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Q24062

- Q24062_DROME

UniProt

Q24062 - Q24062_DROME

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Protein
Submitted name: Black, isoform A
Gene
b, CG7811, Dmel_CG7811
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. aspartate 1-decarboxylase activity Source: FlyBase
  2. glutamate decarboxylase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. beta-alanine biosynthetic process Source: FlyBase
  2. developmental pigmentation Source: FlyBase
  3. uracil catabolic process Source: FlyBase
  4. visual behavior Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_180739. Degradation of cysteine and homocysteine.

Names & Taxonomyi

Protein namesi
Submitted name:
Black, isoform AImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
Submitted name:
Black, isoform BImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
Submitted name:
Glutamate decarboxylaseImported
Submitted name:
LP11089pImported
Gene namesi
Name:bImported
ORF Names:CG7811Imported, Dmel_CG7811Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000153. b.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0080119.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00730000110441.
InParanoidiQ24062.
KOiK01580.
OMAiLQDTSNL.
OrthoDBiEOG7H1JM3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24062-1 [UniParc]FASTAAdd to Basket

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MLASENFPTH HFKESIFKPY STTSGDDLAS VSPLTATAAL VASTSSPADS    50
TSTVAFEQAS KMLANAANNN NNNNNNITST KDDLSSFVAS HPAAEFEGFI 100
RACVDEIIKL AVFQGTNRSS KVVEWHEPAE LRQLFDFQLR EQGESQDKLR 150
ELLRETIRFS VKTGHPYFIN QLYSGVDPYA LVGQWLTDAL NPSVYTYEVA 200
PLFTLMEEQV LAEMRRIVGF PNGGQGDGIF CPGGSIANGY AISCARYRHS 250
PESKKNGLFN AKPLIIFTSE DAHYSVEKLA MFMGFGSDHV RKIATNEVGK 300
MRLSDLEKQV KLCLENGWQP LMVSATAGTT VLGAFDDLAG ISEVCKKYNM 350
WMHVDAAWGG GALMSKKYRH LLNGIERADS VTWNPHKLLA ASQQCSTFLT 400
RHQQVLAQCH STNATYLFQK DKFYDTSFDT GDKHIQCGRR ADVFKFWFMW 450
KAKGTQGLEA HVEKVFRMAE FFTAKVRERP GFELVLESPE CTNISFWYVP 500
PGLREMERNR EFYDRLHKVA PKVKEGMIKK GSMMITYQPL RQLPNFFRLV 550
LQNSCLEESD MVYFLDEIES LAQNL 575
Length:575
Mass (Da):64,796
Last modified:November 1, 1996 - v1
Checksum:i5BE7DBF42247B441
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01239 mRNA. Translation: AAC46466.1.
AE014134 Genomic DNA. Translation: AAF53337.1.
AY069752 mRNA. Translation: AAL39897.1.
AE014134 Genomic DNA. Translation: AFH03699.1.
PIRiJH0827.
RefSeqiNP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGeneiDm.2850.

Genome annotation databases

EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
FBtr0309960; FBpp0301687; FBgn0000153.
GeneIDi34791.
KEGGidme:Dmel_CG7811.
UCSCiCG7811-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01239 mRNA. Translation: AAC46466.1 .
AE014134 Genomic DNA. Translation: AAF53337.1 .
AY069752 mRNA. Translation: AAL39897.1 .
AE014134 Genomic DNA. Translation: AFH03699.1 .
PIRi JH0827.
RefSeqi NP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGenei Dm.2850.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0080119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080542 ; FBpp0080119 ; FBgn0000153 .
FBtr0309960 ; FBpp0301687 ; FBgn0000153 .
GeneIDi 34791.
KEGGi dme:Dmel_CG7811.
UCSCi CG7811-RA. d. melanogaster.

Organism-specific databases

CTDi 34791.
FlyBasei FBgn0000153. b.

Phylogenomic databases

eggNOGi COG0076.
GeneTreei ENSGT00730000110441.
InParanoidi Q24062.
KOi K01580.
OMAi LQDTSNL.
OrthoDBi EOG7H1JM3.

Enzyme and pathway databases

Reactomei REACT_180739. Degradation of cysteine and homocysteine.

Miscellaneous databases

GenomeRNAii 34791.
NextBioi 790241.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases."
    Phillips A.M., Salkoff L.B., Kelly L.E.
    J. Neurochem. 61:1291-1301(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-RImported.
    Tissue: NeuralImported.
  2. Phillips M.A.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-RImported.
    Tissue: NeuralImported.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  10. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  14. FlyBase
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ24062_DROME
AccessioniPrimary (citable) accession number: Q24062
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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