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Protein

ATP synthase subunit O, mitochondrial

Gene

ATPsynO

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-163210 Formation of ATP by chemiosmotic coupling
R-DME-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit O, mitochondrial
Alternative name(s):
Oligomycin sensitivity conferral protein
Short name:
OSCP
Gene namesi
Name:ATPsynOImported
Synonyms:OscpImported
ORF Names:CG4307Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0016691 ATPsynO

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000002650? – 209ATP synthase subunit O, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ24439
PRIDEiQ24439

Expressioni

Gene expression databases

BgeeiFBgn0016691
ExpressionAtlasiQ24439 baseline and differential
GenevisibleiQ24439 DM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi66909, 32 interactors
DIPiDIP-23606N
IntActiQ24439, 6 interactors
MINTiQ24439
STRINGi7227.FBpp0082522

Structurei

3D structure databases

ProteinModelPortaliQ24439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase delta chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1662 Eukaryota
COG0712 LUCA
InParanoidiQ24439
KOiK02137
OMAiMVDNIQD
OrthoDBiEOG091G0L4M
PhylomeDBiQ24439

Family and domain databases

Gene3Di1.10.520.20, 1 hit
HAMAPiMF_01416 ATP_synth_delta_bact, 1 hit
InterProiView protein in InterPro
IPR026015 ATP_synth_OSCP/delta_N_sf
IPR000711 ATPase_OSCP/dsu
PANTHERiPTHR11910 PTHR11910, 1 hit
PfamiView protein in Pfam
PF00213 OSCP, 1 hit
PRINTSiPR00125 ATPASEDELTA
SUPFAMiSSF47928 SSF47928, 1 hit
TIGRFAMsiTIGR01145 ATP_synt_delta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASINKLALL SRTLSSAAAQ ATVKPPVQVF GLEGRYATAL YSAASKLSQL
60 70 80 90 100
DQVEKDLTAL QATIRSDKKL REYVTSPIIN KKVMATALKE ASEKLRFAPA
110 120 130 140 150
TVNLLGLLAD NGRLKKLDTV INAYKTIMAA HRGEVVCEVV TAKPLDASQS
160 170 180 190 200
KQLEGALKSF LKGNESLKIT SRVDPSIIGG LIVSIGDKYV DMSIATKVKL

YTDVIQTAA
Length:209
Mass (Da):22,422
Last modified:December 1, 2000 - v2
Checksum:i50040CE844DFCAB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191D → N in CAA67980 (PubMed:10071211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99666 mRNA Translation: CAA67980.1
AE014297 Genomic DNA Translation: AAF55156.1
AY058261 mRNA Translation: AAL13490.1
RefSeqiNP_524358.2, NM_079634.3
UniGeneiDm.4214

Genome annotation databases

EnsemblMetazoaiFBtr0083063; FBpp0082522; FBgn0016691
GeneIDi41845
KEGGidme:Dmel_CG4307

Entry informationi

Entry nameiATPO_DROME
AccessioniPrimary (citable) accession number: Q24439
Secondary accession number(s): Q9VFA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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