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Reviewed, UniProtKB/Swiss-Prot Q24114 (DALY_DROME)

Last modified February 9, 2010. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Division abnormally delayed protein
      Short name=Dally protein
Gene names
Name: dally
ORF Names: CG4974
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate. Required for cell division patterning during post-embryonic development of the nervous system.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side Potential.

Sequence similarities

Belongs to the glypican family.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
   PTMGPI-anchor
Glycoprotein
Heparan sulfate
Lipoprotein
Proteoglycan
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Traceable author statement. Source: FlyBase

axonogenesis

Inferred from mutant phenotype. Source: FlyBase

bristle morphogenesis

Inferred from mutant phenotype. Source: FlyBase

compound eye development

Inferred from mutant phenotype. Source: FlyBase

decapentaplegic receptor signaling pathway

Inferred from mutant phenotype. Source: FlyBase

dendrite morphogenesis

Inferred from mutant phenotype. Source: FlyBase

imaginal disc-derived leg morphogenesis

Inferred from mutant phenotype. Source: FlyBase

imaginal disc-derived wing vein morphogenesis

Inferred from mutant phenotype. Source: FlyBase

regulation of cell cycle

Inferred from mutant phenotype. Source: FlyBase

regulation of imaginal disc growth

Inferred from mutant phenotype. Source: FlyBase

regulation of multicellular organism growth

Inferred from mutant phenotype. Source: FlyBase

sensory organ boundary specification

Inferred from mutant phenotype. Source: FlyBase

wing disc dorsal/ventral pattern formation

Inferred from genetic interaction. Source: FlyBase

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

cell surface

Inferred from direct assay. Source: FlyBase

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: InterPro

   Molecular functionheparan sulfate proteoglycan binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 602576Division abnormally delayed protein
PRO_0000012327
Propeptide603 – 62624Removed in mature form Potential
PRO_0000012328

Amino acid modifications

Lipidation6021GPI-anchor amidated glycine Potential
Glycosylation971N-linked (GlcNAc...) Ref.4
Glycosylation1011N-linked (GlcNAc...) Ref.4
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation5491O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation5691O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation5731O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation6011O-linked (Xyl...) (heparan sulfate) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q24114-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1182AD8A0D0E4DD3

FASTA62669,031
        10         20         30         40         50         60 
MAARSVRLAQ LLLFTLLCGF VGLSAAKHLD LDGIHHHQHH LHSATTHHRR RLQRDSRAKD 

        70         80         90        100        110        120 
AVGGSTHQCD AVKSYFESID IKSSGTYSEK GAICGGNCCN NATELELRDK AAGMFEQLLH 

       130        140        150        160        170        180 
HHTSSLRGVL ETNAKQFQSH VLELAQISEN MTHSLFSKVY TRMVPSSRMM IHQLYTEIMN 

       190        200        210        220        230        240 
HLIYTSNYTN SNGQLGRRGI GSVQSNLEEA VRHFFVQLFP VAYHQMVHLS KNNLGDLHED 

       250        260        270        280        290        300 
YVNCLQHNFD EMHPFGDIPQ QVQSNLGKSV HMSNVFMNAL LQAAEVLSEA DALYGEQLTD 

       310        320        330        340        350        360 
TCKLHLLKMH YCPNCNGHHS SSRSETKLCY GYCKNVMRGC SAEYAGLLDS PWSGVVDSLN 

       370        380        390        400        410        420 
NLVTTHILSD TGIINVIKHL QTYFSEAIMA AMHNGPELEK KVKKTCGTPS LTPYSSGEPD 

       430        440        450        460        470        480 
ARPPPHKNNV KWATDPDPGM VLFLSTIDKS KEFYTTIVDN FCDEQQHSRD DHSCWSGDRF 

       490        500        510        520        530        540 
GDYTQLLINP GTDSQRYNPE VPFNAKAQTG KLNELVDKLF KIRKSIGAAA PSNSIQATHD 

       550        560        570        580        590        600 
IQNDMGEGSG GGEGQIGDDE EEYGGAHGSG DGSGDGPHTP IEESEGTTTN EVESRDSGKT 

       610        620 
SGSNPLEGTA TWMLLTLVTM LFSSCS

« Hide

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References

« Hide 'large scale' references
[1]"The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila."
Nakato H., Futch T.A., Selleck S.B.
Development 121:3687-3702(1995) [PubMed: 8582281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-97 AND ASN-101, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U31985 mRNA. Translation: AAA97401.1.
AE014296 Genomic DNA. Translation: AAF50358.1.
RefSeqNP_523983.1.
UniGeneDm.2277

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-23816N.
IntActQ24114. 1 interaction.
STRINGQ24114.

Proteomic databases

PRIDEQ24114.

Genome annotation databases

EnsemblFBtr0076583; FBpp0076310; FBgn0011577; Drosophila melanogaster. [Genome view]
GeneID39013.
KEGGdme:Dmel_CG4974.

Organism-specific databases

CTD39013.
FlyBaseFBgn0011577. dally.

Phylogenomic databases

eggNOGinNOG06833.
InParanoidQ24114.
OrthoDBEOG9K0QTQ.
PhylomeDBQ24114.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-015845-MONOMER.

Gene expression databases

BgeeQ24114.
GermOnlineCG4974. Drosophila melanogaster.

Family and domain databases

InterProIPR001863. Glypican.
[Graphical view]
PANTHERPTHR10822. Glypican. 1 hit.
PfamPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEPS01207. GLYPICAN. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio811460.

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Entry information

Entry nameDALY_DROME
AccessionPrimary (citable) accession number: Q24114
Secondary accession number(s): Q9VSQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents