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Protein

Division abnormally delayed protein

Gene

dally

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Required for cell division patterning during post-embryonic development of the nervous system.

GO - Molecular functioni

GO - Biological processi

  • adult chitin-containing cuticle pigmentation Source: FlyBase
  • axonogenesis Source: FlyBase
  • chaeta development Source: FlyBase
  • chaeta morphogenesis Source: FlyBase
  • compound eye development Source: FlyBase
  • decapentaplegic signaling pathway Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • female germ-line stem cell asymmetric division Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • negative regulation of semaphorin-plexin signaling pathway Source: FlyBase
  • positive regulation of BMP signaling pathway Source: FlyBase
  • regulation of BMP signaling pathway Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of imaginal disc growth Source: FlyBase
  • regulation of multicellular organism growth Source: FlyBase
  • sensory organ boundary specification Source: FlyBase
  • wing disc development Source: FlyBase
  • wing disc dorsal/ventral pattern formation Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
  • Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-DME-2022928. HS-GAG biosynthesis.
R-DME-2024096. HS-GAG degradation.
R-DME-5362798. Release of Hh-Np from the secreting cell.
SignaLinkiQ24114.

Names & Taxonomyi

Protein namesi
Recommended name:
Division abnormally delayed protein
Short name:
Dally protein
Gene namesi
Name:dally
ORF Names:CG4974
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0263930. dally.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: FlyBase
  • perivitelline space Source: FlyBase
  • plasma membrane Source: UniProtKB-SubCell
  • proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001232727 – 602Division abnormally delayed proteinAdd BLAST576
PropeptideiPRO_0000012328603 – 626Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi101N-linked (GlcNAc...)1 Publication1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi549O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi569O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi573O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi601O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Lipidationi602GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

PaxDbiQ24114.
PRIDEiQ24114.

Expressioni

Gene expression databases

BgeeiFBgn0263930.
ExpressionAtlasiQ24114. baseline.
GenevisibleiQ24114. DM.

Interactioni

Protein-protein interaction databases

BioGridi64418. 13 interactors.
DIPiDIP-23816N.
IntActiQ24114. 194 interactors.
MINTiMINT-340497.
STRINGi7227.FBpp0297069.

Structurei

3D structure databases

ProteinModelPortaliQ24114.
SMRiQ24114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
InParanoidiQ24114.
KOiK02306.
OMAiLQVCTSK.
OrthoDBiEOG091G06T6.
PhylomeDBiQ24114.

Family and domain databases

InterProiIPR031187. Dally.
IPR001863. Glypican.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 2 hits.
PTHR10822:SF29. PTHR10822:SF29. 2 hits.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSVRLAQ LLLFTLLCGF VGLSAAKHLD LDGIHHHQHH LHSATTHHRR
60 70 80 90 100
RLQRDSRAKD AVGGSTHQCD AVKSYFESID IKSSGTYSEK GAICGGNCCN
110 120 130 140 150
NATELELRDK AAGMFEQLLH HHTSSLRGVL ETNAKQFQSH VLELAQISEN
160 170 180 190 200
MTHSLFSKVY TRMVPSSRMM IHQLYTEIMN HLIYTSNYTN SNGQLGRRGI
210 220 230 240 250
GSVQSNLEEA VRHFFVQLFP VAYHQMVHLS KNNLGDLHED YVNCLQHNFD
260 270 280 290 300
EMHPFGDIPQ QVQSNLGKSV HMSNVFMNAL LQAAEVLSEA DALYGEQLTD
310 320 330 340 350
TCKLHLLKMH YCPNCNGHHS SSRSETKLCY GYCKNVMRGC SAEYAGLLDS
360 370 380 390 400
PWSGVVDSLN NLVTTHILSD TGIINVIKHL QTYFSEAIMA AMHNGPELEK
410 420 430 440 450
KVKKTCGTPS LTPYSSGEPD ARPPPHKNNV KWATDPDPGM VLFLSTIDKS
460 470 480 490 500
KEFYTTIVDN FCDEQQHSRD DHSCWSGDRF GDYTQLLINP GTDSQRYNPE
510 520 530 540 550
VPFNAKAQTG KLNELVDKLF KIRKSIGAAA PSNSIQATHD IQNDMGEGSG
560 570 580 590 600
GGEGQIGDDE EEYGGAHGSG DGSGDGPHTP IEESEGTTTN EVESRDSGKT
610 620
SGSNPLEGTA TWMLLTLVTM LFSSCS
Length:626
Mass (Da):69,031
Last modified:November 1, 1996 - v1
Checksum:i1182AD8A0D0E4DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31985 mRNA. Translation: AAA97401.1.
AE014296 Genomic DNA. Translation: AAF50358.1.
RefSeqiNP_001246685.1. NM_001259756.2.
NP_523983.1. NM_079259.4.
UniGeneiDm.2277.

Genome annotation databases

EnsemblMetazoaiFBtr0076583; FBpp0076310; FBgn0263930.
FBtr0305901; FBpp0297069; FBgn0263930.
GeneIDi39013.
KEGGidme:Dmel_CG4974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31985 mRNA. Translation: AAA97401.1.
AE014296 Genomic DNA. Translation: AAF50358.1.
RefSeqiNP_001246685.1. NM_001259756.2.
NP_523983.1. NM_079259.4.
UniGeneiDm.2277.

3D structure databases

ProteinModelPortaliQ24114.
SMRiQ24114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64418. 13 interactors.
DIPiDIP-23816N.
IntActiQ24114. 194 interactors.
MINTiMINT-340497.
STRINGi7227.FBpp0297069.

Proteomic databases

PaxDbiQ24114.
PRIDEiQ24114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076583; FBpp0076310; FBgn0263930.
FBtr0305901; FBpp0297069; FBgn0263930.
GeneIDi39013.
KEGGidme:Dmel_CG4974.

Organism-specific databases

CTDi39013.
FlyBaseiFBgn0263930. dally.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
InParanoidiQ24114.
KOiK02306.
OMAiLQVCTSK.
OrthoDBiEOG091G06T6.
PhylomeDBiQ24114.

Enzyme and pathway databases

ReactomeiR-DME-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-DME-2022928. HS-GAG biosynthesis.
R-DME-2024096. HS-GAG degradation.
R-DME-5362798. Release of Hh-Np from the secreting cell.
SignaLinkiQ24114.

Miscellaneous databases

GenomeRNAii39013.
PROiQ24114.

Gene expression databases

BgeeiFBgn0263930.
ExpressionAtlasiQ24114. baseline.
GenevisibleiQ24114. DM.

Family and domain databases

InterProiIPR031187. Dally.
IPR001863. Glypican.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 2 hits.
PTHR10822:SF29. PTHR10822:SF29. 2 hits.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDALY_DROME
AccessioniPrimary (citable) accession number: Q24114
Secondary accession number(s): Q9VSQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.