Q24171 (Q24171_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
AT08303p EMBL AAR27881.1

Submitted name:
KSR EMBL AAC46970.1
Submitted name:
Kinase suppressor of ras EMBL AAF52021.1
EC=2.7.10.- EMBL AAF52021.1
EC=2.7.11.- EMBL AAF52021.1

Gene names

Name:	ksr EMBL AAF52021.1 FlyBase FBgn0015402
ORF Names:	CG2899 FlyBase FBgn0015402, Dmel_CG2899 EMBL AAF52021.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	966 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS002219
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307 Contains 1 protein kinase domain. SAAS SAAS002219

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS002219 RuleBase RU000304 Metal-binding SAAS SAAS002219 Nucleotide-binding Zinc SAAS SAAS002219
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS002219 Transferase Tyrosine-protein kinase RuleBase RU000307
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Ras protein signal transduction Inferred from genetic interaction Ref.2. Source: FlyBase anterior/posterior axis specification, embryo Traceable author statement. Source: FlyBase imaginal disc-derived wing morphogenesis Inferred from mutant phenotype. Source: FlyBase torso signaling pathway Non-traceable author statement. Source: FlyBase tracheal outgrowth, open tracheal system Inferred from mutant phenotype. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q24171 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EA9989C39AA161BF	FASTA	966	105,839
	10 20 30 40 50 60 MSSNNNAPAS APDTGSTNAN DPISGSLSVD SNLVIIQDMI DLSANHLEGL RTQCAISSTL 70 80 90 100 110 120 TQQEIRCLES KLVRYFSELL LAKMRLNERI PANGLVPHTT GNELRQWLRV VGLSQGTLTA 130 140 150 160 170 180 CLARLTTLEQ SLRLSDEEIR QLLADSPSQR EEEELRRLTR AMQNLRKCME SLESGTAASN 190 200 210 220 230 240 NDPEQWHWDS WDRPTHIHRG SVGNIGLGNN STASPRTHHR QHGVKGKNSA LANSTNFKSG 250 260 270 280 290 300 RQSPSATEEL NSTQGSQLTL TLTPSPPNSP FTPSSGLSSS LNGTPQRSRG TPPPARKHQT 310 320 330 340 350 360 LLSQSHVQVD GEQLARNRLP TDPSPDSHSS TSSDIFVDPN TNASSGGSSS NVLMVPCSPG 370 380 390 400 410 420 VGHVGMGHAI KHRFTKALGF MATCTLCQKQ VFHRWMKCTD CKYICHKSCA PHVPPSCGLP 430 440 450 460 470 480 REYVDEFRHI KEQGGYASLP HVHGAAKGSP LVKKSTLGKP LHQQHGDSSS PSSSCTSSTP 490 500 510 520 530 540 SSPALFQQRE RELDQAGSSS SANLLPTPSL GKHQPSQFNF PNVTVTSSGG SGGVSLISNE 550 560 570 580 590 600 PVPEQFPTAP ATANGGLDSL VSSSNGHMSS LIGSQTSNAS TAATLTGSLV NSTTTTSTCS 610 620 630 640 650 660 FFPRKLSTAG VDKRTPFTSE YTDTHKSNDS DKTVSLSGSA STDSDRTPVR VDSTEDGDSG 670 680 690 700 710 720 QWRQNSISLK EWDIPYGDLL LLERIGQGRF GTVHRALWHG DVAVKLLNED YLQDEHMLET 730 740 750 760 770 780 FRSEVANFKN TRHENLVLFM GACMNPPYLA IVTSLCKGNT LYTYIHQRRE KFAMNRTLLI 790 800 810 820 830 840 AQQIAQGMGY LHAREIIHKD LRTKNIFIEN GKVIITDFGL FSSTKLLYCD MGLGVPHNWL 850 860 870 880 890 900 CYLAPELIRA LQPEKPRGEC LEFTPYSDVY SFGTVWYELI CGEFTFKDQP AESIIWQVGR 910 920 930 940 950 960 GMKQSLANLQ SGRDVKDLLM LCWTYEKEHR PQFARLLSLL EHLPKKRLAR SPSHPVNLSR SAESVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"KSR, a novel protein kinase required for RAS signal transduction." Therrien M., Chang H.C., Solomon N.M., Karim F.D., Wassarman D.A., Rubin G.M. Cell 83:879-888(1995) [PubMed: 8521512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila." Riley R.M., Jin W., Gibson G. Mol. Ecol. 12:1315-1323(2003) [PubMed: 12694293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[5]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43583 Genomic DNA. Translation: AAC46970.1. AE014297 Genomic DNA. Translation: AAF52021.1. AY135096 Genomic DNA. Translation: AAN17648.1. AY135098 Genomic DNA. Translation: AAN17650.1. AY135101 Genomic DNA. Translation: AAN17653.1. AY135105 Genomic DNA. Translation: AAN17657.1. AY135108 Genomic DNA. Translation: AAN17660.1. AY135110 Genomic DNA. Translation: AAN17662.1. AY135111 Genomic DNA. Translation: AAN17663.1. AY135112 Genomic DNA. Translation: AAN17664.1. AY135113 Genomic DNA. Translation: AAN17665.1. AY135114 Genomic DNA. Translation: AAN17666.1. AY135115 Genomic DNA. Translation: AAN17667.1. BT011010 mRNA. Translation: AAR27881.1.
RefSeq	NP_524236.2. NM_079512.2.
UniGene	Dm.2488.
3D structure databases
HSSP	HSSP built from PDB template 1VR2 based on UniProtKB P35968.
ProteinModelPortal	Q24171.
SMR	Q24171. Positions 666-943.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29739N.
STRING	Q24171.
Proteomic databases
PRIDE	Q24171.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0078766; FBpp0078413; FBgn0015402.
GeneID	40660.
KEGG	dme:Dmel_CG2899.
NMPDR	fig|7227.3.peg.11201.
UCSC	CG2899-RA. d. melanogaster.
Organism-specific databases
CTD	40660.
FlyBase	FBgn0015402. ksr.
Phylogenomic databases
InParanoid	Q24171.
OMA	EGLRTQC.
PhylomeDB	Q24171.
Gene expression databases
ArrayExpress	Q24171.
Bgee	Q24171.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF00130. C1_1. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SMART	SM00109. C1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	819894.

Entry information

Entry name

Q24171_DROME

Accession

Primary (citable) accession number: Q24171

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)