ID   NOC_DROME               Reviewed;         537 AA.
AC   Q24423;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 81.
DE   RecName: Full=Zinc finger protein Noc;
DE   AltName: Full=Zinc finger protein NocA;
GN   Name=noc; Synonyms=nocA; ORFNames=CG4491;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   MEDLINE=94119100; PubMed=8289824;
RA   Cheah P.Y., Meng Y.B., Yang X., Kimbrell D., Ashburner M., Chia W.;
RT   "The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger
RT   protein involved in the development of the embryonic brain and the
RT   adult ocellar structures.";
RL   Mol. Cell. Biol. 14:1487-1499(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   MEDLINE=22426066; PubMed=12537569;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   FUNCTION, INTERACTION WITH ELB, AND DEVELOPMENTAL STAGE.
RX   MEDLINE=22112673; PubMed=12117809;
RA   Dorfman R., Glazer L., Weihe U., Wernet M.F., Shilo B.-Z.;
RT   "Elbow and Noc define a family of zinc finger proteins controlling
RT   morphogenesis of specific tracheal branches.";
RL   Development 129:3585-3596(2002).
RN   [6]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=14757638; DOI=10.1242/dev.00979;
RA   Weihe U., Dorfman R., Wernet M.F., Cohen S.M., Milan M.;
RT   "Proximodistal subdivision of Drosophila legs and wings: the elbow-no
RT   ocelli gene complex.";
RL   Development 131:767-774(2004).
RN   [7]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=17014842; DOI=10.1016/j.ydbio.2006.07.050;
RA   Luque C.M., Milan M.;
RT   "Growth control in the proliferative region of the Drosophila eye-head
RT   primordium: the elbow-noc gene complex.";
RL   Dev. Biol. 301:327-339(2007).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-157 AND SER-208,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- FUNCTION: May negatively regulate Notch-induced cell proliferation
CC       in the eye-head primordium. Required for development of the
CC       supraesophageal ganglion and ocelli. May act in leg and wing
CC       primordia to negatively regulate body-wall specifying genes and
CC       thereby promote appendage formation. Plays a role in tracheal
CC       development.
CC   -!- SUBUNIT: Interacts with elB.
CC   -!- INTERACTION:
CC       Q9W512:-; NbExp=1; IntAct=EBI-88147, EBI-185973;
CC       Q9V3G9:EG:BACR37P7.5; NbExp=1; IntAct=EBI-88147, EBI-162998;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the adult head.
CC   -!- DEVELOPMENTAL STAGE: Expressed from stage 4 in the embryonic
CC       termini and at stage 5/6 in the ectodermal stripes. Expressed in
CC       the invaginating tracheal pits at stage 11, and ubiquitously
CC       throughout the embryo from stage 13. Expressed in the highly
CC       proliferative region of the eye-head primordium. Expressed in the
CC       distal regions of leg and wing imaginal discs. Expressed
CC       predominantly in embryo and pupae.
CC   -!- SIMILARITY: Belongs to the Elbow/Noc family.
CC   -!- SIMILARITY: Contains 1 C2H2-type zinc finger.
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DR   EMBL; L14009; AAA16473.1; -; mRNA.
DR   EMBL; AE014134; AAF53399.1; -; Genomic_DNA.
DR   EMBL; AY070550; AAL48021.1; -; mRNA.
DR   PIR; A55929; A55929.
DR   RefSeq; NP_476917.1; -.
DR   UniGene; Dm.5413; -.
DR   HSSP; P08047; 1SP2.
DR   DIP; DIP:19280N; -.
DR   IntAct; Q24423; 16.
DR   PRIDE; Q24423; -.
DR   Ensembl; FBgn0005771; Drosophila melanogaster.
DR   GeneID; 34847; -.
DR   KEGG; dme:Dmel_CG4491; -.
DR   NMPDR; fig|7227.3.peg.2417; -.
DR   FlyBase; FBgn0005771; noc.
DR   HOGENOM; Q24423; -.
DR   OMA; Q24423; HANPAFR.
DR   NextBio; 790524; -.
DR   ArrayExpress; Q24423; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR   GO; GO:0008283; P:cell proliferation; IGI:FlyBase.
DR   GO; GO:0035218; P:leg disc development; IMP:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0008056; P:ocellus development; IMP:UniProtKB.
DR   GO; GO:0007430; P:terminal branching, open tracheal system; IMP:UniProtKB.
DR   GO; GO:0035220; P:wing disc development; IMP:UniProtKB.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   ProDom; PD000003; Znf_C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; FALSE_NEG.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; DNA-binding; Metal-binding;
KW   Notch signaling pathway; Phosphoprotein; Zinc; Zinc-finger.
FT   CHAIN         1    537       Zinc finger protein Noc.
FT                                /FTId=PRO_0000292212.
FT   ZN_FING     402    430       C2H2-type.
FT   COMPBIAS     72    203       Ser-rich.
FT   COMPBIAS    235    517       Ala-rich.
FT   MOD_RES      98     98       Phosphoserine.
FT   MOD_RES     157    157       Phosphoserine.
FT   MOD_RES     208    208       Phosphoserine.
SQ   SEQUENCE   537 AA;  53996 MW;  D5913F8D502148CB CRC64;
     MVVLEGGGGV VTIGNNQYLQ PDYLAPLPTT MDAKKSPLAL LAQTCSQIGA DSSAVKPLLA
     MDKNKTKPGA CSSSSNSSSS SGSAEISAAK SPSGQAKSPK SSTPISSTAT SASLSNTSTG
     EIKLAFKPYE TNVLSHQNQN SFKSSSSLDA EPTRPSSKNS SSAQERVPSR SKSNATPTDG
     GKAEISAHDS SSSRKTVSPS GSSQRGASPI VRSGMEVLNN ANGTAQHPKE MSSMAAAAAA
     AAAAYKAAGP YGLNPLSALC CPPGMEQHAN PAFRPPFAGG FSHHHAAMLA VAANGGYPGG
     APGGGPAGQP NPYISYQRIK TPAGGEAIVP VCKDPYCQGC PYSAHTQQML MGAPCPAGCT
     QCEHQKYGLA MASAAGLPPA HPYSQAAAAA AANAAAARSA PYVCSWVVGD AYCGKRFQTS
     DELFSHLRTH TGNLSDPAAA AAALAQSQAQ SLLGTLFPPS ALRAGYPTPP LSPMSAAAAA
     ARYHPYAKPP PGALAGGPSP FGAAGAFNPA AAAAAAALGP YYSPYAMYGQ RMGAAHQ
//