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Protein

Metalloendopeptidase

Gene

tok

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi614 – 6141Zinc; catalyticUniRule annotation
Active sitei615 – 6151UniRule annotation
Metal bindingi618 – 6181Zinc; catalyticUniRule annotation
Metal bindingi624 – 6241Zinc; catalyticUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: FlyBase
  • defasciculation of motor neuron axon Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • protein processing Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-2243919. Crosslinking of collagen fibrils.

Protein family/group databases

MEROPSiM12.011.

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:tokImported
ORF Names:CG6863Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0004885. tok.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333UniRule annotationAdd
BLAST
Chaini34 – 14641431MetalloendopeptidaseUniRule annotationPRO_5005142875Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ24132.
PRIDEiQ24132.

Expressioni

Gene expression databases

BgeeiFBgn0004885.
ExpressionAtlasiQ24132. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0084068.

Structurei

3D structure databases

ProteinModelPortaliQ24132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini723 – 839117CUBInterPro annotationAdd
BLAST
Domaini840 – 954115CUBInterPro annotationAdd
BLAST
Domaini954 – 99441EGF-likeInterPro annotationAdd
BLAST
Domaini997 – 1114118CUBInterPro annotationAdd
BLAST
Domaini1114 – 115441EGF-likeInterPro annotationAdd
BLAST
Domaini1158 – 1270113CUBInterPro annotationAdd
BLAST
Domaini1271 – 1391121CUBInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotationSAAS annotation
Contains 2 EGF-like domains.UniRule annotation
Contains 5 CUB domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
OrthoDBiEOG091G009U.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24132-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRRGTPLG VSWTNCVLLL ATGLLVVLIS VHAKNPRPHR GLPAPAPAPV
60 70 80 90 100
PASVDQVATE NAHRREPTVD GSVLQRLSGS DRAVDEDEDV DEDEDEGLKH
110 120 130 140 150
QHLEHRQQFD AYLGTIRRLR RPYRSKYTIE QLMRLHVTPK VSGDIDMDPC
160 170 180 190 200
KAGGFMGDIA LPEGDSGPVV AHTPIDDEEQ ERQEVEQLLA DSPSPVHDPA
210 220 230 240 250
SVSGAANSGP TKFNATFQLD LEKLKQEVYH EGLQVEEEGL TDIIRKKTKL
260 270 280 290 300
PSSGPVNLKA GQSQSQSQSA NEPVKPGSES PSDYAQASSY KNDVLPPSEQ
310 320 330 340 350
RIHTDKPARL TLAEIGPKSS NKTQSLHRNV DTRKIQSDNK DIEDDSGNNF
360 370 380 390 400
VAERRPSQIV PTSLPEQRST PAHVYSNAGG NGMQLDDEVD FLHSRGVVRR
410 420 430 440 450
RHRRGPKQRR SNQHLEHEVK LQRLREELSR PVIEGHHHQS HHQKQAQHRQ
460 470 480 490 500
LHQSHHRKKH RRQQQHHRRR GQSTTQYVNY SPPGFNQSQQ AQQQSVPEMD
510 520 530 540 550
LLKAETSKDE EPLRHRVARA VTAKKERIWD YGVIPYEIDG NFSGIHKALF
560 570 580 590 600
KLAMRHWENS TCIKFVERDP EIHPNYIVFT VRSCGCCSFV GKRGNGPQAI
610 620 630 640 650
SIGRNCDKFG IVVHELGHVV GFWHEHTRPD REKHVVIEHN NIMKGQDYNF
660 670 680 690 700
NMLSPDEVDS LGMAYDYDSI MHYARNTFSK GTYLDTILPI EMKGRKRPEI
710 720 730 740 750
GQRLRLSQGD IAQANLLYKC PKCGRTFQES SGIFASPSHY TAGALSNETE
760 770 780 790 800
HCEWRITATY GERVELKLEN MNIFKSNNCE TDYLEIRDGY FEKSPLIGRF
810 820 830 840 850
CGKVDKEVIR TESSRMLLTY VNTHRIEGFR GFKAEFDVVC GGELSVDDAV
860 870 880 890 900
GRLESPNYPL DYLPNKECVW KITVPESYQV ALKFQSFEVE NHDSCVYDYV
910 920 930 940 950
EVRDGPGQDA PLIGVFCGYK PPPNMKSSGN SMYVKFVSDT SVQKAGFSAV
960 970 980 990 1000
FMKEVDECET QNHGCEHECI NTLGGYECSC RIGFELHSDK KHCEDACGGV
1010 1020 1030 1040 1050
IEYPNGTITS PSFPEMYPLL KECIWEIVAP PKHRISLNFT HFDLEGTAHQ
1060 1070 1080 1090 1100
QSDCGYDSVT VYSKLGENRL KRIGTFCGSS IPPTATSESN ALRLEFHSDK
1110 1120 1130 1140 1150
SIQRSGFAAV FFTDIDECAV NNGGCQHECR NTIGSYICMC HNGYSMHENG
1160 1170 1180 1190 1200
HDCKEGECKY EISAPFGTIF SPNYPDSYPP NADCVWHFIT TPGHRIKLIF
1210 1220 1230 1240 1250
NEFDVESHQE CTYDNVAVYD GESESSSVLG RFCGDKIPFP ISSTSNQMYM
1260 1270 1280 1290 1300
VLKTDKNKQK NGFTASHSTA CGGYLRATSQ VQQFYSHARF GNQDYDDGMD
1310 1320 1330 1340 1350
CEWTIAAPDN SYVQLIFLTF DIESSENCTF DYVQVFSDID DVYGQYGPMY
1360 1370 1380 1390 1400
GQYCGNVLPQ DINSMTHSLL VRFKTDGSVP MKGFSASYVA VPNSGEYDHS
1410 1420 1430 1440 1450
DEDVENSYSS EMVTPFPGSL KSIYIEDTQE ETDEYSDFSG NQLVFNGQYR
1460
GRYSLPKRYY SGKA
Length:1,464
Mass (Da):165,107
Last modified:November 1, 1996 - v1
Checksum:i5955B6DEA9E37170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34777 mRNA. Translation: AAC47015.1.
PIRiS58984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34777 mRNA. Translation: AAC47015.1.
PIRiS58984.

3D structure databases

ProteinModelPortaliQ24132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0084068.

Protein family/group databases

MEROPSiM12.011.

Proteomic databases

PaxDbiQ24132.
PRIDEiQ24132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0004885. tok.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
OrthoDBiEOG091G009U.

Enzyme and pathway databases

ReactomeiR-DME-2243919. Crosslinking of collagen fibrils.

Miscellaneous databases

ChiTaRSitok. fly.

Gene expression databases

BgeeiFBgn0004885.
ExpressionAtlasiQ24132. differential.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24132_DROME
AccessioniPrimary (citable) accession number: Q24132
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.