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Protein
Submitted name:

Black, isoform A

Gene

b

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. aspartate 1-decarboxylase activity Source: FlyBase
  2. glutamate decarboxylase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. beta-alanine biosynthetic process Source: FlyBase
  2. developmental pigmentation Source: FlyBase
  3. uracil catabolic process Source: FlyBase
  4. visual behavior Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_331278. Degradation of cysteine and homocysteine.

Names & Taxonomyi

Protein namesi
Submitted name:
Black, isoform AImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
Submitted name:
Black, isoform BImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
Submitted name:
Glutamate decarboxylaseImported
Submitted name:
LP11089pImported
Gene namesi
Name:bImported
ORF Names:CG7811Imported, Dmel_CG7811Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000153. b.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0080119.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00760000119205.
KOiK01580.
OMAiRFHRANT.
OrthoDBiEOG7H1JM3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASENFPTH HFKESIFKPY STTSGDDLAS VSPLTATAAL VASTSSPADS
60 70 80 90 100
TSTVAFEQAS KMLANAANNN NNNNNNITST KDDLSSFVAS HPAAEFEGFI
110 120 130 140 150
RACVDEIIKL AVFQGTNRSS KVVEWHEPAE LRQLFDFQLR EQGESQDKLR
160 170 180 190 200
ELLRETIRFS VKTGHPYFIN QLYSGVDPYA LVGQWLTDAL NPSVYTYEVA
210 220 230 240 250
PLFTLMEEQV LAEMRRIVGF PNGGQGDGIF CPGGSIANGY AISCARYRHS
260 270 280 290 300
PESKKNGLFN AKPLIIFTSE DAHYSVEKLA MFMGFGSDHV RKIATNEVGK
310 320 330 340 350
MRLSDLEKQV KLCLENGWQP LMVSATAGTT VLGAFDDLAG ISEVCKKYNM
360 370 380 390 400
WMHVDAAWGG GALMSKKYRH LLNGIERADS VTWNPHKLLA ASQQCSTFLT
410 420 430 440 450
RHQQVLAQCH STNATYLFQK DKFYDTSFDT GDKHIQCGRR ADVFKFWFMW
460 470 480 490 500
KAKGTQGLEA HVEKVFRMAE FFTAKVRERP GFELVLESPE CTNISFWYVP
510 520 530 540 550
PGLREMERNR EFYDRLHKVA PKVKEGMIKK GSMMITYQPL RQLPNFFRLV
560 570
LQNSCLEESD MVYFLDEIES LAQNL
Length:575
Mass (Da):64,796
Last modified:November 1, 1996 - v1
Checksum:i5BE7DBF42247B441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01239 mRNA. Translation: AAC46466.1.
AE014134 Genomic DNA. Translation: AAF53337.1.
AY069752 mRNA. Translation: AAL39897.1.
AE014134 Genomic DNA. Translation: AFH03699.1.
PIRiJH0827.
RefSeqiNP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGeneiDm.2850.

Genome annotation databases

EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
FBtr0309960; FBpp0301687; FBgn0000153.
GeneIDi34791.
KEGGidme:Dmel_CG7811.
UCSCiCG7811-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01239 mRNA. Translation: AAC46466.1.
AE014134 Genomic DNA. Translation: AAF53337.1.
AY069752 mRNA. Translation: AAL39897.1.
AE014134 Genomic DNA. Translation: AFH03699.1.
PIRiJH0827.
RefSeqiNP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGeneiDm.2850.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0080119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
FBtr0309960; FBpp0301687; FBgn0000153.
GeneIDi34791.
KEGGidme:Dmel_CG7811.
UCSCiCG7811-RA. d. melanogaster.

Organism-specific databases

CTDi34791.
FlyBaseiFBgn0000153. b.

Phylogenomic databases

eggNOGiCOG0076.
GeneTreeiENSGT00760000119205.
KOiK01580.
OMAiRFHRANT.
OrthoDBiEOG7H1JM3.

Enzyme and pathway databases

ReactomeiREACT_331278. Degradation of cysteine and homocysteine.

Miscellaneous databases

GenomeRNAii34791.
NextBioi790241.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases."
    Phillips A.M., Salkoff L.B., Kelly L.E.
    J. Neurochem. 61:1291-1301(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-RImported.
    Tissue: NeuralImported.
  2. Phillips M.A.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-RImported.
    Tissue: NeuralImported.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ24062_DROME
AccessioniPrimary (citable) accession number: Q24062
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.