Q24062 (Q24062_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Black EMBL AAF53337.1
EC=4.1.1.11 EMBL AAF53337.1
EC=4.1.1.15 EMBL AAF53337.1

Submitted name:
Glutamate decarboxylase EMBL AAC46466.1
Submitted name:
LP11089p EMBL AAL39897.1

Gene names

Name:	b FlyBase FBgn0000153
ORF Names:	CG7811 FlyBase FBgn0000153, Dmel_CG7811 EMBL AAF53337.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL AAC46466.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000382
Sequence similarities	Belongs to the group II decarboxylase family. RuleBase RU000382

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU000382
Molecular function	Lyase RuleBase RU000382 EMBL AAF53337.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	beta-alanine biosynthetic process Traceable author statement PubMed 12957543. Source: FlyBase developmental pigmentation Traceable author statement PubMed 12957543. Source: FlyBase uracil catabolic process Traceable author statement PubMed 12957543. Source: FlyBase visual behavior Inferred from mutant phenotype PubMed 15878647. Source: FlyBase
Molecular_function	aspartate 1-decarboxylase activity Inferred from mutant phenotype PubMed 15878647. Source: FlyBase glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q24062 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5BE7DBF42247B441	FASTA	575	64,796
	10 20 30 40 50 60 MLASENFPTH HFKESIFKPY STTSGDDLAS VSPLTATAAL VASTSSPADS TSTVAFEQAS 70 80 90 100 110 120 KMLANAANNN NNNNNNITST KDDLSSFVAS HPAAEFEGFI RACVDEIIKL AVFQGTNRSS 130 140 150 160 170 180 KVVEWHEPAE LRQLFDFQLR EQGESQDKLR ELLRETIRFS VKTGHPYFIN QLYSGVDPYA 190 200 210 220 230 240 LVGQWLTDAL NPSVYTYEVA PLFTLMEEQV LAEMRRIVGF PNGGQGDGIF CPGGSIANGY 250 260 270 280 290 300 AISCARYRHS PESKKNGLFN AKPLIIFTSE DAHYSVEKLA MFMGFGSDHV RKIATNEVGK 310 320 330 340 350 360 MRLSDLEKQV KLCLENGWQP LMVSATAGTT VLGAFDDLAG ISEVCKKYNM WMHVDAAWGG 370 380 390 400 410 420 GALMSKKYRH LLNGIERADS VTWNPHKLLA ASQQCSTFLT RHQQVLAQCH STNATYLFQK 430 440 450 460 470 480 DKFYDTSFDT GDKHIQCGRR ADVFKFWFMW KAKGTQGLEA HVEKVFRMAE FFTAKVRERP 490 500 510 520 530 540 GFELVLESPE CTNISFWYVP PGLREMERNR EFYDRLHKVA PKVKEGMIKK GSMMITYQPL 550 560 570 RQLPNFFRLV LQNSCLEESD MVYFLDEIES LAQNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases." Phillips A.M., Salkoff L.B., Kelly L.E. J. Neurochem. 61:1291-1301(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon-R EMBL AAC46466.1. Tissue: Neural EMBL AAC46466.1.
[2]	Phillips M.A. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon-R EMBL AAC46466.1. Tissue: Neural EMBL AAC46466.1.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL39897.1.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U01239 mRNA. Translation: AAC46466.1. AE014134 Genomic DNA. Translation: AAF53337.1. AY069752 mRNA. Translation: AAL39897.1.
PIR	JH0827.
RefSeq	NP_001246025.1. NM_001259096.2. NP_476788.1. NM_057440.5.
UniGene	Dm.2850.
3D structure databases
SMR	Q24062. Positions 88-575.
ModBase	Search...
Protein-protein interaction databases
STRING	7227.FBpp0080119.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0080542; FBpp0080119; FBgn0000153. FBtr0309960; FBpp0301687; FBgn0000153.
GeneID	34791.
KEGG	dme:Dmel_CG7811.
UCSC	CG7811-RA. d. melanogaster.
Organism-specific databases
CTD	34791.
FlyBase	FBgn0000153. b.
Phylogenomic databases
eggNOG	COG0076.
GeneTree	ENSGT00550000074275.
InParanoid	Q24062.
KO	K01580.
OMA	LQDTSNL.
OrthoDB	EOG43BK46.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	34791.
NextBio	790241.

Entry information

Entry name

Q24062_DROME

Accession

Primary (citable) accession number: Q24062

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)