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Protein
Submitted name:

Black, isoform A

Gene

b

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  • aspartate 1-decarboxylase activity Source: FlyBase
  • glutamate decarboxylase activity Source: UniProtKB-EC
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • beta-alanine biosynthetic process Source: FlyBase
  • carboxylic acid metabolic process Source: InterPro
  • developmental pigmentation Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • uracil catabolic process Source: FlyBase
  • visual behavior Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Submitted name:
Black, isoform AImported
Submitted name:
Black, isoform BImported (EC:4.1.1.11Imported, EC:4.1.1.15Imported)
Submitted name:
Glutamate decarboxylaseImported
Submitted name:
LP11089pImported
Gene namesi
Name:bImported
ORF Names:CG7811Imported, Dmel_CG7811Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000153. b.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei387N6-(pyridoxal phosphate)lysineUniRule annotation1

Expressioni

Gene expression databases

BgeeiFBgn0000153.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0301687.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
KOiK01580.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASENFPTH HFKESIFKPY STTSGDDLAS VSPLTATAAL VASTSSPADS
60 70 80 90 100
TSTVAFEQAS KMLANAANNN NNNNNNITST KDDLSSFVAS HPAAEFEGFI
110 120 130 140 150
RACVDEIIKL AVFQGTNRSS KVVEWHEPAE LRQLFDFQLR EQGESQDKLR
160 170 180 190 200
ELLRETIRFS VKTGHPYFIN QLYSGVDPYA LVGQWLTDAL NPSVYTYEVA
210 220 230 240 250
PLFTLMEEQV LAEMRRIVGF PNGGQGDGIF CPGGSIANGY AISCARYRHS
260 270 280 290 300
PESKKNGLFN AKPLIIFTSE DAHYSVEKLA MFMGFGSDHV RKIATNEVGK
310 320 330 340 350
MRLSDLEKQV KLCLENGWQP LMVSATAGTT VLGAFDDLAG ISEVCKKYNM
360 370 380 390 400
WMHVDAAWGG GALMSKKYRH LLNGIERADS VTWNPHKLLA ASQQCSTFLT
410 420 430 440 450
RHQQVLAQCH STNATYLFQK DKFYDTSFDT GDKHIQCGRR ADVFKFWFMW
460 470 480 490 500
KAKGTQGLEA HVEKVFRMAE FFTAKVRERP GFELVLESPE CTNISFWYVP
510 520 530 540 550
PGLREMERNR EFYDRLHKVA PKVKEGMIKK GSMMITYQPL RQLPNFFRLV
560 570
LQNSCLEESD MVYFLDEIES LAQNL
Length:575
Mass (Da):64,796
Last modified:November 1, 1996 - v1
Checksum:i5BE7DBF42247B441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01239 mRNA. Translation: AAC46466.1.
AE014134 Genomic DNA. Translation: AAF53337.1.
AY069752 mRNA. Translation: AAL39897.1.
AE014134 Genomic DNA. Translation: AFH03699.1.
PIRiJH0827.
RefSeqiNP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGeneiDm.2850.

Genome annotation databases

EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
FBtr0309960; FBpp0301687; FBgn0000153.
GeneIDi34791.
KEGGidme:Dmel_CG7811.
UCSCiCG7811-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01239 mRNA. Translation: AAC46466.1.
AE014134 Genomic DNA. Translation: AAF53337.1.
AY069752 mRNA. Translation: AAL39897.1.
AE014134 Genomic DNA. Translation: AFH03699.1.
PIRiJH0827.
RefSeqiNP_001246025.1. NM_001259096.2.
NP_476788.1. NM_057440.5.
UniGeneiDm.2850.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0301687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080542; FBpp0080119; FBgn0000153.
FBtr0309960; FBpp0301687; FBgn0000153.
GeneIDi34791.
KEGGidme:Dmel_CG7811.
UCSCiCG7811-RA. d. melanogaster.

Organism-specific databases

CTDi34791.
FlyBaseiFBgn0000153. b.

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
KOiK01580.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.

Enzyme and pathway databases

ReactomeiR-DME-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

GenomeRNAii34791.

Gene expression databases

BgeeiFBgn0000153.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ24062_DROME
AccessioniPrimary (citable) accession number: Q24062
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.