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Protein

Metchnikowin

Gene

Mtk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent antifungal and antibacterial activity against Gram-positive bacteria.

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • antifungal humoral response Source: FlyBase
  • defense response Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • defense response to Gram-positive bacterium Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW
  • response to bacterium Source: FlyBase

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Metchnikowin
Gene namesi
Name:Mtk
ORF Names:CG8175
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0014865 Mtk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000498325 – 261 Publication2
PeptideiPRO_000000498427 – 52MetchnikowinAdd BLAST26

Proteomic databases

PaxDbiQ24395
PRIDEiQ24395

Expressioni

Tissue specificityi

Highest expression in fat body. Maybe blood cells participate in the production of the peptide. In hemolymph 6 hours after immune challenge, levels of expression increase for first 24 hours and persist for the following two weeks.1 Publication

Developmental stagei

Expressed rapidly and strongly at all stages.

Gene expression databases

BgeeiFBgn0014865
GenevisibleiQ24395 DM

Interactioni

Protein-protein interaction databases

DIPiDIP-23804N
IntActiQ24395, 1 interactor
STRINGi7227.FBpp0086518

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EZSX-ray1.90B46-52[»]
SMRiQ24395
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ24395
OMAiFNPNPPR
OrthoDBiEOG091G18O1
PhylomeDBiQ24395

Family and domain databases

InterProiView protein in InterPro
IPR012513 Antimicrobial10
PfamiView protein in Pfam
PF08105 Antimicrobial10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLNLGAIFL ALLGVMATAT SVLAEPHRHQ GPIFDTRPSP FNPNQPRPGP

IY
Length:52
Mass (Da):5,654
Last modified:November 1, 1997 - v1
Checksum:i0B1E2112BAE03129
GO

Mass spectrometryi

Molecular mass is 3045.4 Da from positions 27 - 52. Determined by MALDI. Variant Arg-29.1 Publication

Polymorphismi

There are 2 allelic forms (A1 and A2) varying in two positions. The isoform shown here is A1.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti19A → T in strain: 2CPA51. 1 Publication1
Natural varianti29H → R in strain: 2CPA51. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91060 mRNA Translation: CAA62511.1
X91061 mRNA Translation: CAA62512.1
AF030959 Genomic DNA Translation: AAC64659.1
AY224619 Genomic DNA Translation: AAO72478.1
AY224620 Genomic DNA Translation: AAO72479.1
AY224621 Genomic DNA Translation: AAO72480.1
AY224622 Genomic DNA Translation: AAO72481.1
AY224623 Genomic DNA Translation: AAO72482.1
AY224624 Genomic DNA Translation: AAO72483.1
AY224625 Genomic DNA Translation: AAO72484.1
AY224626 Genomic DNA Translation: AAO72485.1
AY224627 Genomic DNA Translation: AAO72486.1
AY224628 Genomic DNA Translation: AAO72487.1
AY224629 Genomic DNA Translation: AAO72488.1
AY224630 Genomic DNA Translation: AAO72489.1
AE013599 Genomic DNA Translation: AAF58139.1
AY075536 mRNA Translation: AAL68343.1
PIRiS63981
RefSeqiNP_523752.1, NM_079028.3
UniGeneiDm.19934

Genome annotation databases

EnsemblMetazoaiFBtr0087386; FBpp0086518; FBgn0014865
GeneIDi36708
KEGGidme:Dmel_CG8175

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTK_DROME
AccessioniPrimary (citable) accession number: Q24395
Secondary accession number(s): Q24396, Q86BV8, Q9V7B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health