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Protein
Submitted name:

Na/Ca exchange protein

Gene

Calx

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium:sodium antiporter activity Source: FlyBase
  • calcium ion binding Source: FlyBase

GO - Biological processi

  • neuromuscular process controlling posture Source: FlyBase
  • phototransduction Source: FlyBase
  • response to endoplasmic reticulum stress Source: FlyBase
  • sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-425561. Sodium/Calcium exchangers.
R-DME-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Submitted name:
Na/Ca exchange proteinImported
Gene namesi
Name:CalxImported
Synonyms:NCXImported
ORF Names:CG5685Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013995. Calx.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14219HelicalSequence analysisAdd
BLAST
Transmembranei216 – 23722HelicalSequence analysisAdd
BLAST
Transmembranei249 – 27123HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29822HelicalSequence analysisAdd
BLAST
Transmembranei781 – 80222HelicalSequence analysisAdd
BLAST
Transmembranei814 – 83320HelicalSequence analysisAdd
BLAST
Transmembranei853 – 87220HelicalSequence analysisAdd
BLAST
Transmembranei884 – 90421HelicalSequence analysisAdd
BLAST
Transmembranei924 – 94522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 950928Sequence analysisPRO_5004202130Add
BLAST

Proteomic databases

PaxDbiQ24413.

Expressioni

Gene expression databases

BgeeiQ24413.
ExpressionAtlasiQ24413. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0301144.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E9UX-ray2.50A555-709[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ24413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini431 – 530100Calx-betaInterPro annotationAdd
BLAST
Domaini544 – 643100Calx-betaInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sodium/potassium/calcium exchanger family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLLKSIFT CALFVIFVYA TAQSLLKVQE TEARQAYLNV TSSSSSNLSQ
60 70 80 90 100
DDGHFLSRRL RQVSHGEEGD EGAPSQMDDE LEQMTKVHGE APDAEELREC
110 120 130 140 150
SEGLVLPLWM PQRNISVGDR LVRGFVYFVL LIYLFVGVSI IADRFMAAIE
160 170 180 190 200
AITSIERAVV VKGPNNTKQV MHVRIWNETV ANLTLMALGS SAPEILLSVI
210 220 230 240 250
EIYAKDFESG DLGPGTIVGS AAYNLFMIIA VCMIWIPAGE VRRIRHLRVF
260 270 280 290 300
FVTALFSVFA YVWLWLILSV FTPGVILVWE AIVTLLFFPL TVLWAYIAER
310 320 330 340 350
RLLVYKYMDK NYRVNKRGTV VAGEHDQVEM DAEKGPKQPM VTSARGNDAE
360 370 380 390 400
AFDEARREYI TLLTELRQKY PDADLEQLEM MAQEQVLARS SKSRAFYRIQ
410 420 430 440 450
ATRKMVGSGN LMRKIQERAH SDLTEVKAQL HAGDDEEADD PIRMYFEPGH
460 470 480 490 500
YTVMENCGEF EVRVVRRGDI STYASVEYET QDGTASAGTD FVGRKGLLSF
510 520 530 540 550
PPGVDEQRFR IEVIDDDVFE EDECFYIRLF NPSEGVKLAV PMIATVMILD
560 570 580 590 600
DDHAGIFAFT DSVFEITESV GRFELKVMRY SGARGTVIVP YWTENDTATE
610 620 630 640 650
SKDYEGARGE LVFENNESEK FIDLFILEES SYEKDVSFKV HIGEPRLAPD
660 670 680 690 700
DGLAAKIKEV EKKPVQDLTE LDRILLLSKP RNGELTTAYV RIRESQEFKA
710 720 730 740 750
TVDKLVAKAN VSAVLGTSSW KEQFKDALTV IPADESEFDN DDEEEEVPSC
760 770 780 790 800
FSYVSHFVCL FWKVLFAFVP PTDICGGYVT FVVSIFVIGV ITAIIGDAAS
810 820 830 840 850
YFGCALNIKD SVTAILFVAL GTSIPDTFAS MIAAKHDEGA DNCIGNVTGS
860 870 880 890 900
NAVNVFLGIG LAWTIAAVYH SSHGMTFNVE PGTIGFAVAL FCGEALIAIM
910 920 930 940 950
LIMFRRWHKG IGAELGGPKV SKYISAAILV FLWVFYVVIC ILEAYDVIRV
Length:950
Mass (Da):106,077
Last modified:July 1, 1997 - v2
Checksum:iEDA3AB574F1FD0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39835 Genomic DNA. Translation: AAB50166.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39835 Genomic DNA. Translation: AAB50166.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E9UX-ray2.50A555-709[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0301144.

Proteomic databases

PaxDbiQ24413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0013995. Calx.

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.

Enzyme and pathway databases

ReactomeiR-DME-418359. Reduction of cytosolic Ca++ levels.
R-DME-425561. Sodium/Calcium exchangers.
R-DME-5578775. Ion homeostasis.

Miscellaneous databases

EvolutionaryTraceiQ24413.

Gene expression databases

BgeeiQ24413.
ExpressionAtlasiQ24413. differential.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Na+/Ca2+ exchanger in Drosophila: cloning, expression, and transport differences."
    Ruknudin A., Valdivia C., Kofuji P., Lederer W.J., Schulze D.H.
    Am. J. Physiol. 273:C257-C265(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification."
    Wu M., Wang M., Nix J., Hryshko L.V., Zheng L.
    J. Mol. Biol. 387:104-112(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 555-709.

Entry informationi

Entry nameiQ24413_DROME
AccessioniPrimary (citable) accession number: Q24413
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.