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Protein

Dynein light chain 1, cytoplasmic

Gene

ctp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a non-catalytic accessory component of a dynein complex.By similarity1 Publication

GO - Molecular functioni

  • ATPase activity, coupled Source: FlyBase
  • dynein intermediate chain binding Source: FlyBase
  • dynein light intermediate chain binding Source: FlyBase
  • motor activity Source: UniProtKB-KW
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • actin filament bundle assembly Source: FlyBase
  • autophagy Source: FlyBase
  • chaeta development Source: UniProtKB
  • chaeta morphogenesis Source: FlyBase
  • establishment of mitotic spindle orientation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • microtubule anchoring at centrosome Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • neurogenesis Source: FlyBase
  • oogenesis Source: UniProtKB
  • positive regulation of neuron remodeling Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • spermatid nucleus elongation Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase
  • wing disc development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-5620924. Intraflagellar transport.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Cut up protein
Gene namesi
Name:ctp
Synonyms:Cdlc1, ddlc1
ORF Names:CG6998
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0011760. ctp.

Subcellular locationi

  • Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  • centriole Source: FlyBase
  • cytoplasm Source: UniProtKB
  • cytoplasmic dynein complex Source: FlyBase
  • cytoskeleton Source: FlyBase
  • dynein complex Source: FlyBase
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Disruption phenotypei

Flies exhibit defects in bristle and wing development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 1, cytoplasmicPRO_0000195131Add
BLAST

Proteomic databases

PaxDbiQ24117.
PRIDEiQ24117.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiFBgn0011760.
GenevisibleiQ24117. DM.

Interactioni

Subunit structurei

Interacts with spn-F (PubMed:16540510). Forms ternary complexes with spn-F and IKKepsilon (PubMed:26092846, PubMed:26540204).3 Publications

GO - Molecular functioni

  • dynein intermediate chain binding Source: FlyBase
  • dynein light intermediate chain binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi57920. 45 interactions.
DIPiDIP-17520N.
IntActiQ24117. 8 interactions.
MINTiMINT-322013.
STRINGi7227.FBpp0070672.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138Combined sources
Helixi15 – 3117Combined sources
Helixi35 – 5016Combined sources
Beta strandi54 – 618Combined sources
Beta strandi63 – 7816Combined sources
Beta strandi81 – 888Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
5E0LX-ray1.31A3-89[»]
5E0MX-ray1.65A1-89[»]
ProteinModelPortaliQ24117.
SMRiQ24117. Positions 3-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ24117.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
InParanoidiQ24117.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ24117.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,374
Last modified:November 1, 1997 - v1
Checksum:i44871BC030423A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
RefSeqiNP_001245530.1. NM_001258601.3.
NP_525075.1. NM_080336.5.
NP_726942.1. NM_167014.3.
NP_726943.1. NM_167015.3.
UniGeneiDm.5892.

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneIDi31405.
KEGGidme:Dmel_CG6998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
RefSeqiNP_001245530.1. NM_001258601.3.
NP_525075.1. NM_080336.5.
NP_726942.1. NM_167014.3.
NP_726943.1. NM_167015.3.
UniGeneiDm.5892.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
5E0LX-ray1.31A3-89[»]
5E0MX-ray1.65A1-89[»]
ProteinModelPortaliQ24117.
SMRiQ24117. Positions 3-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57920. 45 interactions.
DIPiDIP-17520N.
IntActiQ24117. 8 interactions.
MINTiMINT-322013.
STRINGi7227.FBpp0070672.

Proteomic databases

PaxDbiQ24117.
PRIDEiQ24117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneIDi31405.
KEGGidme:Dmel_CG6998.

Organism-specific databases

CTDi31405.
FlyBaseiFBgn0011760. ctp.

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
InParanoidiQ24117.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG091G15JY.
PhylomeDBiQ24117.

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-5620924. Intraflagellar transport.
R-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

EvolutionaryTraceiQ24117.
GenomeRNAii31405.
PROiQ24117.

Gene expression databases

BgeeiFBgn0011760.
GenevisibleiQ24117. DM.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYL1_DROME
AccessioniPrimary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.