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Protein

Phosphoinositide phospholipase C

Gene

sl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • intracellular signal transduction Source: InterPro
  • negative regulation of cell differentiation Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • phospholipid catabolic process Source: InterPro
  • positive regulation of cell growth Source: FlyBase
  • response to insulin Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-DME-202433. Generation of second messenger molecules.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5654219. Phospholipase C-mediated cascade: FGFR1.
R-DME-5654221. Phospholipase C-mediated cascade, FGFR2.
R-DME-5654227. Phospholipase C-mediated cascade, FGFR3.
R-DME-5654228. Phospholipase C-mediated cascade, FGFR4.
SignaLinkiQ24284.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:slImported
ORF Names:CG4200Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0003416. sl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ24284.
PRIDEiQ24284.

Expressioni

Gene expression databases

BgeeiQ24284.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0074009.

Structurei

3D structure databases

ProteinModelPortaliQ24284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 132119PHInterPro annotationAdd
BLAST
Domaini319 – 462144PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini583 – 684102SH2InterPro annotationAdd
BLAST
Domaini695 – 78389SH2InterPro annotationAdd
BLAST
Domaini818 – 87861SH3InterPro annotationAdd
BLAST
Domaini974 – 1086113PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini1098 – 119093C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
OrthoDBiEOG7W419X.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 3 hits.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPLLGEME QTIGMLERGT IVTKLYGKQR RPDRRHLMLI RETRQLLWAT
60 70 80 90 100
VATQTPRTDY EGAIQLREIR EIRVGKHSKE FRLFADDCQR FESSKCFVIL
110 120 130 140 150
HGNHFKLKSF SVVALSEIEA DNWVRGLRYM VKDTLGAPYP LQIDRWLRRE
160 170 180 190 200
YYQIENVNTH SAKATEQSPA QVTIKDFKLF LAGVSCKMTT GKFMEHFTED
210 220 230 240 250
VRRKHDLKFD DFSRLYQKLL LPNGFASVLS GSGVANFPYS EDQQVVRPAE
260 270 280 290 300
LKQFLETEQR DVSASEISSA AIASFIRDFV QDVERDVQEP YLTFPEFVDF
310 320 330 340 350
LFSKQNDLWN SKYDQVFMDM NLPLSSYWIA SSHNTYLTGD QFSSESSCEA
360 370 380 390 400
YARALRMGCR CIELDCWNGP DNLPYIFHGH TITSKIKFMD VIKTIKDHAF
410 420 430 440 450
TSSEYPVILS IEQNCSLEQQ RNMAQALIEV FGDMLLTQPC DRNEQHLPSP
460 470 480 490 500
YQLRRKIILK HKKLPQFDDI ANGISSTGSL GHRSSLGGAG GGAHGENDGE
510 520 530 540 550
NVRKVFKEGL LYFKDPVDKS WNLYQFVLTH QELIYSSEIN ESRNGNSEDD
560 570 580 590 600
DFGLSSSCSL NSNMQQKQKD TSANDELHFG ENWFHGKLEG GRKEADDLLK
610 620 630 640 650
KYKHFGDGTF LVRESATFVG DYSLSFWRRN RPNHCRIKLK HENGSIKYYL
660 670 680 690 700
VENFVFDSLY SLIVYYRKNM LRSSEFSIIL KEPVPQPKKH EDQEWFHPNT
710 720 730 740 750
TKEQAEQGLY RLEIGSFLVR PSVQSINAFV ISFTINRKIK HCRIMQEGCL
760 770 780 790 800
YGIDTMNFES LVSLINYYTR NPLYRNVKLS HPVSQELLRQ ALAEAAQGDH
810 820 830 840 850
SGGHDDNGAS NYMGSNLEEN VTCKALYSYK ANKPDELSFP KHAIITNVQR
860 870 880 890 900
DNSMWWIGDY GGMIKKHLPA NYVKVIDSTT EDYNSLNEEG TDGRTDSIEI
910 920 930 940 950
FGAVASLFES NDPGIIFKLQ IQTPTMQNPF VIGFDNQETA YEWIKAIQEA
960 970 980 990 1000
ALIASQLASE RRKKERTARV AKEMSDLIIY FRSVPFREHS WIFQEMSSFP
1010 1020 1030 1040 1050
ETKAEKQFFQ QNTQLFLSYH RNQISRVYPK GQRLDSSNFN PMPFWNVGSQ
1060 1070 1080 1090 1100
MIALNYQTGD KAMQLNQAKF RNNGQCGYIL KPSFMKSDSF NPNNPLCDGL
1110 1120 1130 1140 1150
SEVKVSIRLI AARHLFRGGK SNNPQIVVEL IGASFDTGVK YRTKVIENGF
1160 1170 1180 1190 1200
NPVWNESCEF NVRNPQFAIL RFEVQDEDMF AETHFIAQAC YPLTCIRQGY
1210 1220 1230
RSVILRNKFS EELELSSLLI NIKIANVTAP
Length:1,230
Mass (Da):141,372
Last modified:November 1, 1996 - v1
Checksum:iA12C4805A95F221E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29806 mRNA. Translation: BAA06189.1.
PIRiA53970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29806 mRNA. Translation: BAA06189.1.
PIRiA53970.

3D structure databases

ProteinModelPortaliQ24284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0074009.

Proteomic databases

PaxDbiQ24284.
PRIDEiQ24284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0003416. sl.

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
OrthoDBiEOG7W419X.

Enzyme and pathway databases

ReactomeiR-DME-114604. GPVI-mediated activation cascade.
R-DME-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-DME-202433. Generation of second messenger molecules.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5654219. Phospholipase C-mediated cascade: FGFR1.
R-DME-5654221. Phospholipase C-mediated cascade, FGFR2.
R-DME-5654227. Phospholipase C-mediated cascade, FGFR3.
R-DME-5654228. Phospholipase C-mediated cascade, FGFR4.
SignaLinkiQ24284.

Miscellaneous databases

ChiTaRSiSl. fly.

Gene expression databases

BgeeiQ24284.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 3 hits.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages."
    Emori Y., Sugaya R., Akimaru H., Higashijima S., Shishido E., Saigo K., Homma Y.
    J. Biol. Chem. 269:19474-19479(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton-SImported.

Entry informationi

Entry nameiQ24284_DROME
AccessioniPrimary (citable) accession number: Q24284
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.