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Protein

Dynein light chain 1, cytoplasmic

Gene

ctp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a non-catalytic accessory component of a dynein complex.By similarity

GO - Molecular functioni

  • ATPase activity, coupled Source: FlyBase
  • dynein intermediate chain binding Source: FlyBase
  • dynein light intermediate chain binding Source: FlyBase
  • motor activity Source: UniProtKB-KW
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • actin filament bundle assembly Source: FlyBase
  • autophagy Source: FlyBase
  • chaeta development Source: UniProtKB
  • chaeta morphogenesis Source: FlyBase
  • establishment of mitotic spindle orientation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • microtubule anchoring at centrosome Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • neurogenesis Source: FlyBase
  • oogenesis Source: UniProtKB
  • salivary gland cell autophagic cell death Source: FlyBase
  • spermatid nucleus elongation Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm individualization Source: FlyBase
  • wing disc development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Cut up protein
Gene namesi
Name:ctp
Synonyms:Cdlc1, ddlc1
ORF Names:CG6998
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0011760. ctp.

Subcellular locationi

  • Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  • centriole Source: FlyBase
  • cytoplasm Source: UniProtKB
  • dynein complex Source: FlyBase
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Disruption phenotypei

Flies exhibit defects in bristle and wing development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 1, cytoplasmicPRO_0000195131Add
BLAST

Proteomic databases

PaxDbiQ24117.
PRIDEiQ24117.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ24117.
GenevisibleiQ24117. DM.

Interactioni

Protein-protein interaction databases

BioGridi57920. 45 interactions.
DIPiDIP-17520N.
IntActiQ24117. 8 interactions.
MINTiMINT-322013.
STRINGi7227.FBpp0070672.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138Combined sources
Helixi15 – 3117Combined sources
Helixi35 – 5016Combined sources
Beta strandi54 – 618Combined sources
Beta strandi68 – 7811Combined sources
Beta strandi81 – 888Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
ProteinModelPortaliQ24117.
SMRiQ24117. Positions 3-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ24117.

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
InParanoidiQ24117.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ24117.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,374
Last modified:November 1, 1997 - v1
Checksum:i44871BC030423A8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
AE014298 Genomic DNA. Translation: AAN09128.1.
RefSeqiNP_001245530.1. NM_001258601.3.
NP_525075.1. NM_080336.5.
NP_726942.1. NM_167014.3.
NP_726943.1. NM_167015.3.
UniGeneiDm.5892.

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneIDi31405.
KEGGidme:Dmel_CG6998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32855 mRNA. Translation: AAB04148.1.
U48846 mRNA. Translation: AAD00072.1.
U48848 mRNA. Translation: AAD00074.1.
AE014298 Genomic DNA. Translation: AAF45975.1.
AE014298 Genomic DNA. Translation: AAN09126.1.
AE014298 Genomic DNA. Translation: AAN09127.1.
AE014298 Genomic DNA. Translation: AAN09128.1.
RefSeqiNP_001245530.1. NM_001258601.3.
NP_525075.1. NM_080336.5.
NP_726942.1. NM_167014.3.
NP_726943.1. NM_167015.3.
UniGeneiDm.5892.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RHWNMR-A1-89[»]
2P2TX-ray3.00A1-89[»]
2PG1X-ray2.80A/B/C/D1-89[»]
3BRIX-ray1.70A1-89[»]
3BRLX-ray1.90A1-87[»]
3DVHX-ray2.00A/B/C1-89[»]
3DVPX-ray2.50A/B1-89[»]
3DVTX-ray2.30A/B/C/D/E/F1-89[»]
3E2BX-ray2.00A1-89[»]
3FM7X-ray3.50E/F1-89[»]
3GLWX-ray3.15A1-89[»]
4QH7X-ray1.83A/B/E/F1-89[»]
4QH8X-ray1.90A/B/E/F/G/H1-89[»]
ProteinModelPortaliQ24117.
SMRiQ24117. Positions 3-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57920. 45 interactions.
DIPiDIP-17520N.
IntActiQ24117. 8 interactions.
MINTiMINT-322013.
STRINGi7227.FBpp0070672.

Proteomic databases

PaxDbiQ24117.
PRIDEiQ24117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070704; FBpp0070672; FBgn0011760.
FBtr0070706; FBpp0070674; FBgn0011760.
FBtr0070707; FBpp0070675; FBgn0011760.
FBtr0307065; FBpp0297908; FBgn0011760.
GeneIDi31405.
KEGGidme:Dmel_CG6998.

Organism-specific databases

CTDi31405.
FlyBaseiFBgn0011760. ctp.

Phylogenomic databases

eggNOGiNOG312371.
GeneTreeiENSGT00390000000378.
InParanoidiQ24117.
KOiK10418.
OMAiQIKSADM.
OrthoDBiEOG7BZVVQ.
PhylomeDBiQ24117.

Miscellaneous databases

EvolutionaryTraceiQ24117.
GenomeRNAii31405.
NextBioi773472.
PROiQ24117.

Gene expression databases

BgeeiQ24117.
GenevisibleiQ24117. DM.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PANTHERiPTHR11886. PTHR11886. 1 hit.
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."
    Dick T., Ray K., Salz H.K., Chia W.
    Mol. Cell. Biol. 16:1966-1977(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  2. Li M.-G., Serr M., Hays T.S.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Head and Ovary.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiDYL1_DROME
AccessioniPrimary (citable) accession number: Q24117
Secondary accession number(s): A4V3Y5, Q9V3Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.