLETKWGPLK DNESTMAFYS KQILEGLKYL
210 220 230 240 250
HEQDIVHRDI KGDNVLVNTY SGVVKISDFG TSKRLARINP MTETFTGTLQ
260 270 280 290 300
YMAPEVIDQG VRGYGPAADI WSFGCTNVEM ATGKPPFIEL GSAHAAMFKV
310 320 330 340 350
GFYKKHPNIP EELSANAKNF ILRCFAISVM DRPSASQLLE DPFLQDKPRK
360 370 380 390 400
VRPALPINTE FGRSISVPAD RFVHKTTPPL SYNTTCNTPT TPELDITHSS
410 420 430 440 450
SVDIDELPSN QFMLERRNSH GFLLSPEIEP STPSLRTSIS ETSETDGFYR
460 470 480 490 500
LKKDSQRRTT LSKVLALDES KICDIWLKKV DADQNSIAIR KSDLEVLIRG
510 520 530 540 550
LRDYIMNENE KHLEATINEL KQKLNNDAVA LDHLHLALYS FQDAVVCVLR
560 570 580 590 600
YHCIKPHWMF ALDNLVKRAV QAAVTIFSPE LGANLADKDL SGNDDESLRT
610 620 630 640 650
SLMQKGSTES QEKQSLEKVL PTSNTREGVG LTLRNRAGML CPVRWSARAS
Length:650
Mass (Da):73,758
Last modified:November 1, 1996 - v1
Checksum:iC3B653DC1E4762CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42962 mRNA Translation: AAC37267.1
PIRiJC4673

Similar proteinsi

Entry informationi

Entry nameiQ24458_DROME
AccessioniPrimary (citable) accession number: Q24458
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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