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Q24117 (DYL1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Cut up protein
Gene names
Name:ctp
Synonyms:Cdlc1, ddlc1
ORF Names:CG6998
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a non-catalytic accessory component of a dynein complex By similarity. Ref.1

Subcellular location

Cytoplasmcytoskeleton Ref.1.

Tissue specificity

Ubiquitous. Ref.1

Disruption phenotype

Flies exhibit defects in bristle and wing development. Ref.1

Sequence similarities

Belongs to the dynein light chain family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Dynein
Microtubule
   Molecular functionMotor protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from sequence or structural similarity PubMed 10908588. Source: GOC

actin filament bundle assembly

Inferred from mutant phenotype PubMed 15829565. Source: FlyBase

autophagy

Inferred from mutant phenotype PubMed 20080745. Source: FlyBase

chaeta development

Inferred from mutant phenotype Ref.1. Source: UniProtKB

chaeta morphogenesis

Inferred from mutant phenotype PubMed 15020714. Source: FlyBase

establishment of mitotic spindle orientation

Inferred from mutant phenotype PubMed 21920316. Source: FlyBase

imaginal disc-derived wing morphogenesis

Inferred from mutant phenotype PubMed 15020714. Source: FlyBase

microtubule anchoring at centrosome

Inferred from mutant phenotype PubMed 21920316. Source: FlyBase

microtubule-based movement

Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase

neurogenesis

Inferred from mutant phenotype PubMed 21549331. Source: FlyBase

oogenesis

Inferred from mutant phenotype Ref.1. Source: UniProtKB

salivary gland cell autophagic cell death

Inferred from mutant phenotype PubMed 20080745. Source: FlyBase

sperm individualization

Inferred from mutant phenotype PubMed 15829565. Source: FlyBase

spermatid nucleus elongation

Inferred from mutant phenotype PubMed 15829565. Source: FlyBase

spermatogenesis

Inferred from mutant phenotype PubMed 15020714. Source: FlyBase

wing disc development

Inferred from mutant phenotype Ref.1. Source: UniProtKB

   Cellular_componentcentriole

Inferred from direct assay PubMed 21920316. Source: FlyBase

cytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

dynein complex

Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATPase activity, coupled

Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase

dynein intermediate chain binding

Inferred from physical interaction PubMed 17428790. Source: FlyBase

motor activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 17362353. Source: FlyBase

protein homodimerization activity

Inferred from direct assay PubMed 17428790. Source: FlyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8989Dynein light chain 1, cytoplasmic
PRO_0000195131

Secondary structure

............. 89
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q24117 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 44871BC030423A8F

FASTA8910,374
        10         20         30         40         50         60 
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR 

        70         80 
NFGSYVTHET RHFIYFYLGQ VAILLFKSG 

« Hide

References

« Hide 'large scale' references
[1]"Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."
Dick T., Ray K., Salz H.K., Chia W.
Mol. Cell. Biol. 16:1966-1977(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]Li M.-G., Serr M., Hays T.S.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Head and Ovary.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
AE014298 Genomic DNA. Translation: AAN09128.1.
RefSeqNP_001245530.1. NM_001258601.2.
NP_525075.1. NM_080336.4.
NP_726942.1. NM_167014.2.
NP_726943.1. NM_167015.2.
NP_726944.1. NM_167016.2.
UniGeneDm.5892.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
ProteinModelPortalQ24117.
SMRQ24117. Positions 3-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid57920. 45 interactions.
DIPDIP-17520N.
IntActQ24117. 8 interactions.
MINTMINT-322013.

Proteomic databases

PaxDbQ24117.
PRIDEQ24117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070705; FBpp0070673; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneID31405.
KEGGdme:Dmel_CG6998.

Organism-specific databases

CTD31405.
FlyBaseFBgn0011760. ctp.

Phylogenomic databases

eggNOGNOG312371.
GeneTreeENSGT00390000000378.
InParanoidQ24117.
KOK10418.
OMALAILIWK.
OrthoDBEOG7BZVVQ.
PhylomeDBQ24117.

Gene expression databases

BgeeQ24117.

Family and domain databases

Gene3D3.30.740.10. 1 hit.
InterProIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERPTHR11886. PTHR11886. 1 hit.
PfamPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ24117.
GenomeRNAi31405.
NextBio773472.

Entry information

Entry nameDYL1_DROME
AccessionPrimary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase