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Protein

Transcription factor btd

Gene

btd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the development of the antennal, intercalary and mandibular segments of the head.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri333 – 35725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • anterior head segmentation Source: FlyBase
  • cephalic furrow formation Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • specification of segmental identity, head Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ24266.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor btd
Alternative name(s):
Protein buttonhead
Gene namesi
Name:btd
ORF Names:CG12653
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000233. btd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Transcription factor btdPRO_0000046910Add
BLAST

Proteomic databases

PaxDbiQ24266.
PRIDEiQ24266.

Expressioni

Developmental stagei

First expressed in a stripe covering the head anlagen of the syncytial blastoderm embryo, persists through gastrulation and decays during germ band extension. Expressed later in development in a complex spatially restricted pattern.

Gene expression databases

BgeeiQ24266.
GenevisibleiQ24266. DM.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi58350. 4 interactions.
DIPiDIP-20818N.
IntActiQ24266. 2 interactions.
MINTiMINT-928586.
STRINGi7227.FBpp0071314.

Structurei

3D structure databases

ProteinModelPortaliQ24266.
SMRiQ24266. Positions 326-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 8976Gln-richAdd
BLAST
Compositional biasi208 – 22013Poly-AlaAdd
BLAST
Compositional biasi431 – 4344Poly-Ala
Compositional biasi486 – 4927Poly-Pro
Compositional biasi499 – 5024Poly-Thr
Compositional biasi515 – 5195Poly-Ser
Compositional biasi530 – 5367Poly-Ser
Compositional biasi596 – 5994Poly-Ser

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri333 – 35725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
InParanoidiQ24266.
KOiK09200.
OMAiHYAALAM.
OrthoDBiEOG76HQ15.
PhylomeDBiQ24266.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 2 hits.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDAACNYLN PYAQQHQAQQ QQHAQHQQHA QQQQHHLHMQ QAQHHLHLSH
60 70 80 90 100
QQAQQQHMQH LTQQQQQQQQ QQQQQQQQQQ QQQQPQQQQH DFLSAAALLS
110 120 130 140 150
APPSLSGSSS GSSSGSSPLY GKPPMKLELP YPQASSTGTA SPNSSIQSAP
160 170 180 190 200
SSASVSPSIF PSPAQSFASI SASPSTPTTT LAPPTTAAAG ALAGSPTSSS
210 220 230 240 250
PSSSAASAAA AAAAAAAAAA DLGAAAVASA AYGWNTAYSG LGPARSQFPY
260 270 280 290 300
AQYASDYYGN AVGMSSSAAW FSHQERLYQP WSSQSYPGFN FDDIAFQTQL
310 320 330 340 350
QRRSVRCTCP NCTNEMSGLP PIVGPDERGR KQHICHIPGC ERLYGKASHL
360 370 380 390 400
KTHLRWHTGE RPFLCLTCGK RFSRSDELQR HGRTHTNYRP YACPICSKKF
410 420 430 440 450
SRSDHLSKHK KTHFKDKKSK KVLAAEAKEQ AAAAIKLEKK EKKSGKPLTP
460 470 480 490 500
PVEFKQEQPD TTPLVNYAPY ANLYQHSTSA GSSVNPPPPP PPLFQQQMTT
510 520 530 540 550
TTSSAAASFV EQPWSSSSSR AIQPATTSAS SSSSSSASSP AAAVVSAIGS
560 570 580 590 600
ASSPAASATA LAQHHYAALA MQSESQLAAE YGLTMSGLAS GASQDSSSSC
610 620 630 640
HMKSEYAASY PADFGAGTAS YGYPHPHPHH HNAWAAAYHP HATA
Length:644
Mass (Da):68,581
Last modified:November 1, 1996 - v1
Checksum:iA0DB98C2AF938452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29361 Genomic DNA. Translation: CAA82545.1.
AE014298 Genomic DNA. Translation: AAF46518.1.
RefSeqiNP_511100.1. NM_078545.3.
UniGeneiDm.2928.

Genome annotation databases

EnsemblMetazoaiFBtr0071379; FBpp0071314; FBgn0000233.
GeneIDi31912.
KEGGidme:Dmel_CG12653.
UCSCiCG12653-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29361 Genomic DNA. Translation: CAA82545.1.
AE014298 Genomic DNA. Translation: AAF46518.1.
RefSeqiNP_511100.1. NM_078545.3.
UniGeneiDm.2928.

3D structure databases

ProteinModelPortaliQ24266.
SMRiQ24266. Positions 326-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58350. 4 interactions.
DIPiDIP-20818N.
IntActiQ24266. 2 interactions.
MINTiMINT-928586.
STRINGi7227.FBpp0071314.

Proteomic databases

PaxDbiQ24266.
PRIDEiQ24266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071379; FBpp0071314; FBgn0000233.
GeneIDi31912.
KEGGidme:Dmel_CG12653.
UCSCiCG12653-RA. d. melanogaster.

Organism-specific databases

CTDi686.
FlyBaseiFBgn0000233. btd.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
InParanoidiQ24266.
KOiK09200.
OMAiHYAALAM.
OrthoDBiEOG76HQ15.
PhylomeDBiQ24266.

Enzyme and pathway databases

SignaLinkiQ24266.

Miscellaneous databases

GenomeRNAii31912.
PROiQ24266.

Gene expression databases

BgeeiQ24266.
GenevisibleiQ24266. DM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 2 hits.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A Drosophila homologue of human Sp1 is a head-specific segmentation gene."
    Wimmer E.A., Jaeckle H., Pfeifle C., Cohen S.M.
    Nature 366:690-694(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiBTD_DROME
AccessioniPrimary (citable) accession number: Q24266
Secondary accession number(s): Q9W319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.