Q24117 (DYL1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein light chain 1, cytoplasmic

Alternative name(s):
8 kDa dynein light chain
Cut up protein

Gene names

Name:	ctp
Synonyms:	Cdlc1, ddlc1
ORF Names:	CG6998

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a non-catalytic accessory component of a dynein complex By similarity. Ref.1
Subcellular location	Cytoplasm › cytoskeleton Ref.1.
Tissue specificity	Ubiquitous. Ref.1
Disruption phenotype	Flies exhibit defects in bristle and wing development. Ref.1
Sequence similarities	Belongs to the dynein light chain family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Dynein Microtubule
Molecular function	Motor protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament bundle assembly Inferred from mutant phenotype PubMed 15829565. Source: FlyBase autophagy Inferred from mutant phenotype PubMed 20080745. Source: FlyBase chaeta morphogenesis Inferred from mutant phenotype PubMed 15020714. Source: FlyBase establishment of mitotic spindle orientation Inferred from mutant phenotype PubMed 21920316. Source: FlyBase imaginal disc-derived wing morphogenesis Inferred from mutant phenotype PubMed 15020714. Source: FlyBase microtubule anchoring at centrosome Inferred from mutant phenotype PubMed 21920316. Source: FlyBase microtubule-based movement Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase neurogenesis Inferred from mutant phenotype PubMed 21549331. Source: FlyBase oogenesis Inferred from mutant phenotype Ref.1. Source: UniProtKB salivary gland cell autophagic cell death Inferred from mutant phenotype PubMed 20080745. Source: FlyBase sperm individualization Inferred from mutant phenotype PubMed 15829565. Source: FlyBase spermatid nucleus elongation Inferred from mutant phenotype PubMed 15829565. Source: FlyBase
Cellular_component	centriole Inferred from direct assay PubMed 21920316. Source: FlyBase dynein complex Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATPase activity, coupled Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase motor activity Inferred from electronic annotation. Source: UniProtKB-KW protein homodimerization activity Inferred from direct assay PubMed 17428790. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 89

89

Dynein light chain 1, cytoplasmic

PRO_0000195131

Secondary structure

1

.

.

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.

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.

.

.

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89

Helix Strand Turn

Details...

Beta strand

6 – 13

8

Helix

15 – 31

17

Helix

35 – 50

16

Beta strand

54 – 61

8

Beta strand

68 – 78

11

Beta strand

81 – 88

8

Sequences

	Sequence		Length	Mass (Da)
	Q24117 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 44871BC030423A8F	FASTA	89	10,374
	10 20 30 40 50 60 MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR 70 80 NFGSYVTHET RHFIYFYLGQ VAILLFKSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster." Dick T., Ray K., Salz H.K., Chia W. Mol. Cell. Biol. 16:1966-1977(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]	Li M.-G., Serr M., Hays T.S. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Head and Ovary.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
AE014298 Genomic DNA. Translation: AAN09128.1.

RefSeq

NP_001245530.1. NM_001258601.2.
NP_525075.1. NM_080336.4.
NP_726942.1. NM_167014.2.
NP_726943.1. NM_167015.2.
NP_726944.1. NM_167016.2.

UniGene

Dm.5892.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RHW	NMR	-	A	1-89	[»]
2P2T	X-ray	3.00	A	1-89	[»]
2PG1	X-ray	2.80	A/B/C/D	1-89	[»]
3BRI	X-ray	1.70	A	1-89	[»]
3BRL	X-ray	1.90	A	1-87	[»]
3DVH	X-ray	2.00	A/B/C	1-89	[»]
3DVP	X-ray	2.50	A/B	1-89	[»]
3DVT	X-ray	2.30	A/B/C/D/E/F	1-89	[»]
3E2B	X-ray	2.00	A	1-89	[»]
3FM7	X-ray	3.50	E/F	1-89	[»]
3GLW	X-ray	3.15	A	1-89	[»]

ProteinModelPortal

Q24117.

SMR

Q24117. Positions 3-89.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-17520N.

IntAct

Q24117. 8 interactions.

MINT

MINT-322013.

Proteomic databases

PaxDb

Q24117.

PRIDE

Q24117.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070705; FBpp0070673; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.

GeneID

31405.

KEGG

dme:Dmel_CG6998.

Organism-specific databases

CTD

31405.

FlyBase

FBgn0011760. ctp.

Phylogenomic databases

eggNOG

NOG312371.

GeneTree

ENSGT00390000000378.

InParanoid

Q24117.

KO

K10418.

OMA

FVTHETK.

OrthoDB

EOG415DX0.

PhylomeDB

Q24117.

Gene expression databases

Bgee

Q24117.

GermOnline

CG6998. Drosophila melanogaster.

Family and domain databases

Gene3D

3.30.740.10. 1 hit.

InterPro

IPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]

PANTHER

PTHR11886. PTHR11886. 1 hit.

Pfam

PF01221. Dynein_light. 1 hit.
[Graphical view]

SUPFAM

SSF54648. Dynein_light_chain_typ-1/2. 1 hit.

PROSITE

PS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q24117.

GenomeRNAi

31405.

NextBio

773472.

Entry information

Entry name

DYL1_DROME

Accession

Primary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project