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Protein
Submitted name:

Serine/threonine kinase PAK homolog DPAK

Gene

Pak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: FlyBase
  • Rac GTPase binding Source: FlyBase
  • Rho GTPase binding Source: FlyBase
  • SH3 domain binding Source: FlyBase
  • signal transducer, downstream of receptor, with serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • cell adhesion Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, spreading of leading edge cells Source: FlyBase
  • ecdysone-mediated induction of salivary gland cell autophagic cell death Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • JNK cascade Source: FlyBase
  • positive regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • Rac protein signal transduction Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • regulation of synapse structure or activity Source: FlyBase
  • septate junction assembly Source: FlyBase

Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-376172. DSCAM interactions.
R-DME-389359. CD28 dependent Vav1 pathway.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928664. Ephrin signaling.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-445144. Signal transduction by L1.
R-DME-5218920. VEGFR2 mediated vascular permeability.
R-DME-5621575. CD209 (DC-SIGN) signaling.
R-DME-5627123. RHO GTPases activate PAKs.
R-DME-5687128. MAPK6/MAPK4 signaling.
SignaLinkiQ24190.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine kinase PAK homolog DPAKImported
Gene namesi
Name:PakImported
ORF Names:CG10295Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0267698. Pak.

Subcellular locationi

GO - Cellular componenti

  • cell leading edge Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytoskeleton Source: FlyBase
  • lateral plasma membrane Source: FlyBase
  • muscle cell postsynaptic density Source: FlyBase

PTM / Processingi

Proteomic databases

PaxDbiQ24190.
PeptideAtlasiQ24190.
PRIDEiQ24190.

Expressioni

Gene expression databases

BgeeiFBgn0014001.
ExpressionAtlasiQ24190. differential.

Interactioni

GO - Molecular functioni

  • Rac GTPase binding Source: FlyBase
  • Rho GTPase binding Source: FlyBase
  • SH3 domain binding Source: FlyBase

Protein-protein interaction databases

IntActiQ24190. 26 interactors.
MINTiMINT-7952568.

Structurei

3D structure databases

ProteinModelPortaliQ24190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 96CRIBInterPro annotationAdd BLAST14
Domaini430 – 681Protein kinaseInterPro annotationAdd BLAST252

Phylogenomic databases

eggNOGiKOG0578. Eukaryota.
ENOG410XP4K. LUCA.
OrthoDBiEOG091G04H8.

Family and domain databases

CDDicd01093. CRIB_PAK_like. 1 hit.
Gene3Di3.90.810.10. 1 hit.
InterProiView protein in InterPro
IPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR033923. PAK_BD.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEEDKPPA PPVRLTSNRG GNERSGGGVG VGGGGLGGGG MGDVPPDMRP
60 70 80 90 100
LPKEPDDSDR KKKTLKSKIK GSKPSHTDSK PNISYPTNFE HTVHVGFDAV
110 120 130 140 150
TGEFTGMPEA WARLLMNSNI SKQEQKKNPQ AVLDVLKWFD NTTKQRPSSK
160 170 180 190 200
YMTNAITTHS GSSLSRVSSS SPSSTPTDSE LHGSNSGGNL IGVQLGSMTL
210 220 230 240 250
GPNANNVAVA GQILGNHYQQ QQQHLLQQQQ PLLHQNHNQH HMGISQSHSY
260 270 280 290 300
NFVGHTVSSS TSQHSSANED DMLGPQHPQQ QPPPPPVASR PERTKSIYTR
310 320 330 340 350
PIEDLQPAII PMPVAPATTP ATPLQNHRTP GGISAPATSP MMHNNATTTL
360 370 380 390 400
DKNKNNANLY TPEPTVAQVS AGGPSSQVAG NQIAVPQAAV APAATPNTRA
410 420 430 440 450
ANAKKKKMSD EEILEKLRTI VSVGDPNRKY TKMEKIGQGA SGTVYTAIES
460 470 480 490 500
STGMEVAIKQ MNLSQQPKKE LIINEILVMR ENKHPNVVNY LDSYLVSEEL
510 520 530 540 550
WVVMEYLPGG SLTDVVTETC MDEGQIAAVC REVLQALEFL HANQVIHRDI
560 570 580 590 600
KSDNILLGLD GSVKLTDFGF CAQISPEQSK RTTMVGTPYW MAPEVVTRKQ
610 620 630 640 650
YGPKVDLWSL GIMAIEMVEG EPPYLNENPL KALYLIATNG KPEIKEKDKL
660 670 680 690 700
SSAFQDFLDQ CLEVEVDRRA SALDLLKHPF LKLARPLASL TPLIMAAKEA

TKGN
Length:704
Mass (Da):76,217
Last modified:November 1, 1996 - v1
Checksum:iB0A0938CE9408C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49446 mRNA. Translation: AAC47094.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ24190_DROME
AccessioniPrimary (citable) accession number: Q24190
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)