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Q24178

- PSA72_DROME

UniProt

Q24178 - PSA72_DROME

Protein

Proteasome subunit alpha type-7-1A

Gene

Prosalpha4T1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (08 Dec 2000)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-7-1A (EC:3.4.25.1)
    Alternative name(s):
    Testis-specific alpha4-t1 proteasome subunit
    Testis-specific proteasome 28 kDa subunit 1A
    Gene namesi
    Name:Prosalpha4T1
    Synonyms:Pros28.1A
    ORF Names:CG17268
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0265606. Prosalpha4T1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Proteasome subunit alpha type-7-1APRO_0000124154Add
    BLAST

    Proteomic databases

    PaxDbiQ24178.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    BgeeiQ24178.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Protein-protein interaction databases

    BioGridi67432. 1 interaction.
    DIPiDIP-19969N.
    MINTiMINT-1548416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24178.
    SMRiQ24178. Positions 5-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074753.
    InParanoidiQ24178.
    KOiK02731.
    OMAiHEYKATA.
    PhylomeDBiQ24178.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24178-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRYGRALT IFSPDGHLLQ VEYAQEAVRK GSTAVGVRGA NCVVLGVEKS    50
    SVSEMQEDRT VRKISMLDRH VALAFAGLTA DARILINRGQ VECQSHRLNF 100
    ENQVTLEYIT RYLAQLKQKY TQCNGRRPFG ISCLIGGIDA DGSARLFHTE 150
    PSGIFHEYKA TATGRWANTV REFFEKAYSD HEVTTKCDAI KLAMRALLEV 200
    TQMSQMRLEV AVLENGKPMK MLDSVVISEI VKIVQNEKEL QAKAHKMKR 249
    Length:249
    Mass (Da):27,940
    Last modified:December 8, 2000 - v2
    Checksum:i18B642DE3F1AE453
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241A → G in AAC47280. (PubMed:8878681)Curated
    Sequence conflicti123 – 1231C → V in AAC47280. (PubMed:8878681)Curated
    Sequence conflicti127 – 1282RP → PS in AAC47280. (PubMed:8878681)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291R → P in strain: CPA-46.
    Natural varianti236 – 2361N → K in strain: CPA-46.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46008 Genomic DNA. Translation: AAC47280.1.
    AY542403 Genomic DNA. Translation: AAS86247.1.
    AY542404 Genomic DNA. Translation: AAS86248.1.
    AY542405 Genomic DNA. Translation: AAS86249.1.
    AY542406 Genomic DNA. Translation: AAS86250.1.
    AY542407 Genomic DNA. Translation: AAS86251.1.
    AY542408 Genomic DNA. Translation: AAS86252.1.
    AY542409 Genomic DNA. Translation: AAS86253.1.
    AE014297 Genomic DNA. Translation: AAF55802.1.
    AY075276 mRNA. Translation: AAL68143.1.
    PIRiS72225.
    RefSeqiNP_650910.1. NM_142653.3.
    UniGeneiDm.5563.

    Genome annotation databases

    EnsemblMetazoaiFBtr0083928; FBpp0083336; FBgn0017557.
    GeneIDi42457.
    KEGGidme:Dmel_CG17268.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46008 Genomic DNA. Translation: AAC47280.1 .
    AY542403 Genomic DNA. Translation: AAS86247.1 .
    AY542404 Genomic DNA. Translation: AAS86248.1 .
    AY542405 Genomic DNA. Translation: AAS86249.1 .
    AY542406 Genomic DNA. Translation: AAS86250.1 .
    AY542407 Genomic DNA. Translation: AAS86251.1 .
    AY542408 Genomic DNA. Translation: AAS86252.1 .
    AY542409 Genomic DNA. Translation: AAS86253.1 .
    AE014297 Genomic DNA. Translation: AAF55802.1 .
    AY075276 mRNA. Translation: AAL68143.1 .
    PIRi S72225.
    RefSeqi NP_650910.1. NM_142653.3.
    UniGenei Dm.5563.

    3D structure databases

    ProteinModelPortali Q24178.
    SMRi Q24178. Positions 5-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67432. 1 interaction.
    DIPi DIP-19969N.
    MINTi MINT-1548416.

    Proteomic databases

    PaxDbi Q24178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0083928 ; FBpp0083336 ; FBgn0017557 .
    GeneIDi 42457.
    KEGGi dme:Dmel_CG17268.

    Organism-specific databases

    CTDi 42457.
    FlyBasei FBgn0265606. Prosalpha4T1.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074753.
    InParanoidi Q24178.
    KOi K02731.
    OMAi HEYKATA.
    PhylomeDBi Q24178.

    Miscellaneous databases

    GenomeRNAii 42457.
    NextBioi 828889.

    Gene expression databases

    Bgeei Q24178.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Duplicated proteasome subunit genes in Drosophila melanogaster encoding testes-specific isoforms."
      Yuan X., Miller M., Belote J.M.
      Genetics 144:147-157(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila."
      Torgerson D.G., Singh R.S.
      Genetics 168:1421-1432(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CPA-129, CPA-46, Z(H)12, Z(H)16 and Z(H)34.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Testis.

    Entry informationi

    Entry nameiPSA72_DROME
    AccessioniPrimary (citable) accession number: Q24178
    Secondary accession number(s): Q6QH19, Q8T8U0, Q9VDJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: December 8, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3