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Protein

Homeobox protein B-H1

Gene

B-H1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi299 – 35860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chaeta morphogenesis Source: UniProtKB
  • compound eye photoreceptor cell differentiation Source: FlyBase
  • eye-antennal disc morphogenesis Source: UniProtKB
  • eye pigment granule organization Source: UniProtKB
  • leg disc proximal/distal pattern formation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • response to stimulus Source: UniProtKB-KW
  • sensory organ boundary specification Source: UniProtKB
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein B-H1
Alternative name(s):
Homeobox protein BarH1
Gene namesi
Name:B-H1
Synonyms:barh1
ORF Names:CG5529
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0011758. B-H1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Homeobox protein B-H1PRO_0000048832Add
BLAST

Proteomic databases

PaxDbiQ24255.

Expressioni

Tissue specificityi

B-H1 and B-H2 are abundant in the eye-antenna imaginal disk. Expressed in R1 and R6 cells throughout larval stage until 30 hours after puparium formation, at which time expression is seen in the anterior and posterior primary pigment cells. Coexpressed in embryonic glial cells, neurons of the CNS and PNS, most latitudinal anterior cells of the developing notum and the central circular region of the leg and antennal imaginal disk throughout larval development.5 Publications

Developmental stagei

Coexpressed at high levels with B-H1 in embryo and pupae and at low levels in larvae.2 Publications

Gene expression databases

BgeeiFBgn0011758.
ExpressionAtlasiQ24255. differential.
GenevisibleiQ24255. DM.

Interactioni

Protein-protein interaction databases

BioGridi59052. 12 interactions.
DIPiDIP-19778N.
MINTiMINT-881308.
STRINGi7227.FBpp0074204.

Structurei

3D structure databases

ProteinModelPortaliQ24255.
SMRiQ24255. Positions 296-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 174156His-richAdd
BLAST
Compositional biasi105 – 13632Asn-richAdd
BLAST
Compositional biasi187 – 22741Ala-richAdd
BLAST
Compositional biasi474 – 52653Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
InParanoidiQ24255.
KOiK09360.
OMAiYYQSAAA.
OrthoDBiEOG091G13SM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSMSILTQ TPSEPNAAHP QLHHHLSTLQ QQHHQHHLHY GLQPPAVAHS
60 70 80 90 100
IHSTTTMSSG GSTTTASGIG KPNRSRFMIN DILAGSAAAA FYKQQQHHQQ
110 120 130 140 150
LHHHNNNNNS GSSGGSSPAH SNNNNNINGD NCEASNVAGV GVLPSALHHP
160 170 180 190 200
QPHPPTHPHT HPHALMHPHG KLGHFPPTAG GNGLNVAQYA AAMQQHYAAA
210 220 230 240 250
AAAAAARNNA AAAAAAAAAA AAAGVAAPPV DGGVDGGVGL APPAGGDLDD
260 270 280 290 300
SSDYHEENED CDSGNMDDHS VCSNGGKDDD GNSVKSGSTS DMSGLSKKQR
310 320 330 340 350
KARTAFTDHQ LQTLEKSFER QKYLSVQERQ ELAHKLDLSD CQVKTWYQNR
360 370 380 390 400
RTKWKRQTAV GLELLAEAGN FAAFQRLYGG SPYLGAWPYA AAAGAAHGAT
410 420 430 440 450
PHTNIDIYYR QAAAAAAMQK PLPYNLYAGV PSVGVGVGVG VGPAPFSHLS
460 470 480 490 500
ASSSLSSLSS YYQSAAAAAS AANPGGPHPV APPPSVGGGS PPSGLVKPIP
510 520 530 540
AHSASASPPP RPPSTPSPTL NPGSPPGRSV DSCSQSDDED QIQV
Length:544
Mass (Da):56,083
Last modified:June 1, 2003 - v2
Checksum:iBB536E3B00124926
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451P → A in AAA28382 (PubMed:1674606).Curated
Sequence conflicti66 – 661A → E in AAA28382 (PubMed:1674606).Curated
Sequence conflicti218 – 2181A → R in AAA28382 (PubMed:1674606).Curated
Sequence conflicti412 – 4121Missing in AAA28382 (PubMed:1674606).Curated
Sequence conflicti486 – 4861V → G in AAA28382 (PubMed:1674606).Curated
Sequence conflicti504 – 5041A → R in AAA28382 (PubMed:1674606).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73079, M73259, M73078 Genomic DNA. Translation: AAA28382.1.
AE014298 Genomic DNA. Translation: AAF48726.1.
AY058309 mRNA. Translation: AAL13538.1.
PIRiB39369.
RefSeqiNP_523387.1. NM_078663.3.
UniGeneiDm.2610.

Genome annotation databases

EnsemblMetazoaiFBtr0074430; FBpp0074204; FBgn0011758.
GeneIDi32724.
KEGGidme:Dmel_CG5529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73079, M73259, M73078 Genomic DNA. Translation: AAA28382.1.
AE014298 Genomic DNA. Translation: AAF48726.1.
AY058309 mRNA. Translation: AAL13538.1.
PIRiB39369.
RefSeqiNP_523387.1. NM_078663.3.
UniGeneiDm.2610.

3D structure databases

ProteinModelPortaliQ24255.
SMRiQ24255. Positions 296-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59052. 12 interactions.
DIPiDIP-19778N.
MINTiMINT-881308.
STRINGi7227.FBpp0074204.

Proteomic databases

PaxDbiQ24255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074430; FBpp0074204; FBgn0011758.
GeneIDi32724.
KEGGidme:Dmel_CG5529.

Organism-specific databases

CTDi32724.
FlyBaseiFBgn0011758. B-H1.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
InParanoidiQ24255.
KOiK09360.
OMAiYYQSAAA.
OrthoDBiEOG091G13SM.

Miscellaneous databases

GenomeRNAii32724.
PROiQ24255.

Gene expression databases

BgeeiFBgn0011758.
ExpressionAtlasiQ24255. differential.
GenevisibleiQ24255. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBARH1_DROME
AccessioniPrimary (citable) accession number: Q24255
Secondary accession number(s): Q9VX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.