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Protein

Larval serum protein 2

Gene

Lsp2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins.By similarity

GO - Molecular functioni

GO - Biological processi

  • motor neuron axon guidance Source: FlyBase
  • synaptic target inhibition Source: FlyBase

Keywordsi

Molecular functionStorage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Larval serum protein 2
Short name:
LSP-2
Alternative name(s):
Hexamerin-2
Gene namesi
Name:Lsp2
ORF Names:CG6806
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0002565 Lsp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001333622 – 701Larval serum protein 2Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ24388
PRIDEiQ24388

Expressioni

Gene expression databases

BgeeiFBgn0002565
ExpressionAtlasiQ24388 differential
GenevisibleiQ24388 DM

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

BioGridi69593, 29 interactors
IntActiQ24388, 1 interactor
STRINGi7227.FBpp0088363

Structurei

3D structure databases

ProteinModelPortaliQ24388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hemocyanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II6Z Eukaryota
ENOG410XR2D LUCA
InParanoidiQ24388
OMAiNHIKRAS
OrthoDBiEOG091G02IL
PhylomeDBiQ24388

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
1.20.1370.10, 1 hit
2.60.40.1520, 1 hit
InterProiView protein in InterPro
IPR013788 Hemocyanin/hexamerin
IPR000896 Hemocyanin/hexamerin_mid_dom
IPR005203 Hemocyanin_C
IPR037020 Hemocyanin_C_sf
IPR005204 Hemocyanin_N
IPR036697 Hemocyanin_N_sf
IPR014756 Ig_E-set
IPR008922 Unchr_di-copper_centre
PANTHERiPTHR11511 PTHR11511, 1 hit
PfamiView protein in Pfam
PF03723 Hemocyanin_C, 1 hit
PF00372 Hemocyanin_M, 1 hit
PF03722 Hemocyanin_N, 1 hit
PRINTSiPR00187 HAEMOCYANIN
SUPFAMiSSF48050 SSF48050, 1 hit
SSF48056 SSF48056, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00210 HEMOCYANIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFTVIALA AVALLATLGQ AKHLDSKVAD KDFLMKQKFM YQILQHIYQD
60 70 80 90 100
DVFTTPFGGS YVEYKPWEHV ADYVHPEMLE HFFELWQHQP FTDDMVWSVM
110 120 130 140 150
YDKHEEYVVG LVRLFYFAKN WETFQHVVYW ARQHVNKQLF VYAVTIASLF
160 170 180 190 200
RDDMQGVVLP AHYEIHPWSY FDSQALEWAE HYKMHGFHHV KQMDNIYNVV
210 220 230 240 250
IRTNYSNVHG SLNYDHDLAY YLEDVGFNAF YYYFNLDYPF WTKGGEEHVL
260 270 280 290 300
NKDRRGELYL YVHWQLLARW YLERLSHDLG EVPAFNMYVP TESGYASNLR
310 320 330 340 350
TYYGVPQWHR ENHHSFYHEH NYEHIEHVEM YTQRVMDWIH KNEKFDVETI
360 370 380 390 400
NVLGNIIQGN ADSVDKKFYG SLDKLYRFIV NEGHHYGHGD ESFPGLFMHY
410 420 430 440 450
DTSMRDPIFY EVYKTIVSHY WHLMETYPEY HKKDYAFEGV HIDAVHMPES
460 470 480 490 500
LTTYFEHFDS DISNAVNVEP AVEGSADPLY TFGRNSHYKG SSYVIKARQQ
510 520 530 540 550
RLNHKPFEFT LDVTSDKAQD AVVKVFIGPK YDEHGHEIPL EHNYQNFFEL
560 570 580 590 600
EHFKVHLEAG VNHIKRASGD FSFWVNDRTT YLELYQKLMD ATNSDYKFKL
610 620 630 640 650
DQSEAHCGVP NRMMLPRGKK GGQVFQFFYM VYPYHQPEVA QFTGYDPVVS
660 670 680 690 700
CGVGHGSRYV DALPFGFPFN RPVKHDYYFD VHNFKFVDVK IFHRDEHTNV

V
Length:701
Mass (Da):83,349
Last modified:June 21, 2005 - v2
Checksum:i4CC348AC7C05138D
GO

Sequence cautioni

The sequence CAA66371 differs from that shown. Reason: Frameshift at position 700.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271Y → H in CAA66371 (PubMed:9128741).Curated1
Sequence conflicti335V → L in CAA66371 (PubMed:9128741).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97770 Genomic DNA Translation: CAA66371.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49958.1
AY119005 mRNA Translation: AAM50865.1
RefSeqiNP_001287042.1, NM_001300113.1
NP_524816.1, NM_080077.2
UniGeneiDm.19654

Genome annotation databases

EnsemblMetazoaiFBtr0089324; FBpp0088363; FBgn0002565
FBtr0345352; FBpp0311507; FBgn0002565
GeneIDi45326
KEGGidme:Dmel_CG6806

Similar proteinsi

Entry informationi

Entry nameiLSP2_DROME
AccessioniPrimary (citable) accession number: Q24388
Secondary accession number(s): Q9VTT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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