Q24152 (CKS1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinases regulatory subunit

Gene names

Name:	Cks30A
Synonyms:	CDI2, Cks, Cks1
ORF Names:	CG3738

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the catalytic subunit of the cyclin dependent kinases (Cdc2 and Cdc2c) and is essential for their biological function.
Subunit structure	Forms an homohexamer that can probably bind six kinase subunits By similarity.
Sequence similarities	Belongs to the CKS family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW cyclin catabolic process Inferred from mutant phenotype. Source: FlyBase histoblast morphogenesis Inferred from mutant phenotype. Source: FlyBase spindle assembly involved in female meiosis I Inferred from mutant phenotype. Source: FlyBase syncytial blastoderm mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase
Molecular function	cyclin-dependent protein kinase regulator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 74	74	Cyclin-dependent kinases regulatory subunit		PRO_0000206242

Sequences

	Sequence		Length	Mass (Da)
	Q24152 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1AAF5486960FE8AD	FASTA	74	9,122
	10 20 30 40 50 60 MSKDIYYSDK YYDEQFEYRH VVLPKELVKM VPKTHLMTEA EWRSIGVQQS RGWIHYMIHK 70 PEPHILLFRR PKTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators." Finley R.L. Jr., Brent R. Proc. Natl. Acad. Sci. U.S.A. 91:12980-12984(1994) [PubMed: 7809159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40077 mRNA. Translation: AAB02189.1. AE014134 Genomic DNA. Translation: AAF52763.1. AY061285 mRNA. Translation: AAL28833.1.
RefSeq	NP_476947.1. NM_057599.3.
UniGene	Dm.2110.
3D structure databases
ProteinModelPortal	Q24152.
SMR	Q24152. Positions 5-71.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-17394N.
IntAct	Q24152. 1 interaction.
MINT	MINT-880726.
STRING	Q24152.
Proteomic databases
PRIDE	Q24152.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0079799; FBpp0079399; FBgn0010314.
GeneID	34250.
KEGG	dme:Dmel_CG3738.
NMPDR	fig|7227.3.peg.1576.
Organism-specific databases
CTD	34250.
FlyBase	FBgn0010314. Cks30A.
Phylogenomic databases
eggNOG	inNOG11102.
GeneTree	EMGT00050000017140.
InParanoid	Q24152.
OMA	QPEPHIL.
OrthoDB	EOG40VT69.
PhylomeDB	Q24152.
Gene expression databases
Bgee	Q24152.
GermOnline	CG3738. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000789. Cyclin-dep_kinase_reg-sub. [Graphical view]
Gene3D	G3DSA:3.30.170.10. Cyclin-dep_kinase_reg-sub. 1 hit.
KO	K02219.
Pfam	PF01111. CKS. 1 hit. [Graphical view]
PRINTS	PR00296. CYCLINKINASE.
SMART	SM01084. CKS. 1 hit. [Graphical view]
SUPFAM	SSF55637. Cyc_dep_kin_rsub. 1 hit.
PROSITE	PS00944. CKS_1. 1 hit. PS00945. CKS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	787572.

Entry information

Entry name

CKS1_DROME

Accession

Primary (citable) accession number: Q24152
Secondary accession number(s): Q9VLD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project