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Protein

Dynein light chain 1, cytoplasmic

Gene

ctp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a non-catalytic accessory component of a dynein complex.1 Publication

GO - Molecular functioni

  • ATPase activity, coupled Source: FlyBase
  • cytoskeletal protein binding Source: GO_Central
  • disordered domain specific binding Source: CAFA
  • dynein intermediate chain binding Source: FlyBase
  • dynein light intermediate chain binding Source: FlyBase
  • motor activity Source: UniProtKB-KW
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • actin filament bundle assembly Source: FlyBase
  • autophagy Source: FlyBase
  • chaeta development Source: UniProtKB
  • chaeta morphogenesis Source: FlyBase
  • cilium assembly Source: GO_Central
  • establishment of mitotic spindle orientation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • microtubule anchoring at centrosome Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • oogenesis Source: UniProtKB
  • positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • positive regulation of neuron remodeling Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • spermatid nucleus elongation Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase
  • transport along microtubule Source: GO_Central
  • wing disc development Source: UniProtKB

Keywordsi

Molecular functionMotor protein
Biological processTransport

Enzyme and pathway databases

ReactomeiR-DME-1632852 Macroautophagy
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-5620924 Intraflagellar transport
R-DME-6807878 COPI-mediated anterograde transport
R-DME-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Cut up protein
Gene namesi
Name:ctp
Synonyms:Cdlc1, ddlc1
ORF Names:CG6998
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0011760 ctp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Disruption phenotypei

Flies exhibit defects in bristle and wing development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951311 – 89Dynein light chain 1, cytoplasmicAdd BLAST89

Proteomic databases

PaxDbiQ24117
PRIDEiQ24117

PTM databases

iPTMnetiQ24117

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiFBgn0011760
GenevisibleiQ24117 DM

Interactioni

Subunit structurei

Interacts with spn-F (PubMed:16540510). Forms ternary complexes with spn-F and IKKepsilon (PubMed:26092846, PubMed:26540204).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: GO_Central
  • disordered domain specific binding Source: CAFA
  • dynein intermediate chain binding Source: FlyBase
  • dynein light intermediate chain binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi57920, 65 interactors
DIPiDIP-17520N
IntActiQ24117, 47 interactors
STRINGi7227.FBpp0070672

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi15 – 31Combined sources17
Helixi35 – 50Combined sources16
Beta strandi54 – 61Combined sources8
Beta strandi63 – 78Combined sources16
Beta strandi81 – 88Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
5E0LX-ray1.31A3-89[»]
5E0MX-ray1.65A1-89[»]
ProteinModelPortaliQ24117
SMRiQ24117
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ24117

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
InParanoidiQ24117
KOiK10418
OMAiKGPTWHC
OrthoDBiEOG091G15JY
PhylomeDBiQ24117

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR019763 Dynein_light_1/2_CS
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239 DYNEIN_LIGHT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q24117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,374
Last modified:November 1, 1997 - v1
Checksum:i44871BC030423A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32855 mRNA Translation: AAB04148.1
U48846 mRNA Translation: AAD00072.1
U48848 mRNA Translation: AAD00074.1
AE014298 Genomic DNA Translation: AAF45975.1
AE014298 Genomic DNA Translation: AAN09126.1
AE014298 Genomic DNA Translation: AAN09127.1
RefSeqiNP_001245530.1, NM_001258601.3
NP_525075.1, NM_080336.5
NP_726942.1, NM_167014.3
NP_726943.1, NM_167015.3
UniGeneiDm.5892

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760
FBtr0070706; FBpp0070674; FBgn0011760
FBtr0070707; FBpp0070675; FBgn0011760
FBtr0307065; FBpp0297908; FBgn0011760
GeneIDi31405
KEGGidme:Dmel_CG6998

Similar proteinsi

Entry informationi

Entry nameiDYL1_DROME
AccessioniPrimary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health