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Protein

Calcineurin subunit B type 2

Gene

CanB2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.By similarity

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi63 – 742PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi100 – 1113PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi141 – 1524PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase regulator activity Source: FlyBase
  • calcium ion binding Source: FlyBase
  • calmodulin binding Source: FlyBase

GO - Biological processi

  • meiotic cell cycle Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • sarcomere organization Source: FlyBase
  • skeletal muscle myosin thick filament assembly Source: FlyBase
  • sleep Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-2025928 Calcineurin activates NFAT
R-DME-2871809 FCERI mediated Ca+2 mobilization
R-DME-4086398 Ca2+ pathway
R-DME-5607763 CLEC7A (Dectin-1) induces NFAT activation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Protein phosphatase 2B regulatory subunit 2
dCNB2
Gene namesi
Name:CanB2
Synonyms:CNB2
ORF Names:CG11217
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0015614 CanB2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000734891 – 170Calcineurin subunit B type 2Add BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24214
PRIDEiQ24214

PTM databases

iPTMnetiQ24214

Expressioni

Gene expression databases

BgeeiFBgn0015614
ExpressionAtlasiQ24214 baseline and differential
GenevisibleiQ24214 DM

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B) (By similarity). Interacts with sra.By similarity1 Publication

GO - Molecular functioni

  • calmodulin binding Source: FlyBase

Protein-protein interaction databases

BioGridi70250, 4 interactors
IntActiQ24214, 1 interactor
STRINGi7227.FBpp0301600

Structurei

3D structure databases

ProteinModelPortaliQ24214
SMRiQ24214
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133729
InParanoidiQ24214
KOiK06268
OMAiVDKTMME
OrthoDBiEOG091G0R0W
PhylomeDBiQ24214

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q24214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNETSLPME MCSNFDADEI RRLGKRFRKL DLDNSGALSV DEFMSLPELQ
60 70 80 90 100
QNPLVQRVID IFDADGNGEV DFKEFIQGVS QFSVKGDKLS KLRFAFRIYD
110 120 130 140 150
MDNDGYISNG ELFQVLKMMV GNNLKDTQLQ QIVDKTIGFA DKDEDGKISF
160 170
DEFCSVVGNT DIHKKMVVDV
Length:170
Mass (Da):19,267
Last modified:January 11, 2001 - v2
Checksum:iFDB1BD9DB5A4BDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56245 Genomic DNA Translation: AAC47350.1
AE013599 Genomic DNA Translation: AAF59195.2
AY089602 mRNA Translation: AAL90340.1
BT003768 mRNA Translation: AAO41447.1
PIRiJC5174
RefSeqiNP_001246192.1, NM_001259263.2
NP_524874.2, NM_080135.4
UniGeneiDm.1774

Genome annotation databases

EnsemblMetazoaiFBtr0088930; FBpp0088004; FBgn0015614
FBtr0309866; FBpp0301600; FBgn0015614
GeneIDi46456
KEGGidme:Dmel_CG11217

Similar proteinsi

Entry informationi

Entry nameiCANB2_DROME
AccessioniPrimary (citable) accession number: Q24214
Secondary accession number(s): Q9V315
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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