Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Division abnormally delayed protein

Gene

dally

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Required for cell division patterning during post-embryonic development of the nervous system.

GO - Biological processi

  • adult chitin-containing cuticle pigmentation Source: FlyBase
  • axonogenesis Source: FlyBase
  • chaeta development Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • compound eye development Source: FlyBase
  • decapentaplegic signaling pathway Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • female germ-line stem cell asymmetric division Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of semaphorin-plexin signaling pathway Source: FlyBase
  • positive regulation of BMP signaling pathway Source: FlyBase
  • positive regulation of canonical Wnt signaling pathway Source: FlyBase
  • regulation of BMP signaling pathway Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of imaginal disc growth Source: FlyBase
  • regulation of multicellular organism growth Source: FlyBase
  • segment polarity determination Source: FlyBase
  • sensory organ boundary specification Source: FlyBase
  • smoothened signaling pathway Source: Reactome
  • wing disc development Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
  • Wnt signaling pathway Source: InterPro

Enzyme and pathway databases

ReactomeiR-DME-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-DME-2022928 HS-GAG biosynthesis
R-DME-2024096 HS-GAG degradation
R-DME-209471 Formation and transport of the N-HH ligand
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-5362798 Release of Hh-Np from the secreting cell
R-DME-8957275 Post-translational protein phosphorylation
SignaLinkiQ24114

Names & Taxonomyi

Protein namesi
Recommended name:
Division abnormally delayed protein
Short name:
Dally protein
Gene namesi
Name:dally
ORF Names:CG4974
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0263930 dally

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001232727 – 602Division abnormally delayed proteinAdd BLAST576
PropeptideiPRO_0000012328603 – 626Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi569O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi573O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi601O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Lipidationi602GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

PaxDbiQ24114
PRIDEiQ24114

PTM databases

iPTMnetiQ24114

Expressioni

Gene expression databases

BgeeiFBgn0263930
ExpressionAtlasiQ24114 baseline and differential
GenevisibleiQ24114 DM

Interactioni

Protein-protein interaction databases

BioGridi64418, 24 interactors
DIPiDIP-23816N
IntActiQ24114, 194 interactors
STRINGi7227.FBpp0297069

Structurei

3D structure databases

ProteinModelPortaliQ24114
SMRiQ24114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
InParanoidiQ24114
KOiK02306
OMAiFPVAYHQ
OrthoDBiEOG091G06T6
PhylomeDBiQ24114

Family and domain databases

InterProiView protein in InterPro
IPR031187 Dally
IPR001863 Glypican
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF29 PTHR10822:SF29, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSVRLAQ LLLFTLLCGF VGLSAAKHLD LDGIHHHQHH LHSATTHHRR
60 70 80 90 100
RLQRDSRAKD AVGGSTHQCD AVKSYFESID IKSSGTYSEK GAICGGNCCN
110 120 130 140 150
NATELELRDK AAGMFEQLLH HHTSSLRGVL ETNAKQFQSH VLELAQISEN
160 170 180 190 200
MTHSLFSKVY TRMVPSSRMM IHQLYTEIMN HLIYTSNYTN SNGQLGRRGI
210 220 230 240 250
GSVQSNLEEA VRHFFVQLFP VAYHQMVHLS KNNLGDLHED YVNCLQHNFD
260 270 280 290 300
EMHPFGDIPQ QVQSNLGKSV HMSNVFMNAL LQAAEVLSEA DALYGEQLTD
310 320 330 340 350
TCKLHLLKMH YCPNCNGHHS SSRSETKLCY GYCKNVMRGC SAEYAGLLDS
360 370 380 390 400
PWSGVVDSLN NLVTTHILSD TGIINVIKHL QTYFSEAIMA AMHNGPELEK
410 420 430 440 450
KVKKTCGTPS LTPYSSGEPD ARPPPHKNNV KWATDPDPGM VLFLSTIDKS
460 470 480 490 500
KEFYTTIVDN FCDEQQHSRD DHSCWSGDRF GDYTQLLINP GTDSQRYNPE
510 520 530 540 550
VPFNAKAQTG KLNELVDKLF KIRKSIGAAA PSNSIQATHD IQNDMGEGSG
560 570 580 590 600
GGEGQIGDDE EEYGGAHGSG DGSGDGPHTP IEESEGTTTN EVESRDSGKT
610 620
SGSNPLEGTA TWMLLTLVTM LFSSCS
Length:626
Mass (Da):69,031
Last modified:November 1, 1996 - v1
Checksum:i1182AD8A0D0E4DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31985 mRNA Translation: AAA97401.1
AE014296 Genomic DNA Translation: AAF50358.1
RefSeqiNP_001246685.1, NM_001259756.2
NP_523983.1, NM_079259.4
UniGeneiDm.2277

Genome annotation databases

EnsemblMetazoaiFBtr0076583; FBpp0076310; FBgn0263930
FBtr0305901; FBpp0297069; FBgn0263930
GeneIDi39013
KEGGidme:Dmel_CG4974

Similar proteinsi

Entry informationi

Entry nameiDALY_DROME
AccessioniPrimary (citable) accession number: Q24114
Secondary accession number(s): Q9VSQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health