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Protein
Submitted name:

SH2/SH3 adaptor protein

Gene

dock

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • myoblast fusion Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-373753 Nephrin family interactions
R-DME-3928664 Ephrin signaling
R-DME-418885 DCC mediated attractive signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkiQ24218

Names & Taxonomyi

Protein namesi
Submitted name:
SH2/SH3 adaptor proteinImported
Gene namesi
Name:dockImported
ORF Names:CG3727Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0010583 dock

PTM / Processingi

Proteomic databases

PRIDEiQ24218

Expressioni

Gene expression databases

BgeeiFBgn0010583
ExpressionAtlasiQ24218 baseline and differential

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

Protein-protein interaction databases

IntActiQ24218, 3 interactors
MINTiQ24218

Structurei

3D structure databases

ProteinModelPortaliQ24218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3InterPro annotationAdd BLAST60
Domaini114 – 173SH3InterPro annotationAdd BLAST60
Domaini186 – 248SH3InterPro annotationAdd BLAST63
Domaini310 – 404SH2InterPro annotationAdd BLAST95

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4226 Eukaryota
ENOG410XRPF LUCA
OrthoDBiEOG091G0AD0

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304 NCK
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 3 hits
PIRSFiPIRSF037874 Cytoplasmic_NCK, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 3 hits

Sequencei

Sequence statusi: Complete.

Q24218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNMKHGKS QDDVCYVVAK YDYAAQGAQE LDLRKNERYL LLDDSKHWWR
60 70 80 90 100
VQNSRNQSGY VPSNYVKKEK PSLFDSIKKK VKKGSGSKTL PNCSPSRQVE
110 120 130 140 150
SPTMSRRLPP DPAEAIGTAV VKYNYQAQQP DELSLTKGTR ILILEKSNDG
160 170 180 190 200
WWRGQSGNSV GWFPSNYTTE DCDNDGEIHT YAMAENVLDI VVALYSFTSN
210 220 230 240 250
NDQELSFEKG DRLEIVDRPA SDPDWYKARN NQGQVGLVPR NYLQELNDYL
260 270 280 290 300
ATPYRNTSAS AGNGNGGGSN GGAGGGGGND SMERRNEGNK PAAQSSGQPI
310 320 330 340 350
ERPNLAGKSW YYGAITRSQC DTVLNGHGHD GDFLIRDSET NMGDYSVSLK
360 370 380 390 400
APGRNKHFRV HVEQNMYCIG QRKFHSLDQL VDHYQRAPIY TNKQGEKLYL
410
VRSLPKANGT
Length:410
Mass (Da):45,681
Last modified:November 1, 1996 - v1
Checksum:i6B0F0027A4C16CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57816 mRNA Translation: AAB05596.1

Similar proteinsi

Entry informationi

Entry nameiQ24218_DROME
AccessioniPrimary (citable) accession number: Q24218
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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