Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semaphorin-1A

Gene

Sema-1a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in growth cone guidance through its role in axonal repulsion.2 Publications

GO - Molecular functioni

  • heparin binding Source: FlyBase
  • semaphorin receptor binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • brain morphogenesis Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • locomotion involved in locomotory behavior Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of cell size Source: FlyBase
  • semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance Source: FlyBase
  • startle response Source: FlyBase
  • synapse assembly Source: FlyBase
  • synaptic target recognition Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-1A
Alternative name(s):
Semaphorin-I
Short name:
Sema I
Gene namesi
Name:Sema-1a
Synonyms:Dsema-I
ORF Names:CG18405
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0011259. Sema-1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 608ExtracellularSequence analysisAdd BLAST588
Transmembranei609 – 629HelicalSequence analysisAdd BLAST21
Topological domaini630 – 850CytoplasmicSequence analysisAdd BLAST221

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003229720 – 850Semaphorin-1AAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 102PROSITE-ProRule annotation
Disulfide bondi120 ↔ 129PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi239 ↔ 353PROSITE-ProRule annotation
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 312PROSITE-ProRule annotation
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi497 ↔ 516PROSITE-ProRule annotation
Disulfide bondi508 ↔ 525PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24322.
PRIDEiQ24322.

Expressioni

Tissue specificityi

Expressed by subsets of neurons and muscles.1 Publication

Developmental stagei

Expression begins around stage 10, primarily in the developing CNS. In stage 16 embryos, it is expressed at highest levels throughout the CNS, and weak expression is seen in portions of the peripheral nervous system, most clearly in the lateral sensory clusters.1 Publication

Gene expression databases

BgeeiFBgn0011259.
ExpressionAtlasiQ24322. differential.
GenevisibleiQ24322. DM.

Interactioni

GO - Molecular functioni

  • semaphorin receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi60311. 148 interactors.
IntActiQ24322. 122 interactors.
STRINGi7227.FBpp0302962.

Structurei

3D structure databases

ProteinModelPortaliQ24322.
SMRiQ24322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 494SemaPROSITE-ProRule annotationAdd BLAST470

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi689 – 694Poly-Pro6

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000119134.
InParanoidiQ24322.
KOiK06842.
OrthoDBiEOG091G0QST.
PhylomeDBiQ24322.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiView protein in Pfam
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
SMARTiView protein in SMART
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SUPFAMiSSF101912. SSF101912. 1 hit.
PROSITEiView protein in PROSITE
PS51004. SEMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVFLLLTVL VIGNQSAWQE NIRPKLYVEL GPEDVLKFVG NESVVDHFKL
60 70 80 90 100
VTKDGNSLLI GARNTVFNLS IHDLVEQQRL VWTSPEDDTK MCLVKGKDEE
110 120 130 140 150
ACQNYIRIMV VPSPGRLFVC GTNSFRPMCN TYIISDSNYT LEATKNGQAV
160 170 180 190 200
CPYDPRHNST SVLADNELYS GTVADFSGSD PIIYREPLQT EQYDSLSLNA
210 220 230 240 250
PNFVSSFTQG DFVYFFFRET AVEFINCGKA IYSRVARVCK WDKGGPHRFR
260 270 280 290 300
NRWTSFLKSR LNCSIPGDYP FYFNEIQSAS NLVEGQYGSM SSKLIYGVFN
310 320 330 340 350
TPSNSIPGSA VCAFALQDIA DTFEGQFKEQ TGINSNWLPV NNAKVPDPRP
360 370 380 390 400
GSCHNDSRAL PDPTLNFIKT HSLMDENVPA FFSQPILVRT STIYRFTQIA
410 420 430 440 450
VDAQIKTPGG KTYDVIFVGT DHGKIIKSVN AESADSADKV TSVVIEEIDV
460 470 480 490 500
LTKSEPIRNL EIVRTMQYDQ PKDGSYDDGK LIIVTDSQVV AIQLHRCHND
510 520 530 540 550
KITSCSECVA LQDPYCAWDK IAGKCRSHGA PRWLEENYFY QNVATGQHAA
560 570 580 590 600
CPSGKINSKD ANAGEQKGFR NDMDLLDSRR QSKDQEIIDN IDKNFEDIIN
610 620 630 640 650
AQYTVETLVM AVLAGSIFSL LVGFFTGYFC GRRCHKDEDD NLPYPDTEYE
660 670 680 690 700
YFEQRQNVNS FPSSCRIQQE PKLLPQVEEV TYAEPVLLPQ PPPPNKMHSP
710 720 730 740 750
KNTLRKPPMH QMHQGPNSET LFQFQPDGYN TQQSYRGRDN FGTLRSHQVM
760 770 780 790 800
GDNYRRGDGF STTRSVKKAV NNTNTRNRSL GRARRQPPRH GIVTQHRSNS
810 820 830 840 850
PQQQQQQSQQ PHSSSGSSPV MSNSSSSPAP PSSSPSPQES PKNCSYIYRD
Length:850
Mass (Da):95,497
Last modified:March 15, 2004 - v2
Checksum:i57C5369FD37B7455
GO

Sequence cautioni

The sequence AAA88789 differs from that shown. Reason: Frameshift at position 769.Curated
The sequence AAF52696 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26082 mRNA. Translation: AAA88789.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF52696.2. Different initiation.
RefSeqiNP_723407.2. NM_164830.5.
UniGeneiDm.13264.

Genome annotation databases

EnsemblMetazoaiFBtr0079691; FBpp0079302; FBgn0011259.
GeneIDi34192.
KEGGidme:Dmel_CG18405.

Similar proteinsi

Entry informationi

Entry nameiSEM1A_DROME
AccessioniPrimary (citable) accession number: Q24322
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 15, 2004
Last modified: September 27, 2017
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families