Q24151 (STAT_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal transducer and transcription activator
Short name=d-STAT

Alternative name(s):
Protein marelle

Gene names

Name:	Stat92E
Synonyms:	MARE, mrL, Stat
ORF Names:	CG4257

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	761 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.
Subunit structure	Forms a homodimer or a heterodimer with a related family member.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Translocated into the nucleus in response to phosphorylation By similarity.
Developmental stage	Expressed throughout embryonic, larval, pupal, and adult stages, with some decrease in the late embryonic stages. The expression is uniform in unfertilized or just fertilized eggs, suggesting maternally deposited mRNA. At blastoderm stage, expression pattern shows stripes, that are reminiscent of many pair rule genes pattern.
Post-translational modification	Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization. Ref.2
Disruption phenotype	Flies exhibit aberrant expression of the pair rule gene even-skipped at the cellular blastoderm stage, leading to larval segmentation defects. Ref.1 Ref.2
Sequence similarities	Belongs to the transcription factor STAT family. Contains 1 SH2 domain.
Sequence caution	The sequence AAM11192.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	SH2 domain
Ligand	DNA-binding
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	JAK-STAT cascade Traceable author statement PubMed 12194841. Source: FlyBase blastoderm segmentation Inferred from mutant phenotype PubMed 11746233. Source: FlyBase border follicle cell migration Inferred from mutant phenotype PubMed 11779460PubMed 19350016. Source: FlyBase cellular response to X-ray Inferred from mutant phenotype PubMed 18779571. Source: FlyBase cellular response to lipopolysaccharide Inferred from direct assay PubMed 10764759. Source: FlyBase compound eye development Traceable author statement PubMed 11746233. Source: FlyBase defense response Inferred from direct assay PubMed 10764759. Source: FlyBase epithelial cell fate determination, open tracheal system Traceable author statement PubMed 14570584. Source: FlyBase eye-antennal disc morphogenesis Inferred from mutant phenotype PubMed 17079268. Source: FlyBase germ-line stem cell division Traceable author statement PubMed 12459723. Source: FlyBase germ-line stem cell maintenance Inferred from mutant phenotype PubMed 15143218. Source: FlyBase hemocyte proliferation Traceable author statement PubMed 14602069. Source: FlyBase hindgut morphogenesis Inferred from mutant phenotype PubMed 12441298PubMed 14654218. Source: FlyBase humoral immune response Traceable author statement PubMed 15199955. Source: FlyBase imaginal disc-derived wing morphogenesis Non-traceable author statement PubMed 11746233. Source: FlyBase lamellocyte differentiation Non-traceable author statement PubMed 15199955. Source: FlyBase long-term memory Inferred from mutant phenotype PubMed 21518857. Source: FlyBase negative regulation of Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 17079268. Source: FlyBase negative regulation of antimicrobial humoral response Inferred from mutant phenotype PubMed 17803358. Source: FlyBase nervous system development Inferred from mutant phenotype PubMed 14654218. Source: FlyBase oocyte localization involved in germarium-derived egg chamber formation Inferred from mutant phenotype PubMed 14536057. Source: FlyBase ovarian follicle cell stalk formation Inferred from mutant phenotype PubMed 14536057. Source: FlyBase positive regulation of cell proliferation Inferred from mutant phenotype PubMed 21176204. Source: FlyBase primary sex determination Inferred from mutant phenotype PubMed 10882142. Source: FlyBase regulation of JAK-STAT cascade Inferred from mutant phenotype PubMed 20624926. Source: FlyBase segment specification Inferred from mutant phenotype PubMed 16277982. Source: FlyBase somatic stem cell division Traceable author statement PubMed 12459723. Source: FlyBase somatic stem cell maintenance Inferred from mutant phenotype PubMed 20143337. Source: FlyBase
Cellular_component	cytoplasm Inferred from direct assay PubMed 12967563. Source: FlyBase nucleus Inferred from direct assay PubMed 19948068. Source: BHF-UCL
Molecular_function	DNA binding Traceable author statement PubMed 11746233. Source: FlyBase RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 10764759. Source: FlyBase calcium ion binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform F (identifier: Q24151-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q24151-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     699-705: Missing.

Note: No experimental confirmation available.

Isoform C (identifier: Q24151-2)

Also known as: E; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     699-705: Missing.

Isoform G (identifier: Q24151-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 761	761	Signal transducer and transcription activator		PRO_0000182435
Regions
	Domain	594 – 658	65	SH2
Amino acid modifications
	Modified residue	711	1	Phosphotyrosine; by JAK Ref.2 Ref.7
Natural variations
	Alternative sequence	1 – 126	126	Missing in isoform B and isoform G.		VSP_012752
	Alternative sequence	699 – 705	7	Missing in isoform B and isoform C.		VSP_006290
Experimental info
	Sequence conflict	105	1	S → T in AAB02195. Ref.2
	Sequence conflict	648	1	L → H in AAB02195. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform F (Long) [UniParc]. Last modified November 1, 1997. Version 1. Checksum: BF3A622A29899161	FASTA	761	86,415
	10 20 30 40 50 60 MSLWKRISSH VDCEQRMAAY YEEKGMLELR LCLAPWIEDR IMSEQITPNT TDQLERVALK 70 80 90 100 110 120 FNEDLQQKLL STRTASDQAL KFRVVELCAL IQRISAVELY THLRSGLQKE LQLVTEKSVA 130 140 150 160 170 180 ATAGQSMPLN PYNMNNTPMV TGYMVDPSDL LAVSNSCNPP VVQGIGPIHN VQNTGIASPA 190 200 210 220 230 240 LGMVTPKVEL YEVQHQIMQS LNEFGNCANA LKLLAQNYSY MLNSTSSPNA EAAYRSLIDE 250 260 270 280 290 300 KAAIVLTMRR SFMYYESLHE MVIHELKNWR HQQAQAGNGA PFNEGSLDDI QRCFEMLESF 310 320 330 340 350 360 IAHMLAAVKE LMRVRLVTEE PELTHLLEQV QNAQKNLVCS AFIVDKQPPQ VMKTNTRFAA 370 380 390 400 410 420 SVRWLIGSQL GIHNNPPTVE CIIMSEIQSQ RFVTRNTQMD NSSLSGQSSG EIQNASSTME 430 440 450 460 470 480 YQQNNHVFSA SFRNMQLKKI KRAEKKGTES VMDEKFALFF YTTTTVNDFQ IRVWTLSLPV 490 500 510 520 530 540 VVIVHGNQEP QSWATITWDN AFAEIVRDPF MITDRVTWAQ LSVALNIKFG SCTGRSLTID 550 560 570 580 590 600 NLDFLYEKLQ REERSEYITW NQFCKEPMPD RSFTFWEWFF AIMKLTKDHM LGMWKAGCIM 610 620 630 640 650 660 GFINKTKAQT DLLRSVYGIG TFLLRFSDSE LGGVTIAYVN ENGLVTMLAP WTARDFQVLN 670 680 690 700 710 720 LADRIRDLDV LCWLHPSDRN ASPVKRDVAF GEFYSKRQEP EPLVLDPVTG YVKSTLHVHV 730 740 750 760 CRNGENGSTS GTPHHAQESM QLGNGDFGMA DFDTITNFEN F
	Isoform B [UniParc]. Checksum: 841208C04B2A91D0	FASTA	628	71,198
	10 20 30 40 50 60 MPLNPYNMNN TPMVTGYMVD PSDLLAVSNS CNPPVVQGIG PIHNVQNTGI ASPALGMVTP 70 80 90 100 110 120 KVELYEVQHQ IMQSLNEFGN CANALKLLAQ NYSYMLNSTS SPNAEAAYRS LIDEKAAIVL 130 140 150 160 170 180 TMRRSFMYYE SLHEMVIHEL KNWRHQQAQA GNGAPFNEGS LDDIQRCFEM LESFIAHMLA 190 200 210 220 230 240 AVKELMRVRL VTEEPELTHL LEQVQNAQKN LVCSAFIVDK QPPQVMKTNT RFAASVRWLI 250 260 270 280 290 300 GSQLGIHNNP PTVECIIMSE IQSQRFVTRN TQMDNSSLSG QSSGEIQNAS STMEYQQNNH 310 320 330 340 350 360 VFSASFRNMQ LKKIKRAEKK GTESVMDEKF ALFFYTTTTV NDFQIRVWTL SLPVVVIVHG 370 380 390 400 410 420 NQEPQSWATI TWDNAFAEIV RDPFMITDRV TWAQLSVALN IKFGSCTGRS LTIDNLDFLY 430 440 450 460 470 480 EKLQREERSE YITWNQFCKE PMPDRSFTFW EWFFAIMKLT KDHMLGMWKA GCIMGFINKT 490 500 510 520 530 540 KAQTDLLRSV YGIGTFLLRF SDSELGGVTI AYVNENGLVT MLAPWTARDF QVLNLADRIR 550 560 570 580 590 600 DLDVLCWLHP SDRNASPVKR DVAFGEFYSK RQDPVTGYVK STLHVHVCRN GENGSTSGTP 610 620 HHAQESMQLG NGDFGMADFD TITNFENF
	Isoform C (E) (Short) [UniParc]. Checksum: B607B3328A4A4956	FASTA	754	85,637
	10 20 30 40 50 60 MSLWKRISSH VDCEQRMAAY YEEKGMLELR LCLAPWIEDR IMSEQITPNT TDQLERVALK 70 80 90 100 110 120 FNEDLQQKLL STRTASDQAL KFRVVELCAL IQRISAVELY THLRSGLQKE LQLVTEKSVA 130 140 150 160 170 180 ATAGQSMPLN PYNMNNTPMV TGYMVDPSDL LAVSNSCNPP VVQGIGPIHN VQNTGIASPA 190 200 210 220 230 240 LGMVTPKVEL YEVQHQIMQS LNEFGNCANA LKLLAQNYSY MLNSTSSPNA EAAYRSLIDE 250 260 270 280 290 300 KAAIVLTMRR SFMYYESLHE MVIHELKNWR HQQAQAGNGA PFNEGSLDDI QRCFEMLESF 310 320 330 340 350 360 IAHMLAAVKE LMRVRLVTEE PELTHLLEQV QNAQKNLVCS AFIVDKQPPQ VMKTNTRFAA 370 380 390 400 410 420 SVRWLIGSQL GIHNNPPTVE CIIMSEIQSQ RFVTRNTQMD NSSLSGQSSG EIQNASSTME 430 440 450 460 470 480 YQQNNHVFSA SFRNMQLKKI KRAEKKGTES VMDEKFALFF YTTTTVNDFQ IRVWTLSLPV 490 500 510 520 530 540 VVIVHGNQEP QSWATITWDN AFAEIVRDPF MITDRVTWAQ LSVALNIKFG SCTGRSLTID 550 560 570 580 590 600 NLDFLYEKLQ REERSEYITW NQFCKEPMPD RSFTFWEWFF AIMKLTKDHM LGMWKAGCIM 610 620 630 640 650 660 GFINKTKAQT DLLRSVYGIG TFLLRFSDSE LGGVTIAYVN ENGLVTMLAP WTARDFQVLN 670 680 690 700 710 720 LADRIRDLDV LCWLHPSDRN ASPVKRDVAF GEFYSKRQDP VTGYVKSTLH VHVCRNGENG 730 740 750 STSGTPHHAQ ESMQLGNGDF GMADFDTITN FENF
	Isoform G [UniParc]. Checksum: A3B0A8FFC32BCCF3	FASTA	635	71,976
	10 20 30 40 50 60 MPLNPYNMNN TPMVTGYMVD PSDLLAVSNS CNPPVVQGIG PIHNVQNTGI ASPALGMVTP 70 80 90 100 110 120 KVELYEVQHQ IMQSLNEFGN CANALKLLAQ NYSYMLNSTS SPNAEAAYRS LIDEKAAIVL 130 140 150 160 170 180 TMRRSFMYYE SLHEMVIHEL KNWRHQQAQA GNGAPFNEGS LDDIQRCFEM LESFIAHMLA 190 200 210 220 230 240 AVKELMRVRL VTEEPELTHL LEQVQNAQKN LVCSAFIVDK QPPQVMKTNT RFAASVRWLI 250 260 270 280 290 300 GSQLGIHNNP PTVECIIMSE IQSQRFVTRN TQMDNSSLSG QSSGEIQNAS STMEYQQNNH 310 320 330 340 350 360 VFSASFRNMQ LKKIKRAEKK GTESVMDEKF ALFFYTTTTV NDFQIRVWTL SLPVVVIVHG 370 380 390 400 410 420 NQEPQSWATI TWDNAFAEIV RDPFMITDRV TWAQLSVALN IKFGSCTGRS LTIDNLDFLY 430 440 450 460 470 480 EKLQREERSE YITWNQFCKE PMPDRSFTFW EWFFAIMKLT KDHMLGMWKA GCIMGFINKT 490 500 510 520 530 540 KAQTDLLRSV YGIGTFLLRF SDSELGGVTI AYVNENGLVT MLAPWTARDF QVLNLADRIR 550 560 570 580 590 600 DLDVLCWLHP SDRNASPVKR DVAFGEFYSK RQEPEPLVLD PVTGYVKSTL HVHVCRNGEN 610 620 630 GSTSGTPHHA QESMQLGNGD FGMADFDTIT NFENF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs." Hou X.S., Melnick M.B., Perrimon N. Cell 84:411-419(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM F), DISRUPTION PHENOTYPE. Tissue: Embryo.
[2]	"Identification of a Stat gene that functions in Drosophila development." Yan R., Small S., Desplan C., Dearolf C.R., Darnell J.E. Jr. Cell 84:421-430(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), PHOSPHORYLATION AT TYR-711, DISRUPTION PHENOTYPE. Tissue: Embryo.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[5]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM F). Strain: Berkeley. Tissue: Embryo.
[6]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 267-761 (ISOFORM F). Strain: Berkeley. Tissue: Larva and Pupae.
[7]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-711, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40070 mRNA. Translation: AAC46984.1. U46688 mRNA. Translation: AAB02195.1. AE014297 Genomic DNA. Translation: AAN14350.2. AE014297 Genomic DNA. Translation: AAN14351.2. AE014297 Genomic DNA. Translation: AAS65180.1. AE014297 Genomic DNA. Translation: AAX52969.1. BT021314 mRNA. Translation: AAX33462.1. AY094839 mRNA. Translation: AAM11192.1. Different initiation.
RefSeq	NP_001014643.1. NM_001014643.2. NP_001262757.1. NM_001275828.1. NP_001262762.1. NM_001275833.1. NP_732516.2. NM_169899.3. NP_732517.2. NM_169900.3. NP_996242.1. NM_206520.2. NP_996243.1. NM_206521.2.
UniGene	Dm.2627.
3D structure databases
ProteinModelPortal	Q24151.
SMR	Q24151. Positions 235-695.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29510N.
MINT	MINT-301385.
Proteomic databases
PaxDb	Q24151.
PRIDE	Q24151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0089486; FBpp0088489; FBgn0016917.
GeneID	42428.
KEGG	dme:Dmel_CG4257.
Organism-specific databases
CTD	42428.
FlyBase	FBgn0016917. Stat92E.
Phylogenomic databases
eggNOG	NOG245085.
GeneTree	ENSGT00550000074337.
InParanoid	Q24151.
KO	K11224.
OMA	ALNIKFG.
OrthoDB	EOG4RR4ZC.
PhylomeDB	Q24151.
Gene expression databases
Bgee	Q24151.
GermOnline	CG4257. Drosophila melanogaster.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 1.10.532.10. 1 hit. 1.20.1050.20. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR001217. STAT_TF_core. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_sub. IPR013799. STAT_TF_prot_interaction. [Graphical view]
PANTHER	PTHR11801. PTHR11801. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit. [Graphical view]
SMART	SM00252. SH2. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit. SSF47655. STAT. 1 hit.
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	42428.
NextBio	828722.

Entry information

Entry name

STAT_DROME

Accession

Primary (citable) accession number: Q24151
Secondary accession number(s): Q0KI43 , Q24181, Q59DV7, Q5BIB0, Q8IN54, Q8SX55, Q9VDL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project