Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polycomb protein esc

Gene

esc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.1 Publication

GO - Molecular functioni

  • enzyme activator activity Source: FlyBase

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: UniProtKB
  • chromatin silencing Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • gene silencing Source: FlyBase
  • histone H3-K27 methylation Source: FlyBase
  • histone H3-K9 methylation Source: GOC
  • histone methylation Source: FlyBase
  • muscle organ development Source: FlyBase
  • neuron development Source: FlyBase
  • positive regulation of histone methylation Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ24338.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb protein esc
Alternative name(s):
Protein extra sex combs
Gene namesi
Name:esc
ORF Names:CG14941
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000588. esc.

Subcellular locationi

  • Nucleus 2 Publications

GO - Cellular componenti

  • ESC/E(Z) complex Source: FlyBase
  • histone methyltransferase complex Source: FlyBase
  • nuclear chromatin Source: UniProtKB
  • nucleus Source: UniProtKB
  • polytene chromosome Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64Y → F in esc1; induces homeotic transformation; when associated with R-240. 1
Mutagenesisi210 – 211GG → AA: Strongly reduces phosphorylation and the interaction with E(z). 1 Publication2
Mutagenesisi216 – 218RDE → AAA: Strongly reduces phosphorylation and the interaction with E(z). 1 Publication3
Mutagenesisi240L → R in esc1; induces homeotic transformation; when associated with F-64. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509721 – 425Polycomb protein escAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24338.
PRIDEiQ24338.

PTM databases

iPTMnetiQ24338.

Expressioni

Tissue specificityi

Widely expressed.

Developmental stagei

Expressed both maternally and zygotically. Strongly expressed in the oocyte and in early embryos, then decreases at the end of embryogenesis. Weakly expressed in third instar larvae. Transiently required between 2 and 6 hours of embryogenesis to establish PcG silencing and promote viable adults.2 Publications

Gene expression databases

BgeeiFBgn0000588.
GenevisibleiQ24338. DM.

Interactioni

Subunit structurei

Component of the Esc/E(z) complex, composed of Caf1, esc, E(z), Su(z)12, and possibly pho. The Esc/E(z) complex may also associate with Pcl and Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-88911,EBI-88911
Caf1Q2457211EBI-88911,EBI-75924
cortoP410463EBI-88911,EBI-300379
E(z)P4212421EBI-88911,EBI-112315
Rpd3Q9451711EBI-88911,EBI-302197

Protein-protein interaction databases

BioGridi60648. 21 interactors.
DIPiDIP-20069N.
IntActiQ24338. 9 interactors.
MINTiMINT-266724.
STRINGi7227.FBpp0079907.

Structurei

3D structure databases

ProteinModelPortaliQ24338.
SMRiQ24338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati71 – 114WD 1Add BLAST44
Repeati126 – 165WD 2Add BLAST40
Repeati168 – 208WD 3Add BLAST41
Repeati214 – 253WD 4Add BLAST40
Repeati284 – 321WD 5Add BLAST38
Repeati340 – 379WD 6Add BLAST40
Repeati388 – 424WD 7Add BLAST37

Sequence similaritiesi

Belongs to the WD repeat ESC family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1034. Eukaryota.
ENOG410XRQI. LUCA.
GeneTreeiENSGT00510000047334.
InParanoidiQ24338.
KOiK11462.
OMAiWEPITKE.
OrthoDBiEOG091G082Z.
PhylomeDBiQ24338.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDKVKNGN EPEESEESCG DESASYTTNS TTSRSKSPSS STRSKRRGRR
60 70 80 90 100
STKSKPKSRA AYKYDTHVKE NHGANIFGVA FNTLLGKDEP QVFATAGSNR
110 120 130 140 150
VTVYECPRQG GMQLLHCYAD PDPDEVFYTC AWSYDLKTSS PLLAAAGYRG
160 170 180 190 200
VIRVIDVEQN EAVGNYIGHG QAINELKFHP HKLQLLLSGS KDHAIRLWNI
210 220 230 240 250
QSHVCIAILG GVEGHRDEVL SIDFNMRGDR IVSSGMDHSL KLWCLNTPEF
260 270 280 290 300
HHKIELSNTF SQEKSTLPFP TVTKHFPDFS TRDIHRNYVD CVQWFGNFVL
310 320 330 340 350
SKSCENAIVC WKPGQLHQSF EQVKPSDSSC TIIAEFEYDE CEIWFVRFGF
360 370 380 390 400
NPWQKVIALG NQQGKVYVWE LDPSDPEGAH MTTLHNSRSV ATVRQIAFSR
410 420
DASVLVYVCD DATVWRWNRR QTTSI
Length:425
Mass (Da):47,988
Last modified:November 1, 1996 - v1
Checksum:i511C305E5DE86727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41867 Genomic DNA. Translation: AAA86427.1.
AE014134 Genomic DNA. Translation: AAF53124.1.
AY069796 mRNA. Translation: AAL39941.1.
PIRiS58672.
RefSeqiNP_477431.1. NM_058083.4.
UniGeneiDm.1948.

Genome annotation databases

EnsemblMetazoaiFBtr0080325; FBpp0079907; FBgn0000588.
GeneIDi34595.
KEGGidme:Dmel_CG14941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41867 Genomic DNA. Translation: AAA86427.1.
AE014134 Genomic DNA. Translation: AAF53124.1.
AY069796 mRNA. Translation: AAL39941.1.
PIRiS58672.
RefSeqiNP_477431.1. NM_058083.4.
UniGeneiDm.1948.

3D structure databases

ProteinModelPortaliQ24338.
SMRiQ24338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60648. 21 interactors.
DIPiDIP-20069N.
IntActiQ24338. 9 interactors.
MINTiMINT-266724.
STRINGi7227.FBpp0079907.

PTM databases

iPTMnetiQ24338.

Proteomic databases

PaxDbiQ24338.
PRIDEiQ24338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080325; FBpp0079907; FBgn0000588.
GeneIDi34595.
KEGGidme:Dmel_CG14941.

Organism-specific databases

CTDi34595.
FlyBaseiFBgn0000588. esc.

Phylogenomic databases

eggNOGiKOG1034. Eukaryota.
ENOG410XRQI. LUCA.
GeneTreeiENSGT00510000047334.
InParanoidiQ24338.
KOiK11462.
OMAiWEPITKE.
OrthoDBiEOG091G082Z.
PhylomeDBiQ24338.

Enzyme and pathway databases

ReactomeiR-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ24338.

Miscellaneous databases

GenomeRNAii34595.
PROiQ24338.

Gene expression databases

BgeeiFBgn0000588.
GenevisibleiQ24338. DM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESC_DROME
AccessioniPrimary (citable) accession number: Q24338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.