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Q24210

- CSKP_DROME

UniProt

Q24210 - CSKP_DROME

Protein

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 4 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.3 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATPPROSITE-ProRule annotation
    Active sitei141 – 1411By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calmodulin-dependent protein kinase activity Source: FlyBase
    3. neurexin family protein binding Source: BHF-UCL
    4. protein binding Source: IntAct
    5. protein serine/threonine kinase activity Source: FlyBase

    GO - Biological processi

    1. adult locomotory behavior Source: FlyBase
    2. adult walking behavior Source: FlyBase
    3. anesthesia-resistant memory Source: FlyBase
    4. border follicle cell migration Source: FlyBase
    5. cell adhesion Source: FlyBase
    6. establishment or maintenance of cell polarity Source: FlyBase
    7. lateral inhibition Source: FlyBase
    8. locomotion Source: BHF-UCL
    9. long-term memory Source: FlyBase
    10. male courtship behavior Source: FlyBase
    11. medium-term memory Source: FlyBase
    12. neuromuscular synaptic transmission Source: BHF-UCL
    13. neurotransmitter secretion Source: FlyBase
    14. positive regulation of synaptic vesicle endocytosis Source: FlyBase
    15. protein phosphorylation Source: FlyBase
    16. regulation of cell shape Source: FlyBase
    17. regulation of locomotion Source: FlyBase
    18. regulation of neuromuscular synaptic transmission Source: FlyBase
    19. regulation of neurotransmitter secretion Source: FlyBase
    20. regulation of synaptic growth at neuromuscular junction Source: FlyBase
    21. regulation of terminal button organization Source: BHF-UCL
    22. synaptic vesicle docking involved in exocytosis Source: FlyBase
    23. synaptic vesicle endocytosis Source: BHF-UCL
    24. synaptic vesicle targeting Source: FlyBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.17. 1994.
    ReactomeiREACT_184300. Syndecan interactions.
    SignaLinkiQ24210.

    Protein family/group databases

    TCDBi9.B.106.3.2. the pock size-determining protein (psdp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peripheral plasma membrane protein CASK (EC:2.7.11.17)
    Short name:
    dCASK
    Alternative name(s):
    Calcium/calmodulin-dependent protein kinase
    Short name:
    CAKI
    Short name:
    Camguk
    Gene namesi
    Name:CASK
    Synonyms:Caki, cmg
    ORF Names:CG6703
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0013759. CASK.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Eag recruits CASK to the plasma membrane.

    GO - Cellular componenti

    1. calcium- and calmodulin-dependent protein kinase complex Source: FlyBase
    2. neuromuscular junction Source: BHF-UCL
    3. plasma membrane Source: UniProtKB-SubCell
    4. type I terminal bouton Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Increases synapse-specific, activity-dependent autophosphorylation of CaMKII Thr-287.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 898898Peripheral plasma membrane protein CASKPRO_0000094571Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei292 – 2921Phosphothreonine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ24210.

    Expressioni

    Tissue specificityi

    During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.1 Publication

    Gene expression databases

    BgeeiQ24210.

    Interactioni

    Subunit structurei

    Interacts with eag. Interacts with CaMKII.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CaMKIIQ001685EBI-214423,EBI-124595
    eagQ0228010EBI-214423,EBI-85304

    Protein-protein interaction databases

    BioGridi67530. 10 interactions.
    DIPiDIP-19769N.
    IntActiQ24210. 6 interactions.
    STRINGi7227.FBpp0083559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24210.
    SMRiQ24210. Positions 5-462, 492-577, 586-893.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 278267Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini343 – 39755L27 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini402 – 46160L27 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini495 – 57682PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini582 – 65170SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini711 – 883173Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni306 – 31611Calmodulin-bindingAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 2 L27 domains.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000077048.
    InParanoidiQ24210.
    KOiK06103.
    OMAiHEYLEYG.
    OrthoDBiEOG79CXZ5.
    PhylomeDBiQ24210.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR011009. Kinase-like_dom.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00220. S_TKc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: Q24210-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEDEILFDD VYELCEVIGK GPFSIVRRCI HRESNQQFAV KIVDVAKFTA    50
    SPGLSTADLK REATICHMLK HPHIVELLET YSSEGMLYMV FEFMEGSDLC 100
    FEVVRRAVAG FVYSEAVACH YMRQILEALR YCHENDILHR DVRPACALLA 150
    TVDNSAPVKL GGFGSAIQLP GTRETIETHG RVGCPHYMAP EVVTRRLYGK 200
    GCDVWGAGVM LHVLLSGRLP FLGSGVRLQQ SVARGRLSFE APEWKSISAN 250
    AKDLVMKMLA ANPHHRLSIT EVLDHPWIRD RDKLQRTHLA DTVEELKRYN 300
    ARRKLKGAVQ AIAGGTNMDP LYATDADMPI TGATDEWADE EAGIEAVQRI 350
    LDCLDDIYSL QDAHVDADVL RDMLRDNRLH QFLQLFDRIA ATVVTSNGRA 400
    PAAEAVGRCR DVLEQLSSTS GGNSLGGKYA KEELMRLLAA PHMQALLHSH 450
    DVVARDVYGE EALRVTPPPM VPYLNGDELD NVEGGELQHV TRVRLVQFQK 500
    NTDEPMGITL KMTEDGRCIV ARIMHGGMIH RQATLHVGDE IREINGQPVQ 550
    HQSVGQLQRM LREARGSVTF KIVPSYRSAP PPCEIFVRAQ FDYNPLDDEL 600
    IPCAQAGISF QVGDILQIIS KDDHHWWQAR LDTVGGSAGL IPSPELQEWR 650
    IACQTVDKTK QEQVNCSIFG RKKKQCRDKY LAKHNAIFDT LDVVTYEEVV 700
    KVPVGDPNFQ RKTLVLLGAH GVGRRHIKNT LISKYPDKYA YPIPHTTRPA 750
    KPEEENGRSY YFVSHDEMMA DIGANEYLEY GTHEDAMYGT KLDTIRRIHT 800
    EGKMAILDVE PQALKILRTA EFTPYVVFIA APSLQNIADY DGSLERLAKE 850
    SEMLRQLYGH FFDLTIVNND ISETIATLET AIDRVHTTPQ WVPVSWLY 898
    Length:898
    Mass (Da):100,911
    Last modified:August 22, 2003 - v4
    Checksum:i5B16014EC66E0E9B
    GO
    Isoform A (identifier: Q24210-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-317: Missing.
         318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
         584-584: E → ELFRIRPAPVL

    Note: No experimental confirmation available.

    Show »
    Length:591
    Mass (Da):65,197
    Checksum:i645638C40343145C
    GO
    Isoform G (identifier: Q24210-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-317: Missing.
         318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
         584-584: E → ELFRIRPAPVL
         663-663: Q → QGEPGAGCSAHADGCDGSA

    Note: No experimental confirmation available.

    Show »
    Length:609
    Mass (Da):66,741
    Checksum:i7F0A65E1DD31AD9D
    GO

    Sequence cautioni

    The sequence AAM11269.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence AAO39536.1 differs from that shown. Reason: Frameshift at position 114.
    The sequence CAA63940.1 differs from that shown. Reason: Frameshift at positions 537 and 667.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71L → V in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti136 – 1361D → E in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti463 – 4631L → A in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti465 – 47713VTPPP…YLNGD → HPAPDGALPQWR in AAC80169. (PubMed:9178262)CuratedAdd
    BLAST
    Sequence conflicti497 – 4971Q → H in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti523 – 5231I → L in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti632 – 6321D → G in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti740 – 7401A → V in AAC80169. (PubMed:9178262)Curated
    Sequence conflicti759 – 7591S → N in AAO39554. (PubMed:12537569)Curated
    Sequence conflicti886 – 8927HTTPQWV → DIPPRSGC in CAA63940. (PubMed:8617233)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 317317Missing in isoform A and isoform G. 1 PublicationVSP_008088Add
    BLAST
    Alternative sequencei318 – 443126MDPLY…AAPHM → MCQHHGLTSQSLMSGGSHIS LLGSSGSSGMSGSGVGSSGQ SVPQCPAAVAAADAAMMGSN AGGHCRSLSGLSSISIPPPP PALFNPCSSALSLQQAAVTR WGPRTSCPVHSPFRVRVPNG SICSGH in isoform A and isoform G. 1 PublicationVSP_008089Add
    BLAST
    Alternative sequencei584 – 5841E → ELFRIRPAPVL in isoform A and isoform G. 1 PublicationVSP_008090
    Alternative sequencei663 – 6631Q → QGEPGAGCSAHADGCDGSA in isoform G. CuratedVSP_041854

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53190 mRNA. Translation: AAC80169.1.
    X94264 mRNA. Translation: CAA63940.1. Frameshift.
    AE014297 Genomic DNA. Translation: AAF55920.3.
    AE014297 Genomic DNA. Translation: AAF55921.2.
    AE014297 Genomic DNA. Translation: AAF55922.2.
    AY094916 mRNA. Translation: AAM11269.1. Sequence problems.
    BT003532 mRNA. Translation: AAO39536.1. Frameshift.
    BT003550 mRNA. Translation: AAO39554.1.
    BT046172 mRNA. Translation: ACI49771.1.
    PIRiS69210.
    RefSeqiNP_001097862.1. NM_001104392.3. [Q24210-2]
    NP_524441.2. NM_079717.4. [Q24210-3]
    NP_732661.1. NM_169970.2. [Q24210-2]
    NP_732662.2. NM_169971.3. [Q24210-4]
    UniGeneiDm.7404.

    Genome annotation databases

    EnsemblMetazoaiFBtr0084161; FBpp0083559; FBgn0013759. [Q24210-3]
    GeneIDi42567.
    KEGGidme:Dmel_CG6703.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53190 mRNA. Translation: AAC80169.1 .
    X94264 mRNA. Translation: CAA63940.1 . Frameshift.
    AE014297 Genomic DNA. Translation: AAF55920.3 .
    AE014297 Genomic DNA. Translation: AAF55921.2 .
    AE014297 Genomic DNA. Translation: AAF55922.2 .
    AY094916 mRNA. Translation: AAM11269.1 . Sequence problems.
    BT003532 mRNA. Translation: AAO39536.1 . Frameshift.
    BT003550 mRNA. Translation: AAO39554.1 .
    BT046172 mRNA. Translation: ACI49771.1 .
    PIRi S69210.
    RefSeqi NP_001097862.1. NM_001104392.3. [Q24210-2 ]
    NP_524441.2. NM_079717.4. [Q24210-3 ]
    NP_732661.1. NM_169970.2. [Q24210-2 ]
    NP_732662.2. NM_169971.3. [Q24210-4 ]
    UniGenei Dm.7404.

    3D structure databases

    ProteinModelPortali Q24210.
    SMRi Q24210. Positions 5-462, 492-577, 586-893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67530. 10 interactions.
    DIPi DIP-19769N.
    IntActi Q24210. 6 interactions.
    STRINGi 7227.FBpp0083559.

    Protein family/group databases

    TCDBi 9.B.106.3.2. the pock size-determining protein (psdp) family.

    Proteomic databases

    PaxDbi Q24210.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0084161 ; FBpp0083559 ; FBgn0013759 . [Q24210-3 ]
    GeneIDi 42567.
    KEGGi dme:Dmel_CG6703.

    Organism-specific databases

    CTDi 8573.
    FlyBasei FBgn0013759. CASK.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000077048.
    InParanoidi Q24210.
    KOi K06103.
    OMAi HEYLEYG.
    OrthoDBi EOG79CXZ5.
    PhylomeDBi Q24210.

    Enzyme and pathway databases

    BRENDAi 2.7.11.17. 1994.
    Reactomei REACT_184300. Syndecan interactions.
    SignaLinki Q24210.

    Miscellaneous databases

    GenomeRNAii 42567.
    NextBioi 829455.
    PROi Q24210.

    Gene expression databases

    Bgeei Q24210.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR011009. Kinase-like_dom.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00220. S_TKc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains."
      Dimitratos S.D., Woods D.F., Bryant P.J.
      Mech. Dev. 63:127-130(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Strain: Oregon-R.
    2. "A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed."
      Martin J.-R., Ollo R.
      EMBO J. 15:1865-1876(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
      Strain: Berkeley.
      Tissue: Embryo and Head.
    6. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Embryo and Head.
    7. "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation."
      Lu C.S., Hodge J.J., Mehren J., Sun X.X., Griffith L.C.
      Neuron 40:1185-1197(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CAMKII.
    8. "Camguk/CASK enhances Ether-a-go-go potassium current by a phosphorylation-dependent mechanism."
      Marble D.D., Hegle A.P., Snyder E.D. II, Dimitratos S., Bryant P.J., Wilson G.F.
      J. Neurosci. 25:4898-4907(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EAG, SUBCELLULAR LOCATION.
    9. "Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK."
      Hodge J.J., Mullasseril P., Griffith L.C.
      Neuron 51:327-337(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCSKP_DROME
    AccessioniPrimary (citable) accession number: Q24210
    Secondary accession number(s): B5X553
    , Q24272, Q86P03, Q86P17, Q8SX09, Q9VD77, Q9VD78, Q9VD79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 156 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3