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Q24151

- STAT_DROME

UniProt

Q24151 - STAT_DROME

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Protein

Signal transducer and transcription activator

Gene

Stat92E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: FlyBase
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
  4. sequence-specific DNA binding transcription factor activity Source: FlyBase
  5. signal transducer activity Source: InterPro

GO - Biological processi

  1. blastoderm segmentation Source: FlyBase
  2. border follicle cell migration Source: FlyBase
  3. cell dedifferentiation Source: FlyBase
  4. cellular response to lipopolysaccharide Source: FlyBase
  5. cellular response to X-ray Source: FlyBase
  6. compound eye development Source: FlyBase
  7. defense response Source: FlyBase
  8. epithelial cell fate determination, open tracheal system Source: FlyBase
  9. eye-antennal disc morphogenesis Source: FlyBase
  10. germ-line stem cell division Source: FlyBase
  11. germ-line stem cell maintenance Source: FlyBase
  12. hemocyte proliferation Source: FlyBase
  13. hemopoiesis Source: FlyBase
  14. hindgut morphogenesis Source: FlyBase
  15. humoral immune response Source: FlyBase
  16. imaginal disc-derived wing morphogenesis Source: FlyBase
  17. JAK-STAT cascade Source: FlyBase
  18. lamellocyte differentiation Source: FlyBase
  19. larval lymph gland hemopoiesis Source: FlyBase
  20. larval somatic muscle development Source: FlyBase
  21. long-term memory Source: FlyBase
  22. negative regulation of antimicrobial humoral response Source: FlyBase
  23. negative regulation of Wnt signaling pathway Source: FlyBase
  24. nervous system development Source: FlyBase
  25. oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
  26. oogenesis Source: FlyBase
  27. open tracheal system development Source: FlyBase
  28. ovarian follicle cell stalk formation Source: FlyBase
  29. positive regulation of cell proliferation Source: FlyBase
  30. positive regulation of defense response to virus by host Source: FlyBase
  31. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  32. primary sex determination Source: FlyBase
  33. regulation of JAK-STAT cascade Source: FlyBase
  34. segment specification Source: FlyBase
  35. sex determination Source: FlyBase
  36. somatic stem cell division Source: FlyBase
  37. somatic stem cell maintenance Source: FlyBase
  38. stem cell division Source: FlyBase
  39. stem cell maintenance Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_180284. Growth hormone receptor signaling.
REACT_180781. Signaling by FGFR1 fusion mutants.
REACT_180816. Interleukin-7 signaling.
REACT_219000. Interleukin-2 signaling.
REACT_224431. Signaling by Leptin.
REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinkiQ24151.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator
Short name:
d-STAT
Alternative name(s):
Protein marelle
Gene namesi
Name:Stat92E
Synonyms:MARE, mrL, Stat
ORF Names:CG4257
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0016917. Stat92E.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Translocated into the nucleus in response to phosphorylation.By similarity

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies exhibit aberrant expression of the pair rule gene even-skipped at the cellular blastoderm stage, leading to larval segmentation defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Signal transducer and transcription activatorPRO_0000182435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111Phosphotyrosine; by JAK2 Publications

Post-translational modificationi

Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ24151.
PRIDEiQ24151.

Expressioni

Developmental stagei

Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern.

Gene expression databases

BgeeiQ24151.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member.

Protein-protein interaction databases

BioGridi67407. 18 interactions.
DIPiDIP-29510N.

Structurei

3D structure databases

ProteinModelPortaliQ24151.
SMRiQ24151. Positions 235-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini594 – 65865SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG245085.
GeneTreeiENSGT00760000119236.
InParanoidiQ24151.
KOiK11224.
OMAiALNIKFG.
OrthoDBiEOG73JKTT.
PhylomeDBiQ24151.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform F (identifier: Q24151-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLWKRISSH VDCEQRMAAY YEEKGMLELR LCLAPWIEDR IMSEQITPNT
60 70 80 90 100
TDQLERVALK FNEDLQQKLL STRTASDQAL KFRVVELCAL IQRISAVELY
110 120 130 140 150
THLRSGLQKE LQLVTEKSVA ATAGQSMPLN PYNMNNTPMV TGYMVDPSDL
160 170 180 190 200
LAVSNSCNPP VVQGIGPIHN VQNTGIASPA LGMVTPKVEL YEVQHQIMQS
210 220 230 240 250
LNEFGNCANA LKLLAQNYSY MLNSTSSPNA EAAYRSLIDE KAAIVLTMRR
260 270 280 290 300
SFMYYESLHE MVIHELKNWR HQQAQAGNGA PFNEGSLDDI QRCFEMLESF
310 320 330 340 350
IAHMLAAVKE LMRVRLVTEE PELTHLLEQV QNAQKNLVCS AFIVDKQPPQ
360 370 380 390 400
VMKTNTRFAA SVRWLIGSQL GIHNNPPTVE CIIMSEIQSQ RFVTRNTQMD
410 420 430 440 450
NSSLSGQSSG EIQNASSTME YQQNNHVFSA SFRNMQLKKI KRAEKKGTES
460 470 480 490 500
VMDEKFALFF YTTTTVNDFQ IRVWTLSLPV VVIVHGNQEP QSWATITWDN
510 520 530 540 550
AFAEIVRDPF MITDRVTWAQ LSVALNIKFG SCTGRSLTID NLDFLYEKLQ
560 570 580 590 600
REERSEYITW NQFCKEPMPD RSFTFWEWFF AIMKLTKDHM LGMWKAGCIM
610 620 630 640 650
GFINKTKAQT DLLRSVYGIG TFLLRFSDSE LGGVTIAYVN ENGLVTMLAP
660 670 680 690 700
WTARDFQVLN LADRIRDLDV LCWLHPSDRN ASPVKRDVAF GEFYSKRQEP
710 720 730 740 750
EPLVLDPVTG YVKSTLHVHV CRNGENGSTS GTPHHAQESM QLGNGDFGMA
760
DFDTITNFEN F
Length:761
Mass (Da):86,415
Last modified:November 1, 1997 - v1
Checksum:iBF3A622A29899161
GO
Isoform B (identifier: Q24151-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     699-705: Missing.

Note: No experimental confirmation available.

Show »
Length:628
Mass (Da):71,198
Checksum:i841208C04B2A91D0
GO
Isoform C (identifier: Q24151-2) [UniParc]FASTAAdd to Basket

Also known as: E, Short

The sequence of this isoform differs from the canonical sequence as follows:
     699-705: Missing.

Show »
Length:754
Mass (Da):85,637
Checksum:iB607B3328A4A4956
GO
Isoform G (identifier: Q24151-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.

Show »
Length:635
Mass (Da):71,976
Checksum:iA3B0A8FFC32BCCF3
GO

Sequence cautioni

The sequence AAM11192.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051S → T in AAB02195. (PubMed:8608596)Curated
Sequence conflicti648 – 6481L → H in AAB02195. (PubMed:8608596)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 126126Missing in isoform B and isoform G. CuratedVSP_012752Add
BLAST
Alternative sequencei699 – 7057Missing in isoform B and isoform C. 1 PublicationVSP_006290

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40070 mRNA. Translation: AAC46984.1.
U46688 mRNA. Translation: AAB02195.1.
AE014297 Genomic DNA. Translation: AAN14350.2.
AE014297 Genomic DNA. Translation: AAN14351.2.
AE014297 Genomic DNA. Translation: AAS65180.1.
AE014297 Genomic DNA. Translation: AAX52969.1.
BT021314 mRNA. Translation: AAX33462.1.
AY094839 mRNA. Translation: AAM11192.1. Different initiation.
RefSeqiNP_001014643.1. NM_001014643.2. [Q24151-4]
NP_001262757.1. NM_001275828.1. [Q24151-4]
NP_001262762.1. NM_001275833.1. [Q24151-1]
NP_732516.2. NM_169899.3. [Q24151-2]
NP_732517.2. NM_169900.3. [Q24151-3]
NP_996242.1. NM_206520.2. [Q24151-2]
NP_996243.1. NM_206521.2. [Q24151-1]
UniGeneiDm.2627.

Genome annotation databases

EnsemblMetazoaiFBtr0089486; FBpp0088489; FBgn0016917. [Q24151-1]
GeneIDi42428.
KEGGidme:Dmel_CG4257.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40070 mRNA. Translation: AAC46984.1 .
U46688 mRNA. Translation: AAB02195.1 .
AE014297 Genomic DNA. Translation: AAN14350.2 .
AE014297 Genomic DNA. Translation: AAN14351.2 .
AE014297 Genomic DNA. Translation: AAS65180.1 .
AE014297 Genomic DNA. Translation: AAX52969.1 .
BT021314 mRNA. Translation: AAX33462.1 .
AY094839 mRNA. Translation: AAM11192.1 . Different initiation.
RefSeqi NP_001014643.1. NM_001014643.2. [Q24151-4 ]
NP_001262757.1. NM_001275828.1. [Q24151-4 ]
NP_001262762.1. NM_001275833.1. [Q24151-1 ]
NP_732516.2. NM_169899.3. [Q24151-2 ]
NP_732517.2. NM_169900.3. [Q24151-3 ]
NP_996242.1. NM_206520.2. [Q24151-2 ]
NP_996243.1. NM_206521.2. [Q24151-1 ]
UniGenei Dm.2627.

3D structure databases

ProteinModelPortali Q24151.
SMRi Q24151. Positions 235-695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67407. 18 interactions.
DIPi DIP-29510N.

Proteomic databases

PaxDbi Q24151.
PRIDEi Q24151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0089486 ; FBpp0088489 ; FBgn0016917 . [Q24151-1 ]
GeneIDi 42428.
KEGGi dme:Dmel_CG4257.

Organism-specific databases

CTDi 42428.
FlyBasei FBgn0016917. Stat92E.

Phylogenomic databases

eggNOGi NOG245085.
GeneTreei ENSGT00760000119236.
InParanoidi Q24151.
KOi K11224.
OMAi ALNIKFG.
OrthoDBi EOG73JKTT.
PhylomeDBi Q24151.

Enzyme and pathway databases

Reactomei REACT_180284. Growth hormone receptor signaling.
REACT_180781. Signaling by FGFR1 fusion mutants.
REACT_180816. Interleukin-7 signaling.
REACT_219000. Interleukin-2 signaling.
REACT_224431. Signaling by Leptin.
REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinki Q24151.

Miscellaneous databases

GenomeRNAii 42428.
NextBioi 828722.

Gene expression databases

Bgeei Q24151.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs."
    Hou X.S., Melnick M.B., Perrimon N.
    Cell 84:411-419(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F), DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  2. "Identification of a Stat gene that functions in Drosophila development."
    Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Jr.
    Cell 84:421-430(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), PHOSPHORYLATION AT TYR-711, DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM F).
    Strain: Berkeley.
    Tissue: Embryo.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 267-761 (ISOFORM F).
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-711, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSTAT_DROME
AccessioniPrimary (citable) accession number: Q24151
Secondary accession number(s): Q0KI43
, Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3