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Protein

Dual specificity mitogen-activated protein kinase kinase dSOR1

Gene

Dsor1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ATPPROSITE-ProRule annotation1
Active sitei209Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 101ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: FlyBase
  • protein kinase activity Source: FlyBase
  • protein serine/threonine kinase activity Source: GO_Central
  • protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cellular response to X-ray Source: FlyBase
  • defense response to virus Source: FlyBase
  • ERK1 and ERK2 cascade Source: FlyBase
  • hemocyte differentiation Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • MAPK cascade Source: FlyBase
  • mitotic DNA replication checkpoint Source: FlyBase
  • mitotic G2 DNA damage checkpoint Source: FlyBase
  • photoreceptor cell development Source: UniProtKB
  • protein phosphorylation Source: FlyBase
  • regulation of apoptotic process Source: GO_Central
  • signal transduction Source: FlyBase
  • stress-activated protein kinase signaling cascade Source: GO_Central
  • terminal region determination Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.4.1.222 1994
2.7.12.2 1994
ReactomeiR-DME-110056 MAPK3 (ERK1) activation
R-DME-112411 MAPK1 (ERK2) activation
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-432553 Phosphorylation of PER and TIM
R-DME-445144 Signal transduction by L1
R-DME-5673000 RAF activation
R-DME-5674135 MAP2K and MAPK activation
R-DME-5674499 Negative feedback regulation of MAPK pathway
SignaLinkiQ24324

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase dSOR1 (EC:2.7.12.2)
Short name:
Downstream of RAF
Short name:
MAPKK
Gene namesi
Name:Dsor1
ORF Names:CG15793
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0010269 Dsor1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859281 – 396Dual specificity mitogen-activated protein kinase kinase dSOR1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237Phosphoserine; by RAFBy similarity1
Modified residuei241Phosphoserine; by RAFBy similarity1

Post-translational modificationi

Phosphorylation on Ser/Thr by MAP kinase kinase kinases regulates positively the kinase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24324
PRIDEiQ24324

Expressioni

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0010269
ExpressionAtlasiQ24324 baseline and differential
GenevisibleiQ24324 DM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi58322, 103 interactors
DIPiDIP-29770N
IntActiQ24324, 3 interactors
MINTiQ24324
STRINGi7227.FBpp0071248

Structurei

3D structure databases

ProteinModelPortaliQ24324
SMRiQ24324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 364Protein kinasePROSITE-ProRule annotationAdd BLAST278

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0581 Eukaryota
ENOG410XQ5A LUCA
GeneTreeiENSGT00760000119199
InParanoidiQ24324
KOiK04368
OrthoDBiEOG091G0DEC
PhylomeDBiQ24324

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q24324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNKLNLVL PPVNTEATVA AATVAPTPPF KTPSGTDTHS LLGKPKTSID
60 70 80 90 100
ALTETLEGLD MGDTERKRIK MFLSQKEKIG ELSDEDLEKL GELGSGNGGV
110 120 130 140 150
VMKVRHTHTH LIMARKLIHL EVKPAIKKQI LRELKVLHEC NFPHIVGFYG
160 170 180 190 200
AFYSDGEISI CMEYMDGGSL DLILKRAGRI PESILGRITL AVLKGLSYLR
210 220 230 240 250
DNHAIIHRDV KPSNILVNSS GEIKICDFGV SGQLIDSMAN SFVGTRSYMS
260 270 280 290 300
PERLQGTHYS VQSDIWSLGL SLVEMAIGMY PIPPPNTATL ESIFADNAEE
310 320 330 340 350
SGQPTDEPRA MAIFELLDYI VNEPPPKLEH KIFSTEFKDF VDICLKKQPD
360 370 380 390
ERADLKTLLS HPWIRKAELE EVDISGWVCK TMDLPPSTPK RNTSPN
Length:396
Mass (Da):43,870
Last modified:August 16, 2005 - v2
Checksum:i9245CED1DA750C33
GO

Sequence cautioni

The sequence BAA02925 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti394S → L in strain: Reids2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13782 Genomic DNA Translation: BAA02925.1 Sequence problems.
AY135075 Genomic DNA Translation: AAN17587.1
AY135076 Genomic DNA Translation: AAN17588.1
AY135077 Genomic DNA Translation: AAN17589.1
AY135078 Genomic DNA Translation: AAN17590.1
AY135079 Genomic DNA Translation: AAN17591.1
AY135080 Genomic DNA Translation: AAN17592.1
AY135081 Genomic DNA Translation: AAN17593.1
AY135082 Genomic DNA Translation: AAN17594.1
AY135083 Genomic DNA Translation: AAN17595.1
AY135084 Genomic DNA Translation: AAN17596.1
AY135085 Genomic DNA Translation: AAN17597.1
AY135086 Genomic DNA Translation: AAN17598.1
AY135087 Genomic DNA Translation: AAN17599.1
AY135088 Genomic DNA Translation: AAN17600.1
AY135089 Genomic DNA Translation: AAN17601.1
AY135090 Genomic DNA Translation: AAN17602.1
AY135091 Genomic DNA Translation: AAN17603.1
AY135092 Genomic DNA Translation: AAN17604.1
AY135093 Genomic DNA Translation: AAN17605.1
AE014298 Genomic DNA Translation: AAF46475.1
AY058692 mRNA Translation: AAL13921.1
PIRiA45176
RefSeqiNP_001285044.1, NM_001298115.1
NP_511098.1, NM_078543.4
UniGeneiDm.2620

Genome annotation databases

EnsemblMetazoaiFBtr0071313; FBpp0071248; FBgn0010269
GeneIDi31872
KEGGidme:Dmel_CG15793

Similar proteinsi

Entry informationi

Entry nameiDSOR1_DROME
AccessioniPrimary (citable) accession number: Q24324
Secondary accession number(s): Q8ISE0, Q9W360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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