Q24332 (NT56_DROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lethal(2)neighbour of Tid protein

Alternative name(s):
NOT58

Gene names

Name:	l(2)not
Synonyms:	not

Organism

Drosophila virilis (Fruit fly)

Taxonomic identifier

7244 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Developmental stage	Expressed only during embryonic stages.
Sequence similarities	Belongs to the glycosyltransferase 58 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring hexosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Lethal(2)neighbour of Tid protein		PRO_0000080570
Regions
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	232 – 252	21	Helical; Potential
	Transmembrane	294 – 314	21	Helical; Potential
	Transmembrane	405 – 425	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q24332 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C71A91DD0861A397	FASTA	526	61,280
	10 20 30 40 50 60 MAPPRTNNRP VTRRKKPSNL LLLLKEKYVN WNFIKYLAFE PAALPIVSVL IVLAEAVINV 70 80 90 100 110 120 LVIQRVPYTE IDWKAYMQEC EGFLNGTTNY SLLRGDTGPL VYPAAFVYIY SGLYYLTGQG 130 140 150 160 170 180 TNVRLAQYIF ACIYLLQMCL VLRLYTKSRK VPPYVLVLSA FTSYRIHSIY VLRLFNDPVA 190 200 210 220 230 240 ILLLYAALNL FLDQRWTLGS ICYSLAVGVK MNILLFAPAL LLFYLANLGV LRTLVQLTIC 250 260 270 280 290 300 AVLQLFIGAP FLRTHPMEYL RGSFDLGRIF EHKWTVNYRF LSKELFEQRE FHLVLLALHL 310 320 330 340 350 360 LLLLCFAKPT WTFFRSYLRL REVQQQIVPQ ILHKNREQQN QAKIQAKKSK QLVEQQQEEE 370 380 390 400 410 420 DEQLSAEQKS FLKAFERSLQ QSTGQKSLEP HLNQKQEQYD IYFEPCTQLA LLPFFLCNFI 430 440 450 460 470 480 GVACARSLHY QFYIWYFHSL PYLVWSTPYS LGVRYLILGI IEYCWNTYPS TMESSIALHL 490 500 510 520 CHLILLVGVA RHVYRILRLN ATVKQQQRQE QSTLQNGQPK TSKKSQ

References

[1]	"Sequence, molecular organization and products of the Drosophila virilis homologs of the D. melanogaster nested genes lethal(2) tumorous imaginal discs [l(2)tid] and lethal(2) neighbour of tid [l(2)not]." Kaymer M., Debes A., Kress H., Kurzik-Dumke U. Gene 204:91-103(1997) [PubMed: 9434170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07700 Genomic DNA. Translation: CAA68963.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q24332.
Protein family/group databases
CAZy	GT58. Glycosyltransferase Family 58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0016537. Dvir\l(2)not.
Phylogenomic databases
GeneTree	EMGT00050000014681.
InParanoid	Q24332.
OrthoDB	EOG40GB6F.
Family and domain databases
InterPro	IPR007873. Glycosyltransferase_ALG3. [Graphical view]
PANTHER	PTHR12646. ALG3. 1 hit.
Pfam	PF05208. ALG3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NT56_DROVI

Accession

Primary (citable) accession number: Q24332

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project