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Q24117

- DYL1_DROME

UniProt

Q24117 - DYL1_DROME

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Protein
Dynein light chain 1, cytoplasmic
Gene
ctp, Cdlc1, ddlc1, CG6998
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a non-catalytic accessory component of a dynein complex By similarity.1 Publication

GO - Molecular functioni

  1. ATPase activity, coupled Source: FlyBase
  2. dynein intermediate chain binding Source: FlyBase
  3. motor activity Source: UniProtKB-KW
  4. protein binding Source: FlyBase
  5. protein homodimerization activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. actin filament bundle assembly Source: FlyBase
  3. autophagy Source: FlyBase
  4. chaeta development Source: UniProtKB
  5. chaeta morphogenesis Source: FlyBase
  6. establishment of mitotic spindle orientation Source: FlyBase
  7. imaginal disc-derived wing morphogenesis Source: FlyBase
  8. microtubule anchoring at centrosome Source: FlyBase
  9. microtubule-based movement Source: FlyBase
  10. neurogenesis Source: FlyBase
  11. oogenesis Source: UniProtKB
  12. salivary gland cell autophagic cell death Source: FlyBase
  13. sperm individualization Source: FlyBase
  14. spermatid nucleus elongation Source: FlyBase
  15. spermatogenesis Source: FlyBase
  16. wing disc development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Cut up protein
Gene namesi
Name:ctp
Synonyms:Cdlc1, ddlc1
ORF Names:CG6998
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0011760. ctp.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. centriole Source: FlyBase
  2. cytoplasm Source: UniProtKB
  3. dynein complex Source: FlyBase
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Disruption phenotypei

Flies exhibit defects in bristle and wing development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 1, cytoplasmic
PRO_0000195131Add
BLAST

Proteomic databases

PaxDbiQ24117.
PRIDEiQ24117.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ24117.

Interactioni

Protein-protein interaction databases

BioGridi57920. 45 interactions.
DIPiDIP-17520N.
IntActiQ24117. 8 interactions.
MINTiMINT-322013.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138
Helixi15 – 3117
Helixi35 – 5016
Beta strandi54 – 618
Beta strandi68 – 7811
Beta strandi81 – 888

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
ProteinModelPortaliQ24117.
SMRiQ24117. Positions 3-89.

Miscellaneous databases

EvolutionaryTraceiQ24117.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
InParanoidiQ24117.
KOiK10418.
OMAiLAILIWK.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ24117.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24117-1 [UniParc]FASTAAdd to Basket

« Hide

MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY   50
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG 89
Length:89
Mass (Da):10,374
Last modified:November 1, 1997 - v1
Checksum:i44871BC030423A8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
AE014298 Genomic DNA. Translation: AAN09128.1.
RefSeqiNP_001245530.1. NM_001258601.2.
NP_525075.1. NM_080336.4.
NP_726942.1. NM_167014.2.
NP_726943.1. NM_167015.2.
NP_726944.1. NM_167016.2.
UniGeneiDm.5892.

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070705; FBpp0070673; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneIDi31405.
KEGGidme:Dmel_CG6998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32855 mRNA. Translation: AAB04148.1 .
U48846 mRNA. Translation: AAD00072.1 .
U48848 mRNA. Translation: AAD00074.1 .
AE014298 Genomic DNA. Translation: AAF45975.1 .
AE014298 Genomic DNA. Translation: AAN09126.1 .
AE014298 Genomic DNA. Translation: AAN09127.1 .
AE014298 Genomic DNA. Translation: AAN09128.1 .
RefSeqi NP_001245530.1. NM_001258601.2.
NP_525075.1. NM_080336.4.
NP_726942.1. NM_167014.2.
NP_726943.1. NM_167015.2.
NP_726944.1. NM_167016.2.
UniGenei Dm.5892.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RHW NMR - A 1-89 [» ]
2P2T X-ray 3.00 A 1-89 [» ]
2PG1 X-ray 2.80 A/B/C/D 1-89 [» ]
3BRI X-ray 1.70 A 1-89 [» ]
3BRL X-ray 1.90 A 1-87 [» ]
3DVH X-ray 2.00 A/B/C 1-89 [» ]
3DVP X-ray 2.50 A/B 1-89 [» ]
3DVT X-ray 2.30 A/B/C/D/E/F 1-89 [» ]
3E2B X-ray 2.00 A 1-89 [» ]
3FM7 X-ray 3.50 E/F 1-89 [» ]
3GLW X-ray 3.15 A 1-89 [» ]
4QH7 X-ray 1.83 A/B/E/F 1-89 [» ]
4QH8 X-ray 1.90 A/B/E/F/G/H 1-89 [» ]
ProteinModelPortali Q24117.
SMRi Q24117. Positions 3-89.
ModBasei Search...

Protein-protein interaction databases

BioGridi 57920. 45 interactions.
DIPi DIP-17520N.
IntActi Q24117. 8 interactions.
MINTi MINT-322013.

Proteomic databases

PaxDbi Q24117.
PRIDEi Q24117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0070704 ; FBpp0070672 ; FBgn0011760 .
FBtr0070705 ; FBpp0070673 ; FBgn0011760 .
FBtr0070706 ; FBpp0070674 ; FBgn0011760 .
FBtr0070707 ; FBpp0070675 ; FBgn0011760 .
FBtr0307065 ; FBpp0297908 ; FBgn0011760 .
GeneIDi 31405.
KEGGi dme:Dmel_CG6998.

Organism-specific databases

CTDi 31405.
FlyBasei FBgn0011760. ctp.

Phylogenomic databases

eggNOGi NOG312371.
GeneTreei ENSGT00390000000378.
InParanoidi Q24117.
KOi K10418.
OMAi LAILIWK.
OrthoDBi EOG7BZVVQ.
PhylomeDBi Q24117.

Miscellaneous databases

EvolutionaryTracei Q24117.
GenomeRNAii 31405.
NextBioi 773472.

Gene expression databases

Bgeei Q24117.

Family and domain databases

Gene3Di 3.30.740.10. 1 hit.
InterProi IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view ]
PANTHERi PTHR11886. PTHR11886. 1 hit.
Pfami PF01221. Dynein_light. 1 hit.
[Graphical view ]
PROSITEi PS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."
    Dick T., Ray K., Salz H.K., Chia W.
    Mol. Cell. Biol. 16:1966-1977(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  2. Li M.-G., Serr M., Hays T.S.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head and Ovary.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiDYL1_DROME
AccessioniPrimary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi