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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

nrv1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-DME-210991 Basigin interactions
R-DME-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-DME-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Protein nervana 1
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:nrv1
ORF Names:CG9258
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015776 nrv1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 309ExtracellularSequence analysisAdd BLAST243

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191201 – 309Sodium/potassium-transporting ATPase subunit beta-1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi143 ↔ 155By similarity
Disulfide bondi165 ↔ 179By similarity
Glycosylationi211N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi225 ↔ 282By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24046
PRIDEiQ24046

PTM databases

iPTMnetiQ24046

Expressioni

Tissue specificityi

In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it is concentrated in the thorax and abdomen (muscle tissue, digestive system and Malpighian tubules) and weakly expressed in the head. Expression is diffuse in the nervous system.2 Publications

Developmental stagei

Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage.1 Publication

Gene expression databases

BgeeiFBgn0015776
ExpressionAtlasiQ24046 differential
GenevisibleiQ24046 DM

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with nkain.Curated1 Publication

Protein-protein interaction databases

BioGridi60104, 6 interactors
DIPiDIP-20098N
IntActiQ24046, 3 interactors
STRINGi7227.FBpp0079012

Structurei

3D structure databases

ProteinModelPortaliQ24046
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
InParanoidiQ24046
KOiK01540
OMAiQVPQIQK
OrthoDBiEOG091G0EKJ
PhylomeDBiQ24046

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q24046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNNGKGAK GEFEFPQPAK KQTFSEMIYN PQEGTFFGRT GKSWSQLLLF
60 70 80 90 100
YTIFYIVLAA LFTICMQGLL STISDTEPKW KLQDSLIGTN PGLGFRPLSE
110 120 130 140 150
QTERGSVIAF DGKKPAESDY WIELIDDFLR DYNHTEGRDM KHCGFGQVLE
160 170 180 190 200
PTDVCVVNTD LFGGCSKANN YGYKTNQPCI FLKLNKIFGW IPEVYDKEEK
210 220 230 240 250
DMPDDLKKVI NETKTEERQQ VWVSCNGHLG KDKENFQNIR YFPSQGFPSY
260 270 280 290 300
YYPFLNQPGY LSPLVAVQFN SPPKGQMLDV ECRAWAKNIQ YSGSVRDRKG

SVTFQILLD
Length:309
Mass (Da):35,309
Last modified:December 1, 2000 - v2
Checksum:i35EA43910B86D84F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205D → N in AAM52659 (PubMed:12537569).Curated1
Sequence conflicti219 – 220QQ → HE in AAC46608 (PubMed:7777518).Curated2
Sequence conflicti226N → F in AAC46608 (PubMed:7777518).Curated1
Sequence conflicti295V → A in AAC46608 (PubMed:7777518).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22438 mRNA Translation: AAC46608.1
AE014134 Genomic DNA Translation: AAF52437.1
AY122147 mRNA Translation: AAM52659.1
RefSeqiNP_001260163.1, NM_001273234.1
NP_477167.1, NM_057819.4
UniGeneiDm.4821

Genome annotation databases

EnsemblMetazoaiFBtr0079384; FBpp0079012; FBgn0015776
FBtr0332370; FBpp0304646; FBgn0015776
GeneIDi33952
KEGGidme:Dmel_CG9258

Similar proteinsi

Entry informationi

Entry nameiATPB1_DROME
AccessioniPrimary (citable) accession number: Q24046
Secondary accession number(s): Q8MR34, Q9VM86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health