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Protein

Transcription factor Dp

Gene

Dp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription.1 Publication

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • DNA binding transcription factor activity Source: InterPro
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase
  • eggshell chorion gene amplification Source: FlyBase
  • endomitotic cell cycle Source: FlyBase
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of gene expression Source: FlyBase
  • positive regulation of nurse cell apoptotic process Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: GOC
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-1538133 G0 and Early G1
R-DME-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-DME-69231 Cyclin D associated events in G1
R-DME-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Dp
Gene namesi
Name:Dp
ORF Names:CG4654
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011763 Dp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194791 – 445Transcription factor DpAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei398Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24318
PRIDEiQ24318

PTM databases

iPTMnetiQ24318

Expressioni

Gene expression databases

BgeeiFBgn0011763
ExpressionAtlasiQ24318 baseline and differential
GenevisibleiQ24318 DM

Interactioni

Subunit structurei

Heterodimer of E2f and Dp. Cooperate to give sequence-specific DNA binding and optimal trans-activation. Component of the DREAM complex at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l3mbt.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RbfQ244723EBI-530830,EBI-145741

GO - Molecular functioni

  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi62224, 28 interactors
IntActiQ24318, 12 interactors
STRINGi7227.FBpp0086853

Structurei

3D structure databases

ProteinModelPortaliQ24318
SMRiQ24318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2829 Eukaryota
ENOG410Y9QP LUCA
GeneTreeiENSGT00390000018222
InParanoidiQ24318
KOiK09394
OMAiSNQGQFI
OrthoDBiEOG091G0AVY
PhylomeDBiQ24318

Family and domain databases

CDDicd14458 DP_DD, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.140.80, 1 hit
InterProiView protein in InterPro
IPR037241 E2F-DP_heterodim
IPR003316 E2F_WHTH_DNA-bd_dom
IPR038168 TF_DP_C_sf
IPR014889 Transc_factor_DP_C
IPR015648 Transcrpt_fac_DP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12548 PTHR12548, 1 hit
PfamiView protein in Pfam
PF08781 DP, 1 hit
PF02319 E2F_TDP, 1 hit
PIRSFiPIRSF009404 Transcription_factor_DP, 1 hit
SMARTiView protein in SMART
SM01138 DP, 1 hit
SM01372 E2F_TDP, 1 hit
SUPFAMiSSF144074 SSF144074, 1 hit
SSF46785 SSF46785, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q24318-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHSTGGTVK TDEVNFFFRN EHGQISKMLK PAQNKSEMEG GKPVAVVYAT
60 70 80 90 100
GSSARNSGSA SGIGNVGRMG AFSQMGSQGQ FIRLQDNGLS IPKTEAGTTY
110 120 130 140 150
TTVSAQKTSG AGSGHYDLPL KGDRYVKFTP NPIKMKSKLH AIQSNSLHSM
160 170 180 190 200
SASSSSVQRK RKPDKAGKGL RHFSMKVCEK VEEKGKTTYN EVADDLVSEE
210 220 230 240 250
MKNNAYDNNC DQKNIRRRVY DALNVLMAIN VISKDKKEIR WIGLPANSTE
260 270 280 290 300
TFLALEEENC QRRERIKQKN EMLREMIMQH VAFKGLVERN KRNESQGVVP
310 320 330 340 350
SPNASIQLPF IIVNTHKSTK INCSVTNDKS EYIFKFDKTF EMHDDIEVLK
360 370 380 390 400
RMGFLLGLDK GECTPENIER VKSWVPPNLA KYVEAYGTGK TGENMYESDD
410 420 430 440
EDNEFNGYLE SANESQGFAQ HSAQHTTDGE FKLEMDDDEL DDDID
Length:445
Mass (Da):49,750
Last modified:June 21, 2005 - v2
Checksum:i87F4DBB26CFE4E42
GO
Isoform B (identifier: Q24318-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MAHSTGGTVKTDEVNFFFRNEH → MCISETKEPPHLPISNSA

Show »
Length:441
Mass (Da):49,179
Checksum:iAAD836B2A83E8EC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117D → G in AAO24938 (Ref. 4) Curated1
Sequence conflicti343H → L in AAB87765 (PubMed:9271122).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141461 – 22MAHST…FRNEH → MCISETKEPPHLPISNSA in isoform B. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58403.1
AE013599 Genomic DNA Translation: AAM68602.1
AY069526 mRNA Translation: AAL39671.1
BT003183 mRNA Translation: AAO24938.1
BT056266 mRNA Translation: ACL68713.1
X79708 mRNA Translation: CAA56147.2
AF011362 Genomic DNA Translation: AAB87765.1
PIRiB55745
RefSeqiNP_477039.1, NM_057691.4 [Q24318-1]
NP_725267.1, NM_165974.3 [Q24318-2]
UniGeneiDm.6412

Genome annotation databases

EnsemblMetazoaiFBtr0087740; FBpp0086853; FBgn0011763 [Q24318-1]
FBtr0087741; FBpp0086854; FBgn0011763 [Q24318-2]
GeneIDi36461
KEGGidme:Dmel_CG4654

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTFDP_DROME
AccessioniPrimary (citable) accession number: Q24318
Secondary accession number(s): B8A3X4
, O17472, O44080, Q86PE0, Q8ML56, Q9V6M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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