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Protein
Submitted name:

SH2/SH3 adaptor protein

Gene

dock

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • axonogenesis Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • myoblast fusion Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-373753. Nephrin family interactions.
R-DME-3928664. Ephrin signaling.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiQ24218.

Names & Taxonomyi

Protein namesi
Submitted name:
SH2/SH3 adaptor proteinImported
Gene namesi
Name:dockImported
ORF Names:CG3727Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0010583. dock.

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiQ24218.
PRIDEiQ24218.

Expressioni

Gene expression databases

BgeeiFBgn0010583.
ExpressionAtlasiQ24218. differential.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

Protein-protein interaction databases

IntActiQ24218. 5 interactors.
MINTiMINT-98926.

Structurei

3D structure databases

ProteinModelPortaliQ24218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3InterPro annotationAdd BLAST60
Domaini114 – 173SH3InterPro annotationAdd BLAST60
Domaini186 – 248SH3InterPro annotationAdd BLAST63
Domaini310 – 404SH2InterPro annotationAdd BLAST95

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4226. Eukaryota.
ENOG410XRPF. LUCA.
OrthoDBiEOG091G0AD0.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR017304. NCK.
IPR000980. SH2.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 3 hits.
PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 3 hits.
SUPFAMiSSF50044. SSF50044. 3 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 3 hits.

Sequencei

Sequence statusi: Complete.

Q24218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNMKHGKS QDDVCYVVAK YDYAAQGAQE LDLRKNERYL LLDDSKHWWR
60 70 80 90 100
VQNSRNQSGY VPSNYVKKEK PSLFDSIKKK VKKGSGSKTL PNCSPSRQVE
110 120 130 140 150
SPTMSRRLPP DPAEAIGTAV VKYNYQAQQP DELSLTKGTR ILILEKSNDG
160 170 180 190 200
WWRGQSGNSV GWFPSNYTTE DCDNDGEIHT YAMAENVLDI VVALYSFTSN
210 220 230 240 250
NDQELSFEKG DRLEIVDRPA SDPDWYKARN NQGQVGLVPR NYLQELNDYL
260 270 280 290 300
ATPYRNTSAS AGNGNGGGSN GGAGGGGGND SMERRNEGNK PAAQSSGQPI
310 320 330 340 350
ERPNLAGKSW YYGAITRSQC DTVLNGHGHD GDFLIRDSET NMGDYSVSLK
360 370 380 390 400
APGRNKHFRV HVEQNMYCIG QRKFHSLDQL VDHYQRAPIY TNKQGEKLYL
410
VRSLPKANGT
Length:410
Mass (Da):45,681
Last modified:November 1, 1996 - v1
Checksum:i6B0F0027A4C16CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57816 mRNA. Translation: AAB05596.1.

Similar proteinsi

Entry informationi

Entry nameiQ24218_DROME
AccessioniPrimary (citable) accession number: Q24218
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)