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Protein

Abhydrolase domain-containing protein 2

Gene

Hydr2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192Charge relay systemBy similarity1
Active sitei328Charge relay systemBy similarity1
Active sitei359Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: GO_Central
  • lipase activity Source: FlyBase

GO - Biological processi

  • acylglycerol catabolic process Source: GO_Central
  • chaeta development Source: FlyBase
  • lipid metabolic process Source: FlyBase
  • sperm capacitation Source: GO_Central
  • steroid hormone mediated signaling pathway Source: GO_Central
  • wing disc development Source: FlyBase

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERidrome-abhd2. abh_upf0017.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 2 (EC:3.1.1.-)
Gene namesi
Name:Hydr2
Synonyms:anon-23D, anon-23Da
ORF Names:CG3488
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0014906. Hydr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 22Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini23 – 398ExtracellularSequence analysisAdd BLAST376

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124591 – 398Abhydrolase domain-containing protein 2Add BLAST398

Proteomic databases

PaxDbiQ24093.
PRIDEiQ24093.

Expressioni

Developmental stagei

Expressed in embryos.1 Publication

Gene expression databases

BgeeiFBgn0014906.
ExpressionAtlasiQ24093. differential.
GenevisibleiQ24093. DM.

Interactioni

Protein-protein interaction databases

BioGridi59747. 2 interactors.
DIPiDIP-17906N.
IntActiQ24093. 1 interactor.
MINTiMINT-320574.
STRINGi7227.FBpp0300634.

Structurei

3D structure databases

ProteinModelPortaliQ24093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 365AB hydrolase-1Sequence analysisAdd BLAST253

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1838. Eukaryota.
COG0429. LUCA.
GeneTreeiENSGT00530000062981.
InParanoidiQ24093.
KOiK13697.
OMAiYPQTQLV.
OrthoDBiEOG091G08XK.
PhylomeDBiQ24093.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. AB_hydrolase_4_CS.
IPR012020. ABHD4.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS01133. UPF0017. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAFLTLIA VIVCILFRIL NVHSQPLKPS VWCLDAHFLD CLYKIAPVLR
60 70 80 90 100
EPYIPPRLWG FSGHVQTVLH SIVGRVRCPW PLGERVYMSL KDGSTLTYDL
110 120 130 140 150
YQPLNEQEDD ITVAICPGIA NSSESVYIRT FVHLAQCNGY RCAVLNHIGA
160 170 180 190 200
LRSVQVTSTR IFTYGHTEDF AAMVEHLHQK YRQSRIVAVG FSLGGNLVTK
210 220 230 240 250
YMGEDQKTKP DKVIGGISIC QGYNAVEGTK WLLNWQNFRR FYLYIMTENV
260 270 280 290 300
KSIILRHRHI LLSDEVKARH NLNEREIIAA ATLPELDEAY TRRVYNFPST
310 320 330 340 350
QELYKWSSSL FYFDTIKKPM IFINAKDDPL IPEDLLHPIK EYATTRQNTA
360 370 380 390
YVEVAHGGHL GFYEGGFLYP NPVTWLDRTL VAMVGSLVMM HEVGKVAP
Length:398
Mass (Da):45,402
Last modified:January 27, 2003 - v2
Checksum:i89A2F30F8DE3ECDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211D → N in AAA99735 (Ref. 1) Curated1
Sequence conflicti223Y → I in AAA99735 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29170 mRNA. Translation: AAA99735.1.
AE014134 Genomic DNA. Translation: AAF51139.1.
BT010082 mRNA. Translation: AAQ22551.1.
RefSeqiNP_001245852.1. NM_001258923.2.
NP_608751.2. NM_134907.4.
UniGeneiDm.3835.

Genome annotation databases

EnsemblMetazoaiFBtr0077576; FBpp0077265; FBgn0014906.
FBtr0308315; FBpp0300634; FBgn0014906.
GeneIDi33532.
KEGGidme:Dmel_CG3488.
UCSCiCG3488-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiABHD2_DROME
AccessioniPrimary (citable) accession number: Q24093
Secondary accession number(s): Q9VQM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: August 30, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families