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Protein
Submitted name:

SH2/SH3 adaptor protein

Gene

dock

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • axonogenesis Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • myoblast fusion Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-373753. Nephrin interactions.
R-DME-3928664. Ephrin signaling.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiQ24218.

Names & Taxonomyi

Protein namesi
Submitted name:
SH2/SH3 adaptor proteinImported
Gene namesi
Name:dockImported
ORF Names:CG3727Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0010583. dock.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ24218.
PRIDEiQ24218.

Expressioni

Gene expression databases

BgeeiFBgn0010583.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase
  • insulin receptor binding Source: FlyBase
  • protein kinase binding Source: FlyBase
  • SH3/SH2 adaptor activity Source: FlyBase

Protein-protein interaction databases

IntActiQ24218. 3 interactors.
MINTiMINT-98926.
STRINGi7227.FBpp0077679.

Structurei

3D structure databases

ProteinModelPortaliQ24218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3InterPro annotationAdd BLAST60
Domaini114 – 173SH3InterPro annotationAdd BLAST60
Domaini186 – 248SH3InterPro annotationAdd BLAST63
Domaini310 – 404SH2InterPro annotationAdd BLAST95

Sequence similaritiesi

Contains 3 SH3 domains.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4226. Eukaryota.
ENOG410XRPF. LUCA.
OrthoDBiEOG091G0AD0.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR017304. NCK.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10663:SF159. PTHR10663:SF159. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNMKHGKS QDDVCYVVAK YDYAAQGAQE LDLRKNERYL LLDDSKHWWR
60 70 80 90 100
VQNSRNQSGY VPSNYVKKEK PSLFDSIKKK VKKGSGSKTL PNCSPSRQVE
110 120 130 140 150
SPTMSRRLPP DPAEAIGTAV VKYNYQAQQP DELSLTKGTR ILILEKSNDG
160 170 180 190 200
WWRGQSGNSV GWFPSNYTTE DCDNDGEIHT YAMAENVLDI VVALYSFTSN
210 220 230 240 250
NDQELSFEKG DRLEIVDRPA SDPDWYKARN NQGQVGLVPR NYLQELNDYL
260 270 280 290 300
ATPYRNTSAS AGNGNGGGSN GGAGGGGGND SMERRNEGNK PAAQSSGQPI
310 320 330 340 350
ERPNLAGKSW YYGAITRSQC DTVLNGHGHD GDFLIRDSET NMGDYSVSLK
360 370 380 390 400
APGRNKHFRV HVEQNMYCIG QRKFHSLDQL VDHYQRAPIY TNKQGEKLYL
410
VRSLPKANGT
Length:410
Mass (Da):45,681
Last modified:November 1, 1996 - v1
Checksum:i6B0F0027A4C16CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57816 mRNA. Translation: AAB05596.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57816 mRNA. Translation: AAB05596.1.

3D structure databases

ProteinModelPortaliQ24218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ24218. 3 interactors.
MINTiMINT-98926.
STRINGi7227.FBpp0077679.

Proteomic databases

PaxDbiQ24218.
PRIDEiQ24218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0010583. dock.

Phylogenomic databases

eggNOGiKOG4226. Eukaryota.
ENOG410XRPF. LUCA.
OrthoDBiEOG091G0AD0.

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-373753. Nephrin interactions.
R-DME-3928664. Ephrin signaling.
R-DME-418885. DCC mediated attractive signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiQ24218.

Miscellaneous databases

ChiTaRSidock. fly.

Gene expression databases

BgeeiFBgn0010583.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR017304. NCK.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10663:SF159. PTHR10663:SF159. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24218_DROME
AccessioniPrimary (citable) accession number: Q24218
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.