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Protein

Optomotor-blind protein

Gene

bi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential protein that may function as a transcription regulator. Vital for pupal development. Required for proper development of the optic lobes and wings, and abdominal pigmentation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi332 – 513T-boxPROSITE-ProRule annotationAdd BLAST182

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • compound eye morphogenesis Source: FlyBase
  • developmental pigmentation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • organ growth Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • wing disc anterior/posterior pattern formation Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Optomotor-blind protein
Alternative name(s):
Lethal(1)optomotor-blind
Short name:
L(1)omb
Protein bifid
Gene namesi
Name:bi
Synonyms:OMB
ORF Names:CG3578
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000179. bi.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844661 – 972Optomotor-blind proteinAdd BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei887Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24432.
PRIDEiQ24432.

PTM databases

iPTMnetiQ24432.

Expressioni

Tissue specificityi

In third-instar larvae, expressed in the brain region that will develop into optic lobes and more weakly in the thoracic part of the ventral ganglion.

Developmental stagei

The peak periods of expression are: mid-embryogenesis, the second day of pupal development and in the adult.

Gene expression databases

BgeeiFBgn0000179.
GenevisibleiQ24432. DM.

Interactioni

Protein-protein interaction databases

BioGridi57896. 16 interactors.
IntActiQ24432. 1 interactor.
MINTiMINT-907193.
STRINGi7227.FBpp0303589.

Structurei

3D structure databases

ProteinModelPortaliQ24432.
SMRiQ24432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 140Asn-richAdd BLAST90
Compositional biasi104 – 107Poly-Thr4
Compositional biasi155 – 282Pro-richAdd BLAST128
Compositional biasi179 – 184Poly-Ser6
Compositional biasi229 – 236Poly-Gln8
Compositional biasi571 – 574Poly-Asp4
Compositional biasi604 – 689Ala-richAdd BLAST86
Compositional biasi820 – 829Poly-Gly10
Compositional biasi907 – 913Poly-Ala7
Compositional biasi922 – 963Gln/His-richAdd BLAST42

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
InParanoidiQ24432.
KOiK10176.
OrthoDBiEOG091G0I8R.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR021101. Optomoror-blind_N.
IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF11078. Optomotor-blind. 1 hit.
PF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDVQELLL HQSAEDPFAR FANGMAYHPF LQLTQRPTDF SVSSLLTAGS
60 70 80 90 100
NNNNSGNTNS GNNNSNSNNN TNSNTNNTNN LVAVSPTGGG AQLSPQSNHS
110 120 130 140 150
SSNTTTTSNT NNSSSNNNNN NSTHNNNNNH TNNNNNNNNN TSQKQGHHLS
160 170 180 190 200
TTEEPPSPAG TPPPTIVGLP PIPPPNNNSS SSSSNNSASA AAHPSHHPTA
210 220 230 240 250
AHHSPSTGAA APPAGPTGLP PPTPPHHLQQ QQQQQQHPAP PPPPYFPAAA
260 270 280 290 300
LAALAGSPAG PHPGLYPGGG LRFPPHHPGA HPHAHHLGSA YTTAEDVVLA
310 320 330 340 350
SAVAHQLHPA MRPLRALQPE DDGVVDDPKV TLEGKDLWEK FHKLGTEMVI
360 370 380 390 400
TKSGRQMFPQ MKFRVSGLDA KAKYILLLDI VAADDYRYKF HNSRWMVAGK
410 420 430 440 450
ADPEMPKRMY IHPDSPTTGE QWMQKVVSFH KLKLTNNISD KHGFVSTTIL
460 470 480 490 500
NSMHKYQPRF HLVRANDILK LPYSTFRTYV FKETEFIAVT AYQNEKITQL
510 520 530 540 550
KIDNNPFAKG FRDTGAGKRE KKQALMSNRG SDSDKLNPTH VSSSRAPLHL
560 570 580 590 600
GHAGRPPHLH PHAALLDNQQ DDDDKLLDVV GPPQSPLLPL SHSLQQMHAH
610 620 630 640 650
QHSAALAAWF NHLAGAGAGA SEHAAAAAAN ASAEDALRRR LQADADVERD
660 670 680 690 700
GSDSSCSESV GGSTGGAFRP TSTGSPKEAV GAAAAAAAAG LNPGGGSYPS
710 720 730 740 750
PNISVGPPIH PSPHLLPYLY PHGLYPPPHL GLLHNPAAAA AMSPAGLNPG
760 770 780 790 800
LLFNAQLALA AQHPALFGHA YAAAGHTPVS PLQGLKSHRF SPYSLPGSLG
810 820 830 840 850
SAFDAVTPGS NANRSGDPPG GGGGGLGGGV VENGPRSLSS SPRPRPASHS
860 870 880 890 900
PPTRPISMSP TTPPSLMKQP RGGGAGAGVA QSQHSPSELK SMEKMVNGLE
910 920 930 940 950
VQHNGSAAAA AAALQLAEEA AQHHHHTQAH HQQQQHQSHH QQQHHQQPAQ
960 970
PHPHHQTHLH SHHGATTGGT DQ
Length:972
Mass (Da):102,557
Last modified:February 28, 2003 - v3
Checksum:i61D2B3576DC6B853
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10L → F in AAF45946 (PubMed:10731132).Curated1
Sequence conflicti216P → A in AAF45946 (PubMed:10731132).Curated1
Sequence conflicti511F → L in AAA28736 (PubMed:1741374).Curated1
Sequence conflicti522K → NCYR in AAA28736 (PubMed:1741374).Curated1
Sequence conflicti820Missing in AAA28736 (PubMed:1741374).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81796 mRNA. Translation: AAA28736.1.
AE014298 Genomic DNA. Translation: AAF45946.2.
S61732, S61727, S61729 Genomic DNA. Translation: AAB26697.1.
S61744, S61743, S61955 Genomic DNA. Translation: AAB26699.1.
PIRiA40213.
RefSeqiNP_001162662.1. NM_001169191.1.
NP_001162663.1. NM_001169192.2.
NP_525070.2. NM_080331.3.
UniGeneiDm.1683.

Genome annotation databases

GeneIDi31379.
KEGGidme:Dmel_CG3578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81796 mRNA. Translation: AAA28736.1.
AE014298 Genomic DNA. Translation: AAF45946.2.
S61732, S61727, S61729 Genomic DNA. Translation: AAB26697.1.
S61744, S61743, S61955 Genomic DNA. Translation: AAB26699.1.
PIRiA40213.
RefSeqiNP_001162662.1. NM_001169191.1.
NP_001162663.1. NM_001169192.2.
NP_525070.2. NM_080331.3.
UniGeneiDm.1683.

3D structure databases

ProteinModelPortaliQ24432.
SMRiQ24432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57896. 16 interactors.
IntActiQ24432. 1 interactor.
MINTiMINT-907193.
STRINGi7227.FBpp0303589.

PTM databases

iPTMnetiQ24432.

Proteomic databases

PaxDbiQ24432.
PRIDEiQ24432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31379.
KEGGidme:Dmel_CG3578.

Organism-specific databases

CTDi31379.
FlyBaseiFBgn0000179. bi.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
InParanoidiQ24432.
KOiK10176.
OrthoDBiEOG091G0I8R.

Miscellaneous databases

ChiTaRSibi. fly.
GenomeRNAii31379.
PROiQ24432.

Gene expression databases

BgeeiFBgn0000179.
GenevisibleiQ24432. DM.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR021101. Optomoror-blind_N.
IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF11078. Optomotor-blind. 1 hit.
PF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMB_DROME
AccessioniPrimary (citable) accession number: Q24432
Secondary accession number(s): Q27917, Q9W4K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 28, 2003
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.