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Protein

Transcription factor btd

Gene

btd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the development of the antennal, intercalary and mandibular segments of the head.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 357C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri363 – 385C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding transcription factor activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • anterior head segmentation Source: FlyBase
  • cephalic furrow formation Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of neuroblast proliferation Source: UniProtKB
  • regulation of neuron differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ24266

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor btd
Alternative name(s):
Protein buttonhead
Gene namesi
Name:btd
ORF Names:CG12653
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0000233 btd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469101 – 644Transcription factor btdAdd BLAST644

Proteomic databases

PaxDbiQ24266
PRIDEiQ24266

Expressioni

Developmental stagei

First expressed in a stripe covering the head anlagen of the syncytial blastoderm embryo, persists through gastrulation and decays during germ band extension. Expressed later in development in a complex spatially restricted pattern.

Gene expression databases

BgeeiFBgn0000233
GenevisibleiQ24266 DM

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi58350, 9 interactors
DIPiDIP-20818N
IntActiQ24266, 2 interactors
STRINGi7227.FBpp0071314

Structurei

3D structure databases

ProteinModelPortaliQ24266
SMRiQ24266
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 89Gln-richAdd BLAST76
Compositional biasi208 – 220Poly-AlaAdd BLAST13
Compositional biasi431 – 434Poly-Ala4
Compositional biasi486 – 492Poly-Pro7
Compositional biasi499 – 502Poly-Thr4
Compositional biasi515 – 519Poly-Ser5
Compositional biasi530 – 536Poly-Ser7
Compositional biasi596 – 599Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 357C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri363 – 385C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
InParanoidiQ24266
KOiK09200
OMAiHYAALAM
OrthoDBiEOG091G0HX6
PhylomeDBiQ24266

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q24266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDAACNYLN PYAQQHQAQQ QQHAQHQQHA QQQQHHLHMQ QAQHHLHLSH
60 70 80 90 100
QQAQQQHMQH LTQQQQQQQQ QQQQQQQQQQ QQQQPQQQQH DFLSAAALLS
110 120 130 140 150
APPSLSGSSS GSSSGSSPLY GKPPMKLELP YPQASSTGTA SPNSSIQSAP
160 170 180 190 200
SSASVSPSIF PSPAQSFASI SASPSTPTTT LAPPTTAAAG ALAGSPTSSS
210 220 230 240 250
PSSSAASAAA AAAAAAAAAA DLGAAAVASA AYGWNTAYSG LGPARSQFPY
260 270 280 290 300
AQYASDYYGN AVGMSSSAAW FSHQERLYQP WSSQSYPGFN FDDIAFQTQL
310 320 330 340 350
QRRSVRCTCP NCTNEMSGLP PIVGPDERGR KQHICHIPGC ERLYGKASHL
360 370 380 390 400
KTHLRWHTGE RPFLCLTCGK RFSRSDELQR HGRTHTNYRP YACPICSKKF
410 420 430 440 450
SRSDHLSKHK KTHFKDKKSK KVLAAEAKEQ AAAAIKLEKK EKKSGKPLTP
460 470 480 490 500
PVEFKQEQPD TTPLVNYAPY ANLYQHSTSA GSSVNPPPPP PPLFQQQMTT
510 520 530 540 550
TTSSAAASFV EQPWSSSSSR AIQPATTSAS SSSSSSASSP AAAVVSAIGS
560 570 580 590 600
ASSPAASATA LAQHHYAALA MQSESQLAAE YGLTMSGLAS GASQDSSSSC
610 620 630 640
HMKSEYAASY PADFGAGTAS YGYPHPHPHH HNAWAAAYHP HATA
Length:644
Mass (Da):68,581
Last modified:November 1, 1996 - v1
Checksum:iA0DB98C2AF938452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29361 Genomic DNA Translation: CAA82545.1
AE014298 Genomic DNA Translation: AAF46518.1
RefSeqiNP_511100.1, NM_078545.3
UniGeneiDm.2928

Genome annotation databases

EnsemblMetazoaiFBtr0071379; FBpp0071314; FBgn0000233
GeneIDi31912
KEGGidme:Dmel_CG12653
UCSCiCG12653-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiBTD_DROME
AccessioniPrimary (citable) accession number: Q24266
Secondary accession number(s): Q9W319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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