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Protein

Metchnikowin

Gene

Mtk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent antifungal and antibacterial activity against Gram-positive bacteria.

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • antifungal humoral response Source: FlyBase
  • defense response Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • defense response to Gram-positive bacterium Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW
  • response to bacterium Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Metchnikowin
Gene namesi
Name:Mtk
ORF Names:CG8175
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0014865. Mtk.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000498325 – 261 Publication2
PeptideiPRO_000000498427 – 52MetchnikowinAdd BLAST26

Proteomic databases

PaxDbiQ24395.
PRIDEiQ24395.

Expressioni

Tissue specificityi

Highest expression in fat body. Maybe blood cells participate in the production of the peptide. In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks.1 Publication

Developmental stagei

Expressed rapidly and strongly at all stages.

Gene expression databases

BgeeiFBgn0014865.
GenevisibleiQ24395. DM.

Interactioni

Protein-protein interaction databases

DIPiDIP-23804N.
MINTiMINT-344578.
STRINGi7227.FBpp0086518.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EZSX-ray1.90B46-52[»]
SMRiQ24395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ24395.
OMAiCVMAMAT.
OrthoDBiEOG091G18O1.
PhylomeDBiQ24395.

Family and domain databases

InterProiIPR012513. Antimicrobial10.
[Graphical view]
PfamiPF08105. Antimicrobial10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLNLGAIFL ALLGVMATAT SVLAEPHRHQ GPIFDTRPSP FNPNQPRPGP

IY
Length:52
Mass (Da):5,654
Last modified:November 1, 1997 - v1
Checksum:i0B1E2112BAE03129
GO

Mass spectrometryi

Molecular mass is 3045.4 Da from positions 27 - 52. Determined by MALDI. Variant Arg-29.1 Publication

Polymorphismi

There are 2 allelic forms (A1 and A2) varying in two positions. The isoform shown here is A1.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti19A → T in strain: 2CPA51. 1 Publication1
Natural varianti29H → R in strain: 2CPA51. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91060 mRNA. Translation: CAA62511.1.
X91061 mRNA. Translation: CAA62512.1.
AF030959 Genomic DNA. Translation: AAC64659.1.
AY224619 Genomic DNA. Translation: AAO72478.1.
AY224620 Genomic DNA. Translation: AAO72479.1.
AY224621 Genomic DNA. Translation: AAO72480.1.
AY224622 Genomic DNA. Translation: AAO72481.1.
AY224623 Genomic DNA. Translation: AAO72482.1.
AY224624 Genomic DNA. Translation: AAO72483.1.
AY224625 Genomic DNA. Translation: AAO72484.1.
AY224626 Genomic DNA. Translation: AAO72485.1.
AY224627 Genomic DNA. Translation: AAO72486.1.
AY224628 Genomic DNA. Translation: AAO72487.1.
AY224629 Genomic DNA. Translation: AAO72488.1.
AY224630 Genomic DNA. Translation: AAO72489.1.
AE013599 Genomic DNA. Translation: AAF58139.1.
AY075536 mRNA. Translation: AAL68343.1.
PIRiS63981.
RefSeqiNP_523752.1. NM_079028.3.
UniGeneiDm.19934.

Genome annotation databases

EnsemblMetazoaiFBtr0087386; FBpp0086518; FBgn0014865.
GeneIDi36708.
KEGGidme:Dmel_CG8175.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91060 mRNA. Translation: CAA62511.1.
X91061 mRNA. Translation: CAA62512.1.
AF030959 Genomic DNA. Translation: AAC64659.1.
AY224619 Genomic DNA. Translation: AAO72478.1.
AY224620 Genomic DNA. Translation: AAO72479.1.
AY224621 Genomic DNA. Translation: AAO72480.1.
AY224622 Genomic DNA. Translation: AAO72481.1.
AY224623 Genomic DNA. Translation: AAO72482.1.
AY224624 Genomic DNA. Translation: AAO72483.1.
AY224625 Genomic DNA. Translation: AAO72484.1.
AY224626 Genomic DNA. Translation: AAO72485.1.
AY224627 Genomic DNA. Translation: AAO72486.1.
AY224628 Genomic DNA. Translation: AAO72487.1.
AY224629 Genomic DNA. Translation: AAO72488.1.
AY224630 Genomic DNA. Translation: AAO72489.1.
AE013599 Genomic DNA. Translation: AAF58139.1.
AY075536 mRNA. Translation: AAL68343.1.
PIRiS63981.
RefSeqiNP_523752.1. NM_079028.3.
UniGeneiDm.19934.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EZSX-ray1.90B46-52[»]
SMRiQ24395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-23804N.
MINTiMINT-344578.
STRINGi7227.FBpp0086518.

Proteomic databases

PaxDbiQ24395.
PRIDEiQ24395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087386; FBpp0086518; FBgn0014865.
GeneIDi36708.
KEGGidme:Dmel_CG8175.

Organism-specific databases

CTDi36708.
FlyBaseiFBgn0014865. Mtk.

Phylogenomic databases

InParanoidiQ24395.
OMAiCVMAMAT.
OrthoDBiEOG091G18O1.
PhylomeDBiQ24395.

Miscellaneous databases

GenomeRNAii36708.
PROiQ24395.

Gene expression databases

BgeeiFBgn0014865.
GenevisibleiQ24395. DM.

Family and domain databases

InterProiIPR012513. Antimicrobial10.
[Graphical view]
PfamiPF08105. Antimicrobial10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTK_DROME
AccessioniPrimary (citable) accession number: Q24395
Secondary accession number(s): Q24396, Q86BV8, Q9V7B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.