Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q24210

- CSKP_DROME

UniProt

Q24210 - CSKP_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATPPROSITE-ProRule annotation
Active sitei141 – 1411By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: FlyBase
  3. neurexin family protein binding Source: BHF-UCL
  4. protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  1. adult locomotory behavior Source: FlyBase
  2. adult walking behavior Source: FlyBase
  3. anesthesia-resistant memory Source: FlyBase
  4. border follicle cell migration Source: FlyBase
  5. cell adhesion Source: FlyBase
  6. establishment or maintenance of cell polarity Source: FlyBase
  7. lateral inhibition Source: FlyBase
  8. locomotion Source: BHF-UCL
  9. long-term memory Source: FlyBase
  10. male courtship behavior Source: FlyBase
  11. medium-term memory Source: FlyBase
  12. neuromuscular synaptic transmission Source: BHF-UCL
  13. neurotransmitter secretion Source: FlyBase
  14. positive regulation of synaptic vesicle endocytosis Source: FlyBase
  15. protein phosphorylation Source: FlyBase
  16. regulation of cell shape Source: FlyBase
  17. regulation of locomotion Source: FlyBase
  18. regulation of neuromuscular synaptic transmission Source: FlyBase
  19. regulation of neurotransmitter secretion Source: FlyBase
  20. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  21. regulation of terminal button organization Source: BHF-UCL
  22. synaptic vesicle docking involved in exocytosis Source: FlyBase
  23. synaptic vesicle endocytosis Source: BHF-UCL
  24. synaptic vesicle targeting Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 1994.
ReactomeiREACT_184300. Syndecan interactions.
REACT_256915. Nephrin interactions.
SignaLinkiQ24210.

Protein family/group databases

TCDBi9.B.106.3.2. the pock size-determining protein (psdp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.17)
Short name:
dCASK
Alternative name(s):
Calcium/calmodulin-dependent protein kinase
Short name:
CAKI
Short name:
Camguk
Gene namesi
Name:CASK
Synonyms:Caki, cmg
ORF Names:CG6703
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013759. CASK.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Eag recruits CASK to the plasma membrane.

GO - Cellular componenti

  1. calcium- and calmodulin-dependent protein kinase complex Source: FlyBase
  2. neuromuscular junction Source: BHF-UCL
  3. plasma membrane Source: UniProtKB-KW
  4. type I terminal bouton Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increases synapse-specific, activity-dependent autophosphorylation of CaMKII Thr-287.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 898898Peripheral plasma membrane protein CASKPRO_0000094571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24210.

Expressioni

Tissue specificityi

During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.1 Publication

Gene expression databases

BgeeiQ24210.
ExpressionAtlasiQ24210. differential.

Interactioni

Subunit structurei

Interacts with eag. Interacts with CaMKII.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CaMKIIQ001685EBI-214423,EBI-124595
eagQ0228010EBI-214423,EBI-85304

Protein-protein interaction databases

BioGridi67530. 10 interactions.
DIPiDIP-19769N.
IntActiQ24210. 6 interactions.
STRINGi7227.FBpp0083559.

Structurei

3D structure databases

ProteinModelPortaliQ24210.
SMRiQ24210. Positions 6-387, 403-462, 492-577, 586-893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 278267Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini343 – 39755L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini402 – 46160L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini495 – 57682PDZPROSITE-ProRule annotationAdd
BLAST
Domaini582 – 65170SH3PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 883173Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni306 – 31611Calmodulin-bindingAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118866.
InParanoidiQ24210.
KOiK06103.
OMAiHEYLEYG.
OrthoDBiEOG79CXZ5.
PhylomeDBiQ24210.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform B (identifier: Q24210-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEDEILFDD VYELCEVIGK GPFSIVRRCI HRESNQQFAV KIVDVAKFTA
60 70 80 90 100
SPGLSTADLK REATICHMLK HPHIVELLET YSSEGMLYMV FEFMEGSDLC
110 120 130 140 150
FEVVRRAVAG FVYSEAVACH YMRQILEALR YCHENDILHR DVRPACALLA
160 170 180 190 200
TVDNSAPVKL GGFGSAIQLP GTRETIETHG RVGCPHYMAP EVVTRRLYGK
210 220 230 240 250
GCDVWGAGVM LHVLLSGRLP FLGSGVRLQQ SVARGRLSFE APEWKSISAN
260 270 280 290 300
AKDLVMKMLA ANPHHRLSIT EVLDHPWIRD RDKLQRTHLA DTVEELKRYN
310 320 330 340 350
ARRKLKGAVQ AIAGGTNMDP LYATDADMPI TGATDEWADE EAGIEAVQRI
360 370 380 390 400
LDCLDDIYSL QDAHVDADVL RDMLRDNRLH QFLQLFDRIA ATVVTSNGRA
410 420 430 440 450
PAAEAVGRCR DVLEQLSSTS GGNSLGGKYA KEELMRLLAA PHMQALLHSH
460 470 480 490 500
DVVARDVYGE EALRVTPPPM VPYLNGDELD NVEGGELQHV TRVRLVQFQK
510 520 530 540 550
NTDEPMGITL KMTEDGRCIV ARIMHGGMIH RQATLHVGDE IREINGQPVQ
560 570 580 590 600
HQSVGQLQRM LREARGSVTF KIVPSYRSAP PPCEIFVRAQ FDYNPLDDEL
610 620 630 640 650
IPCAQAGISF QVGDILQIIS KDDHHWWQAR LDTVGGSAGL IPSPELQEWR
660 670 680 690 700
IACQTVDKTK QEQVNCSIFG RKKKQCRDKY LAKHNAIFDT LDVVTYEEVV
710 720 730 740 750
KVPVGDPNFQ RKTLVLLGAH GVGRRHIKNT LISKYPDKYA YPIPHTTRPA
760 770 780 790 800
KPEEENGRSY YFVSHDEMMA DIGANEYLEY GTHEDAMYGT KLDTIRRIHT
810 820 830 840 850
EGKMAILDVE PQALKILRTA EFTPYVVFIA APSLQNIADY DGSLERLAKE
860 870 880 890
SEMLRQLYGH FFDLTIVNND ISETIATLET AIDRVHTTPQ WVPVSWLY
Length:898
Mass (Da):100,911
Last modified:August 22, 2003 - v4
Checksum:i5B16014EC66E0E9B
GO
Isoform A (identifier: Q24210-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL

Note: No experimental confirmation available.

Show »
Length:591
Mass (Da):65,197
Checksum:i645638C40343145C
GO
Isoform G (identifier: Q24210-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL
     663-663: Q → QGEPGAGCSAHADGCDGSA

Note: No experimental confirmation available.

Show »
Length:609
Mass (Da):66,741
Checksum:i7F0A65E1DD31AD9D
GO

Sequence cautioni

The sequence AAM11269.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence AAO39536.1 differs from that shown. Reason: Frameshift at position 114. Curated
The sequence CAA63940.1 differs from that shown. Reason: Frameshift at positions 537 and 667. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → V in AAC80169. (PubMed:9178262)Curated
Sequence conflicti136 – 1361D → E in AAC80169. (PubMed:9178262)Curated
Sequence conflicti463 – 4631L → A in AAC80169. (PubMed:9178262)Curated
Sequence conflicti465 – 47713VTPPP…YLNGD → HPAPDGALPQWR in AAC80169. (PubMed:9178262)CuratedAdd
BLAST
Sequence conflicti497 – 4971Q → H in AAC80169. (PubMed:9178262)Curated
Sequence conflicti523 – 5231I → L in AAC80169. (PubMed:9178262)Curated
Sequence conflicti632 – 6321D → G in AAC80169. (PubMed:9178262)Curated
Sequence conflicti740 – 7401A → V in AAC80169. (PubMed:9178262)Curated
Sequence conflicti759 – 7591S → N in AAO39554. (PubMed:12537569)Curated
Sequence conflicti886 – 8927HTTPQWV → DIPPRSGC in CAA63940. (PubMed:8617233)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 317317Missing in isoform A and isoform G. 1 PublicationVSP_008088Add
BLAST
Alternative sequencei318 – 443126MDPLY…AAPHM → MCQHHGLTSQSLMSGGSHIS LLGSSGSSGMSGSGVGSSGQ SVPQCPAAVAAADAAMMGSN AGGHCRSLSGLSSISIPPPP PALFNPCSSALSLQQAAVTR WGPRTSCPVHSPFRVRVPNG SICSGH in isoform A and isoform G. 1 PublicationVSP_008089Add
BLAST
Alternative sequencei584 – 5841E → ELFRIRPAPVL in isoform A and isoform G. 1 PublicationVSP_008090
Alternative sequencei663 – 6631Q → QGEPGAGCSAHADGCDGSA in isoform G. CuratedVSP_041854

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53190 mRNA. Translation: AAC80169.1.
X94264 mRNA. Translation: CAA63940.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF55920.3.
AE014297 Genomic DNA. Translation: AAF55921.2.
AE014297 Genomic DNA. Translation: AAF55922.2.
AY094916 mRNA. Translation: AAM11269.1. Sequence problems.
BT003532 mRNA. Translation: AAO39536.1. Frameshift.
BT003550 mRNA. Translation: AAO39554.1.
BT046172 mRNA. Translation: ACI49771.1.
PIRiS69210.
RefSeqiNP_001097862.1. NM_001104392.3. [Q24210-2]
NP_524441.2. NM_079717.4. [Q24210-3]
NP_732661.1. NM_169970.2. [Q24210-2]
NP_732662.2. NM_169971.3. [Q24210-4]
UniGeneiDm.7404.

Genome annotation databases

EnsemblMetazoaiFBtr0084161; FBpp0083559; FBgn0013759. [Q24210-3]
GeneIDi42567.
KEGGidme:Dmel_CG6703.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53190 mRNA. Translation: AAC80169.1 .
X94264 mRNA. Translation: CAA63940.1 . Frameshift.
AE014297 Genomic DNA. Translation: AAF55920.3 .
AE014297 Genomic DNA. Translation: AAF55921.2 .
AE014297 Genomic DNA. Translation: AAF55922.2 .
AY094916 mRNA. Translation: AAM11269.1 . Sequence problems.
BT003532 mRNA. Translation: AAO39536.1 . Frameshift.
BT003550 mRNA. Translation: AAO39554.1 .
BT046172 mRNA. Translation: ACI49771.1 .
PIRi S69210.
RefSeqi NP_001097862.1. NM_001104392.3. [Q24210-2 ]
NP_524441.2. NM_079717.4. [Q24210-3 ]
NP_732661.1. NM_169970.2. [Q24210-2 ]
NP_732662.2. NM_169971.3. [Q24210-4 ]
UniGenei Dm.7404.

3D structure databases

ProteinModelPortali Q24210.
SMRi Q24210. Positions 6-387, 403-462, 492-577, 586-893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67530. 10 interactions.
DIPi DIP-19769N.
IntActi Q24210. 6 interactions.
STRINGi 7227.FBpp0083559.

Protein family/group databases

TCDBi 9.B.106.3.2. the pock size-determining protein (psdp) family.

Proteomic databases

PaxDbi Q24210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084161 ; FBpp0083559 ; FBgn0013759 . [Q24210-3 ]
GeneIDi 42567.
KEGGi dme:Dmel_CG6703.

Organism-specific databases

CTDi 8573.
FlyBasei FBgn0013759. CASK.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118866.
InParanoidi Q24210.
KOi K06103.
OMAi HEYLEYG.
OrthoDBi EOG79CXZ5.
PhylomeDBi Q24210.

Enzyme and pathway databases

BRENDAi 2.7.11.17. 1994.
Reactomei REACT_184300. Syndecan interactions.
REACT_256915. Nephrin interactions.
SignaLinki Q24210.

Miscellaneous databases

GenomeRNAii 42567.
NextBioi 829455.
PROi Q24210.

Gene expression databases

Bgeei Q24210.
ExpressionAtlasi Q24210. differential.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains."
    Dimitratos S.D., Woods D.F., Bryant P.J.
    Mech. Dev. 63:127-130(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Strain: Oregon-R.
  2. "A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed."
    Martin J.-R., Ollo R.
    EMBO J. 15:1865-1876(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo and Head.
  6. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Embryo and Head.
  7. "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation."
    Lu C.S., Hodge J.J., Mehren J., Sun X.X., Griffith L.C.
    Neuron 40:1185-1197(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CAMKII.
  8. "Camguk/CASK enhances Ether-a-go-go potassium current by a phosphorylation-dependent mechanism."
    Marble D.D., Hegle A.P., Snyder E.D. II, Dimitratos S., Bryant P.J., Wilson G.F.
    J. Neurosci. 25:4898-4907(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EAG, SUBCELLULAR LOCATION.
  9. "Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK."
    Hodge J.J., Mullasseril P., Griffith L.C.
    Neuron 51:327-337(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCSKP_DROME
AccessioniPrimary (citable) accession number: Q24210
Secondary accession number(s): B5X553
, Q24272, Q86P03, Q86P17, Q8SX09, Q9VD77, Q9VD78, Q9VD79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 22, 2003
Last modified: November 26, 2014
This is version 158 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3