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Protein

Abhydrolase domain-containing protein 2

Gene

Hydr2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Charge relay systemBy similarity
Active sitei328 – 3281Charge relay systemBy similarity
Active sitei359 – 3591Charge relay systemBy similarity

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: UniProtKB-KW
  • lipase activity Source: FlyBase

GO - Biological processi

  • chaeta development Source: FlyBase
  • lipid metabolic process Source: FlyBase
  • wing disc development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERidrome-abhd2. abh_upf0017.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 2 (EC:3.1.1.-)
Gene namesi
Name:Hydr2
Synonyms:anon-23D, anon-23Da
ORF Names:CG3488
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0014906. Hydr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence analysis
Transmembranei5 – 2218Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini23 – 398376ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Abhydrolase domain-containing protein 2PRO_0000212459Add
BLAST

Proteomic databases

PaxDbiQ24093.

Expressioni

Developmental stagei

Expressed in embryos.1 Publication

Gene expression databases

BgeeiQ24093.
ExpressionAtlasiQ24093. differential.
GenevisibleiQ24093. DM.

Interactioni

Protein-protein interaction databases

BioGridi59747. 2 interactions.
DIPiDIP-17906N.
IntActiQ24093. 1 interaction.
MINTiMINT-320574.
STRINGi7227.FBpp0300634.

Structurei

3D structure databases

ProteinModelPortaliQ24093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1838. Eukaryota.
COG0429. LUCA.
GeneTreeiENSGT00530000062981.
InParanoidiQ24093.
KOiK13697.
OMAiVIVGYAN.
OrthoDBiEOG7RBZ87.
PhylomeDBiQ24093.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. AB_hydrolase_4_CS.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAFLTLIA VIVCILFRIL NVHSQPLKPS VWCLDAHFLD CLYKIAPVLR
60 70 80 90 100
EPYIPPRLWG FSGHVQTVLH SIVGRVRCPW PLGERVYMSL KDGSTLTYDL
110 120 130 140 150
YQPLNEQEDD ITVAICPGIA NSSESVYIRT FVHLAQCNGY RCAVLNHIGA
160 170 180 190 200
LRSVQVTSTR IFTYGHTEDF AAMVEHLHQK YRQSRIVAVG FSLGGNLVTK
210 220 230 240 250
YMGEDQKTKP DKVIGGISIC QGYNAVEGTK WLLNWQNFRR FYLYIMTENV
260 270 280 290 300
KSIILRHRHI LLSDEVKARH NLNEREIIAA ATLPELDEAY TRRVYNFPST
310 320 330 340 350
QELYKWSSSL FYFDTIKKPM IFINAKDDPL IPEDLLHPIK EYATTRQNTA
360 370 380 390
YVEVAHGGHL GFYEGGFLYP NPVTWLDRTL VAMVGSLVMM HEVGKVAP
Length:398
Mass (Da):45,402
Last modified:January 27, 2003 - v2
Checksum:i89A2F30F8DE3ECDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111D → N in AAA99735 (Ref. 1) Curated
Sequence conflicti223 – 2231Y → I in AAA99735 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29170 mRNA. Translation: AAA99735.1.
AE014134 Genomic DNA. Translation: AAF51139.1.
BT010082 mRNA. Translation: AAQ22551.1.
RefSeqiNP_001245852.1. NM_001258923.2.
NP_608751.2. NM_134907.4.
UniGeneiDm.3835.

Genome annotation databases

EnsemblMetazoaiFBtr0077576; FBpp0077265; FBgn0014906.
FBtr0308315; FBpp0300634; FBgn0014906.
GeneIDi33532.
KEGGidme:Dmel_CG3488.
UCSCiCG3488-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29170 mRNA. Translation: AAA99735.1.
AE014134 Genomic DNA. Translation: AAF51139.1.
BT010082 mRNA. Translation: AAQ22551.1.
RefSeqiNP_001245852.1. NM_001258923.2.
NP_608751.2. NM_134907.4.
UniGeneiDm.3835.

3D structure databases

ProteinModelPortaliQ24093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59747. 2 interactions.
DIPiDIP-17906N.
IntActiQ24093. 1 interaction.
MINTiMINT-320574.
STRINGi7227.FBpp0300634.

Protein family/group databases

ESTHERidrome-abhd2. abh_upf0017.

Proteomic databases

PaxDbiQ24093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077576; FBpp0077265; FBgn0014906.
FBtr0308315; FBpp0300634; FBgn0014906.
GeneIDi33532.
KEGGidme:Dmel_CG3488.
UCSCiCG3488-RA. d. melanogaster.

Organism-specific databases

CTDi33532.
FlyBaseiFBgn0014906. Hydr2.

Phylogenomic databases

eggNOGiKOG1838. Eukaryota.
COG0429. LUCA.
GeneTreeiENSGT00530000062981.
InParanoidiQ24093.
KOiK13697.
OMAiVIVGYAN.
OrthoDBiEOG7RBZ87.
PhylomeDBiQ24093.

Miscellaneous databases

GenomeRNAii33532.
NextBioi784065.
PROiQ24093.

Gene expression databases

BgeeiQ24093.
ExpressionAtlasiQ24093. differential.
GenevisibleiQ24093. DM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000952. AB_hydrolase_4_CS.
IPR012020. ABHD4.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a Drosophila gene with sequence similarity to human pHPS1-2."
    Chartoff E.H., Gelbart W.M.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Alpha/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity."
    Wisotzkey R.G., Johnson A.N., Takaesu N.T., Newfeld S.J.
    J. Mol. Evol. 56:351-361(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiABHD2_DROME
AccessioniPrimary (citable) accession number: Q24093
Secondary accession number(s): Q9VQM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.