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Q24117

- DYL1_DROME

UniProt

Q24117 - DYL1_DROME

Protein

Dynein light chain 1, cytoplasmic

Gene

ctp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as a non-catalytic accessory component of a dynein complex.By similarity

    GO - Molecular functioni

    1. ATPase activity, coupled Source: FlyBase
    2. dynein intermediate chain binding Source: FlyBase
    3. motor activity Source: UniProtKB-KW
    4. protein binding Source: FlyBase
    5. protein homodimerization activity Source: FlyBase

    GO - Biological processi

    1. actin filament bundle assembly Source: FlyBase
    2. ATP catabolic process Source: GOC
    3. autophagy Source: FlyBase
    4. chaeta development Source: UniProtKB
    5. chaeta morphogenesis Source: FlyBase
    6. establishment of mitotic spindle orientation Source: FlyBase
    7. imaginal disc-derived wing morphogenesis Source: FlyBase
    8. microtubule anchoring at centrosome Source: FlyBase
    9. microtubule-based movement Source: FlyBase
    10. neurogenesis Source: FlyBase
    11. oogenesis Source: UniProtKB
    12. salivary gland cell autophagic cell death Source: FlyBase
    13. spermatid nucleus elongation Source: FlyBase
    14. spermatogenesis Source: FlyBase
    15. sperm individualization Source: FlyBase
    16. wing disc development Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Alternative name(s):
    8 kDa dynein light chain
    Cut up protein
    Gene namesi
    Name:ctp
    Synonyms:Cdlc1, ddlc1
    ORF Names:CG6998
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0011760. ctp.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. centriole Source: FlyBase
    2. cytoplasm Source: UniProtKB
    3. dynein complex Source: FlyBase
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Disruption phenotypei

    Flies exhibit defects in bristle and wing development.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8989Dynein light chain 1, cytoplasmicPRO_0000195131Add
    BLAST

    Proteomic databases

    PaxDbiQ24117.
    PRIDEiQ24117.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiQ24117.

    Interactioni

    Protein-protein interaction databases

    BioGridi57920. 45 interactions.
    DIPiDIP-17520N.
    IntActiQ24117. 8 interactions.
    MINTiMINT-322013.

    Structurei

    Secondary structure

    1
    89
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 138
    Helixi15 – 3117
    Helixi35 – 5016
    Beta strandi54 – 618
    Beta strandi68 – 7811
    Beta strandi81 – 888

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RHWNMR-A1-89[»]
    2P2TX-ray3.00A1-89[»]
    2PG1X-ray2.80A/B/C/D1-89[»]
    3BRIX-ray1.70A1-89[»]
    3BRLX-ray1.90A1-87[»]
    3DVHX-ray2.00A/B/C1-89[»]
    3DVPX-ray2.50A/B1-89[»]
    3DVTX-ray2.30A/B/C/D/E/F1-89[»]
    3E2BX-ray2.00A1-89[»]
    3FM7X-ray3.50E/F1-89[»]
    3GLWX-ray3.15A1-89[»]
    4QH7X-ray1.83A/B/E/F1-89[»]
    4QH8X-ray1.90A/B/E/F/G/H1-89[»]
    ProteinModelPortaliQ24117.
    SMRiQ24117. Positions 3-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ24117.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dynein light chain family.Curated

    Phylogenomic databases

    eggNOGiNOG312371.
    GeneTreeiENSGT00390000000378.
    InParanoidiQ24117.
    KOiK10418.
    OMAiLAILIWK.
    OrthoDBiEOG7BZVVQ.
    PhylomeDBiQ24117.

    Family and domain databases

    Gene3Di3.30.740.10. 1 hit.
    InterProiIPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view]
    PANTHERiPTHR11886. PTHR11886. 1 hit.
    PfamiPF01221. Dynein_light. 1 hit.
    [Graphical view]
    PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24117-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY   50
    NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG 89
    Length:89
    Mass (Da):10,374
    Last modified:November 1, 1997 - v1
    Checksum:i44871BC030423A8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32855 mRNA. Translation: AAB04148.1.
    U48846 mRNA. Translation: AAD00072.1.
    U48848 mRNA. Translation: AAD00074.1.
    AE014298 Genomic DNA. Translation: AAF45975.1.
    AE014298 Genomic DNA. Translation: AAN09126.1.
    AE014298 Genomic DNA. Translation: AAN09127.1.
    AE014298 Genomic DNA. Translation: AAN09128.1.
    RefSeqiNP_001245530.1. NM_001258601.2.
    NP_525075.1. NM_080336.4.
    NP_726942.1. NM_167014.2.
    NP_726943.1. NM_167015.2.
    NP_726944.1. NM_167016.2.
    UniGeneiDm.5892.

    Genome annotation databases

    EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
    FBtr0070705; FBpp0070673; FBgn0011760.
    FBtr0070706; FBpp0070674; FBgn0011760.
    FBtr0070707; FBpp0070675; FBgn0011760.
    FBtr0307065; FBpp0297908; FBgn0011760.
    GeneIDi31405.
    KEGGidme:Dmel_CG6998.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32855 mRNA. Translation: AAB04148.1 .
    U48846 mRNA. Translation: AAD00072.1 .
    U48848 mRNA. Translation: AAD00074.1 .
    AE014298 Genomic DNA. Translation: AAF45975.1 .
    AE014298 Genomic DNA. Translation: AAN09126.1 .
    AE014298 Genomic DNA. Translation: AAN09127.1 .
    AE014298 Genomic DNA. Translation: AAN09128.1 .
    RefSeqi NP_001245530.1. NM_001258601.2.
    NP_525075.1. NM_080336.4.
    NP_726942.1. NM_167014.2.
    NP_726943.1. NM_167015.2.
    NP_726944.1. NM_167016.2.
    UniGenei Dm.5892.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RHW NMR - A 1-89 [» ]
    2P2T X-ray 3.00 A 1-89 [» ]
    2PG1 X-ray 2.80 A/B/C/D 1-89 [» ]
    3BRI X-ray 1.70 A 1-89 [» ]
    3BRL X-ray 1.90 A 1-87 [» ]
    3DVH X-ray 2.00 A/B/C 1-89 [» ]
    3DVP X-ray 2.50 A/B 1-89 [» ]
    3DVT X-ray 2.30 A/B/C/D/E/F 1-89 [» ]
    3E2B X-ray 2.00 A 1-89 [» ]
    3FM7 X-ray 3.50 E/F 1-89 [» ]
    3GLW X-ray 3.15 A 1-89 [» ]
    4QH7 X-ray 1.83 A/B/E/F 1-89 [» ]
    4QH8 X-ray 1.90 A/B/E/F/G/H 1-89 [» ]
    ProteinModelPortali Q24117.
    SMRi Q24117. Positions 3-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57920. 45 interactions.
    DIPi DIP-17520N.
    IntActi Q24117. 8 interactions.
    MINTi MINT-322013.

    Proteomic databases

    PaxDbi Q24117.
    PRIDEi Q24117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0070704 ; FBpp0070672 ; FBgn0011760 .
    FBtr0070705 ; FBpp0070673 ; FBgn0011760 .
    FBtr0070706 ; FBpp0070674 ; FBgn0011760 .
    FBtr0070707 ; FBpp0070675 ; FBgn0011760 .
    FBtr0307065 ; FBpp0297908 ; FBgn0011760 .
    GeneIDi 31405.
    KEGGi dme:Dmel_CG6998.

    Organism-specific databases

    CTDi 31405.
    FlyBasei FBgn0011760. ctp.

    Phylogenomic databases

    eggNOGi NOG312371.
    GeneTreei ENSGT00390000000378.
    InParanoidi Q24117.
    KOi K10418.
    OMAi LAILIWK.
    OrthoDBi EOG7BZVVQ.
    PhylomeDBi Q24117.

    Miscellaneous databases

    EvolutionaryTracei Q24117.
    GenomeRNAii 31405.
    NextBioi 773472.

    Gene expression databases

    Bgeei Q24117.

    Family and domain databases

    Gene3Di 3.30.740.10. 1 hit.
    InterProi IPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view ]
    PANTHERi PTHR11886. PTHR11886. 1 hit.
    Pfami PF01221. Dynein_light. 1 hit.
    [Graphical view ]
    PROSITEi PS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."
      Dick T., Ray K., Salz H.K., Chia W.
      Mol. Cell. Biol. 16:1966-1977(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    2. Li M.-G., Serr M., Hays T.S.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Head and Ovary.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.

    Entry informationi

    Entry nameiDYL1_DROME
    AccessioniPrimary (citable) accession number: Q24117
    Secondary accession number(s): A4V3Y5, Q9V3Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3