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Protein

Signal transducer and transcription activator

Gene

Stat92E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.

GO - Molecular functioni

  • cytokine receptor binding Source: FlyBase
  • DNA binding Source: FlyBase
  • DNA binding transcription factor activity Source: FlyBase
  • histone binding Source: FlyBase
  • signal transducer activity Source: InterPro
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • blastoderm segmentation Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cell dedifferentiation Source: FlyBase
  • cellular response to lipopolysaccharide Source: FlyBase
  • cellular response to X-ray Source: FlyBase
  • compound eye development Source: FlyBase
  • defense response Source: FlyBase
  • epithelial cell fate determination, open tracheal system Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • hemocyte proliferation Source: FlyBase
  • hemopoiesis Source: FlyBase
  • hindgut morphogenesis Source: FlyBase
  • humoral immune response Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • JAK-STAT cascade Source: FlyBase
  • lamellocyte differentiation Source: FlyBase
  • larval lymph gland hemopoiesis Source: FlyBase
  • larval somatic muscle development Source: FlyBase
  • long-term memory Source: FlyBase
  • negative regulation of antimicrobial humoral response Source: FlyBase
  • negative regulation of stem cell differentiation Source: FlyBase
  • nervous system development Source: FlyBase
  • oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of defense response to virus by host Source: FlyBase
  • positive regulation of heterochromatin assembly Source: FlyBase
  • primary sex determination Source: FlyBase
  • segment specification Source: FlyBase
  • sex determination Source: FlyBase
  • somatic stem cell division Source: FlyBase
  • somatic stem cell population maintenance Source: FlyBase
  • stem cell division Source: FlyBase
  • stem cell population maintenance Source: FlyBase

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-1251985 Nuclear signaling by ERBB4
R-DME-1266695 Interleukin-7 signaling
R-DME-1433557 Signaling by SCF-KIT
R-DME-209228 Formation of the activated STAT92E dimer and transport to the nucleus
R-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-210671 Transcriptional repression by nuclear factors
R-DME-210675 Transcriptional activation by phosphorylated STAT92E dimer
R-DME-210688 Dephosphorylation by PTP61F phosphatases
R-DME-210693 STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
R-DME-2586552 Signaling by Leptin
R-DME-3249367 STAT6-mediated induction of chemokines
R-DME-512988 Interleukin-3, 5 and GM-CSF signaling
R-DME-6785807 Interleukin-4 and 13 signaling
R-DME-9020558 Interleukin-2 signaling
R-DME-982772 Growth hormone receptor signaling
SignaLinkiQ24151

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator
Short name:
d-STAT
Alternative name(s):
Protein marelle
Gene namesi
Name:Stat92E
Synonyms:MARE, mrL, Stat
ORF Names:CG4257
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0016917 Stat92E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies exhibit aberrant expression of the pair rule gene even-skipped at the cellular blastoderm stage, leading to larval segmentation defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824351 – 761Signal transducer and transcription activatorAdd BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei711Phosphotyrosine; by JAK2 Publications1

Post-translational modificationi

Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24151
PRIDEiQ24151

PTM databases

iPTMnetiQ24151

Expressioni

Developmental stagei

Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern.

Gene expression databases

BgeeiFBgn0016917
ExpressionAtlasiQ24151 differential
GenevisibleiQ24151 DM

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member.

GO - Molecular functioni

  • cytokine receptor binding Source: FlyBase
  • histone binding Source: FlyBase

Protein-protein interaction databases

BioGridi67407, 50 interactors
DIPiDIP-29510N
IntActiQ24151, 3 interactors
STRINGi7227.FBpp0088489

Structurei

3D structure databases

ProteinModelPortaliQ24151
SMRiQ24151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini594 – 658SH2PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
InParanoidiQ24151
KOiK11224
OrthoDBiEOG091G03O3
PhylomeDBiQ24151

Family and domain databases

Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform F (identifier: Q24151-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLWKRISSH VDCEQRMAAY YEEKGMLELR LCLAPWIEDR IMSEQITPNT
60 70 80 90 100
TDQLERVALK FNEDLQQKLL STRTASDQAL KFRVVELCAL IQRISAVELY
110 120 130 140 150
THLRSGLQKE LQLVTEKSVA ATAGQSMPLN PYNMNNTPMV TGYMVDPSDL
160 170 180 190 200
LAVSNSCNPP VVQGIGPIHN VQNTGIASPA LGMVTPKVEL YEVQHQIMQS
210 220 230 240 250
LNEFGNCANA LKLLAQNYSY MLNSTSSPNA EAAYRSLIDE KAAIVLTMRR
260 270 280 290 300
SFMYYESLHE MVIHELKNWR HQQAQAGNGA PFNEGSLDDI QRCFEMLESF
310 320 330 340 350
IAHMLAAVKE LMRVRLVTEE PELTHLLEQV QNAQKNLVCS AFIVDKQPPQ
360 370 380 390 400
VMKTNTRFAA SVRWLIGSQL GIHNNPPTVE CIIMSEIQSQ RFVTRNTQMD
410 420 430 440 450
NSSLSGQSSG EIQNASSTME YQQNNHVFSA SFRNMQLKKI KRAEKKGTES
460 470 480 490 500
VMDEKFALFF YTTTTVNDFQ IRVWTLSLPV VVIVHGNQEP QSWATITWDN
510 520 530 540 550
AFAEIVRDPF MITDRVTWAQ LSVALNIKFG SCTGRSLTID NLDFLYEKLQ
560 570 580 590 600
REERSEYITW NQFCKEPMPD RSFTFWEWFF AIMKLTKDHM LGMWKAGCIM
610 620 630 640 650
GFINKTKAQT DLLRSVYGIG TFLLRFSDSE LGGVTIAYVN ENGLVTMLAP
660 670 680 690 700
WTARDFQVLN LADRIRDLDV LCWLHPSDRN ASPVKRDVAF GEFYSKRQEP
710 720 730 740 750
EPLVLDPVTG YVKSTLHVHV CRNGENGSTS GTPHHAQESM QLGNGDFGMA
760
DFDTITNFEN F
Length:761
Mass (Da):86,415
Last modified:November 1, 1997 - v1
Checksum:iBF3A622A29899161
GO
Isoform B (identifier: Q24151-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     699-705: Missing.

Note: No experimental confirmation available.
Show »
Length:628
Mass (Da):71,198
Checksum:i841208C04B2A91D0
GO
Isoform C (identifier: Q24151-2) [UniParc]FASTAAdd to basket
Also known as: E, Short

The sequence of this isoform differs from the canonical sequence as follows:
     699-705: Missing.

Show »
Length:754
Mass (Da):85,637
Checksum:iB607B3328A4A4956
GO
Isoform G (identifier: Q24151-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:635
Mass (Da):71,976
Checksum:iA3B0A8FFC32BCCF3
GO

Sequence cautioni

The sequence AAM11192 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → T in AAB02195 (PubMed:8608596).Curated1
Sequence conflicti648L → H in AAB02195 (PubMed:8608596).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127521 – 126Missing in isoform B and isoform G. CuratedAdd BLAST126
Alternative sequenceiVSP_006290699 – 705Missing in isoform B and isoform C. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40070 mRNA Translation: AAC46984.1
U46688 mRNA Translation: AAB02195.1
AE014297 Genomic DNA Translation: AAN14350.2
AE014297 Genomic DNA Translation: AAN14351.2
AE014297 Genomic DNA Translation: AAS65180.1
AE014297 Genomic DNA Translation: AAX52969.1
BT021314 mRNA Translation: AAX33462.1
AY094839 mRNA Translation: AAM11192.1 Different initiation.
RefSeqiNP_001014643.1, NM_001014643.2 [Q24151-4]
NP_001262757.1, NM_001275828.1 [Q24151-4]
NP_001262762.1, NM_001275833.1 [Q24151-1]
NP_732516.2, NM_169899.3 [Q24151-2]
NP_732517.2, NM_169900.3 [Q24151-3]
NP_996242.1, NM_206520.2 [Q24151-2]
NP_996243.1, NM_206521.2 [Q24151-1]
UniGeneiDm.2627

Genome annotation databases

EnsemblMetazoaiFBtr0089484; FBpp0088487; FBgn0016917 [Q24151-3]
FBtr0089485; FBpp0088488; FBgn0016917 [Q24151-2]
FBtr0089486; FBpp0088489; FBgn0016917 [Q24151-1]
FBtr0089487; FBpp0088978; FBgn0016917 [Q24151-2]
FBtr0100457; FBpp0099882; FBgn0016917 [Q24151-4]
FBtr0334581; FBpp0306648; FBgn0016917 [Q24151-4]
FBtr0334586; FBpp0306653; FBgn0016917 [Q24151-1]
GeneIDi42428
KEGGidme:Dmel_CG4257

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTAT_DROME
AccessioniPrimary (citable) accession number: Q24151
Secondary accession number(s): Q0KI43
, Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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