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Q24062

- Q24062_DROME

UniProt

Q24062 - Q24062_DROME

Protein
Submitted name:

Black, isoform A

Gene

b

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: FlyBase
    2. glutamate decarboxylase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. beta-alanine biosynthetic process Source: FlyBase
    2. developmental pigmentation Source: FlyBase
    3. uracil catabolic process Source: FlyBase
    4. visual behavior Source: FlyBase

    Keywords - Molecular functioni

    LyaseUniRule annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_180739. Degradation of cysteine and homocysteine.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Black, isoform AImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
    Submitted name:
    Black, isoform BImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
    Submitted name:
    Glutamate decarboxylaseImported
    Submitted name:
    LP11089pImported
    Gene namesi
    Name:bImported
    ORF Names:CG7811Imported, Dmel_CG7811Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0000153. b.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0080119.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    GeneTreeiENSGT00730000110441.
    InParanoidiQ24062.
    KOiK01580.
    OMAiLQDTSNL.
    OrthoDBiEOG7H1JM3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q24062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLASENFPTH HFKESIFKPY STTSGDDLAS VSPLTATAAL VASTSSPADS    50
    TSTVAFEQAS KMLANAANNN NNNNNNITST KDDLSSFVAS HPAAEFEGFI 100
    RACVDEIIKL AVFQGTNRSS KVVEWHEPAE LRQLFDFQLR EQGESQDKLR 150
    ELLRETIRFS VKTGHPYFIN QLYSGVDPYA LVGQWLTDAL NPSVYTYEVA 200
    PLFTLMEEQV LAEMRRIVGF PNGGQGDGIF CPGGSIANGY AISCARYRHS 250
    PESKKNGLFN AKPLIIFTSE DAHYSVEKLA MFMGFGSDHV RKIATNEVGK 300
    MRLSDLEKQV KLCLENGWQP LMVSATAGTT VLGAFDDLAG ISEVCKKYNM 350
    WMHVDAAWGG GALMSKKYRH LLNGIERADS VTWNPHKLLA ASQQCSTFLT 400
    RHQQVLAQCH STNATYLFQK DKFYDTSFDT GDKHIQCGRR ADVFKFWFMW 450
    KAKGTQGLEA HVEKVFRMAE FFTAKVRERP GFELVLESPE CTNISFWYVP 500
    PGLREMERNR EFYDRLHKVA PKVKEGMIKK GSMMITYQPL RQLPNFFRLV 550
    LQNSCLEESD MVYFLDEIES LAQNL 575
    Length:575
    Mass (Da):64,796
    Last modified:November 1, 1996 - v1
    Checksum:i5BE7DBF42247B441
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01239 mRNA. Translation: AAC46466.1.
    AE014134 Genomic DNA. Translation: AAF53337.1.
    AY069752 mRNA. Translation: AAL39897.1.
    AE014134 Genomic DNA. Translation: AFH03699.1.
    PIRiJH0827.
    RefSeqiNP_001246025.1. NM_001259096.2.
    NP_476788.1. NM_057440.5.
    UniGeneiDm.2850.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
    FBtr0309960; FBpp0301687; FBgn0000153.
    GeneIDi34791.
    KEGGidme:Dmel_CG7811.
    UCSCiCG7811-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01239 mRNA. Translation: AAC46466.1 .
    AE014134 Genomic DNA. Translation: AAF53337.1 .
    AY069752 mRNA. Translation: AAL39897.1 .
    AE014134 Genomic DNA. Translation: AFH03699.1 .
    PIRi JH0827.
    RefSeqi NP_001246025.1. NM_001259096.2.
    NP_476788.1. NM_057440.5.
    UniGenei Dm.2850.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0080119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080542 ; FBpp0080119 ; FBgn0000153 .
    FBtr0309960 ; FBpp0301687 ; FBgn0000153 .
    GeneIDi 34791.
    KEGGi dme:Dmel_CG7811.
    UCSCi CG7811-RA. d. melanogaster.

    Organism-specific databases

    CTDi 34791.
    FlyBasei FBgn0000153. b.

    Phylogenomic databases

    eggNOGi COG0076.
    GeneTreei ENSGT00730000110441.
    InParanoidi Q24062.
    KOi K01580.
    OMAi LQDTSNL.
    OrthoDBi EOG7H1JM3.

    Enzyme and pathway databases

    Reactomei REACT_180739. Degradation of cysteine and homocysteine.

    Miscellaneous databases

    GenomeRNAii 34791.
    NextBioi 790241.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases."
      Phillips A.M., Salkoff L.B., Kelly L.E.
      J. Neurochem. 61:1291-1301(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Oregon-RImported.
      Tissue: NeuralImported.
    2. Phillips M.A.
      Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Oregon-RImported.
      Tissue: NeuralImported.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    9. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    11. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    14. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ24062_DROME
    AccessioniPrimary (citable) accession number: Q24062
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3