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Protein

Phosphoinositide phospholipase C

Gene

sl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • negative regulation of cell differentiation Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • phospholipid catabolic process Source: InterPro
  • positive regulation of cell growth Source: FlyBase
  • response to insulin Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1169408. ISG15 antiviral mechanism.
R-DME-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-DME-202433. Generation of second messenger molecules.
R-DME-212718. EGFR interacts with phospholipase C-gamma.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5654219. Phospholipase C-mediated cascade: FGFR1.
R-DME-5654221. Phospholipase C-mediated cascade, FGFR2.
R-DME-5654227. Phospholipase C-mediated cascade, FGFR3.
R-DME-5654228. Phospholipase C-mediated cascade, FGFR4.
SignaLinkiQ24284.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:slImported
ORF Names:CG4200Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0003416. sl.

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiQ24284.
PRIDEiQ24284.

Expressioni

Gene expression databases

BgeeiFBgn0003416.

Structurei

3D structure databases

ProteinModelPortaliQ24284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 132PHInterPro annotationAdd BLAST119
Domaini319 – 462PI-PLC X-boxInterPro annotationAdd BLAST144
Domaini583 – 684SH2InterPro annotationAdd BLAST102
Domaini695 – 783SH2InterPro annotationAdd BLAST89
Domaini818 – 878SH3InterPro annotationAdd BLAST61
Domaini974 – 1086PI-PLC Y-boxInterPro annotationAdd BLAST113
Domaini1098 – 1190C2InterPro annotationAdd BLAST93

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
OrthoDBiEOG091G07R3.

Family and domain databases

CDDicd09932. SH2_C-SH2_PLC_gamma_like. 1 hit.
cd10341. SH2_N-SH2_PLC_gamma_like. 1 hit.
Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR011992. EF-hand-dom_pair.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR035023. PLC-gamma_C-SH2.
IPR035024. PLC-gamma_N-SH2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 3 hits.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPLLGEME QTIGMLERGT IVTKLYGKQR RPDRRHLMLI RETRQLLWAT
60 70 80 90 100
VATQTPRTDY EGAIQLREIR EIRVGKHSKE FRLFADDCQR FESSKCFVIL
110 120 130 140 150
HGNHFKLKSF SVVALSEIEA DNWVRGLRYM VKDTLGAPYP LQIDRWLRRE
160 170 180 190 200
YYQIENVNTH SAKATEQSPA QVTIKDFKLF LAGVSCKMTT GKFMEHFTED
210 220 230 240 250
VRRKHDLKFD DFSRLYQKLL LPNGFASVLS GSGVANFPYS EDQQVVRPAE
260 270 280 290 300
LKQFLETEQR DVSASEISSA AIASFIRDFV QDVERDVQEP YLTFPEFVDF
310 320 330 340 350
LFSKQNDLWN SKYDQVFMDM NLPLSSYWIA SSHNTYLTGD QFSSESSCEA
360 370 380 390 400
YARALRMGCR CIELDCWNGP DNLPYIFHGH TITSKIKFMD VIKTIKDHAF
410 420 430 440 450
TSSEYPVILS IEQNCSLEQQ RNMAQALIEV FGDMLLTQPC DRNEQHLPSP
460 470 480 490 500
YQLRRKIILK HKKLPQFDDI ANGISSTGSL GHRSSLGGAG GGAHGENDGE
510 520 530 540 550
NVRKVFKEGL LYFKDPVDKS WNLYQFVLTH QELIYSSEIN ESRNGNSEDD
560 570 580 590 600
DFGLSSSCSL NSNMQQKQKD TSANDELHFG ENWFHGKLEG GRKEADDLLK
610 620 630 640 650
KYKHFGDGTF LVRESATFVG DYSLSFWRRN RPNHCRIKLK HENGSIKYYL
660 670 680 690 700
VENFVFDSLY SLIVYYRKNM LRSSEFSIIL KEPVPQPKKH EDQEWFHPNT
710 720 730 740 750
TKEQAEQGLY RLEIGSFLVR PSVQSINAFV ISFTINRKIK HCRIMQEGCL
760 770 780 790 800
YGIDTMNFES LVSLINYYTR NPLYRNVKLS HPVSQELLRQ ALAEAAQGDH
810 820 830 840 850
SGGHDDNGAS NYMGSNLEEN VTCKALYSYK ANKPDELSFP KHAIITNVQR
860 870 880 890 900
DNSMWWIGDY GGMIKKHLPA NYVKVIDSTT EDYNSLNEEG TDGRTDSIEI
910 920 930 940 950
FGAVASLFES NDPGIIFKLQ IQTPTMQNPF VIGFDNQETA YEWIKAIQEA
960 970 980 990 1000
ALIASQLASE RRKKERTARV AKEMSDLIIY FRSVPFREHS WIFQEMSSFP
1010 1020 1030 1040 1050
ETKAEKQFFQ QNTQLFLSYH RNQISRVYPK GQRLDSSNFN PMPFWNVGSQ
1060 1070 1080 1090 1100
MIALNYQTGD KAMQLNQAKF RNNGQCGYIL KPSFMKSDSF NPNNPLCDGL
1110 1120 1130 1140 1150
SEVKVSIRLI AARHLFRGGK SNNPQIVVEL IGASFDTGVK YRTKVIENGF
1160 1170 1180 1190 1200
NPVWNESCEF NVRNPQFAIL RFEVQDEDMF AETHFIAQAC YPLTCIRQGY
1210 1220 1230
RSVILRNKFS EELELSSLLI NIKIANVTAP
Length:1,230
Mass (Da):141,372
Last modified:November 1, 1996 - v1
Checksum:iA12C4805A95F221E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29806 mRNA. Translation: BAA06189.1.
PIRiA53970.

Similar proteinsi

Entry informationi

Entry nameiQ24284_DROME
AccessioniPrimary (citable) accession number: Q24284
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)