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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

nrv1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-DME-210991. Basigin interactions.
R-DME-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Protein nervana 1
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:nrv1
ORF Names:CG9258
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015776. nrv1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 309ExtracellularSequence analysisAdd BLAST243

GO - Cellular componenti

  • plasma membrane Source: FlyBase
  • sodium:potassium-exchanging ATPase complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191201 – 309Sodium/potassium-transporting ATPase subunit beta-1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...)1 Publication1
Disulfide bondi143 ↔ 155By similarity
Disulfide bondi165 ↔ 179By similarity
Glycosylationi211N-linked (GlcNAc...)1 Publication1
Disulfide bondi225 ↔ 282By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24046.
PRIDEiQ24046.

Expressioni

Tissue specificityi

In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it is concentrated in the thorax and abdomen (muscle tissue, digestive system and Malpighian tubules) and weakly expressed in the head. Expression is diffuse in the nervous system.2 Publications

Developmental stagei

Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage.1 Publication

Gene expression databases

BgeeiFBgn0015776.
ExpressionAtlasiQ24046. baseline.
GenevisibleiQ24046. DM.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta (By similarity). Interacts with nkain.By similarity1 Publication

Protein-protein interaction databases

BioGridi60104. 3 interactors.
DIPiDIP-20098N.
MINTiMINT-1012223.
STRINGi7227.FBpp0079012.

Structurei

3D structure databases

ProteinModelPortaliQ24046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
InParanoidiQ24046.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0EKJ.
PhylomeDBiQ24046.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNNGKGAK GEFEFPQPAK KQTFSEMIYN PQEGTFFGRT GKSWSQLLLF
60 70 80 90 100
YTIFYIVLAA LFTICMQGLL STISDTEPKW KLQDSLIGTN PGLGFRPLSE
110 120 130 140 150
QTERGSVIAF DGKKPAESDY WIELIDDFLR DYNHTEGRDM KHCGFGQVLE
160 170 180 190 200
PTDVCVVNTD LFGGCSKANN YGYKTNQPCI FLKLNKIFGW IPEVYDKEEK
210 220 230 240 250
DMPDDLKKVI NETKTEERQQ VWVSCNGHLG KDKENFQNIR YFPSQGFPSY
260 270 280 290 300
YYPFLNQPGY LSPLVAVQFN SPPKGQMLDV ECRAWAKNIQ YSGSVRDRKG

SVTFQILLD
Length:309
Mass (Da):35,309
Last modified:December 1, 2000 - v2
Checksum:i35EA43910B86D84F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205D → N in AAM52659 (PubMed:12537569).Curated1
Sequence conflicti219 – 220QQ → HE in AAC46608 (PubMed:7777518).Curated2
Sequence conflicti226N → F in AAC46608 (PubMed:7777518).Curated1
Sequence conflicti295V → A in AAC46608 (PubMed:7777518).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22438 mRNA. Translation: AAC46608.1.
AE014134 Genomic DNA. Translation: AAF52437.1.
AY122147 mRNA. Translation: AAM52659.1.
RefSeqiNP_001260163.1. NM_001273234.1.
NP_477167.1. NM_057819.4.
UniGeneiDm.4821.

Genome annotation databases

EnsemblMetazoaiFBtr0079384; FBpp0079012; FBgn0015776.
FBtr0332370; FBpp0304646; FBgn0015776.
GeneIDi33952.
KEGGidme:Dmel_CG9258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22438 mRNA. Translation: AAC46608.1.
AE014134 Genomic DNA. Translation: AAF52437.1.
AY122147 mRNA. Translation: AAM52659.1.
RefSeqiNP_001260163.1. NM_001273234.1.
NP_477167.1. NM_057819.4.
UniGeneiDm.4821.

3D structure databases

ProteinModelPortaliQ24046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60104. 3 interactors.
DIPiDIP-20098N.
MINTiMINT-1012223.
STRINGi7227.FBpp0079012.

Proteomic databases

PaxDbiQ24046.
PRIDEiQ24046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079384; FBpp0079012; FBgn0015776.
FBtr0332370; FBpp0304646; FBgn0015776.
GeneIDi33952.
KEGGidme:Dmel_CG9258.

Organism-specific databases

CTDi33952.
FlyBaseiFBgn0015776. nrv1.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
InParanoidiQ24046.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0EKJ.
PhylomeDBiQ24046.

Enzyme and pathway databases

ReactomeiR-DME-210991. Basigin interactions.
R-DME-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Miscellaneous databases

GenomeRNAii33952.
PROiQ24046.

Gene expression databases

BgeeiFBgn0015776.
ExpressionAtlasiQ24046. baseline.
GenevisibleiQ24046. DM.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPB1_DROME
AccessioniPrimary (citable) accession number: Q24046
Secondary accession number(s): Q8MR34, Q9VM86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.