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Protein

Protein cappuccino

Gene

capu

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an actin nucleation factor and promotes assembly of actin filaments together with spir. May play a role in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport.1 Publication

GO - Molecular functioni

  • actin binding Source: FlyBase
  • microtubule binding Source: FlyBase

GO - Biological processi

  • actin filament-based process Source: FlyBase
  • actin filament organization Source: FlyBase
  • actin nucleation Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • oogenesis Source: FlyBase
  • pole plasm assembly Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • pole plasm RNA localization Source: FlyBase
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processProtein transport, Stress response, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cappuccino
Gene namesi
Name:capu
ORF Names:CG3399
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000256. capu.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1049K → A or D: Abolishes interaction with spir. 1 Publication1
Mutagenesisi1051R → A or D: Abolishes interaction with spir. 1 Publication1
Mutagenesisi1055R → A or D: Abolishes interaction with spir. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948841 – 1059Protein cappuccinoAdd BLAST1059

Proteomic databases

PaxDbiQ24120.
PRIDEiQ24120.

Expressioni

Gene expression databases

BgeeiFBgn0000256.
ExpressionAtlasiQ24120. differential.
GenevisibleiQ24120. DM.

Interactioni

Subunit structurei

Interacts with wash. Interacts with spir.2 Publications

GO - Molecular functioni

  • actin binding Source: FlyBase
  • microtubule binding Source: FlyBase

Protein-protein interaction databases

BioGridi59814. 12 interactors.
IntActiQ24120. 3 interactors.
STRINGi7227.FBpp0288517.

Structurei

3D structure databases

ProteinModelPortaliQ24120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 560FH1Add BLAST81
Domaini585 – 1032FH2PROSITE-ProRule annotationAdd BLAST448

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1049 – 1059Important for interaction with spirAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1922. Eukaryota.
ENOG410XQWC. LUCA.
GeneTreeiENSGT00870000136417.
HOGENOMiHOG000247006.
InParanoidiQ24120.
KOiK02184.
OrthoDBiEOG091G0XIA.

Family and domain databases

InterProiView protein in InterPro
IPR015425. FH2_Formin.
IPR001265. Formin_Cappuccino_subfam.
PfamiView protein in Pfam
PF02181. FH2. 1 hit.
PRINTSiPR00828. FORMIN.
SMARTiView protein in SMART
SM00498. FH2. 1 hit.
PROSITEiView protein in PROSITE
PS51444. FH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQLGKKLA QVLGSGAGSP LTPGTMEPCA AGSGSPLANG ELFNVSKAKK
60 70 80 90 100
VELQNLSSRF TAAVTQTPPG VTSSTPNESG VTGPAGPLGA TTSSPSLETQ
110 120 130 140 150
STVIISFKSS QTPVQSQTNS AASENVEDDT APLPLPPPPP GFGTPTTPLL
160 170 180 190 200
SSNVLKKVAS FTVEKSSAGN NSSNPPNLCP TSDETTLLAT PCSSSLTVAT
210 220 230 240 250
LPPEIAVGAA AGGVAGGAGS RRGSSYVPEK LSFAAYEKFE GQMLIKWLIS
260 270 280 290 300
TMQSNPKSSS GDANQELFNT LALQFCNNLK YVGVLKQISN EHLDCGFSPY
310 320 330 340 350
EMYQWTHTEQ PTTSLPLTPG KLDKVAAWPF SSTPSGIRAL ESASLASLGA
360 370 380 390 400
GGVAGSLATI ATASTASSDN QKTLQQILKK RLLNCTTLAE VHAVVNELLS
410 420 430 440 450
SVDEPPRRPS KRCVNLTELL NASEATVYEY NKTGAEGCVK SFTDAETQTE
460 470 480 490 500
SEDCEGTCKC GQSSTKVSDN ESAKEDGEKP HAVAPPPPPP PPPLHAFVAP
510 520 530 540 550
PPPPPPPPPP PPPLANYGAP PPPPPPPPGS GSAPPPPPPA PIEGGGGIPP
560 570 580 590 600
PPPPMSASPS KTTISPAPLP DPAEGNWFHR TNTMRKSAVN PPKPMRPLYW
610 620 630 640 650
TRIVTSAPPA PRPPSVANST DSTENSGSSP DEPPAANGAD APPTAPPATK
660 670 680 690 700
EIWTEIEETP LDNIDEFTEL FSRQAIAPVS KPKELKVKRA KSIKVLDPER
710 720 730 740 750
SRNVGIIWRS LHVPSSEIEH AIYHIDTSVV SLEALQHMSN IQATEDELQR
760 770 780 790 800
IKEAAGGDIP LDHPEQFLLD ISLISMASER ISCIVFQAEF EESVTLLFRK
810 820 830 840 850
LETVSQLSQQ LIESEDLKLV FSIILTLGNY MNGGNRQRGQ ADGFNLDILG
860 870 880 890 900
KLKDVKSKES HTTLLHFIVR TYIAQRRKEG VHPLEIRLPI PEPADVERAA
910 920 930 940 950
QMDFEEVQQQ IFDLNKKFLG CKRTTAKVLA ASRPEIMEPF KSKMEEFVEG
960 970 980 990 1000
ADKSMAKLHQ SLDECRDLFL ETMRFYHFSP KACTLTLAQC TPDQFFEYWT
1010 1020 1030 1040 1050
NFTNDFKDIW KKEITSLLNE LMKKSKQAQI ESRRNVSTKV EKSGRISLKE

RMLMRRSKN
Length:1,059
Mass (Da):113,864
Last modified:February 21, 2001 - v2
Checksum:i009B0E24F61B6EA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260S → C in AAC46925 (PubMed:7590229).Curated1
Sequence conflicti364S → T in AAC46925 (PubMed:7590229).Curated1
Sequence conflicti386T → S in AAC46925 (PubMed:7590229).Curated1
Sequence conflicti471E → K in AAC46925 (PubMed:7590229).Curated1
Sequence conflicti495H → P in AAC46925 (PubMed:7590229).Curated1
Sequence conflicti513Missing in AAC46925 (PubMed:7590229).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34258 mRNA. Translation: AAC46925.1.
AE014134 Genomic DNA. Translation: AAF51054.1.
PIRiT13286.
RefSeqiNP_476966.1. NM_057618.3.
UniGeneiDm.4776.

Genome annotation databases

EnsemblMetazoaiFBtr0077513; FBpp0077202; FBgn0000256.
FBtr0290078; FBpp0288517; FBgn0000256.
FBtr0290081; FBpp0288520; FBgn0000256.
GeneIDi33611.
KEGGidme:Dmel_CG3399.
UCSCiCG3399-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiCAPU_DROME
AccessioniPrimary (citable) accession number: Q24120
Secondary accession number(s): Q9VQV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: October 25, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families