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Protein

Semaphorin-1A

Gene

Sema-1a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in growth cone guidance through its role in axonal repulsion.2 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • heparin binding Source: FlyBase
  • semaphorin receptor binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • brain morphogenesis Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • locomotion involved in locomotory behavior Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of axon extension involved in axon guidance Source: GO_Central
  • negative regulation of cell size Source: FlyBase
  • neural crest cell migration Source: GO_Central
  • positive regulation of cell migration Source: GO_Central
  • semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance Source: FlyBase
  • startle response Source: FlyBase
  • synapse assembly Source: FlyBase
  • synaptic target recognition Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-1A
Alternative name(s):
Semaphorin-I
Short name:
Sema I
Gene namesi
Name:Sema-1a
Synonyms:Dsema-I
ORF Names:CG18405
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011259. Sema-1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 608588ExtracellularSequence analysisAdd
BLAST
Transmembranei609 – 62921HelicalSequence analysisAdd
BLAST
Topological domaini630 – 850221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 850831Semaphorin-1APRO_0000032297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 ↔ 102PROSITE-ProRule annotation
Disulfide bondi120 ↔ 129PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi239 ↔ 353PROSITE-ProRule annotation
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi263 ↔ 312PROSITE-ProRule annotation
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi497 ↔ 516PROSITE-ProRule annotation
Disulfide bondi508 ↔ 525PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24322.

Expressioni

Tissue specificityi

Expressed by subsets of neurons and muscles.1 Publication

Developmental stagei

Expression begins around stage 10, primarily in the developing CNS. In stage 16 embryos, it is expressed at highest levels throughout the CNS, and weak expression is seen in portions of the peripheral nervous system, most clearly in the lateral sensory clusters.1 Publication

Gene expression databases

BgeeiFBgn0011259.
ExpressionAtlasiQ24322. differential.
GenevisibleiQ24322. DM.

Interactioni

GO - Molecular functioni

  • semaphorin receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi60311. 129 interactions.
IntActiQ24322. 121 interactions.
STRINGi7227.FBpp0302962.

Structurei

3D structure databases

ProteinModelPortaliQ24322.
SMRiQ24322. Positions 57-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 494470SemaPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi689 – 6946Poly-Pro

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
InParanoidiQ24322.
KOiK06842.
OrthoDBiEOG091G0QST.
PhylomeDBiQ24322.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVFLLLTVL VIGNQSAWQE NIRPKLYVEL GPEDVLKFVG NESVVDHFKL
60 70 80 90 100
VTKDGNSLLI GARNTVFNLS IHDLVEQQRL VWTSPEDDTK MCLVKGKDEE
110 120 130 140 150
ACQNYIRIMV VPSPGRLFVC GTNSFRPMCN TYIISDSNYT LEATKNGQAV
160 170 180 190 200
CPYDPRHNST SVLADNELYS GTVADFSGSD PIIYREPLQT EQYDSLSLNA
210 220 230 240 250
PNFVSSFTQG DFVYFFFRET AVEFINCGKA IYSRVARVCK WDKGGPHRFR
260 270 280 290 300
NRWTSFLKSR LNCSIPGDYP FYFNEIQSAS NLVEGQYGSM SSKLIYGVFN
310 320 330 340 350
TPSNSIPGSA VCAFALQDIA DTFEGQFKEQ TGINSNWLPV NNAKVPDPRP
360 370 380 390 400
GSCHNDSRAL PDPTLNFIKT HSLMDENVPA FFSQPILVRT STIYRFTQIA
410 420 430 440 450
VDAQIKTPGG KTYDVIFVGT DHGKIIKSVN AESADSADKV TSVVIEEIDV
460 470 480 490 500
LTKSEPIRNL EIVRTMQYDQ PKDGSYDDGK LIIVTDSQVV AIQLHRCHND
510 520 530 540 550
KITSCSECVA LQDPYCAWDK IAGKCRSHGA PRWLEENYFY QNVATGQHAA
560 570 580 590 600
CPSGKINSKD ANAGEQKGFR NDMDLLDSRR QSKDQEIIDN IDKNFEDIIN
610 620 630 640 650
AQYTVETLVM AVLAGSIFSL LVGFFTGYFC GRRCHKDEDD NLPYPDTEYE
660 670 680 690 700
YFEQRQNVNS FPSSCRIQQE PKLLPQVEEV TYAEPVLLPQ PPPPNKMHSP
710 720 730 740 750
KNTLRKPPMH QMHQGPNSET LFQFQPDGYN TQQSYRGRDN FGTLRSHQVM
760 770 780 790 800
GDNYRRGDGF STTRSVKKAV NNTNTRNRSL GRARRQPPRH GIVTQHRSNS
810 820 830 840 850
PQQQQQQSQQ PHSSSGSSPV MSNSSSSPAP PSSSPSPQES PKNCSYIYRD
Length:850
Mass (Da):95,497
Last modified:March 15, 2004 - v2
Checksum:i57C5369FD37B7455
GO

Sequence cautioni

The sequence AAA88789 differs from that shown. Reason: Frameshift at position 769. Curated
The sequence AAF52696 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26082 mRNA. Translation: AAA88789.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF52696.2. Different initiation.
RefSeqiNP_723407.2. NM_164830.5.
UniGeneiDm.13264.

Genome annotation databases

GeneIDi34192.
KEGGidme:Dmel_CG18405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26082 mRNA. Translation: AAA88789.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF52696.2. Different initiation.
RefSeqiNP_723407.2. NM_164830.5.
UniGeneiDm.13264.

3D structure databases

ProteinModelPortaliQ24322.
SMRiQ24322. Positions 57-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60311. 129 interactions.
IntActiQ24322. 121 interactions.
STRINGi7227.FBpp0302962.

Proteomic databases

PaxDbiQ24322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi34192.
KEGGidme:Dmel_CG18405.

Organism-specific databases

CTDi34192.
FlyBaseiFBgn0011259. Sema-1a.

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
InParanoidiQ24322.
KOiK06842.
OrthoDBiEOG091G0QST.
PhylomeDBiQ24322.

Miscellaneous databases

ChiTaRSiSema-1a. fly.
GenomeRNAii34192.
PROiQ24322.

Gene expression databases

BgeeiFBgn0011259.
ExpressionAtlasiQ24322. differential.
GenevisibleiQ24322. DM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM1A_DROME
AccessioniPrimary (citable) accession number: Q24322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 15, 2004
Last modified: September 7, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.