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Protein

40S ribosomal protein S5a

Gene

RpS5a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal small subunit assembly Source: GO_Central
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S5a
Gene namesi
Name:RpS5a
Synonyms:M(1)15D, RpS5
ORF Names:CG8922
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0002590. RpS5a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • cytosolic ribosome Source: FlyBase
  • cytosolic small ribosomal subunit Source: GO_Central
  • nuclear chromosome Source: FlyBase
  • nucleolus Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245301 – 22840S ribosomal protein S5aAdd BLAST228

Proteomic databases

PaxDbiQ24186.
PRIDEiQ24186.

Expressioni

Gene expression databases

BgeeiFBgn0002590.
GenevisibleiQ24186. DM.

Interactioni

Protein-protein interaction databases

BioGridi59029. 13 interactors.
DIPiDIP-18111N.
IntActiQ24186. 1 interactor.
MINTiMINT-960786.
STRINGi7227.FBpp0074180.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AF1-228[»]
ProteinModelPortaliQ24186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S7P family.Curated

Phylogenomic databases

eggNOGiKOG3291. Eukaryota.
COG0049. LUCA.
InParanoidiQ24186.
KOiK02989.
OMAiKLFGRWN.
OrthoDBiEOG091G0KXZ.
PhylomeDBiQ24186.

Family and domain databases

CDDicd14867. uS7_Eukaryote. 1 hit.
Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR005716. Ribosomal_S5/S7_euk/arc.
IPR020606. Ribosomal_S7_CS.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF002122. RPS7p_RPS7a_RPS5e_RPS7o. 1 hit.
SUPFAMiSSF47973. SSF47973. 1 hit.
TIGRFAMsiTIGR01028. uS7_euk_arch. 1 hit.
PROSITEiPS00052. RIBOSOMAL_S7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVAENVVE TFEEPAAPME AEVAETILET NVVSTTELPE IKLFGRWSCD
60 70 80 90 100
DVTVNDISLQ DYISVKEKFA RYLPHSAGRY AAKRFRKAQC PIVERLTCSL
110 120 130 140 150
MMKGRNNGKK LMACRIVKHS FEIIHLLTGE NPLQILVSAI INSGPREDST
160 170 180 190 200
RIGRAGTVRR QAVDVSPLRR VNQAIWLLCT GAREAAFRNI KTIAECLADE
210 220
LINAAKGSSN SYAIKKKDEL ERVAKSNR
Length:228
Mass (Da):25,434
Last modified:November 1, 1996 - v1
Checksum:i9206E1D8FE470C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48394 mRNA. Translation: AAB61633.1.
AE014298 Genomic DNA. Translation: AAF48700.1.
AY075368 mRNA. Translation: AAL68215.1.
RefSeqiNP_001285360.1. NM_001298431.1.
NP_001285361.1. NM_001298432.1.
NP_001285362.1. NM_001298433.1.
NP_523382.1. NM_078658.3.
UniGeneiDm.2690.

Genome annotation databases

EnsemblMetazoaiFBtr0074406; FBpp0074180; FBgn0002590.
FBtr0343292; FBpp0309957; FBgn0002590.
FBtr0343293; FBpp0309958; FBgn0002590.
FBtr0345132; FBpp0311353; FBgn0002590.
GeneIDi32700.
KEGGidme:Dmel_CG8922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48394 mRNA. Translation: AAB61633.1.
AE014298 Genomic DNA. Translation: AAF48700.1.
AY075368 mRNA. Translation: AAL68215.1.
RefSeqiNP_001285360.1. NM_001298431.1.
NP_001285361.1. NM_001298432.1.
NP_001285362.1. NM_001298433.1.
NP_523382.1. NM_078658.3.
UniGeneiDm.2690.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AF1-228[»]
ProteinModelPortaliQ24186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59029. 13 interactors.
DIPiDIP-18111N.
IntActiQ24186. 1 interactor.
MINTiMINT-960786.
STRINGi7227.FBpp0074180.

Proteomic databases

PaxDbiQ24186.
PRIDEiQ24186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074406; FBpp0074180; FBgn0002590.
FBtr0343292; FBpp0309957; FBgn0002590.
FBtr0343293; FBpp0309958; FBgn0002590.
FBtr0345132; FBpp0311353; FBgn0002590.
GeneIDi32700.
KEGGidme:Dmel_CG8922.

Organism-specific databases

CTDi32700.
FlyBaseiFBgn0002590. RpS5a.

Phylogenomic databases

eggNOGiKOG3291. Eukaryota.
COG0049. LUCA.
InParanoidiQ24186.
KOiK02989.
OMAiKLFGRWN.
OrthoDBiEOG091G0KXZ.
PhylomeDBiQ24186.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpS5a. fly.
GenomeRNAii32700.
PROiQ24186.

Gene expression databases

BgeeiFBgn0002590.
GenevisibleiQ24186. DM.

Family and domain databases

CDDicd14867. uS7_Eukaryote. 1 hit.
Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR005716. Ribosomal_S5/S7_euk/arc.
IPR020606. Ribosomal_S7_CS.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF002122. RPS7p_RPS7a_RPS5e_RPS7o. 1 hit.
SUPFAMiSSF47973. SSF47973. 1 hit.
TIGRFAMsiTIGR01028. uS7_euk_arch. 1 hit.
PROSITEiPS00052. RIBOSOMAL_S7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS5A_DROME
AccessioniPrimary (citable) accession number: Q24186
Secondary accession number(s): Q9VX78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.