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Q24210

- CSKP_DROME

UniProt

Q24210 - CSKP_DROME

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Protein

Peripheral plasma membrane protein CASK

Gene
CASK, Caki, cmg, CG6703
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP By similarity
Active sitei141 – 1411 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: FlyBase
  3. neurexin family protein binding Source: BHF-UCL
  4. protein binding Source: IntAct
  5. protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  1. adult locomotory behavior Source: FlyBase
  2. adult walking behavior Source: FlyBase
  3. anesthesia-resistant memory Source: FlyBase
  4. border follicle cell migration Source: FlyBase
  5. cell adhesion Source: FlyBase
  6. establishment or maintenance of cell polarity Source: FlyBase
  7. lateral inhibition Source: FlyBase
  8. locomotion Source: BHF-UCL
  9. long-term memory Source: FlyBase
  10. male courtship behavior Source: FlyBase
  11. medium-term memory Source: FlyBase
  12. neuromuscular synaptic transmission Source: BHF-UCL
  13. neurotransmitter secretion Source: FlyBase
  14. positive regulation of synaptic vesicle endocytosis Source: FlyBase
  15. protein phosphorylation Source: FlyBase
  16. regulation of cell shape Source: FlyBase
  17. regulation of locomotion Source: FlyBase
  18. regulation of neuromuscular synaptic transmission Source: FlyBase
  19. regulation of neurotransmitter secretion Source: FlyBase
  20. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  21. regulation of terminal button organization Source: BHF-UCL
  22. synaptic vesicle docking involved in exocytosis Source: FlyBase
  23. synaptic vesicle endocytosis Source: BHF-UCL
  24. synaptic vesicle targeting Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 1994.
ReactomeiREACT_184300. Syndecan interactions.
SignaLinkiQ24210.

Protein family/group databases

TCDBi9.B.106.3.2. the pock size-determining protein (psdp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.17)
Short name:
dCASK
Alternative name(s):
Calcium/calmodulin-dependent protein kinase
Short name:
CAKI
Short name:
Camguk
Gene namesi
Name:CASK
Synonyms:Caki, cmg
ORF Names:CG6703
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013759. CASK.

Subcellular locationi

Cell membrane; Peripheral membrane protein
Note: Eag recruits CASK to the plasma membrane.1 Publication

GO - Cellular componenti

  1. calcium- and calmodulin-dependent protein kinase complex Source: FlyBase
  2. neuromuscular junction Source: BHF-UCL
  3. plasma membrane Source: UniProtKB-SubCell
  4. type I terminal bouton Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increases synapse-specific, activity-dependent autophosphorylation of CaMKII Thr-287.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 898898Peripheral plasma membrane protein CASKPRO_0000094571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921Phosphothreonine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24210.

Expressioni

Tissue specificityi

During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.1 Publication

Gene expression databases

BgeeiQ24210.

Interactioni

Subunit structurei

Interacts with eag. Interacts with CaMKII.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CaMKIIQ001685EBI-214423,EBI-124595
eagQ0228010EBI-214423,EBI-85304

Protein-protein interaction databases

BioGridi67530. 10 interactions.
DIPiDIP-19769N.
IntActiQ24210. 6 interactions.
STRINGi7227.FBpp0083559.

Structurei

3D structure databases

ProteinModelPortaliQ24210.
SMRiQ24210. Positions 5-462, 492-577, 586-893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 278267Protein kinaseAdd
BLAST
Domaini343 – 39755L27 1Add
BLAST
Domaini402 – 46160L27 2Add
BLAST
Domaini495 – 57682PDZAdd
BLAST
Domaini582 – 65170SH3Add
BLAST
Domaini711 – 883173Guanylate kinase-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni306 – 31611Calmodulin-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.
Contains 2 L27 domains.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00560000077048.
InParanoidiQ24210.
KOiK06103.
OMAiHEYLEYG.
OrthoDBiEOG79CXZ5.
PhylomeDBiQ24210.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform B (identifier: Q24210-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTEDEILFDD VYELCEVIGK GPFSIVRRCI HRESNQQFAV KIVDVAKFTA    50
SPGLSTADLK REATICHMLK HPHIVELLET YSSEGMLYMV FEFMEGSDLC 100
FEVVRRAVAG FVYSEAVACH YMRQILEALR YCHENDILHR DVRPACALLA 150
TVDNSAPVKL GGFGSAIQLP GTRETIETHG RVGCPHYMAP EVVTRRLYGK 200
GCDVWGAGVM LHVLLSGRLP FLGSGVRLQQ SVARGRLSFE APEWKSISAN 250
AKDLVMKMLA ANPHHRLSIT EVLDHPWIRD RDKLQRTHLA DTVEELKRYN 300
ARRKLKGAVQ AIAGGTNMDP LYATDADMPI TGATDEWADE EAGIEAVQRI 350
LDCLDDIYSL QDAHVDADVL RDMLRDNRLH QFLQLFDRIA ATVVTSNGRA 400
PAAEAVGRCR DVLEQLSSTS GGNSLGGKYA KEELMRLLAA PHMQALLHSH 450
DVVARDVYGE EALRVTPPPM VPYLNGDELD NVEGGELQHV TRVRLVQFQK 500
NTDEPMGITL KMTEDGRCIV ARIMHGGMIH RQATLHVGDE IREINGQPVQ 550
HQSVGQLQRM LREARGSVTF KIVPSYRSAP PPCEIFVRAQ FDYNPLDDEL 600
IPCAQAGISF QVGDILQIIS KDDHHWWQAR LDTVGGSAGL IPSPELQEWR 650
IACQTVDKTK QEQVNCSIFG RKKKQCRDKY LAKHNAIFDT LDVVTYEEVV 700
KVPVGDPNFQ RKTLVLLGAH GVGRRHIKNT LISKYPDKYA YPIPHTTRPA 750
KPEEENGRSY YFVSHDEMMA DIGANEYLEY GTHEDAMYGT KLDTIRRIHT 800
EGKMAILDVE PQALKILRTA EFTPYVVFIA APSLQNIADY DGSLERLAKE 850
SEMLRQLYGH FFDLTIVNND ISETIATLET AIDRVHTTPQ WVPVSWLY 898
Length:898
Mass (Da):100,911
Last modified:August 22, 2003 - v4
Checksum:i5B16014EC66E0E9B
GO
Isoform A (identifier: Q24210-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL

Note: No experimental confirmation available.

Show »
Length:591
Mass (Da):65,197
Checksum:i645638C40343145C
GO
Isoform G (identifier: Q24210-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-443: MDPLYATDAD...LMRLLAAPHM → MCQHHGLTSQ...VPNGSICSGH
     584-584: E → ELFRIRPAPVL
     663-663: Q → QGEPGAGCSAHADGCDGSA

Note: No experimental confirmation available.

Show »
Length:609
Mass (Da):66,741
Checksum:i7F0A65E1DD31AD9D
GO

Sequence cautioni

The sequence AAM11269.1 differs from that shown. Reason: Probable cloning artifact.
The sequence AAO39536.1 differs from that shown. Reason: Frameshift at position 114.
The sequence CAA63940.1 differs from that shown. Reason: Frameshift at positions 537 and 667.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 317317Missing in isoform A and isoform G. VSP_008088Add
BLAST
Alternative sequencei318 – 443126MDPLY…AAPHM → MCQHHGLTSQSLMSGGSHIS LLGSSGSSGMSGSGVGSSGQ SVPQCPAAVAAADAAMMGSN AGGHCRSLSGLSSISIPPPP PALFNPCSSALSLQQAAVTR WGPRTSCPVHSPFRVRVPNG SICSGH in isoform A and isoform G. VSP_008089Add
BLAST
Alternative sequencei584 – 5841E → ELFRIRPAPVL in isoform A and isoform G. VSP_008090
Alternative sequencei663 – 6631Q → QGEPGAGCSAHADGCDGSA in isoform G. VSP_041854

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → V in AAC80169. 1 Publication
Sequence conflicti136 – 1361D → E in AAC80169. 1 Publication
Sequence conflicti463 – 4631L → A in AAC80169. 1 Publication
Sequence conflicti465 – 47713VTPPP…YLNGD → HPAPDGALPQWR in AAC80169. 1 PublicationAdd
BLAST
Sequence conflicti497 – 4971Q → H in AAC80169. 1 Publication
Sequence conflicti523 – 5231I → L in AAC80169. 1 Publication
Sequence conflicti632 – 6321D → G in AAC80169. 1 Publication
Sequence conflicti740 – 7401A → V in AAC80169. 1 Publication
Sequence conflicti759 – 7591S → N in AAO39554. 1 Publication
Sequence conflicti886 – 8927HTTPQWV → DIPPRSGC in CAA63940. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53190 mRNA. Translation: AAC80169.1.
X94264 mRNA. Translation: CAA63940.1. Frameshift.
AE014297 Genomic DNA. Translation: AAF55920.3.
AE014297 Genomic DNA. Translation: AAF55921.2.
AE014297 Genomic DNA. Translation: AAF55922.2.
AY094916 mRNA. Translation: AAM11269.1. Sequence problems.
BT003532 mRNA. Translation: AAO39536.1. Frameshift.
BT003550 mRNA. Translation: AAO39554.1.
BT046172 mRNA. Translation: ACI49771.1.
PIRiS69210.
RefSeqiNP_001097862.1. NM_001104392.3. [Q24210-2]
NP_524441.2. NM_079717.4. [Q24210-3]
NP_732661.1. NM_169970.2. [Q24210-2]
NP_732662.2. NM_169971.3. [Q24210-4]
UniGeneiDm.7404.

Genome annotation databases

EnsemblMetazoaiFBtr0084161; FBpp0083559; FBgn0013759. [Q24210-3]
GeneIDi42567.
KEGGidme:Dmel_CG6703.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53190 mRNA. Translation: AAC80169.1 .
X94264 mRNA. Translation: CAA63940.1 . Frameshift.
AE014297 Genomic DNA. Translation: AAF55920.3 .
AE014297 Genomic DNA. Translation: AAF55921.2 .
AE014297 Genomic DNA. Translation: AAF55922.2 .
AY094916 mRNA. Translation: AAM11269.1 . Sequence problems.
BT003532 mRNA. Translation: AAO39536.1 . Frameshift.
BT003550 mRNA. Translation: AAO39554.1 .
BT046172 mRNA. Translation: ACI49771.1 .
PIRi S69210.
RefSeqi NP_001097862.1. NM_001104392.3. [Q24210-2 ]
NP_524441.2. NM_079717.4. [Q24210-3 ]
NP_732661.1. NM_169970.2. [Q24210-2 ]
NP_732662.2. NM_169971.3. [Q24210-4 ]
UniGenei Dm.7404.

3D structure databases

ProteinModelPortali Q24210.
SMRi Q24210. Positions 5-462, 492-577, 586-893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67530. 10 interactions.
DIPi DIP-19769N.
IntActi Q24210. 6 interactions.
STRINGi 7227.FBpp0083559.

Protein family/group databases

TCDBi 9.B.106.3.2. the pock size-determining protein (psdp) family.

Proteomic databases

PaxDbi Q24210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084161 ; FBpp0083559 ; FBgn0013759 . [Q24210-3 ]
GeneIDi 42567.
KEGGi dme:Dmel_CG6703.

Organism-specific databases

CTDi 8573.
FlyBasei FBgn0013759. CASK.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00560000077048.
InParanoidi Q24210.
KOi K06103.
OMAi HEYLEYG.
OrthoDBi EOG79CXZ5.
PhylomeDBi Q24210.

Enzyme and pathway databases

BRENDAi 2.7.11.17. 1994.
Reactomei REACT_184300. Syndecan interactions.
SignaLinki Q24210.

Miscellaneous databases

GenomeRNAii 42567.
NextBioi 829455.
PROi Q24210.

Gene expression databases

Bgeei Q24210.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains."
    Dimitratos S.D., Woods D.F., Bryant P.J.
    Mech. Dev. 63:127-130(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Strain: Oregon-R.
  2. "A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed."
    Martin J.-R., Ollo R.
    EMBO J. 15:1865-1876(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo and Head.
  6. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.
    Tissue: Embryo and Head.
  7. "Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation."
    Lu C.S., Hodge J.J., Mehren J., Sun X.X., Griffith L.C.
    Neuron 40:1185-1197(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CAMKII.
  8. "Camguk/CASK enhances Ether-a-go-go potassium current by a phosphorylation-dependent mechanism."
    Marble D.D., Hegle A.P., Snyder E.D. II, Dimitratos S., Bryant P.J., Wilson G.F.
    J. Neurosci. 25:4898-4907(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EAG, SUBCELLULAR LOCATION.
  9. "Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK."
    Hodge J.J., Mullasseril P., Griffith L.C.
    Neuron 51:327-337(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCSKP_DROME
AccessioniPrimary (citable) accession number: Q24210
Secondary accession number(s): B5X553
, Q24272, Q86P03, Q86P17, Q8SX09, Q9VD77, Q9VD78, Q9VD79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 22, 2003
Last modified: September 3, 2014
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi