Q24423 (NOC_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein Noc

Alternative name(s):
Zinc finger protein NocA

Gene names

Name:	noc
Synonyms:	nocA
ORF Names:	CG4491

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development. Ref.1 Ref.5 Ref.6 Ref.7
Subunit structure	Interacts with elB. Ref.5
Tissue specificity	Highly expressed in the adult head. Ref.1
Developmental stage	Expressed from stage 4 in the embryonic termini and at stage 5/6 in the ectodermal stripes. Expressed in the invaginating tracheal pits at stage 11, and ubiquitously throughout the embryo from stage 13. Expressed in the highly proliferative region of the eye-head primordium. Expressed in the distal regions of leg and wing imaginal discs. Expressed predominantly in embryo and pupae. Ref.1 Ref.5 Ref.6 Ref.7
Sequence similarities	Belongs to the Elbow/Noc family. Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
Biological process	Notch signaling pathway
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Notch signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW brain development Inferred from mutant phenotype Ref.1. Source: UniProtKB cell proliferation Inferred from genetic interaction Ref.7. Source: FlyBase inter-male aggressive behavior Inferred from mutant phenotype. Source: FlyBase leg disc development Inferred from mutant phenotype Ref.6. Source: UniProtKB ocellus development Inferred from mutant phenotype Ref.1. Source: UniProtKB terminal branching, open tracheal system Inferred from mutant phenotype Ref.5. Source: UniProtKB wing disc development Inferred from mutant phenotype Ref.6. Source: UniProtKB
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction Ref.5. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG17777	Q9W512	1	EBI-88147,EBI-185973
EG:BACR37P7.5	Q9V3G9	1	EBI-88147,EBI-162998

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 537	537	Zinc finger protein Noc		PRO_0000292212
Regions
	Zinc finger	402 – 430	29	C2H2-type
	Compositional bias	72 – 203	132	Ser-rich
	Compositional bias	235 – 517	283	Ala-rich
Amino acid modifications
	Modified residue	98	1	Phosphoserine Ref.8
	Modified residue	157	1	Phosphoserine Ref.8
	Modified residue	208	1	Phosphoserine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q24423 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D5913F8D502148CB	FASTA	537	53,996
	10 20 30 40 50 60 MVVLEGGGGV VTIGNNQYLQ PDYLAPLPTT MDAKKSPLAL LAQTCSQIGA DSSAVKPLLA 70 80 90 100 110 120 MDKNKTKPGA CSSSSNSSSS SGSAEISAAK SPSGQAKSPK SSTPISSTAT SASLSNTSTG 130 140 150 160 170 180 EIKLAFKPYE TNVLSHQNQN SFKSSSSLDA EPTRPSSKNS SSAQERVPSR SKSNATPTDG 190 200 210 220 230 240 GKAEISAHDS SSSRKTVSPS GSSQRGASPI VRSGMEVLNN ANGTAQHPKE MSSMAAAAAA 250 260 270 280 290 300 AAAAYKAAGP YGLNPLSALC CPPGMEQHAN PAFRPPFAGG FSHHHAAMLA VAANGGYPGG 310 320 330 340 350 360 APGGGPAGQP NPYISYQRIK TPAGGEAIVP VCKDPYCQGC PYSAHTQQML MGAPCPAGCT 370 380 390 400 410 420 QCEHQKYGLA MASAAGLPPA HPYSQAAAAA AANAAAARSA PYVCSWVVGD AYCGKRFQTS 430 440 450 460 470 480 DELFSHLRTH TGNLSDPAAA AAALAQSQAQ SLLGTLFPPS ALRAGYPTPP LSPMSAAAAA 490 500 510 520 530 ARYHPYAKPP PGALAGGPSP FGAAGAFNPA AAAAAAALGP YYSPYAMYGQ RMGAAHQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger protein involved in the development of the embryonic brain and the adult ocellar structures." Cheah P.Y., Meng Y.B., Yang X., Kimbrell D., Ashburner M., Chia W. Mol. Cell. Biol. 14:1487-1499(1994) [PubMed: 8289824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches." Dorfman R., Glazer L., Weihe U., Wernet M.F., Shilo B.-Z. Development 129:3585-3596(2002) [PubMed: 12117809] [Abstract] Cited for: FUNCTION, INTERACTION WITH ELB, DEVELOPMENTAL STAGE.
[6]	"Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex." Weihe U., Dorfman R., Wernet M.F., Cohen S.M., Milan M. Development 131:767-774(2004) [PubMed: 14757638] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[7]	"Growth control in the proliferative region of the Drosophila eye-head primordium: the elbow-noc gene complex." Luque C.M., Milan M. Dev. Biol. 301:327-339(2007) [PubMed: 17014842] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[8]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-157 AND SER-208, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14009 mRNA. Translation: AAA16473.1. AE014134 Genomic DNA. Translation: AAF53399.1. AY070550 mRNA. Translation: AAL48021.1.
PIR	A55929.
RefSeq	NP_476917.1. NM_057569.2.
UniGene	Dm.5413.
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ProteinModelPortal	Q24423.
SMR	Q24423. Positions 401-433.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19280N.
IntAct	Q24423. 3 interactions.
MINT	MINT-286833.
STRING	Q24423.
Proteomic databases
PRIDE	Q24423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0080643; FBpp0080215; FBgn0005771.
GeneID	34847.
KEGG	dme:Dmel_CG4491.
NMPDR	fig|7227.3.peg.2417.
Organism-specific databases
CTD	34847.
FlyBase	FBgn0005771. noc.
Phylogenomic databases
eggNOG	inNOG04419.
GeneTree	EMGT00050000008088.
InParanoid	Q24423.
OMA	ARSAPYV.
OrthoDB	EOG4NGF36.
PhylomeDB	Q24423.
Gene expression databases
ArrayExpress	Q24423.
Bgee	Q24423.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
SMART	SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. False negative. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	790524.

Entry information

Entry name

NOC_DROME

Accession

Primary (citable) accession number: Q24423

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project