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Protein

Gamma-aminobutyric acid receptor alpha-like

Gene

Grd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels.1 Publication

GO - Molecular functioni

  • cation channel activity Source: UniProtKB
  • extracellular-glycine-gated ion channel activity Source: FlyBase
  • GABA-A receptor activity Source: UniProtKB
  • GABA-gated chloride ion channel activity Source: FlyBase
  • ligand-gated ion channel activity Source: UniProtKB

GO - Biological processi

  • ion transport Source: UniProtKB

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-DME-975298. Ligand-gated ion channel transport.
R-DME-977441. GABA A receptor activation.

Protein family/group databases

TCDBi1.A.9.5.6. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor alpha-like
Alternative name(s):
GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila
Short name:
GRD
Gene namesi
Name:Grd
ORF Names:CG7446
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001134. Grd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini97 – 393ExtracellularSequence analysisAdd BLAST297
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei424 – 441HelicalSequence analysisAdd BLAST18
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 650CytoplasmicSequence analysisAdd BLAST174
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • chloride channel complex Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: FlyBase
  • postsynaptic membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 58Sequence analysisAdd BLAST58
ChainiPRO_000000045159 – 686Gamma-aminobutyric acid receptor alpha-likeAdd BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 247By similarity
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24352.
PRIDEiQ24352.

Expressioni

Gene expression databases

BgeeiFBgn0001134.
GenevisibleiQ24352. DM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with Lcch3 (beta chain).1 Publication

Protein-protein interaction databases

STRINGi7227.FBpp0074905.

Structurei

3D structure databases

ProteinModelPortaliQ24352.
SMRiQ24352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi589 – 609Ala-richAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
InParanoidiQ24352.
KOiK05175.
OMAiHPSEYSM.
OrthoDBiEOG091G0805.
PhylomeDBiQ24352.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTMPATRDA SGSGDASTDL IAARSLSSHQ GQRSNLRIFK LLISCCLLML
60 70 80 90 100
CIYPNAWPWS IGPGSGPFSV SADSIKGRGD THRLGEMGTS LSSSLPSSWL
110 120 130 140 150
TQSNNHANIS ELLDNLLRGY DNSIRPDFGG PPATIEVDIM VRSMGPISEV
160 170 180 190 200
DMTYSMDCYF RQSWVDKRLA FEGAQDTLAL SVSMLARIWK PDTYFYNGKQ
210 220 230 240 250
SYLHTITTPN KFVRIYQNGR VLYSSRLTIK AGCPMNLADF PMDIQKCPLK
260 270 280 290 300
FGSFGYTTSD VIYRWNKERP PVAIAEDMKL SQFDLVDCPA GNLTDIVYKA
310 320 330 340 350
AAPRPQRRPF NNKDPPRPTS KVMTTFAGPA AKNQHVRGTG LKLDKGAFGT
360 370 380 390 400
GRDATGGSGS TTGLSGTITL ETNHPSEYSM LMVNFHLQRH MGNFLIQVYG
410 420 430 440 450
PCCLLVVLSW VSFWLNREAT ADRVSLGITT VLTMTFLGLE ARTDLPKVSY
460 470 480 490 500
PTALDFFVFL SFGFIFATIL QFAVVHYYTK YGSGECYFII EELDSESGES
510 520 530 540 550
ETEPLTSDFR GSTESKIYEV IPLSMCAISM PPPPTRLGML TSRNRRPRNR
560 570 580 590 600
RHGLWSMKLL GLFDWRRRRK PPRADSDEDE DDEQTQLRAN EAPTTSAAAA
610 620 630 640 650
AAQAAAQAAR ISPPTGGRRR MSYYRREEME ARRKGKRTPQ YNSVSKIDRA
660 670 680
SRIVFPLLFI LINVFYWYGY LSRSSRILAN TPDAST
Length:686
Mass (Da):76,558
Last modified:November 1, 1996 - v1
Checksum:iE2BD771B7E3BAC7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78349 mRNA. Translation: CAA55144.1.
AE014296 Genomic DNA. Translation: AAF49298.2.
PIRiS60749.
RefSeqiNP_524131.1. NM_079407.3.
UniGeneiDm.2530.

Genome annotation databases

EnsemblMetazoaiFBtr0075139; FBpp0074905; FBgn0001134.
GeneIDi39984.
KEGGidme:Dmel_CG7446.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGBRAL_DROME
AccessioniPrimary (citable) accession number: Q24352
Secondary accession number(s): Q9TX50, Q9VVL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families